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Pancreas radiology

Sophie Turpin, Marjorie Perron, Stéphanie Vairy, Sébastien Bénali, Amélie Damphousse
Pancreatic neoplasm is very rare in the pediatric population. Malignant tumors represent less than 0.2% of pediatric cancer-related mortality. Pancreas lesions can be from exocrine or endocrine origin or present themselves as cystic masses. Clinical, biological, and radiological findings usually are sufficient to establish diagnosis, but in some cases, they may be misleading. We present the case of a young patient presenting a pancreatic mass where anatomical and metabolic characteristics of the lesion were discordant to the final diagnosis...
August 4, 2018: Clinical Nuclear Medicine
Kalyan Sharma, Sudhir Kumar Yadav, Bimbadhar Valluru, Ling Liu
RATIONALE: Clear cell sarcoma of tendon and aponeurosis (CCSTA) or soft parts is a rare malignant melanin producing tumor entity that is derived from the neural crest cells originating from soft tissues displaying melanocytic differentiation. Diagnosis of CCSTA is difficult as it is dependent on age, size, location, necrosis, calcifications, cystic degeneration, and local to distant metastatic deposits. These tumors have very poor prognosis with a survival rate of 5-10 years because of local recurrence, early to late metastasis to lymph nodes, lungs, bones, and liver...
August 2018: Medicine (Baltimore)
Erica Dugnani, Valentina Pasquale, Paolo Marra, Daniela Liberati, Tamara Canu, Laura Perani, Francesco De Sanctis, Stefano Ugel, Francesca Invernizzi, Antonio Citro, Massimo Venturini, Claudio Doglioni, Antonio Esposito, Lorenzo Piemonti
Background: The widely-used genetically engineered mouse LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre, termed KPC, spontaneously develops pancreatic cancer mirroring all phases of the carcinogenesis but in asynchronous manner. Preclinical studies need defined criteria for the enrollment of the KPC sharing the same stage of carcinogenesis. Aim: To define a tumor staging criteria using magnetic resonance and ultrasound and then to correlate the imaging stage with overall survival of KPC mice...
July 24, 2018: Carcinogenesis
Richard Azagoh-Kouadio, Line Guei Couitchéré, Mohamed Kouyaté, Jean-Jacques Yao Atteby, Jacob Slanziahuelie Enoh, Lassina Cissé, Soumahoro Oulai
Solid pseudopapillary tumor of the pancreas (SPTP) is rare. It most often affects young women. It was first described by Frantz in 1959, but its pathogenesis remains unclear. This tumor has a good prognosis. Treatment is based on radical surgery. We here report the case of a 11-year old girl with SPTP. Symptomatology was acute, including compression syndrome and epigastralgias. Clinical examination showed a solid mass in the left hypochondrium. Scan showed mixed mass structure of the pancreas tail. Left splenopancreatectomy was performed...
2018: Pan African Medical Journal
Hicham Hachlaf, Abdelhamid Madani
We here report an unusual case of ectopic pheochromocytoma without the presence of any clinical symptoms. Radiological examinations showed tumor in contact with the pancreas. Intraoperatively, after surgical manipulation of the tumor, the patient had tachycardia, hypertensive peaks and severe ventricular rhythm disorders followed by hypotension after tumor resection and shock. The management of severe intraoperative adverse events revealing pheochromocytoma is discussed in this case study.
2018: Pan African Medical Journal
Akikazu Yago, Mitsuko Furuya, Ryutaro Mori, Yasuhiro Yabushita, Yu Sawada, Takafumi Kumamoto, Ryusei Matsuyama, Michio Shimizu, Itaru Endo
BACKGROUND: Medullary carcinoma of the pancreas (MCP) is a rare malignant pancreatic tumor. The World Health Organization classification defines the tumor as a subtype of pancreatic ductal carcinomas. MCP is histologically characterized as having highly pleomorphic cells with syncytial morphology, expansive tumor growth, and necrosis. The pathogenesis and clinical course of MCP are largely unknown. Herein, we report an unusual case of MCP that was radiologically followed up for 9 years prior to surgical intervention...
July 24, 2018: Surgical Case Reports
Marcin Białecki, Agnieszka Białecka, Kaja Męcińska-Jundziłł, Urszula Adamska, Anna Kasperska, Rafał Czajkowski
Purpose: Disseminated malignancies are a diagnostic and therapeutic challenge that is often encountered in radiology. Finding the primary tumour is crucial for planning proper surgical and oncological treatment. Computed tomography (CT) of the thorax and abdomen is typically the initial examination. However, abdominal magnetic resonance imaging (MRI) or positron emission tomography (PET/CT) or PET/MRI are often subsequently performed. Histopathological examination of metastatic tumours is performed as well, followed by immunohistochemistry...
2018: Polish Journal of Radiology
S R Markar, B Brodie, S-T Chin, A Romano, D Spalding, G B Hanna
BACKGROUND: Pancreatic cancer has a very poor prognosis as most patients are diagnosed at an advanced stage when curative treatments are not possible. Breath volatile organic compounds (VOCs) have shown potential as novel biomarkers to detect cancer. The aim of the study was to quantify differences in exhaled breath VOCs of patients with pancreatic cancers compared with cohorts without cancer. METHODS: Patients were recruited to an initial development cohort and a second validation cohort...
July 18, 2018: British Journal of Surgery
Robin Klasek, Samantha A Kuten, Samir J Patel, Edward A Graviss, Duc T Nguyen, Mark J Hobeika, Osama A Gaber, Hemangshu Podder, Richard J Knight
BACKGROUND: Fever occurs frequently early after pancreas transplant, however the exact cause is often undetermined. Limited data are available on pancreas recipients experiencing unexplained, non-infectious fever. This study aims to characterize unexplained fever (UF) in pancreas recipients and its effect on patient and graft outcomes. METHODS: We performed a retrospective cohort study of UF among consecutive pancreas or simultaneous pancreas-kidney transplant recipients from January 1, 2011 to August 31, 2015...
July 17, 2018: Clinical Transplantation
Franka Messner, Claudia Bösmüller, Rupert Oberhuber, Manuel Maglione, Benno Cardini, Thomas Resch, Stefan Scheidl, Dietmar Öfner, Stefan Schneeberger, Christian Margreiter
In response to a number of late, repetitive bleeding episodes from the site of the enteric anastomosis, we herein analyze the clinical courses and etiologies of 379 consecutively performed pancreas transplants between January 2000 and December 2016. Duodenojejunostomies for enteric drainage were performed at the upper jejunum in a side to side, double layer fashion. Five patients (1.3%) developed recurrent late hemorrhagic episodes originating from the graft duodenal anastomosis. Bleeding from the anastomotic site was associated with hematochezia, hemodynamic instability and decrease of serum hemoglobin...
July 14, 2018: Clinical Transplantation
M Heckler, L Brieger, U Heger, T Pausch, C Tjaden, J Kaiser, M Tanaka, T Hackert, C W Michalski
Background: Estimation of the risk of malignancy in intraductal papillary mucinous neoplasia (IPMN) of the pancreas is a clinical challenge. Several routinely used clinical factors form the basis of the current consensus guidelines. This study aimed to determine the predictive values of the most commonly assessed risk factors. Methods: A meta-analysis of individual risk factors of malignancy in IPMN was performed. Contingency tables were derived from these data, and sensitivity, specificity, negative and positive predictive values, and diagnostic odds ratios (DOR) were determined...
February 2018: BJS open
Ilsung Cho, Young Seok Seo, WonGyun Jung, Mi-Sook Kim
The Korea Heavy Ion Medical Accelerator project focuses on the development of medical accelerator facilities for delivering carbon-ion beams to cancer patients. The purpose of the present study was to estimate the clinical need for carbon-ion therapy in Korea. Seven tumor sites, namely head and neck, liver, lung, colon and rectum, prostate, bone and soft tissue, and pancreas were selected as eligible sites for receiving carbon-ion radiotherapy (RT) by radiation oncologists of the Korea Institute of Radiological and Medical Sciences...
June 25, 2018: Journal of Radiation Research
Wei Zhang, Sirong He, Yao Cheng, Jie Xia, Mingliang Lai, Nansheng Cheng, Zuojin Liu
BACKGROUND: The use of surgical drains has been considered mandatory after pancreatic surgery. The role of prophylactic abdominal drainage to reduce postoperative complications after pancreatic surgery is controversial. OBJECTIVES: To assess the benefits and harms of routine abdominal drainage after pancreatic surgery, compare the effects of different types of surgical drains, and evaluate the optimal time for drain removal. SEARCH METHODS: For the last version of this review, we searched CENTRAL (2016, Issue 8), and MEDLINE, Embase, Science Citation Index Expanded, and Chinese Biomedical Literature Database (CBM) to 28 August 2016)...
June 21, 2018: Cochrane Database of Systematic Reviews
DengLiang Wang, Quan Kang, ShuJun Shi, Wei Hu
To summarize the clinical characteristics, diagnosis, treatment and prognosis among 152 children with annular pancreas (AP). A retrospective review of 152 patients with AP who were treated with surgical repair between January 2009 and August 2017 was performed at our pediatric surgical units. Presenting symptoms, birth weight, radiological findings, associated anomalies, the type of surgery performed were analyzed. (1) 152 patients were identified, out of which 82 were males, and 70 were females; (2) the average birth weight of children with AP was less than that of healthy newborns...
June 16, 2018: Pediatric Surgery International
Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccolò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi
BACKGROUND/OBJECTIVES: Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. METHODS: A retrospective analysis of a prospectively maintained database was performed for all the patients referred for pancreatic cystic lesions (PCL) between January 2005 and March 2016. RESULTS: Overall, there were 1488 patients with PCL, including 1271 (85...
June 8, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Andrea Boni, Giovanni Cochetti, Stefano Ascani, Michele Del Zingaro, Francesca Quadrini, Alessio Paladini, Diego Cocca, Ettore Mearini
BACKGROUND: The management of metastatic Renal Cell Carcinoma (RCC) has changed dramatically in the last 20 years, and the role of surgery in the immunotherapy's era is under debate. Metastatic lesions interesting pancreas are infrequent, but those harbouring from RCC have an high incidence. If metachronous resections are not rare, synchronous resection of primary RCC and its pancreatic metastasis is uncommonly reported, and accounts for a bad prognosis. CASE PRESENTATION: We report the case of a 68 years old woman, who presented hematuria at hospital incoming, with radiological appearance of a 13 cm left renal mass, with a 2...
June 13, 2018: BMC Surgery
Abhishek Bhurwal, Muhammad Masoodul Haq, Sunil Sapru, Matthew Tortora, Dhanasekaran Ramasamy
Isolated pancreatic tuberculosis is an exceedingly rare condition, even in areas of the world where the disease is highly prevalent. Abdominal tuberculosis is a common form of extrapulmonary tuberculosis but involvement of the pancreas is very rare. We report a case of isolated pancreatic tuberculosis presenting as a pancreatic mass in a patient with persistent abdominal pain and jaundice. Clinically and radiologically, the mass mimicked a malignant pancreatic tumor with a vastly different prognostic implication and therapeutic approach...
2018: Case Reports in Gastrointestinal Medicine
Isabelle Moneke, Christoph Zeisel, Mirjam Elze, Benedikt Haager, Bernward Passlick, Gian Kayser
Mucinous cystadenoma is a benign tumor commonly found in the pancreas, the ovaries or the appendix. Only very few cases of these tumors originating from the lungs have been reported worldwide, with even less cases describing malignant transformation. We present the case of a 58-year-old woman with a history of recurrent pulmonary infections who underwent left upper lobectomy for lung abscess and was initially diagnosed with pulmonary mucinous cystadenoma (PMCA). Upon thorough immunohistochemical workup, especially due to carcinoembryonic antigen (CEA) positivity, intramucinous singlet cells were eventually diagnostic for invasive carcinoma, in this case a mucinous cystadenocarcinoma arising from a PCMA...
April 2018: Journal of Thoracic Disease
Paula Gallego Ferrero, Juan Crespo Del Pozo
Pancreatic transplantation is a therapeutic option for both poorly controlled cases of diabetes mellitus and patients with advanced diabetic nephropathy. It is important for radiologists to know the different surgical techniques as well as the typical radiological appearance after pancreatic transplantation, in order to accurately identify the complications. These complications can be classified according to the period of time after the transplantation in which they typically occur: immediate (first 24 hours), early (24-72 hours), intermediate (72 hours to weeks) and late (months)...
May 28, 2018: Journal of Medical Imaging and Radiation Oncology
Marcia Irene Canto, Jose Alejandro Almario, Richard D Schulick, Charles J Yeo, Alison Klein, Amanda Blackford, Eun Ji Shin, Abanti Sanyal, Gayane Yenokyan, Anne Marie Lennon, Ihab R Kamel, Elliot K Fishman, Christopher Wolfgang, Matthew Weiss, Ralph H Hruban, Michael Goggins
BACKGROUND & AIMS: Screening of individuals who have a high risk of pancreatic ductal adenocarcinoma (PDAC), due to genetic factors, frequently leads to identification of pancreatic lesions. We investigated the incidence of PDAC and risk factors for neoplastic progression in individuals at high risk for PDAC enrolled in a long-term screening study. METHODS: We analyzed data from 354 individuals at high risk for PDAC (based on genetic factors of family history), enrolled in Cancer of the Pancreas Screening cohort studies at tertiary care academic centers from 1998 through 2014 (median follow-up time, 5...
May 24, 2018: Gastroenterology
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