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Neoadjuvant chemotherapy

Jing Wang, Hongyu Gao, Guohui Liu, Lina Gu, Chang Yang, Fengmin Zhang, Tianbo Liu
We explored the correlation of tumor necrosis factor α-induced protein 8 (TNFAIP8) with platinum resistance in ovarian cancers (OCs) treated with neoadjuvant chemotherapy (NACT). We observed a significant trend of decreased TNFAIP8 expression after NACT (P=.042), and the extent of decreased TNFAIP8 expression following NACT was positively associated with response to NACT (P=.013). Interestingly, in patients treated with NACT, the extent of decreased TNFAIP8 expression following NACT in tumor (change in immunohistochemistry [ΔIHC] score≤-1 vs...
August 11, 2018: Human Pathology
Domenico Rubello, Maria Cristina Marzola, Patrick M Colletti
Published experiences related to the prognostic relevance of negative or positive FDG PET/CT in patients treated for ovarian cancer for progression-free survival and overall survival are typically heterogeneous retrospective analyses. Several points have been well defined, these are as follows: (a) there is a correlation between FDG tumor uptake and prognosis; (b) ovarian cancer patients treated by neoadjuvant or adjuvant chemotherapy can be divided into responders with reduction in tumor FDG uptake during and after treatment and nonresponders where tumor FDG uptake remains stable or increases after treatment;...
August 13, 2018: Clinical Nuclear Medicine
Sjors Klompmaker, Ugo Boggi, Thilo Hackert, Roberto Salvia, Matthew Weiss, Hiroki Yamaue, Herbert J Zeh, Marc G Besselink
Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients-where the cancer only involves the celiac axis-may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy...
August 13, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Luis Gil, Xabier de Aretxabala, Javier Lendoire, Fernando Duek, Juan Hepp, Oscar Imventarza
BACKGROUND: Residual disease (RD) has been described as one of the most relevant prognostic factors after radical surgical resection for incidental gallbladder cancer (IGC). The purpose of the present study was to analyze patterns of RD and determinant prognostic factors in patients undergoing re-resection for IGC. METHODS: Patients undergoing re-exploration due to IGC between 1990 and 2014 were identified in two referral centers from different South-American countries...
August 13, 2018: World Journal of Surgery
Youn Joo Lee, Sung Hun Kim, Bong Joo Kang, Yun Ju Kim
PURPOSE:  To evaluate the time-intensity curve (TIC) parameters on contrast-enhanced ultrasound (CEUS) for early prediction of the response of breast cancer to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:  This prospective study included 41 patients with breast cancer. CEUS was performed before and after the first cycle of NAC. TIC parameters were analyzed for different regions of interest (ROIs). ROI 1 targeted the hotspot area of greatest enhancement, ROI 2 delineated the area of hyperenhancement, ROI 3 included the entire tumor on grayscale ultrasound, and ROI 4 encircled the normal parenchyma...
August 13, 2018: Ultraschall in der Medizin
Ying Wang, Changli Yue, Jugao Fang, Lili Gong, Meng Lian, Ru Wang, Ling Feng, Hongzhi Ma, Zhihong Ma, Honggang Liu
Background: Hypopharyngeal squamous cell carcinoma (HPSCC) is an aggressive head and neck squamous cell carcinoma with poor prognosis. Neoadjuvant chemotherapy (NACT) followed by concurrent chemoradiotherapy could provide better efficacy in HPSCC treatment. Identification of predictive biomarkers is critically needed to improve selection of patients who derive the most benefit from NACT. The aim of this study was to investigate whether transcobalamin I (TCN1) could be a novel predictive biomarker for NACT in HPSCC...
2018: OncoTargets and Therapy
David Groheux
After an overview of the principles of fludeoxyglucose-PET/computed tomography (CT) in breast cancer, its advantages and limits to evaluate treatment response are discussed. The metabolic information is helpful for early assessment of the response to neoadjuvant chemotherapy and could be used to monitor treatment, especially in aggressive breast cancer subtypes. PET/CT is also a powerful method for early assessment of the treatment response in the metastatic setting. It allows evaluation of different sites of metastases in a single examination and detection of a heterogeneous response...
July 2018: PET Clinics
Wenjie Zhu, Mei Liu, Ying Fan, Fei Ma, Ningzhi Xu, Binghe Xu
BACKGROUND: Circulating microRNAs (miRNAs) have been indicated as predictive biomarkers in breast cancer. We aimed to explore the association of plasma miRNA dynamics with response to neoadjuvant chemotherapy (NCT) and disclose early markers for predicting sensitivity. METHODS: One hundred and nine patients with operable or locally advanced breast cancer, who participated in a prospective clinical trial and received NCT, were analyzed. Blood samples were collected before random assignment, after two cycles of chemotherapy (C2) and before surgery...
August 11, 2018: Cancer Medicine
Khodamorad Jamshidi, Mehdi Ramezan Shirazi, Abolfazl Bagherifard, Alireza Mirzaei
PURPOSE: Although wide resection is the standard treatment for Ewing's sarcoma (ES), it has complications especially in children. In this study, we compared the oncologic and functional outcomes of wide resection with extended curettage and local adjuvant therapy (phenolization and cementation), as a less extensive surgery for paediatric ES with a complete radiologic response to neoadjuvant chemotherapy. METHODS: Children aged ≤ ten years, with ES of non-expendable long-bones and complete radiologic response to neoadjuvant chemotherapy, were included in this case-control study...
August 11, 2018: International Orthopaedics
Fernanda Barbosa C Rocha, Ana Beatriz Falcone, Antonio Carlos Buzaid, Juliana Martins Pimenta, Gustavo Schvartsman, Antonio Luiz Frasson
PURPOSE: Breast cancer neoadjuvant chemotherapy (NAC) consists of the administration of cytotoxic and targeted drugs prior to breast surgery, with the objective of reducing the tumor burden to allow breast conservation. NAC also aims to improve long-term treatment outcomes such as disease-free and overall survival. To optimize clinical practice with the best available evidence for breast cancer patients in the setting of neoadjuvant treatment, the Brazilian Society of Breast Surgeons (Sociedade Brasileira de Mastologia-SBM) held a consensus conference to develop this guideline...
August 11, 2018: Breast Cancer Research and Treatment
Ziyu Li, Fei Shan, Xiangji Ying, Lianhai Zhang, Hui Ren, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Yinkui Wang, Chao Yan, Yan Zhang, Fei Pang, Jiafu Ji
INTRODUCTION: Current guidelines recommend open gastrectomy with D2 lymph node dissection and adjuvant chemotherapy as the standard treatment for advanced gastric cancer. However, the prognosis is not satisfactory. Perioperative chemotherapy has been proposed to improve survival. Although still in debate, the efficacy of laparoscopic distal gastrectomy (LDG) in patients with advanced gastric cancer has been demonstrated in a few trials. Therefore, LDG after neoadjuvant chemotherapy can be a candidate for future standard treatment on advanced distal gastric cancer...
August 10, 2018: BMJ Open
Loïc Lelièvre, Philippe Clézardin, Laurent Magaud, Laurent Roche, Nicole Tubiana-Mathieu, Jean-Dominique Tigaud, Delphine Topart, Nadia Raban, Marie-Ange Mouret-Reynier, Patrice Mathevet
INTRODUCTION: Neoadjuvant chemotherapy has become the treatment of choice for locally advanced breast cancer. Zoledronic acid (ZA) is a bisphosphonate initially used in the treatment of bone metastases because of its antibone resorption effect. Antitumor effects of ZA, including the inhibition of cell adhesion to mineralized bone or the antiangiogenic effect, have been demonstrated. However, the clinical significance of these effects remains to be determined. MATERIALS AND METHODS: We undertook a multicenter open-label randomized trial to analyze the value of adding ZA to neoadjuvant chemotherapy for TNM clinical stage T2/T3 breast cancer...
July 10, 2018: Clinical Breast Cancer
Soon Leong Yong, Safilah Dahian, Aznim Hani Ramlan, Marcus Kang
Normal-sized ovarian carcinoma syndrome (NOCS) is a rare condition characterised by malignancy identified in ovaries of normal size with abdominal metastasis. We report two cases of advanced ovarian carcinoma with ovaries of normal size. The first case was a 13-year-old adolescent with malignant ascites and bilateral normal sized multicystic ovaries detected on ultrasound. Serum cancer antigen 125 (CA 125) and lactate dehydrogenase were markedly raised. A computed tomography (CT) scan showed the presence of thick omental cake but no ovarian tumour...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
Ilaria Trestini, Luisa Carbognin, Sara Monteverdi, Sara Zanelli, Alessandro De Toma, Clelia Bonaiuto, Rolando Nortilli, Elena Fiorio, Sara Pilotto, Massimo Di Maio, Antonio Gasbarrini, Giovanni Scambia, Giampaolo Tortora, Emilio Bria
Breast cancer represents the most frequent cancer among women in Western countries. Although physicians and patients have witnessed a significant evolution in both treatment strategies and personalized medicine (the identification of featured patients' subsets such as HER2-driven disease), the identification of additional prognostic clinical predictors referring to patients' dietary habits represents a research area aiming to further improve the overall management of this disease. In this regard, body composition (i...
September 2018: Critical Reviews in Oncology/hematology
Lakshmi Shree Mahadevan, James Zhong, BhanuPrasad Venkatesulu, Harmeet Kaur, Shreerang Bhide, Bruce Minsky, William Chu, Martijn Intven, Uulke A van der Heide, Baukelien van Triest, Sunil Krishnan, William Hall
The treatment protocols for rectal cancer continue to evolve, with increasing acceptance of a watch-and-wait policy for clinical complete responders to neoadjuvant chemoradiation therapy. It still, however, remains unclear who is likely to achieve a pathological complete response, which unequivocally portends a very favorable overall prognosis. Evolution of modern imaging techniques has paved the way for potential prediction of treatment response based on baseline, on-treatment, early post-treatment and subsequent follow-up imaging alone...
September 2018: Critical Reviews in Oncology/hematology
Nicole D Fleming, Alpa M Nick, Robert L Coleman, Shannon N Westin, Pedro T Ramirez, Pamela T Soliman, Bryan Fellman, Larissa A Meyer, Kathleen M Schmeler, Karen H Lu, Anil K Sood
OBJECTIVE: To estimate the effects of a laparoscopic scoring algorithm to triage patients with advanced ovarian cancer to immediate or delayed debulking to improve complete gross surgical resection rates and determine the resulting clinical outcomes. METHODS: We prospectively performed laparoscopic assessment on patients with suspected advanced-stage ovarian cancer from April 2013 to December 2016 to determine primary resectability at tumor reductive surgery. Patients with medically inoperable or distant metastatic disease received neoadjuvant chemotherapy...
August 6, 2018: Obstetrics and Gynecology
S Manekeller, J C Kalff
BACKGROUND: Although the treatment and diagnostic regimens of gall bladder carcinoma and extrahepatic bile duct cancer have improved over the past years, the outcome and overall survival as prognostic values still remain poor. Early tumor stages of gall bladder carcinoma are the only exception. OBJECTIVE: This article focuses on the latest surgical therapy approaches including neoadjuvant, adjuvant and palliative therapy regimens. RESULTS: Neoadjuvant treatment concepts have so far been insufficiently evaluated and can therefore only be recommended within the framework of studies...
August 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Xiaoyuan Gao, Yang Zhang, Fei Yuan, Bei Ding, Qianchen Ma, Wenjie Yang, Jing Yan, Lianjun Du, Baisong Wang, Fuhua Yan, Martin Sedlmair, Zilai Pan, Huan Zhang
PURPOSE: Pathologic response to neoadjuvant chemotherapy is a prognostic factor in many cancer types. However, the existing evaluative criteria are deficient. We sought to prospectively evaluate the total iodine uptake derived from dual-energy computed tomography (DECT) in predicting treatment efficacy and progression-free survival (PFS) time in gastric cancer after neoadjuvant chemotherapy. METHODS: From October 2012 to December 2015, 44 patients with locally advanced gastric cancer were examined with DECT 1 week before and three cycles after neoadjuvant chemotherapy...
August 9, 2018: Journal of Cancer Research and Clinical Oncology
Christopher Nevala-Plagemann, Samual Francis, Courtney Cavalieri, Randa Tao, Jonathan Whisenant, Robert Glasgow, Courtney Scaife, Shane Lloyd, Ignacio Garrido-Laguna
Background: Oesophageal cancer (OC) survival rates have improved since the widespread adoption of neoadjuvant chemoradiation therapy (NACRT) followed by oesophagectomy (trimodality therapy). Unfortunately, the overall prognosis for patients with locally advanced disease remains poor. In this study, we sought to assess the effect of adjuvant chemotherapy (AC) in patients treated with trimodality therapy. Methods: Using the National Cancer Database we retrospectively identified 6785 patients with locally advanced (cT1b-T4a, N0-N+, M0) OC who were treated with trimodality therapy from 2006 to 2014...
2018: ESMO Open
Yoshitaka Fujiki, Yutaka Yamamoto, Aiko Sueta, Mutsuko Yamamoto-Ibusuki, Lisa Goto-Yamaguchi, Mai Tomiguchi, Takashi Takeshita, Hirotaka Iwase
Background: Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B (APOBEC3B) is a gene editing enzyme with cytidine deaminase activity and high expression of its mRNA in breast tumors have been shown to be associated with progressive cases and poor prognosis. In this study, we aimed to examine the relationship between the expression of APOBEC3B and the effect of neoadjuvant chemotherapy (NAC) using pretreatment biopsy tissue, and examined whether the expression of APOBEC3B influenced chemotherapy efficacy...
July 17, 2018: Oncotarget
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