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intensity-modulated radiation therapy

Gabriel B Ayala, Kieu A Doan, Hie Ji Ko, Peter K Park, Edwin D Santiago, Shirly J Kuruvila, Amol J Ghia, Tina M Briere, Zhifei Wen
Spine stereotactic radiosurgery (SSRS) is a noninvasive treatment for metastatic spine lesions. MD Anderson Cancer Center reports a quality assurance (QA) failure rate approaching 15% for SSRS cases, which we hypothesized is due to difficulties in accurately calculating dose resulting from a large number of small-area segments. Clinical plans typically use 9 beams with an average of 10 segments per beam and minimum segment area of 2-3 cm2 . The purpose of this study was to identify a set of intensity-modulated radiation therapy (IMRT) planning parameters that attempts to optimize the balance among QA passing rate, plan quality, dose calculation accuracy, and delivery time for SSRS plans...
December 1, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Hendrik Dapper, Iván Rodríguez, Stefan Münch, Jan C Peeken, Kai Borm, Stephanie E Combs, Daniel Habermehl
BACKGROUND: Neoadjuvant radio- or chemoradiation (nIRT) therapy is the standard treatment for loco-regional advanced rectal cancer patients of the lower or middle third. Currently, intensity modulated radiation therapy (IMRT) is not the recommended radiation technique even though IMRT has advantages compared to 3D-radiation regarding dose sparing to organs at risk like small bowel and urinary bladder. So far, the benefit of IMRT concerning the anal sphincter complex is not examined. With this study we intended to evaluate the dose distribution on the anal sphincters of rectal cancer patients treated with IMRT in comparison with 3D-techniques...
December 3, 2018: Radiation Oncology
Alice Y Ho, Ase Ballangrud, Guang Li, Gaorav P Gupta, Beryl McCormick, Richard Gewanter, Daphna Gelblum, Melissa Zinovoy, Boris Mueller, Borys Mychalczak, Pinaki Dutta, Karen Borofsky, Preeti Parhar, Marsha Reyngold, Lior Braunstein, Mohit Chawla, Kate Krause, Natasha Freeman, Chun Ting Siu, Zachary Cost, Brittany B Arnold, Zhigang Zhang, Simon N Powell
BACKGROUND: Multi-beam IMRT enhances the therapeutic index by increasing the dosimetric coverage of the targeted tumor tissues while minimizing volumes of adjacent organs receiving high doses of RT. The tradeoff is that a greater volume of lung is exposed to low doses of RT, raising concern about the risk of radiation pneumonitis (RP). METHODS: Between 7/2010-1/2013, patients with node-positive breast cancer received inverse-planned, multibeam IMRT to the breast/chest wall and regional nodes including the internal mammary nodes (IMN)...
November 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Dana L Casey, Leonard H Wexler, Suzanne L Wolden
PURPOSE: Recent trends including the use of proton therapy and administration of reduced-doses of cyclophosphamide have been adapted in head and neck rhabdomyosarcoma (HN-RMS) to reduce late morbidity. Our primary goal was to analyze local control and survival outcomes after photon versus proton irradiation in pediatric patients with HN-RMS, with the secondary goal of analyzing the effect of cyclophosphamide dose on disease outcomes. METHODS AND MATERIALS: This single-institution cohort study was comprised of 76 pediatric HN-RMS patients treated with definitive chemoradiation from 2000 to 2018...
November 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Giacomo Bertazzoni, Alberto Schreiber, Marco Ferrari, Piero Nicolai
PURPOSE OF REVIEW: To illustrate the latest developments and trends in the management of juvenile angiofibroma. RECENT FINDINGS: Endoscopic surgery is currently the primary management strategy for juvenile angiofibroma. Recent reports on the use of multiportal approaches have contributed to further extend its indications. Studies from different countries suggest that the lesion can display variable growth rates not only in relation to patient age. The same concept applies to residual lesions...
November 30, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
A Fondevilla Soler, J L López-Guerra, A García Fernández, M A Samaniego Conde, M J Belmonte González, J M Praena-Fernandez, E Rivin Del Campo, M Alcaraz, I Azinovic
PURPOSE: The present work aims at evaluating intensity-modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) in squamous cell carcinomas (SCC) of the larynx and hypopharynx. METHODS/PATIENTS: We performed a single institutional retrospective analysis on 116 pharyngo (29%)-laryngeal (71%) SCC patients (93% male) treated with IMRT-SIB to 66-69.96 Gy in 33 fractions between 2008 and 2016. Those who underwent surgery (54%) received adjuvant radiation of 66 Gy at 2 Gy/fraction to the surgical bed...
November 30, 2018: Clinical & Translational Oncology
Shun Lu, Xinhao Peng, Bingwen Zou, Cheng Zhou, Mei Feng, Jinyi Lang
Aim: The aim of this study was to confirm whether patients with sacral chordoma benefit from adjuvant radiotherapy and to determine the optimal photon radiotherapy module for comprehensive treatment. Background: Chordoma is a rare slow-growing neoplasm arisen from cellular remnants of the notochord. About 50% occur in the sacrococcygeal region. Surgical resection and adjuvant radiation therapy are recommended treatment due to the improving local control rate. Materials and methods: 118 patients treated by surgery and adjuvant radiotherapy from August 2003 to May 2015 were retrospectively analyzed...
January 2019: Reports of Practical Oncology and Radiotherapy
Gopa Ghosh, Gaurav Gupta, Anupam Malviya, Dinesh Saroj
Background: About 74% of head and neck cancer (HNC) patients need to undergo either definitive or postoperative radiation therapy because of aggressive nature of disease. The transition from two-dimensional conventional radiotherapy to three-dimensional conformal radiotherapy (3D-CRT) and further technological evolutions led to the successful clinical implementation of intensity modulated radiation therapy (IMRT), which constitutes an evolution of 3D-CRT. The IMRT technique gives the ability to create treatment fields with varying beam intensity using inverse planning and optimization algorithms to treat irregularly shaped target volumes with high precision...
October 2018: Journal of Cancer Research and Therapeutics
Javed Mahmood, Hem D Shukla, Sandrine Soman, Santanu Samanta, Prerna Singh, Shriya Kamlapurkar, Ali Saeed, Neha P Amin, Zeljko Vujaskovic
Pancreatic cancer (PC) has the highest mortality rate amongst all other cancers in both men and women, with a one-year relative survival rate of 20%, and a five-year relative survival rate of 8% for all stages of PC combined. The Whipple procedure, or pancreaticoduodenectomy, can increase survival for patients with resectable PC, however, less than 20% of patients are candidates for surgery at time of presentation. Most of the patients are diagnosed with advanced PC, often with regional and distant metastasis...
November 28, 2018: Cancers
Stefan A Koerber, Ben Seither, Alla Slynko, Matthias F Haefner, David Krug, Jakob Liermann, Sebastian Adeberg, Klaus Herfarth, Juergen Debus, Florian Sterzing
INTRODUCTION: We evaluated acute and chronic side effects of 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) in female patients with anal carcinoma and accessed correlations between dosimetric parameters and the considered toxicities. METHODS: For 70 women with anal cancer treated at our department, acute and chronic side effects and quality of life (QoL) were evaluated with questionnaires using the Common Terminology Criteria for Adverse Events (CTCAE v...
November 28, 2018: Tumori
Shane Mesko, Daniel Gomez
Non-small cell lung cancer (NSCLC) accounts for 85% of new lung cancer cases and has 5-year survival rates ranging from 92% in early-stage disease to as low as 13% in locally advanced cases. Radiation therapy is a key component in the treatment repertoire for NSCLC, where it is currently used alone or in combinations with chemotherapy and surgery. Despite the broad use of modern photon radiation techniques, as many as 25% of patients experience isolated locoregional recurrences, and toxicity has been proven to be a limiting factor in many cases...
November 27, 2018: Current Treatment Options in Oncology
B A Jereczek-Fossa, A Maucieri, G Marvaso, S Gandini, C Fodor, D Zerini, G Riva, O Alessandro, A Surgo, S Volpe, G Fanetti, S Arculeo, M A Zerella, S Parisi, P Maisonneuve, A Vavassori, F Cattani, R Cambria, C Garibaldi, A Starzyńska, G Musi, O De Cobelli, M Ferro, F Nolè, D Ciardo, R Orecchia
To report toxicity and efficacy outcome of moderately hypofractionated image-guided external-beam radiotherapy in a large series of patients treated for prostate cancer (PCa). Between 10/2006 and 12/2015, 572 T1-T3N0M0 PCa patients received 70.2 Gy in 26 fractions at 2.7 Gy/fraction: 344 patients (60%) with three-dimensional conformal radiotherapy (3D-CRT) and 228 (40%) with intensity-modulated radiotherapy (IMRT). Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria and Houston definition (nadir + 2) were used for toxicity and biochemical failure evaluation, respectively...
November 27, 2018: Medical Oncology
Christopher Chin, Emma S Lunking, Macarena de la Fuente, Nagi G Ayad
Glioblastoma Multiforme (GBM) is the most common malignant primary brain tumor. Despite aggressive multimodality treatment it remains one of the most challenging and intractable cancers (1]. While current standard of care treatment for GBM is maximal safe surgical resection, systemic chemotherapy with Temozolimide (TMZ), and radiation therapy, the current prognosis of GBM patients remains poor, with a median overall survival of 12-15 months (2, 3). Therefore, other treatments are needed to provide better outcomes for GBM patients...
2018: Frontiers in Oncology
A Ghareeb, K Paramasevon, P Mokool, H van der Voet, M Jha
INTRODUCTION: The definitive treatment of anal cancer with chemoradiotherapy spares abdominoperineal resection for salvage treatment but carries a high burden of toxicity. Intensity-modulated radiation therapy has been implemented to reduce toxicity, reduce treatment breaks and improve survival. However, large and long-term studies are lacking. We aimed to investigate the toxicities and long-term survival of anal cancer patients treated with intensity-modulated radiation therapy at James Cook University Hospital, Middlesbrough...
November 28, 2018: Annals of the Royal College of Surgeons of England
Crispen Chamunyonga, Julie Burbery, Peter Caldwell, Peta Rutledge, Andrew Fielding, Scott Crowe
The use of three-dimensional virtual reality technologies in education has been widely reported in the literature. The goal of this article is to review how the virtual environment for radiotherapy training (VERT) can be utilised to support the teaching of intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy, and dynamic conformal arc therapy techniques. Utilising Pinnacle v14 (Philips Radiation Oncology Systems, Madison, WI) and Monaco v 5.10 (Elekta CMS, Maryland Heights, MO), we exported IMRT, volumetric-modulated arc therapy, and dynamic conformal arc therapy treatment plans to VERT...
March 2018: Journal of Medical Imaging and Radiation Sciences
Alison Giddings, Luminita Nica, John French, Carol-Anne Davis, Marcia Smoke, Amanda Bolderston
PURPOSE: Radiation therapy has changed rapidly over the past decade due to the application of technological advances. A survey was conducted of radiation treatment centres in Canada to establish current patterns of practice across the country. Areas of inquiry included treatment techniques and image verification, as well as roles and responsibilities of radiation therapists (RTs). METHODS AND MATERIALS: In January 2016, a survey was sent to managers of the 46 radiation treatment centres in Canada...
March 2018: Journal of Medical Imaging and Radiation Sciences
Chuanmeng Niu, Minghui Li, Hui Yan, Chenlei Guo, Jianrong Dai
To introduce a beam angle selection method based on the patient coordinate system for treatment planning of noncoplanar intensity-modulated radiation therapy (IMRT). Traditionally, in radiotherapy planning, beam directions are selected in the machine coordinate system. A noncoplanar beam direction is established through a treatment table rotation followed by a gantry rotation. However, visualizing the beam direction relative to the patient is difficult. The suggestion here is to describe the beam direction in the patient coordinate system...
November 23, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Pei-Chieh Yu, Ching-Jung Wu, Yu-Lun Tsai, Suzun Shaw, Shih-Yu Sung, Louis Tak Lui, Hsin-Hua Nien
BACKGROUND: Tangent-based intensity modulated radiation therapy (TIMRT) is a common adjuvant radiotherapy strategy for breast cancer patients. This study compared the dosimetric characteristics of tangent-based volumetric modulated arc therapy (TVMAT) and TIMRT for left breast cancer patients during deep inspiration breath-hold (DIBH) and free breathing (FB) techniques. METHODS: Fourteen patients with left breast cancer after breast-conserving surgery were included...
November 26, 2018: Radiation Oncology
P Papi, E Brauner, S Di Carlo, D Musio, M Tombolini, F De Angelis, V Valentini, V Tombolini, A Polimeni, G Pompa
The aim of this prospective cohort study was to evaluate how the radiation technique can affect crestal bone loss and the implant survival rate in head and neck cancer patients treated with radiotherapy. In this study, the type of radiotherapy treatment, i.e. three-dimensional conformal radiotherapy (3D-CRT) or intensity modulated radiation therapy (IMRT), was the predictor variable. The primary outcome variable was crestal bone loss, recorded at implant placement and after 3, 6, 12, and 24 months. A descriptive analysis and ANOVA test were performed; significance was set at P<0...
November 21, 2018: International Journal of Oral and Maxillofacial Surgery
Hendrik Dapper, Markus Oechsner, Christoph Hirche, Stefan Münch, Christina Sauter, Kai Borm, Jan C Peeken, Stephanie E Combs, Daniel Habermehl
INTRODUCTION: The ano-inguinal lymphatic drainage (AILD) is located in the subcutaneous adipose tissue of the proximal medial thigh. Currently, there are no recommendations for an inclusion of the 'true' AILD in the clinical target volume (CTV) of definitive chemoradiation for anal cancer patients. To estimate the relevance of inguinal recurrence, we compared the incidental dose to the AILD in anal cancer (AC) patients who were treated either with Volumetric Arc Therapy - Intensity Modulated Radiation Therapy (VMAT-IMRT) or conventional 3D-radiation technique...
November 22, 2018: Radiation Oncology
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