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intensity-modulated radiation therapy

Tomohiro Kajikawa, Noriyuki Kadoya, Kengo Ito, Yoshiki Takayama, Takahito Chiba, Seiji Tomori, Ken Takeda, Keiichi Jingu
The quality of radiotherapy has greatly improved due to the high precision achieved by intensity-modulated radiation therapy (IMRT). Studies have been conducted to increase the quality of planning and reduce the costs associated with planning through automated planning method; however, few studies have used the deep learning method for optimization of planning. The purpose of this study was to propose an automated method based on a convolutional neural network (CNN) for predicting the dosimetric eligibility of patients with prostate cancer undergoing IMRT...
August 14, 2018: Radiological Physics and Technology
Karen E Hoffman, K Ranh Voong, Lawrence B Levy, Pamela K Allen, Seungtaek Choi, Pamela J Schlembach, Andrew K Lee, Sean E McGuire, Quynh Nguyen, Thomas J Pugh, Steven J Frank, Rajat J Kudchadker, Weiliang Du, Deborah A Kuban
Purpose Hypofractionated radiotherapy delivers larger daily doses of radiation and may increase the biologically effective dose delivered to the prostate. We conducted a randomized trial testing the hypothesis that dose-escalated, moderately hypofractionated intensity-modulated radiation therapy (HIMRT) improves prostate cancer control compared with conventionally fractionated IMRT (CIMRT) for men with localized prostate cancer. Patients and Methods Men were randomly assigned to 75.6 Gy in 1.8-Gy fractions delivered over 8...
August 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Thomas Hendrix Beckham, Paul Bernard Romesser, Andries Hijlke Groen, Christopher Sabol, Ashok R Shaha, Mona Sabra, Thomas Brinkman, Daniel J Spielsinger, Sean McBride, Jillian Tsai, Nadeem Riaz, R Michael Tuttle, James A Fagin, Eric J Sherman, Richard J Wong, Nancy Y Lee
BACKGROUND: Differentiated thyroid cancer typically has an indolent clinical course but can cause significant morbidity by local progression. Surgery can be difficult due to the proximity to critical normal structures in the neck. Our objective was to review the safety, feasibility, and outcomes of definitive-intent intensity modulated radiation therapy (IMRT) and to analyze whether patients receiving concurrent chemotherapy (CC-IMRT) had higher rates of disease control and survival over IMRT alone in patients with unresectable or gross residual disease (GRD)...
August 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Fei Qi, Wei-Hu Wang, Xiao-Hui He, Bo Chen, Lin Gui, Hui Fang, Peng Liu, Shu-Lian Wang, Jian-Liang Yang, Yong-Wen Song, Sheng Yang, Shu-Nan Qi, Sheng-Yu Zhou, Ye-Xiong Li, Mei Dong
PURPOSE: To investigate the efficacy and toxicity profile of sequential intensity modulated radiation therapy (IMRT) followed by gemcitabine, dexamethasone, and cisplatin (GDP) on previously untreated high-risk, early stage upper aerodigestive tract natural killer/T-cell lymphoma (UADT-NKTCL). METHODS AND MATERIALS: A phase 2 study was designed, and 40 high-risk patients with stage I(E)/II(E) UADT-NKTCL were enrolled between June 2010 and June 2014. High-risk patients were defined as those with at least 1 predefined risk factor: age >60 years, elevated serum lactate dehydrogenase, regional lymph node involvement, B symptoms, and primary tumor invasion...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Landon S Wootton, Matthew J Nyflot, W Art Chaovalitwongse, Eric Ford
PURPOSE: To improve the detection of errors in intensity-modulated radiation therapy (IMRT) with a novel method that uses quantitative image features from radiomics to analyze gamma distributions generated during patient specific quality assurance (QA). METHODS AND MATERIALS: One hundred eighty-six IMRT beams from 23 patient treatments were delivered to a phantom and measured with electronic portal imaging device dosimetry. The treatments spanned a range of anatomic sites; half were head and neck treatments, and the other half were drawn from treatments for lung and rectal cancers, sarcoma, and glioblastoma...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Anne Ducassou, Laetitia Padovani, Leonor Chaltiel, Stéphanie Bolle, Jean-Louis Habrand, Line Claude, Christian Carrie, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Stéphane Supiot, Charlotte Demoor-Goldschmidt, Valerie Bernier-Chastagner, Aymeri Huchet, Julie Leseur, Elisabeth Le Prise, Christine Kerr, Gilles Truc, Tan Dat Nguyen, Anne-Isabelle Bertozzi, Didier Frappaz, Sergio Boetto, Annick Sevely, Fatima Tensaouti, Anne Laprie
PURPOSE: The objective of this study was to analyze survival and prognostic factors for children, adolescents, and young adults treated with postoperative radiation therapy (RT) for intracranial ependymoma. METHODS AND MATERIALS: Between 2000 and 2013, 202 patients aged ≤25 years were treated in the 13 main French pediatric RT reference centers. Their medical records were reviewed for information, treatments received, and survival rates. All children had received postoperative RT- conformal, intensity modulated, or proton beam...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Alex K Bryant, Minh-Phuong Huynh-Le, Daniel R Simpson, Loren K Mell, Samir Gupta, James D Murphy
PURPOSE: Compared with conventional radiation therapy, intensity modulated radiation therapy (IMRT) may reduce acute toxicity from anal cancer treatment, potentially leading to improved long-term outcomes. We analyze the effect of IMRT on short- and long-term outcomes among a large sample of US veterans. METHODS AND MATERIALS: From a national Veterans Affairs database, we identified 779 patients (n = 403 conventional radiation therapy, n = 376 IMRT) with locally advanced anal squamous cell carcinoma diagnosed between 2000 and 2015 and treated with concurrent chemoradiation therapy...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Rishabh Kapoor, Drew Moghanaki, Shannon Rexrode, Brian Monzon, Michael Ray, Peter R Hulick, Kevin Albuquerque, Seth A Rosenthal, Jatinder R Palta, Michael P Hagan
Approximately 20,000 US veterans receive radiation oncology services at a Veterans Healthcare Administration (VHA) medical facility each year. They currently have access to advanced technologies, which include image-guided intensity-modulated radiotherapy, stereotactic radiosurgery, and stereotactic body radiation therapy. Although this provides access to cancer therapies that are modern, safe, and efficient, the technical complexities of these treatments and clinical decision making that goes into the patient selection and prescriptions demand quality assurances at each VHA practice...
August 8, 2018: Journal of the American College of Radiology: JACR
María Yicel Bautista Hernandez, Pomponio José Lujan Castilla, Abril Antonia Quézada Bautista
Aim: To evaluate whether hypofractionation with integrated boost to the tumour bed using intensity-modulated radiation therapy is an acceptable option and to determine whether this treatment compromises local control, toxicity and cosmesis. Background: Retrospective studies have demonstrated that patients who are treated with HF and integrated boost experience adequate local control, a dosimetric benefit, decreased toxicity and acceptable cosmesis compared with conventional fractionation...
July 2018: Reports of Practical Oncology and Radiotherapy
Ce Han, Wenliang Yu, Xiaomin Zheng, Yongqiang Zhou, Changfei Gong, Congying Xie, Xiance Jin
The aim of this study was to investigate the feasibility and sensitivity of using individual volume-based 3D gamma indices for composite dose-volume histogram (DVH)-based intensity-modulated radiation therapy (IMRT) quality assurance (QA). Composite IMRT QA for 15 cervical cancer patients was performed with ArcCHECK. The percentage dosimetric errors (%DEs) of DVH metrics when comparing treatment planning system and QA-reconstructed dose distribution, percentage gamma passing rates (%GPs) with different criteria for individual volumes and global gamma indices were evaluated, as well as their correlations...
July 31, 2018: Journal of Radiation Research
Kiyonao Nakamura, Itaru Ikeda, Haruo Inokuchi, Kenji Takayama, Takahiro Inoue, Tomomi Kamba, Osamu Ogawa, Masahiro Hiraoka, Takashi Mizowaki
The purpose of this pilot study was to evaluate the feasibility of highly hypofractionated intensity-modulated radiation therapy (IMRT) in 15 fractions over 3 weeks for treating localized prostate cancer based on prostate position-based image-guided radiation therapy. Twenty-five patients with National Comprehensive Cancer Network (NCCN) very low- to unfavorable intermediate-risk prostate cancer were enrolled in this study from April 2014 to September 2015 to receive highly hypofractionated IMRT (without intraprostatic fiducial markers) delivering 54 Gy in 15 fractions over 3 weeks...
July 31, 2018: Journal of Radiation Research
Sana D Karam, Krishna Reddy, Patrick Blatchford, Tim Waxweiler, Alicia M DeLouize, Ayman Oweida, Hilary Somerset, Carrie Marshall, Christian Young, Kurtis D Davies, Madeleine Kane, Aik-Choon Tan, Xiao-Jing Wang, Antonio Jimeno, Dara L Aisner, Daniel W Bowles, David Raben
PURPOSE: Our goal was to evaluate the safety and toxicity of combining a PARP inhibitor, olaparib with cetuximab and fractionated intensity modulated radiation therapy for patients with locally advanced head and neck cancer and heavy smoking histories. EXPERIMENTAL DESIGN: Patients with ≥10 pack/year history of smoking were treated with olaparib at doses ranging from 25 mg-200 mg orally twice daily (BID) beginning ~10 days prior to initiation of and with concurrent radiation (69...
July 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Yen-Kuang Lin, Mao-Chih Hsieh, Chia-Lun Chang, Jyh-Ming Chow, Kevin Sheng-Po Yuan, Alexander T H Wu, Szu-Yuan Wu
PURPOSE: In the era of intensity-modulation radiation therapy (IMRT), no prospective randomized trial has evaluated the efficacy of IMRT exclusively, such as concurrent chemoradiotherapy (CCRT), sequential induction chemotherapy followed by radiotherapy (CT-RT), and systemic chemotherapy (CT) alone, for treating unresectable pancreatic adenocarcinomas (PAs) without metastasis. Through propensity score matching, we designed a nationwide, population-based, head-to-head cohort study to determine the effects of various treatments on unresectable PAs...
August 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Penny Fang, Yutaka Shiraishi, Vivek Verma, Wen Jiang, Juhee Song, Brian P Hobbs, Steven H Lin
Purpose: To assess whether radiation treatment modality with proton beam therapy (PBT) or intensity-modulated radiation therapy (IMRT) is associated with lymphopenia in patients treated with definitive chemoradiation for esophageal cancer. Methods and Materials: Patients with esophageal cancer treated with bimodality therapy (n = 448) between 2004 and 2016 were retrospectively reviewed. Patients treated with PBT were matched by propensity score with those treated with IMRT, based on key patient and disease factors, and stratified by clinical disease stage...
2018: International Journal of Particle Therapy
James Botros, Jack M Raisanen, Tarek Y El Ahmadieh, Jean-Luc Kabangu, Edward Pan, Wayne Gluf
BACKGROUND: Paraspinal masses are a relatively uncommon but diverse group of lesions that can be neoplastic or non-neoplastic. Peripheral primitive neuroectodermal tumor of the lumbar paraspinal region with diffuse and strong glial differentiation have never been reported before. CASE DESCRIPTION: We report a primary paraspinal primitive neuroectodermal tumor with overwhelming glial differentiation in a 23-year-old female patient who presented with intractable right lower extremity pain...
August 1, 2018: World Neurosurgery
Charles C Vu, Kevin G Blas, Thomas B Lanni, Gary S Gustafson, Daniel J Krauss
PURPOSE: The recently published ASCENDE-RT randomized clinical trial demonstrated improved biochemical control, albeit with increased toxicity, for a prostate boost with brachytherapy versus external beam radiation therapy alone in patients with intermediate-high risk prostate cancer. In this study, we investigated the cost-effectiveness of these two modalities in the treatment of intermediate-high risk prostate cancer. METHODS AND MATERIALS: A multistate Markov model was created to model a patient with intermediate-high risk prostate cancer...
July 31, 2018: Brachytherapy
A Boros, V Ribrag, É Deutsch, C Chargari, F Izar
The optimization of radiotherapy in these young and long-lived survivors raises the question about the interest of using modern techniques to allow a better distribution of the dose. The choice of the irradiation technique must take into account the incidence of side effects related to radiation. In this context, the definition of the target volumes as well as the verification and monitoring of the delivered processing are essential. International recommendations for treatment fields are based on the "involved node radiotherapy" concept...
July 31, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Shengjun Ji, Qunchao Hu, Jiahao Zhu, Jie Chen, Qingqing Chen, Zhengcao Liu, Chen Shen, Ru Yang, Haoyao Sun, Jinchang Wu, Ke Gu
BACKGROUND: Cisplatin-based chemoradiation is the standard of care for patients with locally advanced cervical cancer. Nevertheless, an increasing number of radio-resistant tumors still recur. METHODS AND DESIGN: Three hundred cervical cancer patients with FIGO stages IB2-IVA and no para-aortic lymphadenopathy (> 10 mm) will be enrolled. All patients will be randomly divided into four arms to receive either (1) intensity modulated radiation therapy (IMRT), (2) RapidArc, (3) positron emission tomography/computed tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG), or (4) Comet assay-guided IMRT, PET/CT, and Comet assay-guided RapidArc...
August 3, 2018: Trials
Seiji Tomori, Noriyuki Kadoya, Yoshiki Takayama, Tomohiro Kajikawa, Katsumi Shima, Kakutarou Narazaki, Keiichi Jingu
PURPOSE: Patient-specific quality assurance (QA) measurement is conducted to confirm the accuracy of dose delivery. However, measurement is time-consuming and places a heavy workload on the medical physicists and radiological technologists. In this study, we proposed a prediction model for gamma evaluation, based on deep learning. We applied the model to a QA measurement dataset of prostate cancer cases to evaluate its practicality. METHODS: Sixty pretreatment verification plans from prostate cancer patients treated using intensity modulated radiation therapy were collected...
July 31, 2018: Medical Physics
Zacariah E Labby, Brendan Barraclough, R Adam Bayliss, Abigail E Besemer, David A P Dunkerley, Steven P Howard
The management of a pregnant patient in radiation oncology is an infrequent event requiring careful consideration by both the physician and physicist. The aim of this manuscript was to highlight treatment planning techniques and detail measurements of fetal dose for a pregnant patient recently requiring treatment for a brain cancer. A 27-year-old woman was treated during gestational weeks 19-25 for a resected grade 3 astrocytoma to 50.4 Gy in 28 fractions, followed by an additional 9 Gy boost in five fractions...
July 30, 2018: Journal of Applied Clinical Medical Physics
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