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https://www.readbyqxmd.com/read/30516868/role-of-systemic-high-dose-methotrexate-and-combined-approaches-in-the-management-of-vitreoretinal-lymphoma-a-single-center-experience-1990-2018
#1
Alessia Castellino, Jose S Pulido, Patrick B Johnston, Kay M Ristow, N Nora Bennani, David J Inwards, William R Macon, Ivana N M Micallef, Rebecca L King, Diva R Salomao, Thomas E Witzig, Thomas M Habermann, Grzegorz S Nowakowski
Vitreoretinal lymphoma (VRL) management remains a challenge. We present 72 patients with VRL, diagnosed at Mayo Clinic between 1990-2018. Three nondiffuse large B-cell lymphoma (DLBCL) histology cases were excluded. Among 69 DLBCL, 33 patients had primary VRL (PVRL), 18 concurrent intraocular and central nervous system (CNS) or systemic disease and 18 secondary VRL. Patients received intraocular chemotherapy (intraocular injections of rituximab or metothrexate or steroids or in combination), radiotherapy, systemic or combined systemic plus intraocular treatment in 9, 10, 35, and 15 cases, respectively...
December 5, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/30515646/omitting-the-lower-neck-and-sparing-the-glottic-larynx-in-node-negative-nasopharyngeal-carcinoma-was-safe-and-feasible-and-improved-patient-reported-voice-outcomes
#2
F Xiao, S Dou, Y Li, W Qian, F Liang, L Kong, X Wang, K Wu, C Hu, G Zhu
BACKGROUND: Worsening voice and speech quality was frequently reported in head-and-neck patients after radiotherapy to the neck; omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma (NPC) patients might be safe and feasible, and improve voice and speech outcomes. METHODS: From January 2009 to January 2013, 71 patients were analyzed. All patients received bilateral neck irradiation. Upper group (UG) patients spared the glottic larynx while lower group (LG) patients did not...
December 4, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30515211/risk-factors-for-fatal-pulmonary-hemorrhage-following-concurrent-chemoradiotherapy-in-stage-3b-c-squamous-cell-lung-carcinoma-patients
#3
Erkan Topkan, Ugur Selek, Yurday Ozdemir, Ali A Besen, Ozan C Guler, Berna A Yildirim, Huseyin Mertsoylu, Alper Findikcioglu, Ozgur Ozyilkan, Berrin Pehlivan
We aimed to identify the fatal pulmonary hemorrhage- (FPH-) related risk factors in stage 3B/C squamous-cell lung carcinoma (SqCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Medical records of 505 stage 3B/C SqCLC patients who underwent 66 Gy radiotherapy plus 1-3 cycles of concurrent chemotherapy with available pretreatment thoracic computerized tomography scans were retrospectively analyzed. Primary end-point was the identification of FPH-related risk factors. Examined factors included the basal patient and tumor characteristics with specific emphasis on the tumor cavitation (TC) status, tumor size (TS) and cavitation size (CS), tumor volume and cavitation volume (TV and CV), relative cavitation size (RCS = CS/TS), and relative cavitation volume (RCV=CV/TV)...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30515050/myxoid-liposarcoma-treatment-outcomes-from-chemotherapy-and-radiation-therapy
#4
Varun Chowdhry, Saveli Goldberg, Thomas F DeLaney, Gregory M Cote, Ivan Chebib, Jason Kim, Santiago A Lozano-Calderón, Karen De Amorim Bernstein
Introduction: Myxoid liposarcoma (MLS) is a subtype of liposarcoma characterized morphologically by lipomatous differentiation with a myxoid stroma. The purpose of this study was to review clinical and pathological information for patients treated for MLS at our institution to better understand neoadjuvant and adjuvant therapy. Materials and Methods: An institutional database of sarcomas was queried for patients who were treated for MLS at our institution between 1992 and 2013...
2018: Sarcoma
https://www.readbyqxmd.com/read/30511047/biological-mesh-is-a-safe-and-effective-method-of-abdominal-wall-reconstruction-in-cytoreductive-surgery-for-peritoneal-malignancy
#5
A Tzivanakis, S P Dayal, S J Arnold, F Mohamed, T D Cecil, A K Venkatasubramaniam, B J Moran
Background: Patients with peritoneal malignancy often have multiple laparotomies before referral for cytoreductive surgery (CRS). Some have substantial abdominal wall herniation and tumour infiltration of abdominal incisions. CRS involves complete macroscopic tumour removal and hyperthermic intraperitoneal chemotherapy (HIPEC). Abdominal wall reconstruction is problematic in these patients. The aim of this study was to establish immediate and long-term outcomes of abdominal wall reconstruction with biological mesh in a single centre...
December 2018: BJS open
https://www.readbyqxmd.com/read/30510431/clinical-evaluation-of-vascular-normalization-induced-by-recombinant-human-endostatin-in-nasopharyngeal-carcinoma-via-dynamic-contrast-enhanced-ultrasonography
#6
Zhendong Yang, Min Kang, Shangyong Zhu, Jianyuan Huang, Xigui Li, Rensheng Wang
Background: The present study confirmed the presence and exact range of "vascular normalization window" induced by recombinant human endostatin (RHES) in patients with nasopharyngeal carcinoma (NPC) by analyzing the variation of dynamic contrast-enhanced ultrasonography (DCE-US) quantitative parameters. Also, the clinical application of DCE-US in the evaluation of vascular normalization was assessed. Materials and methods: A total of 30 previously untreated patients with stage III-IVA NPC were enrolled in the present study and were randomly but equally divided into RHES (endostar [ES]) and normal saline (NS) groups...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30507435/molecular-biomarkers-in-bladder-preservation-therapy-for-muscle-invasive-bladder-cancer
#7
REVIEW
David T Miyamoto, Kent W Mouw, Felix Y Feng, William U Shipley, Jason A Efstathiou
Although muscle-invasive bladder cancer is commonly treated with radical cystectomy, a standard alternative is bladder preservation therapy, consisting of maximum transurethral bladder tumour resection followed by radiotherapy with concurrent chemotherapy. Although no successfully completed randomised comparisons are available, the two treatment paradigms seem to have similar long-term outcomes; however, clinicopathologic parameters can be insufficient to provide clear guidance in the selection of one treatment over the other...
December 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30505595/can-we-downstage-locally-advanced-pancreatic-cancer-to-resectable-a-phase-i-ii-study-of-induction-oxaliplatin-and-5-fu-chemoradiation
#8
Salvatore Amodeo, Antonio Masi, Marcovalerio Melis, Theresa Ryan, Howard S Hochster, Deirdre J Cohen, Anurag Chandra, H Leon Pachter, Elliot Newman
Background: Half of patients with pancreatic adenocarcinoma (PC) present with regionally advanced disease. This includes borderline resectable and locally advanced unresectable tumors as defined by current NCCN guidelines for resectability. Chemoradiation (CH-RT) is used in this setting in attempt to control local disease, and possibly downstage to resectable disease. We report a phase I/II trial of a combination of 5FU/Oxaliplatin with concurrent radiation in patients presenting with borderline resectable and locally advanced unresectable pancreatic cancer...
October 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30504412/radiation-therapy-for-anal-squamous-cell-carcinoma-a-retrospective-multicenter-study
#9
Hyeon Kang Koh, Kyubo Kim, Won Il Jang, Chang Hoon Song, Ah Ram Chang, Hae Jin Park, Kyung Su Kim, Ji Hyun Chang, Mi-Sook Kim
AIM: To analyze the treatment outcomes, patterns of failures and prognostic factors for patients with anal cancer treated with radiotherapy (RT). MATERIALS AND METHODS: Between January 2000 and December 2015, 83 patients with anal squamous cell carcinoma were treated with definitive RT. The median RT dose applied to the primary carcinoma site was 55 (range=45-64) Gy. Seventy-six patients (91.6%) received concurrent chemotherapy, and the most common regimen was 5-fluorouracil plus mitomycin C...
December 2018: Anticancer Research
https://www.readbyqxmd.com/read/30503564/molecular-and-pathologic-characterization-of-aml-with-double-inv-3-q21q26-2
#10
Jennelle C Hodge, David Bosler, Lauren Rubinstein, Navid Sadri, Shashirekha Shetty
The inv(3)(q21q26.2) altering a single chromosome 3 homolog is an established myeloid malignancy-associated entity. Comparatively, double inv(3) cases involving both homologs are exceedingly rare with 13 reports across AML, CML and MDS. This scarcity was confirmed by finding only 2 new cases out of 34,898 bone marrows collected during a 55 year period at a large medical center (0.0005%). The double inv(3) was detected by karyotype and confirmed by FISH on both homologs in a 41 year old female and a 72 year old male with AML...
November 16, 2018: Cancer Genetics
https://www.readbyqxmd.com/read/30503267/the-fallopian-tube-precursor-escape-and-narrowing-the-knowledge-gap-to-the-origins-of-high-grade-serous-carcinoma
#11
REVIEW
Thing Rinda Soong, Brooke E Howitt, Neil Horowitz, Marisa R Nucci, Christopher P Crum
Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. However, although most early or incidentally discovered HGSCs manifest in the tube with STICs, many advanced HGSCs are not accompanied by a malignancy in the fimbria...
November 29, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30499082/comparative-effectiveness-and-safety-of-monoclonal-antibodies-bevacizumab-cetuximab-and-panitumumab-in-combination-with-chemotherapy-for-metastatic-colorectal-cancer-a-systematic-review-and-meta-analysis
#12
REVIEW
Wânia Cristina da Silva, Vânia Eloisa de Araujo, Ellias Magalhães E Abreu Lima, Jessica Barreto Ribeiro Dos Santos, Michael Ruberson Ribeiro da Silva, Paulo Henrique Ribeiro Fernandes Almeida, Francisco de Assis Acurcio, Brian Godman, Amanj Kurdi, Mariângela Leal Cherchiglia, Eli Iola Gurgel Andrade
BACKGROUND: The last decade has seen the increasing use of biological medicines in combination with chemotherapy containing 5-fluorouracil/oxaliplatin or irinotecan for the treatment of metastatic colorectal cancer (mCRC). These combinations have resulted in increased progression-free survival (PFS) in patients with mCRC; however, there are remaining concerns over the extent of their effect on overall survival (OS). Published studies to date suggest no major differences between the three currently available monoclonal antibodies (MoAbs); however, there are differences in costs...
November 30, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/30496584/phase-i-dose-escalation-study-of-pemetrexed-and-concurrent-thoracic-radiation-in-elderly-patients-with-non-squamous-non-small-cell-lung-cancer
#13
Kyoichi Kaira, Akihiro Ono, Yosuke Kamide, Noriaki Sunaga, Yasuhiko Koga, Jun-Ichi Saitoh, Katsuyuki Shirai, Takeshi Ebara, Takeshi Hisada, Tamotsu Ishizuka
The aim of our study was to determine the maximum tolerated dose (MTD) and recommended dose of pemetrexed with concurrent thoracic radiation therapy for elderly patients with previously untreated locally advanced non-squamous non-small-cell lung cancer (NSCLC). Pemetrexed was administered intravenously on Days 1, 22, 43, 64, 85 and 106. The initial doses of pemetrexed were planned as follows: Level 1 (400 mg/m2) and Level 2 (500 mg/m2). Concurrent thoracic radiation therapy was administered in 2-Gy fractions five times weekly, to a total of 60 Gy...
November 29, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/30496377/impact-of-perineural-invasion-as-a-histopathological-prognostic-factor-in-ypstage-ii-iii-oesophageal-squamous-cell-carcinoma
#14
Po-Kuei Hsu, Ling-I Chien, Chih-Hung Lin, Yi-Chen Yeh, Cheng-Yen Chuang, Han-Shui Hsu, Yu-Chung Wu, Chung-Ping Hsu
OBJECTIVES: The 8th edition American Joint Committee on Cancer Tumour-Nodes-Metastasis (TNM) staging system distinguishes between the clinical (c), pathological (p) and post-neoadjuvant pathological (yp) stage groups. However, the ability to discriminate between ypStage II and ypStage III is poor. We aim to identify prognostic factors in patients with ypStage II/III oesophageal squamous cell carcinoma. METHODS: The data of 150 patients with ypStage II/III oesophageal squamous cell carcinoma from 2 medical centres were retrospectively reviewed...
November 27, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/30488865/comparison-three-dimensional-conformal-radiotherapy-versus-intensity-modulated-radiation-therapy-in-local-control-of-head-and-neck-cancer
#15
Gopa Ghosh, Gaurav Gupta, Anupam Malviya, Dinesh Saroj
Background: About 74% of head and neck cancer (HNC) patients need to undergo either definitive or postoperative radiation therapy because of aggressive nature of disease. The transition from two-dimensional conventional radiotherapy to three-dimensional conformal radiotherapy (3D-CRT) and further technological evolutions led to the successful clinical implementation of intensity modulated radiation therapy (IMRT), which constitutes an evolution of 3D-CRT. The IMRT technique gives the ability to create treatment fields with varying beam intensity using inverse planning and optimization algorithms to treat irregularly shaped target volumes with high precision...
October 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30488859/cd105-endoglin-expression-as-a-prognostic-marker-of-angiogenesis-in-squamous-cell-cervical-cancer-treated-with-radical-radiotherapy
#16
Evrim Metcalfe, Deniz Arik, Tufan Oge, Durmus Etiz, Omer Tarik Yalcin, Sare Kabukcuoglu, Ozgul Pasaoglu, S Sinan Ozalp
Introduction: Increased levels of endoglin may represent a new reagent of active neovascularization and angiogenesis process in various cancer types. The prognostic value of tumor CD105 (endoglin) expression in cervical squamous cell cancer (CSCC) patients treated with radical radiotherapy (RT) ± chemotherapy was investigated. Materials and Methods: CD105 (endoglin) expression was assessed by immunohistochemical methods in seventy patients, who were treated with radical RT ± chemotherapy for CSCC...
October 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30488294/increase-of-pseudoprogression-and-other-treatment-related-effects-in-low-grade-glioma-patients-treated-with-proton-radiation-and-temozolomide
#17
Michael Dworkin, William Mehan, Andrzej Niemierko, Sophia C Kamran, Nayan Lamba, Jorg Dietrich, Maria Martinez-Lage, Kevin S Oh, Tracy T Batchelor, Patrick Y Wen, Jay S Loeffler, Helen A Shih
INTRODUCTION: Concurrent radiotherapy and temozolomide (TMZ) is associated with radiographic pseudoprogression (PsP) in glioblastoma. The occurrence of PsP and other treatment effects is less well understood in low-grade gliomas (LGG). The purpose of this study is to evaluate whether the addition of TMZ to radiotherapy increases the incidence of PsP in adults with LGG treated with proton radiotherapy (PRT). METHODS: Chart review and volumetric MRI-analysis was performed on radiotherapy-naive adults with WHO grade II or IDH mutant WHO grade III gliomas treated with PRT between 2005 and 2015...
November 28, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30486745/altered-methotrexate-clearance-in-the-treatment-of-cns-lymphoma-with-concurrent-use-of-nitrofurantoin-for-a-urinary-tract-infection
#18
Jasmine L Gowarty, Ina J Patel, Jon D Herrington
Methotrexate is a widely used chemotherapy agent with a propensity for drug interactions placing the patient at risk for toxicities. There are several modes for altering methotrexate clearance including concomitant drugs leading to toxic effects on the kidneys, medications producing an acidic urine pH, and agents interfering with methotrexate transporters including the organic anion transporter and breast cancer resistance protein efflux pump. We report a case of a patient with central nervous system non-Hodgkin's lymphoma receiving high-dose methotrexate and being concomitantly treated for a urinary tract infection with nitrofurantoin...
November 28, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/30479698/a-phase-2-trial-of-neoadjuvant-metformin-in-combination-with-trastuzumab-and-chemotherapy-in-women-with-early-her2-positive-breast-cancer-the-metten-study
#19
Begoña Martin-Castillo, Sonia Pernas, Joan Dorca, Isabel Álvarez, Susana Martínez, Jose Manuel Pérez-Garcia, Norberto Batista-López, César A Rodríguez-Sánchez, Kepa Amillano, Severina Domínguez, Maria Luque, Agostina Stradella, Idoia Morilla, Gemma Viñas, Javier Cortés, Elisabet Cuyàs, Sara Verdura, Álvaro Fernández-Ochoa, Salvador Fernández-Arroyo, Antonio Segura-Carretero, Jorge Joven, Elsa Pérez, Neus Bosch, Margarita Garcia, Eugeni López-Bonet, Samiha Saidani, Maria Buxó, Javier A Menendez
The METTEN study assessed the efficacy, tolerability, and safety of adding metformin to neoadjuvant chemotherapy plus trastuzumab in early HER2-positive breast cancer (BC). Women with primary, non-metastatic HER2-positive BC were randomized (1:1) to receive metformin (850 mg twice-daily) for 24 weeks concurrently with 12 cycles of weekly paclitaxel plus trastuzumab, followed by four cycles of 3-weekly FE75C plus trastuzumab (arm A), or equivalent regimen without metformin (arm B), followed by surgery. Primary endpoint was the rate of pathological complete response (pCR) in the per-protocol efficacy population...
November 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/30479617/the-analysis-of-the-long-term-outcomes-in-elderly-women-treated-for-locally-advanced-cervical-cancer
#20
Krzysztof Koper, Konrad Dziobek, Roman Makarewicz, Joanna Terlikiewicz, Magdalena Dutsch-Wicherek
Purpose: Locally advanced cervical cancer (LACC) should be treated with a combination of external irradiation and brachytherapy with concurrent chemotherapy. However, as cervical carcinoma cells can disperse by way of the lymphatic system to either pelvic or para-aortic nodes, planning the extent of radiation requires precise information about the spread of the disease to the lymph nodes, especially to the para-aortic area. Material and methods: All of the 75 women included in our study underwent chemoradiotherapy, which started with brachytherapy...
October 2018: Journal of Contemporary Brachytherapy
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