Daniel K Benjamin, Mark L Hudak, Shahnaz Duara, David A Randolph, Margarita Bidegain, Gratias T Mundakel, Girija Natarajan, David J Burchfield, Robert D White, Karen E Shattuck, Natalie Neu, Catherine M Bendel, M Roger Kim, Neil N Finer, Dan L Stewart, Antonio C Arrieta, Kelly C Wade, David A Kaufman, Paolo Manzoni, Kristi O Prather, Daniela Testoni, Katherine Y Berezny, P Brian Smith
IMPORTANCE: Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown. OBJECTIVE: To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low-birth-weight infants. DESIGN, SETTING, AND PATIENTS: This study was a randomized, blinded, placebo-controlled trial of fluconazole in premature infants...
May 7, 2014: JAMA