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Vasopressinase

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https://www.readbyqxmd.com/read/27834335/a-pcr-rflp-method-for-detection-of-the-lnpep-encoding-human-insulin-regulated-aminopeptidase-irap-rs4869317-polymorphism
#1
MarIa Jesús RamIrez-Expósito, Jos Manuel MartInez-Martos, Teresa Palomeque, Pedro Lorite
BACKGROUND & OBJECTIVES: Insulin regulated aminopeptidase (IRAP) has been related to certain pathologies such as breast cancer, Alzheimer΄s disease and septic shock. IRAP is encoded by the leucyl/cystinyl aminopeptidase (LNPEP) gene. The genetic variation in the LNPEP gene has been analyzed in relation with the mortality and vasopressin clearance in septic shock. The LNPEP rs4869317 SNP (single nucleotide polymorphism) was the most significantly associated SNP with vasopressinase activity, being TT genotype associated with increased mortality...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27172867/diabetes-insipidus-and-pregnancy
#2
Philippe Chanson, Sylvie Salenave
Diabetes insipidus (DI) is a rare complication of pregnancy. It is usually transient, being due to increased placental production of vasopressinase that inactivates circulating vasopressin. Gestational, transient DI occurs late in pregnancy and disappears few days after delivery. Acquired central DI can also occur during pregnancy, for example in a patient with hypophysitis or neuroinfundibulitis during late pregnancy or postpartum. Finally, pre-existing central or nephrogenic DI may occasionally be unmasked by pregnancy...
June 2016: Annales D'endocrinologie
https://www.readbyqxmd.com/read/27156766/diabetes-insipidus-during-pregnancy
#3
REVIEW
Sonia Ananthakrishnan
Diabetes insipidus (DI) in pregnancy is a heterogeneous syndrome, most classically presenting with polyuria and polydipsia that can complicate approximately 1 in 30,000 pregnancies. The presentation can involve exacerbation of central or nephrogenic DI during pregnancy, which may have been either overt or subclinical prior to pregnancy. Women without preexisting DI can also be affected by the actions of placental vasopressinase which increases in activity between the 4th and 38th weeks of gestation, leading to accelerated metabolism of AVP and causing a transient form of DI of pregnancy...
March 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/26524979/transient-diabetes-insipidus-in-pregnancy
#4
Pedro Marques, Kavinga Gunawardana, Ashley Grossman
UNLABELLED: Gestational diabetes insipidus (DI) is a rare complication of pregnancy, usually developing in the third trimester and remitting spontaneously 4-6 weeks post-partum. It is mainly caused by excessive vasopressinase activity, an enzyme expressed by placental trophoblasts which metabolises arginine vasopressin (AVP). Its diagnosis is challenging, and the treatment requires desmopressin. A 38-year-old Chinese woman was referred in the 37th week of her first single-gestation due to polyuria, nocturia and polydipsia...
2015: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/26366890/vasopressinase-activity-a-potential-early-biomarker-for-detecting-cardiopulmonary-bypass-associated-acute-kidney-injury
#5
Namhee Kim, Si Yuan Dai, Victoria Pang, C David Mazer
Background Acute kidney injury (AKI) is a common and serious complication of surgeries that include cardiopulmonary bypass (CPB). Currently, increases in serum creatinine levels are used to diagnose AKI, but this change may be slow to detect. Animal studies pertaining to renal hypoxia suggest a correlation between vasopressinase activity and AKI. The objective of this study is to determine if vasopressinase activity can be used as an early biomarker for renal hypoxia and CPB-associated AKI. This could potentially help improve the diagnosis and subsequent treatment of the condition...
October 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/25832854/acute-presentation-of-gestational-diabetes-insipidus-with-pre-eclampsia-complicated-by-cerebral-vasoconstriction-a-case-report-and-review-of-the-published-work
#6
Amir Mor, Yael Fuchs, Kathleen Zafra, Shoshana Haberman, Reshef Tal
Gestational diabetes insipidus (GDI) is a rare, self-limited complication of pregnancy. As it is related to excess placental vasopressinase enzyme activity, which is metabolized in the liver, GDI is more common in pregnancies complicated by conditions associated with liver dysfunction. We present a case of a 41-year-old woman at 38 weeks' gestation who presented with pre-eclampsia with severe features, including impaired liver function and renal insufficiency. Following cesarean section she was diagnosed with GDI, which was further complicated by cerebral vasoconstriction as demonstrated by magnetic resonance angiography...
August 2015: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/25819424/interaction-of-neuropeptidase-activities-in-cortico-limbic-regions-after-acute-restraint-stress
#7
Joaquín Hernández, Isabel Prieto, Ana B Segarra, Marc de Gasparo, Rosemary Wangensteen, Ana B Villarejo, Inmaculada Banegas, Francisco Vives, Justo Cobo, Manuel Ramírez-Sánchez
Brain enkephalin, vasopressin and oxytocin are anxiolytic agents involved in the stress response. Acute restraint stress influences certain neuropeptidase activities, such as some enkephalin-degrading peptidases and vasopressinase/oxytocinase, in the medial prefrontal cortex (mPFC), amygdala (AM) or hippocampus (HC), which are involved in this response. Because these regions form a unified circuit and cooperate in their response to stress, it is important to analyze the profile of the regional distribution of these activities as well as their inter-regional model of interaction in this circuit...
2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/25787398/-49-or-vasopressin-secretion-in-human-pregnancy-predicts-the-development-of-preeclampsia-as-early-as-the-sixth-week-of-gestation
#8
Mark Santillan, Donna Santillan, Sabrina Scroggins, James Min, Kimberly Leslie, Stephen Hunter, Gideon Zamba, Katherine Gibson-Corley, Justin Grobe
OBJECTIVES: The objective of this study is to determine: (1) if circulating copeptin, a stable biomarker of vasopressin secretion, is higher throughout gestation in pregnant women who develop preeclampsia in comparison to controls, and (2) if copeptin predicts the development of preeclampsia. METHODS: In this case-control study, coded plasma from mothers who developed preeclampsia (n=50, PE), pregnant controls (n=54, PC), and nonpregnant controls (n=33, NC) with their annotated clinical patient information were obtained through the University of Iowa IRB-approved Women's Health Tissue Repository...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/24627106/relationship-of-angiotensinase-and-vasopressinase-activities-between-hypothalamus-heart-and-plasma-in-l-name-treated-wky-and-shr
#9
A B Villarejo, I Prieto, A B Segarra, I Banegas, R Wangensteen, F Vives, M de Gasparo, M Ramírez-Sánchez
The renin-angiotensin system (RAS), vasopressin, and nitric oxide (NO) interact to regulate blood pressure at central and peripheral level. To improve our understanding of their interaction and their relationship with the hypothalamus and the cardiovascular system, we analyzed angiotensin- and vasopressin-metabolizing activities in hypothalamus (HT), left ventricle (LV), and plasma, collected from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) treated or not with L-NAME [N(G)-nitro-L-arginine methyl ester], which inhibits the formation of NO and over-activates the sympathetic nervous system...
July 2014: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/24555139/gestational-diabetes-insipidus-associated-with-hellp-syndrome-a-case-report
#10
Renela Gambito, Michael Chan, Mohamed Sheta, Precious Ramirez-Arao, Harmeet Gurm, Allan Tunkel, Noel Nivera
Gestational diabetes insipidus is a rare, but well recognized, complication of pregnancy. It is related to excess vasopressinase enzyme activity which is metabolized in the liver. A high index of suspicion of gestational diabetes insipidus is required in a correct clinical setting especially in the presence of other risk factors such as preeclampsia, HELLP syndrome, and twin pregnancies. We are presenting a case of gestational diabetes insipidus in a patient with HELLP syndrome. The newborn in this case also had hypernatremia thereby raising possibilities of vasopressinase crossing the placenta...
2012: Case Reports in Nephrology
https://www.readbyqxmd.com/read/24538745/-effect-of-cytochrome-c-on-the-oxytocinase-and-vasopressinase-activity-of-the-blood
#11
H CROXATTO, J CESPEDES
No abstract text is available yet for this article.
January 1950: Revista de Medicina y Alimentación
https://www.readbyqxmd.com/read/24342488/renal-aquaporins-and-water-balance-disorders
#12
REVIEW
Marleen L A Kortenoeven, Robert A Fenton
BACKGROUND: Aquaporins (AQPs) are a family of proteins that can act as water channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body water homeostasis. Eight AQPs are expressed in the kidney of which five have been shown to play a role in body water balance; AQP1, AQP2, AQP3, AQP4 and AQP7. AQP2 in particular is regulated by vasopressin. SCOPE OF REVIEW: This review summarizes our current knowledge of the underlying mechanisms of various water balance disorders and their treatment strategies...
May 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23808742/-impact-of-pregnancy-on-pituitary-disorders
#13
REVIEW
J Marek
In pregnancy, the volume of pituitary increases by multiplication of lactotopic and gonadotropic cells and developing placenta is the source of numerous hormones and enzymes that significantly affect and alter the function of the endocrine system. This naturally has an impact on the course of pituitary disorders and their treatment. The most common disorders of pituitary gland, which we can meet in pregnancy, are adenomas, particularly prolactinomas, and functionless adenomas. During pregnancy we avoid the treatment of microprolactinomas, but in macroprolactinomas where there is the risk of their enlargement by stimulation of placental estrogens, we administer preventively the dopaminergic agonists...
June 2013: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/23393172/acute-diabetes-insipidus-mediated-by-vasopressinase-after-placental-abruption
#14
Amisha Wallia, Aigerim Bizhanova, Wenyu Huang, Susan L Goldsmith, Dana R Gossett, Peter Kopp
CONTEXT: Postpartum, diabetes insipidus (DI) can be part of Sheehan's syndrome or lymphocytic hypophysitis in combination with anterior pituitary hormone deficiencies. In contrast, acute onset of isolated DI in the postpartum period is unusual. CASE PRESENTATION: This patient presented at 33 weeks gestation with placental abruption, prompting a cesarean delivery of twins. Immediately after delivery, she developed severe DI. The DI could be controlled with the vasopressinase-resistant 1-deamino-8-D-arginine vasopressin (DDAVP), but not with arginine vasopressin (AVP), and it resolved within a few weeks...
March 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23207288/response-of-the-renal-inner-medulla-to-hypoxia-possible-defense-mechanisms
#15
Namhee Kim, Laura Voicu, Gregory M T Hare, Surinder Cheema-Dhadli, Chee Kiong Chong, Stephen K W Chan, Daniel G Bichet, Mitchell L Halperin, C David Mazer
BACKGROUND/AIMS: Owing to the precarious blood supply to the renal medulla and the high metabolic requirement of the medullary thick ascending limb of Henle's loop, this nephron segment should be especially vulnerable when its supply of O(2) declines. METHODS: Rats were exposed to 8 or 21% O(2) at different time points up to 5 h, and samples were collected for urine flow rate, urine (U(osm)) and renal papillary (RP(osm)) osmolality, urinary excretion of Na(+), Cl(-), K(+) and Mg(2+), blood gases, erythropoietin and vasopressinase activity in plasma...
2012: Nephron. Physiology
https://www.readbyqxmd.com/read/22967849/clinical-practice-guideline-for-hypotalamic-pituitary-disturbances-in-pregnancy-and-the-postpartum-period
#16
Irene Halperin Rabinovich, Gabriel Obiols Alfonso, Alfonso Soto Moreno, Elena Torres Vela, Frederic Tortosa Henzi, Miguel Català Bauset, Alberto Gilsanz Peral, Juan Girbés Borràs, Basilio Moreno Esteban, Antonio Picó Alfonso, Carlos Del Pozo Picó, Ana Zugasti Murillo, Tomás Lucas Morante, Concha Páramo Fernández, César Varela da Sousa, Carles Villabona Artero
During pregnancy, the body undergoes a major adaptation process as a result of the interaction between mother, placenta and fetus. Major anatomical and histological changes are produced in the pituitary, with an increase of up to 40% in the size of the gland. There are wide variations in the function of the hypothalamus-pituitary-thyroid axis that effect iodine balance, the overall activity of the gland, as well as transport of thyroid hormones in plasma and peripheral metabolism of thyroid hormones. The incidence of goiter and thyroid nodules increases throughout pregnancy...
January 2008: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/22592189/postoperative-diabetes-insipidus-associated-with-pituitary-apoplexy-during-pregnancy
#17
Daisuke Kita, Yasuhiko Hayashi, Hiroki Sano, Toshinari Takamura, Yutaka Hayashi, Osamu Tachibana, Jun-ichiro Hamada
BACKGROUND: Pituitary apoplexy during pregnancy is so rare that only 15 cases (12 pituitary adenomas, 2 lymphocytic neurohypophysitis, and 1 normal pituitary gland) have been published to date. Here, we report the case of a pregnant woman presenting with pituitary apoplexy from a nonfunctioning pituitary adenoma and provide a possible mechanism and management option for postoperative diabetes insipidus (DI). CASE PRESENTATION: A 26-year-old woman presented with sudden onset of headache and bitemporal hemianopsia in the 26th week of her first pregnancy...
2012: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/22245314/the-contributions-of-oxytocin-and-vasopressin-pathway-genes-to-human-behavior
#18
REVIEW
Richard P Ebstein, Ariel Knafo, David Mankuta, Soo Hong Chew, Poh San Lai
Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans. There is intense interest in how these simple nonapeptides mediate normal and abnormal behavior, especially regarding disorders of the social brain such as autism that are characterized by deficits in social communication and social skills. The current review examines in detail the behavioral genetics of the first level of human AVP-OXT pathway genes including arginine vasopressin 1a receptor (AVPR1a), oxytocin receptor (OXTR), AVP (AVP-neurophysin II [NPII]) and OXT (OXT neurophysin I [NPI]), oxytocinase/vasopressinase (LNPEP), ADP-ribosyl cyclase (CD38) and arginine vasopressin 1b receptor (AVPR1b)...
March 2012: Hormones and Behavior
https://www.readbyqxmd.com/read/22203440/angiotensinase-and-vasopressinase-activities-in-hypothalamus-plasma-and-kidney-after-inhibition-of-angiotensin-converting-enzyme-basis-for-a-new-working-hypothesis
#19
A B Villarejo, A B Segarra, M Ramírez, I Banegas, R Wangensteen, M de Gasparo, J Cobo, F Alba, F Vives, I Prieto
Reducing angiotensin II (Ang II) production via angiotensin-converting enzyme (ACE) inhibitors is a key approach for the treatment of hypertension. However, these inhibitors may also affect other enzymes, such as angiotensinases and vasopressinase, responsible for the metabolism of other peptides also involved in blood pressure control, such as Ang 2-10, Ang III, Ang IV, and vasopressin. We analyzed the activity of these enzymes in the hypothalamus, plasma, and kidney of normotensive adult male rats after inhibition of ACE with captopril...
February 2012: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/21330387/leucyl-cystinyl-aminopeptidase-gene-variants-in-septic-shock
#20
Taka-aki Nakada, James A Russell, Hugh Wellman, John H Boyd, Emiri Nakada, Katherine R Thain, Simone A Thair, Hiroyuki Hirasawa, Shigeto Oda, Keith R Walley
BACKGROUND: Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock. METHODS: We tested for association between single nucleotide polymorphisms (SNPs) in vasopressin pathway genes and altered outcome in derivation (n = 589) and replication (n = 616) cohorts of patients with septic shock. The primary outcome was 28-day mortality and the secondary outcome was vasopressin clearance. In a third cardiac surgical cohort (n = 977), we tested for locus-specific heritability of serum sodium concentrations...
May 2011: Chest
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