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CKD OR "Chronic Kidney Disease"

Andres M Pineda, J Kevin Harrison, Neal S Kleiman, Michael J Reardon, John V Conte, Daniel P O'Hair, Stanley J Chetcuti, Jian Huang, Steven J Yakubov, Jeffrey J Popma, Nirat Beohar
OBJECTIVES: To assess the treatment effect of TAVR versus SAVR on clinical outcomes to 3 years in patients stratified by chronic kidney disease (CKD) by retrospectively studying patients randomized to TAVR or SAVR. BACKGROUND: The impact of CKD on mid-term outcomes of patients undergoing TAVR versus SAVR is unclear. METHODS: Patients randomized to TAVR or SAVR in the CoreValve US Pivotal High Risk Trial were retrospectively stratified by eGFR: none/mild or moderate/severe CKD...
October 20, 2018: Catheterization and Cardiovascular Interventions
Suresh Chandra Dash, Sanjay Kumar Agarwal, Ansuman Panigrahi, Jayanti Mishra, Debadutta Dash
Objectives: The study was designed to find out frequency of (i) Diabetes mellitus (DM) as a cause Chronic Kidney Disease (CKD), (ii) Association between diabetic-CKD (diabetic patients who subsequently developed CKD as complication), hypertension (HT) and obesity. Further assessment was made to (iii) Identify percentage of diabetics attending medical and nephrology OPD had prior testing for proteinuria and or creatinine. Methods: After ethical consideration this prospective observational study was conducted on consecutive 6175 patients who gave consent to participate in two major referral hospitals one in Delhi and other in Bhubaneswar (BBSR)...
March 2018: Journal of the Association of Physicians of India
Yoshihiko Imamura, Yasunori Takahashi, Toshihide Hayashi, Masateru Iwamoto, Rie Nakamura, Mikiko Goto, Kazuyo Takeba, Makoto Shinohara, Shun Kubo, Nobuhiko Joki
BACKGROUND: Comprehensive education about lifestyle, nutrition, medications and other types of treatment is important to prevent renal dysfunction in patients with chronic kidney disease (CKD). However, the effectiveness of multidisciplinary care on CKD progression has not been evaluated in detail. We aimed to determine whether multidisciplinary care at our hospital could help prevent worsening renal function associated with CKD. METHODS: A total of 150 pre-dialysis CKD outpatients accompanied (n = 68) or not (n = 82) with diabetes mellitus (DM) were enrolled into this study...
October 19, 2018: Clinical and Experimental Nephrology
Shinji Machida, Yugo Shibagaki, Tsutomu Sakurada
BACKGROUND: Chronic kidney disease (CKD) is a significant health problem in Japan, and prevention programs to slow disease progression are necessary. In this study, we evaluated the effectiveness of a 1-week inpatient education program, delivered during the predialysis stage of CKD, in slowing the deterioration in renal function over the subsequent 2 years, and identified factors influencing the program's effectiveness. METHODS: We retrospectively evaluated the estimated glomerular filtration rate (eGFR) of 105 consecutive patients who completed the program, at the following time points: 6 months prior to program initiation, at program initiation and, at 6, 12, 18, and 24 months after the program...
October 19, 2018: Clinical and Experimental Nephrology
Chengguo Wei, Khadija Banu, Felipe Garzon, John M Basgen, Nimrod Philippe, Zhengzi Yi, Ruijie Liu, Jui Choudhuri, Miguel Fribourg, Tong Liu, Arun Cumpelik, Jenny Wong, Mubeen Khan, Bhaskar Das, Karen Keung, Fadi Salem, Kirk N Campbell, Lewis Kaufman, Paolo Cravedi, Weijia Zhang, Philip J O'Connell, John Cijiang He, Barbara Murphy, Madhav C Menon
BACKGROUND: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin-binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development. METHODS: We used human data, Shroom3 knockdown podocytes, and inducible shRNA-mediated knockdown mice to study the role of Shroom3 in adult glomeruli...
October 19, 2018: Journal of the American Society of Nephrology: JASN
Yoshitaka Furuto, Hirotsugu Hashimoto, Akio Namikawa, Haruki Outi, Hiroko Takahashi, Hajime Horiuti, Kazuho Honda, Yuko Shibuya
BACKGROUND: Lenvatinib is a tyrosine kinase inhibitor with novel binding ability. It is considered the standard of care for metastatic thyroid cancer; moreover, whether it is indicated for other malignant tumors has been examined. Lenvatinib increases the risk of kidney injury in some patients. In comparison with sorafenib, which is a conventional tyrosine kinase inhibitor (TKI), lenvatinib results in more side effects, including hypertension and proteinuria. We describe a case of secondary focal segmental glomerulosclerosis (FSGS) that developed following treatment of metastatic thyroid cancer with lenvatinib and reviewed the mechanisms of renal impairment...
October 19, 2018: BMC Nephrology
Cindy George, Yandiswa Y Yako, Ikechi G Okpechi, Tandi E Matsha, Francois J Kaze Folefack, Andre P Kengne
BACKGROUND: Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking. METHODS: We conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) with prevalent CKD, end-stage renaldisease (ESRD) or CKD-associated traits...
October 19, 2018: BMC Medical Genetics
Zhi-Hao Zhang, Jun-Qiu He, Wei-Wei Qin, Ying-Yong Zhao, Ning-Hua Tan
Chronic kidney disease (CKD) has become a major public health problem worldwide and has a great impact on the quality of life of millions of people. Long-term obstructive uropathy is an important cause of CKD. We hypothesized diagnostic biomarkers for early stage obstructive nephropathy can be discovered by metabolomic profiling of biofluid. Unilateral ureteral occlusion (UUO) surgery was performed on rats to induce renal interstitial fibrosis. Sham-operated rats were used as controls. Plasma and urine metabolites were analyzed by UPLC-MS based metabolomic approach...
October 16, 2018: Chemico-biological Interactions
Benjamin O Yarnoff, Thomas J Hoerger, Sundar S Shrestha, Siobhan K Simpson, Nilka R Burrows, Amanda H Anderson, Dawei Xie, Hsiang-Yu Chen, Meda E Pavkov
RATIONALE & OBJECTIVE: As the prevalence of obesity continues to rise in the United States, it is important to understand its impact on the lifetime risk of chronic kidney disease (CKD). STUDY DESIGN: The CKD Health Policy Model was used to simulate the lifetime risk of CKD for those with and without obesity at baseline. Model structure was updated for glomerular filtration rate (GFR) decline to incorporate new longitudinal data from the Chronic Renal Insufficiency Cohort (CRIC) study...
2018: PloS One
Justin B Echouffo-Tcheugui, Meghan I Short, Vanessa Xanthakis, Patrick Field, Todd R Sponholtz, Martin G Larson, Ramachandran S Vasan
Context: The natural histories of obesity sub-phenotypes are incompletely delineated. Objectives: To investigate dynamic changes in obesity sub-phenotypes and associations with outcomes. Design, setting, participants and measurements: Framingham Offspring Cohort participants (n= 4,291) who attended the examination cycles 2 (1979-1983) to 7 (1998-2001) - 26,508 participant-observations. Obesity sub-phenotypes (metabolically healthy non-obese [MHNO], metabolically healthy obese [MHO], metabolically unhealthy non-obese [MUNO], metabolically unhealthy obese [MUO]) were ascertained based on metabolic health (<2 Adult Treatment Panel-III criteria)...
October 18, 2018: Journal of Clinical Endocrinology and Metabolism
Sumeet K Asrani, Linda W Jennings, James F Trotter, Josh Levitsky, Mitra K Nadim, W R Kim, Stevan A Gonzalez, Bernard Fischbach, Ranjeeta Bahirwani, Michael Emmett, Goran Klintmalm
Estimation of glomerular filtration rate (eGFR) in patients with liver disease is suboptimal in presence of renal dysfunction. We developed a model for GFR Assessment In Liver disease (GRAIL) before and after liver transplantation (LT). GRAIL was derived using objective variables (creatinine, blood urea nitrogen, age, gender, race, albumin) to estimate GFR based on timing of measurement relative to LT and degree of renal dysfunction. Measured GFR (mGFR) by iothalamate clearance (n=12,122, 1985-2015) at protocol time points before/after LT was used as reference...
October 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Francisco Ivison Rodrigues Limeira, Monica Yamauti, Allyson Nogueira Moreira, Tuélita Marques Galdino, Cláudia Silami de Magalhães, Lucas Guimarães Abreu
OBJECTIVE: To evaluate studies assessing the prevalence of dental caries and developmental defects of enamel (DDE) in individuals with chronic kidney disease (CKD) in comparison with individuals without CKD. MATERIALS AND METHODS: Electronic searches were performed in Pubmed, Web of Science, Scopus, Medline via Ovid and ProQuest databases from their inception date until February 2018. Two review authors independently selected the studies, extracted data, and assessed the methodological quality...
October 18, 2018: Oral Diseases
Emily C Moody, Steven G Coca, Alison P Sanders
PURPOSE OF REVIEW: Arsenic (As), cadmium (Cd), and lead (Pb) are ubiquitous toxicants with evidence of adverse kidney impacts at high exposure levels. There is less evidence whether environmental exposure to As, Cd, or Pb plays a role in development of chronic kidney disease (CKD). We conducted a systematic review to summarize the recent epidemiologic literature examining the relationship between As, Cd, or Pb with CKD. RECENT FINDINGS: We included peer-reviewed studies published in English between January 2013 and April 2018 for As and Cd, and all dates prior to April 2018 for Pb...
October 18, 2018: Current Environmental Health Reports
Mohinder R Vindhyal, Sinan Khayyat, Adnan Shaaban, Brent A Duran, K James Kallail
Introduction Heart failure (HF) is one of the most common causes of hospitalization and readmissions. Approximately six million Americans are living with HF. Among patients with HF, hospitalization rate in the United States is higher for those over age 65, making it one of the leading causes of hospitalization in this age group. Furthermore, about 15% of those who were hospitalized with HF were readmitted within 30 days and 30% within 60 days. HF and chronic kidney disease (CKD) share many risk factors; therefore, it is expected that CKD is more prevalent in HF...
August 9, 2018: Curēus
Marina A Aleksinskaya, Matthieu Monge, Michiel Siebelt, Edith M Slot, Karin M Koekkoek, Ruben G de Bruin, Ziad A Massy, Harrie Weinans, Ton J Rabelink, Willem E Fibbe, Anton Jan van Zonneveld, Melissa van Pel
In chronic kidney disease (CKD), endothelial injury, is associated with disease progression and an increased risk for cardiovascular complications. Circulating cells with vascular reparative functions are hematopoietic and also reduced in CKD. To explore the mechanistic basis behind these observations, we have investigated hematopoietic stem cell (HSC) homeostasis in a mouse model for non-progressive CKD-mineral and bone disorder with experimentally induced chronic renal failure (CRF). In mice subjected to 12 weeks of CRF, bone marrow HSC frequencies were decreased and transplantation of bone marrow cells from CRF donors showed a decrease in long-term HSC repopulation compared to controls...
October 18, 2018: Scientific Reports
Esteban A Cedillo-Couvert, Jesse Y Hsu, Ana C Ricardo, Michael J Fischer, Ben S Gerber, Edward J Horwitz, John W Kusek, Eva Lustigova, Amada Renteria, Sylvia E Rosas, Milda Saunders, Daohang Sha, Anne Slaven, James P Lash
BACKGROUND AND OBJECTIVES: In the general population, the quality of the patient experience with their primary care physician may influence health outcomes but this has not been evaluated in CKD. This is relevant for the growing Hispanic CKD population, which potentially faces challenges to the quality of the patient experience related to language or cultural factors. We evaluated the association between the patient experience with their primary care physician and outcomes in Hispanics with CKD...
October 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Delphine S Tuot
No abstract text is available yet for this article.
October 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Pedrum Mohammadi-Shemirani, Jennifer Sjaarda, Hertzel C Gerstein, Darin J Treleaven, Michael Walsh, Johannes F Mann, Matthew J McQueen, Sibylle Hess, Guillaume Paré
BACKGROUND: Identifying markers of chronic kidney disease (CKD) that occur early in the disease process and are specific to loss of kidney function rather than other underlying causes of disease may allow earlier, more accurate identification of patients who will develop CKD. We therefore sought to identify diagnostic blood markers of early CKD that are caused by loss of kidney function by using an innovative "reverse Mendelian randomization" (MR) approach. METHODS: We applied this technique to genetic and biomarker data from 4147 participants in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial, all with known type 2 diabetes, impaired fasting glucose, or impaired glucose tolerance...
October 18, 2018: Clinical Chemistry
Marco Hatem-Vaquero, Sergio de Frutos, Alicia Luengo, Alba González Abajo, Mercedes Griera, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros
BACKGROUND: Patients with chronic kidney disease present with an accumulation of uraemic toxins, which have been identified as pathogenic agents associated with cardiovascular mortality, which is very high is this patient group. A phenomenon common to the progressive renal dysfunction and associated vascular damage, is the abnormal accumulation of extracellular matrix (ECM) proteins in the renal or vascular structures. OBJECTIVE: To determine the contribution of uraemia or the uraemic toxins to the production of cytokinins and ECM in aortas of uraemic animals or human aortic smooth muscle cells (HASMCs)...
October 15, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Jeff Murray, Abilash Balmuri, Alok Saurav, Aiman Smer, Venkata Mahesh Alla
Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. Coronary angiography (CAG) and percutaneous coronary intervention (PCI) are frequently performed in patients presenting with a non-ST elevation myocardial infarction (NSTEMI). Utilizing the National Inpatient Sample database, we assessed the trends in utilization of CAG, PCI, and coronary artery bypass grafting in 3,654,586 admissions with NSTEMI from 2001 to 2012. The rates of CAG were 54%, 36.1%, and 45.9%, respectively, in patients with normal renal function, patients with CKD not on renal replacement therapy (RRT), and patients with CKD requiring RRT...
September 8, 2018: American Journal of Cardiology
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