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Leonardo Calza, Vincenzo Colangeli, Marco Borderi, Simona Coladonato, Beatrice Tazza, Isabella Bon, Maria Carla Re, Pierluigi Viale
Objectives: An observational, prospective, cohort study was performed to assess changes in insulin sensitivity and serum leptin level after a switch from a ritonavir-boosted PI (PI/r) to raltegravir or dolutegravir in HIV-infected adults on stable combination ART (cART). Methods: Non-diabetic HIV-infected patients receiving suppressive cART including tenofovir disoproxil fumarate/emtricitabine plus one PI/r, who underwent a switch from the PI/r to raltegravir (group A) or dolutegravir (group B), were enrolled in the study...
December 12, 2018: Journal of Antimicrobial Chemotherapy
Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole
Background: Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium. Objectives: The aim of this study was to test the hypothesis that magnesium supplementation differentially affects vitamin D metabolism dependent on baseline 25-hydroxyvitamin D [25(OH)D] concentration...
December 1, 2018: American Journal of Clinical Nutrition
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design: Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015...
December 1, 2018: American Journal of Clinical Nutrition
Gaetano Ruocco, Isabella Evangelista, Beatrice Franci, Barbara Lucani, Simona Martini, Ranuccio Nuti, Alberto Palazzuoli
BACKGROUND: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. METHODS: We performed an echocardiographic examination and measured ST-2 and BNP within 24 h of hospital admission...
December 11, 2018: Journal of Cardiovascular Medicine
Maëlle Le Thiec, Daniela Rusu, Vincent Fleury, Francoise Kraeber-Bodéré, Caroline Rousseau
Peritoneal carcinomatosis in prostate cancer is extremely rare and has been described in only few cases with high PSA level, androgen deprivation, or in symptomatic patients. To date, 2 cases of Ga-PSMA PET positive peritoneal metastases have been reported. We report a case of urachus metastases showed on Ga-PSMA PET/CT performed for biochemical recurrence with a very low PSA level at 0.50 ng/mL.
January 2019: Clinical Nuclear Medicine
Russell Jude Chander, Heidi Foo, Tingting Yong, Levinia Lim, Jayne Tan, Ming-Ching Wen, Adeline Ng, Shahul Hameed, Simon Ting, Juan Zhou, Nagaendran Kandiah
Individuals with mild cognitive impairment (MCI) exhibit varying serial position effect (SPE) performances. The relationship between SPE performance in word list recall and clinical, genetic, and neuroimaging features of MCI requires elucidation. 119 MCI and 68 cognitively normal (CN) participants underwent cognitive assessment, apolipoprotein E (ApoE) genotyping, and volumetric MRI brain scans processed via voxel-based morphometry. A 10-word recall task was used to assess SPE performance in relation to recency and primacy recall...
December 12, 2018: Aging
Daniel Onimisi Avazi, Augustine Cheh Awasum, Adamu Zoaka Hassan, Joseph Olusegun Ayo, Tagang Aluwong, Sa'idu Tanko Muhammed, Ayo Yila Simon, Mohammad Hadi Suleiman, Ayuba Caleb Kudi
The aim of the study was to investigate the time-course of serum and wound fluids interleukin (IL)-6 and IL-8 levels in dogs with cutaneous wounds and their relationship with some haematologic parameters. The experimental group comprised of six adult dogs that underwent surgery with wounds (n = 6) on the mid lateral aspect of the right antebrachium; and control group of six, apparently, healthy intact (free from cutaneous wounds) adult dogs, comprising equal number of both sexes. Vital signs evaluated were within normal limits...
January 2019: Cytokine
Darby G Brooke, Gunnar Cervin, Olivier Champeau, D Tim Harwood, Henrik Pavia, Andrew I Selwood, Johan Svenson, Louis A Tremblay, Patrick L Cahill
A range of natural products from marine invertebrates, bacteria and fungi have been assessed as leads for nature-inspired antifouling (AF) biocides, but little attention has been paid to microalgal-derived compounds. This study assessed the AF activity of the spirocyclic imine portimine (1), which is produced by the benthic mat-forming dinoflagellate Vulcanodinium rugosum. Portimine displayed potent AF activity in a panel of four macrofouling bioassays (EC50 0.06-62.5 ng ml-1 ), and this activity was distinct from that of the related compounds gymnodimine-A (2), 13-desmethyl spirolide C (3), and pinnatoxin-F (4)...
December 12, 2018: Biofouling
Tara B Hendry-Hofer, Patrick C Ng, Alyssa E Witeof, Sari B Mahon, Matthew Brenner, Gerry R Boss, Vikhyat S Bebarta
Cyanide, a metabolic poison, is a rising chemial threat and ingestion is the most common route of exposure. Terrorist organizations have threatened to attack the USA and international food and water supplies. The toxicokinetics and toxicodynamics of oral cyanide are unique, resulting in high-dose exposures, severe symptoms, and slower onset of symptoms. There are no FDA-approved therapies tested for oral cyanide ingestions and no approved intramuscular or oral therapies, which would be valuable in mass casualty settings...
December 11, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Dinesh Sah, Puneet Kumar Verma, K Maharaj Kumari, Anita Lakhani
Samples of PM2.5 were collected from an urban area close to a national highway in Agra, India and sequentially extracted into four different fractions: water soluble (F1), reducible (F2), oxidizable (F3) and residual fraction (F4) for chemical fractionation of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), nickel (Ni) and lead (Pb). The metals were analyzed by inductively coupled plasma optical emission spectroscopy in each fraction. The average mass concentration of PM2.5 was 93 ± 24 μg m-3 ...
December 11, 2018: Environmental Geochemistry and Health
Fuyong Zhong, Xianhui Zhang, Guanghui Li, Zhenwu Tang, Xue Han, Jiali Cheng
More information is required to improve our understanding of the presence of organic ultraviolet absorbents (UVAs) in organisms and the risks posed to biota. Effective removal of lipids in the determination of UVAs in biological samples is a sample-processing bottleneck. In this study, we optimized a multistep purification method for fish tissue samples extracted using an ultrasonic-assisted extraction method. The purification method involved performing Florisil column chromatography, redissolving the extract in ethanol, and then performing dispersive solid-phase extraction using primary and secondary amine, Florisil, and C18 silica sorbents...
December 11, 2018: Environmental Monitoring and Assessment
Teuku Armansyah, Edi Rusmansyah Putra Barat, Cut Vela Risqa Handini, Dwinna Aliza, Amalia Sutriana, Hamdan Hamdan, Budianto Panjaitan, Arman Sayuti, Tongku Nizwan Siregar
This study aimed to determine the effect of seminal vesicle extract administration to increase the concentration and motility of spermatozoa and testosterone level of kacang goat. The experiment was arranged using a randomly completely block design (RCBD). Three kacang goats were used and each goat received three treatments namely P0 (2 mL of 0.9% NaCl), P1 (1.5 mL Capriglandin, PGF2α), and P2 (2 mL of seminal vesicle extract, EVS). Semen and blood were collected two days post-treatment to measure the concentration and motility of spermatozoa and testosterone level...
2018: Open Veterinary Journal
Manh Ha Nguyen, Tien Duc Pham, Thi Lien Nguyen, Hai Anh Vu, Thi Thao Ta, Minh Binh Tu, Thi Hong Yen Nguyen, Dinh Binh Chu
A high-performance liquid chromatography (HPLC) in combination with inductively coupled plasma mass spectrometry (ICP-MS) as an elemental specific detector was used for the speciation analysis of arsenic compounds in urine and serum samples from Vietnam. Five arsenic species including arsenite (AsIII ), arsenate (AsV ), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB) were studied. A gradient elution of ammonium carbonate ((NH4 )2 CO3 ), ethylenediaminetetraacetic acid disodium salt (Na2 EDTA), and methanol at pH 9...
2018: Journal of Analytical Methods in Chemistry
Beata Morawiec, Brygida Przywara-Chowaniec, Piotr Muzyk, Mariusz Opara, Lam Ho, Lui Chun Tat, Olivier Muller, Ewa Nowalany-Kozielska, Damian Kawecki
Background: Clinical short-term risk stratification is a recommended approach in patients with chest pain and possible acute myocardial infarction (AMI) to further improve high safety of biomarker-based rule-out algorithms. The study aim was to assess clinical performance of baseline concentrations of high-sensitivity cardiac troponin T (hs-TnT) and copeptin and the modified HEART score (mHS) in early presenters to the emergency department with chest pain. Methods: This cohort study included patients with chest pain with onset maximum of 6 h before admission and no persistent ST-segment elevation on electrocardiogram...
2018: Disease Markers
Manoj Gupta, Partha Sarathi Choudhury, Sudhir Rawal, Harish Chandra Goel, S Avinash Rao
Purpose: The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), and MD Anderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression...
December 2018: Nuclear Medicine and Molecular Imaging
Wenjie Zheng, Junling Yang, Zhizhen Dong, Li Wang, Miao Fang, Wei Wu, Dengfu Yao, Min Yao
Purpose: High mobility group box 3 (HMGB3) is associated with hepatocytes malignant transformation by our previous work. We continued to investigate the diagnostic and prognostic values of HMGB3 for hepatocellular carcinoma (HCC). Patients and methods: Circulating HMGB3 levels were quantitatively detected in a cohort of 225 patients with chronic liver diseases by ELISA and compared with alpha-fetoprotein by the receiver operating characteristic curve. HMGB3 expression in tissues of 170 HCC was detected by tissue microarray and immunohistochemistry...
2018: Cancer Management and Research
Anas A Youssef, Hisham A Issa, Maha Z Omar, Eman G Behiry, Asmaa A Elfallah, Ali Hasaneen, Mohamed Darwish, Dalia B Ibrahim
Objectives: The aim of this study was to assess serum levels of endocan & VEGF in patients with hepatitis C virus-related HCC and their diagnostic and predictive value of mortality. Methods: A total of 195 patients with CHC were subdivided into the following two groups: 105 HCV cirrhotic patients with HCC and 90 HCV cirrhotic patients without HCC. Sixty apparently healthy subjects served as the control group. The serum VEGF and endocan were assessed by ELISA...
2018: Clinical and Experimental Gastroenterology
Anand Avati, Kenneth Jung, Stephanie Harman, Lance Downing, Andrew Ng, Nigam H Shah
BACKGROUND: Access to palliative care is a key quality metric which most healthcare organizations strive to improve. The primary challenges to increasing palliative care access are a combination of physicians over-estimating patient prognoses, and a shortage of palliative staff in general. This, in combination with treatment inertia can result in a mismatch between patient wishes, and their actual care towards the end of life. METHODS: In this work, we address this problem, with Institutional Review Board approval, using machine learning and Electronic Health Record (EHR) data of patients...
December 12, 2018: BMC Medical Informatics and Decision Making
Wei Gao, Yong Tian, Huan Liu, Yaqi Cai, Aifeng Liu, Yong-Liang Yu, Zongshan Zhao, Guibin Jiang
Rapid detection of ultratrace pollutants in complex matrices is a great challenge for studying their environmental behaviors and impacts. In this work, a method is developed by combining covalent organic framework (COF) based solid phase microextraction (SPME) with constant flow desorption ionization mass spectrometry for rapid detection of trace tetrabromobisphenol A (TBBPA) in multiple water media. The limits of detection and qualification are 0.92 and 3.1 ng L-1 for TBBPA, respectively. The linear range is between 0...
December 12, 2018: Analytical Chemistry
Hwee-Yeong Ng, Yueh-Ting Lee, Wei-Hung Kuo, Pei-Chen Huang, Wei-Chia Lee, Chien-Te Lee
BACKGROUND/AIMS: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. METHODS: Sprague-Dawley rats were fed with high fructose diet (60%) for 3 months (FR-3) and 5 months (FR-5). At the end study, serum and urine biochemical data were compared...
December 7, 2018: Kidney & Blood Pressure Research
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