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Yuan Meng, Xiaohui Liu, Shaoyong Lu, Tingting Zhang, Baichuan Jin, Qiao Wang, Zhurui Tang, Ying Liu, Xiaochun Guo, Junli Zhou, Beidou Xi
Polycyclic aromatic hydrocarbons (PAHs) residues have attracted attention worldwide. This study summarizes the current levels of PAH exposure in the water environments of lakes. In addition, the risk levels from individual PAHs and ΣPAHs in the water environments of lakes in China were evaluated by incremental lifetime cancer risk (ILCR) assessment, the toxic equivalent concentration (TEQBaP ), the risk quotient (RQ), the effects range-low (ERL) and the effects range-median (ERM). The results showed that the concentrations of ∑PAHs in water and sediment ranged from 4...
October 14, 2018: Science of the Total Environment
Tangtian He, Mirabelle Mei Po Tsui, Chih Jui Tan, Ka Yan Ng, Fu Wen Guo, Li Hsueh Wang, Te Hao Chen, Tung Yung Fan, Paul Kwan Sing Lam, Margaret Burkhardt Murphy
The benzophenone (BP) organic ultraviolet (UV) filters have been measured in seawater at ng/L to μg/L levels, but more data on their effects in non-target marine organisms are needed. Corals can be exposed to BPs due to wastewater discharges and coastal recreational activities. In this study, toxicities and bioaccumulation of BP-1 (2,4-dihydroxybenzophenone), BP-3 (oxybenzone), BP-4 (sulisobenzone) and BP-8 (dioxybenzone) to larvae and adults of two coral species, Pocillopora damicornis and Seriatopora caliendrum, were assessed at concentrations ranging from 0...
October 11, 2018: Science of the Total Environment
Praveen Satapute, Milan V Kamble, Shivakantkumar S Adhikari, Sudisha Jogaiah
Pesticides are generally applied to agricultural soil to control crop diseases, with the critical goal of preventing yield loss and optimizing economic returns. However, the excessive utilization of pesticides in agriculture is a severe environmental and human health problem. In the present study, effect of triazole based fungicide, propiconazole on soil physicochemical properties, stimulatory impact of propiconazole residue on soil microbial communities and soil enzyme activities (phosphatise and urease) in contaminated red sandy loam and deep black soils of paddy (Oryza sativa L...
October 9, 2018: Science of the Total Environment
Sung-Hee Seo, Min-Hui Son, Eun-Su Shin, Sung-Deuk Choi, Yoon-Seok Chang
This study investigated perfluoroalkyl substances (PFASs) in multimedia environments to confirm the effects of emission sources of PFASs and to elucidate their spatial distribution. The highest PFAS levels were detected from the samples of air (272.30 pg/m3 ) and surface water (36.54 ng/L) in an industrial complex area, meanwhile high PFAS levels were found from the samples of soil (8.80 ng/g) and sediment (84.98 ng/g) in urban areas and near wastewater treatment plants (WWTPs). Perfluorobutane sulfonate (PFBS) was primarily detected in water, influent and effluent, whereas long chain perfluorocarboxylic acids (PFCAs) and perfluorooctane sulfonate (PFOS) were dominant in dust, soil, sediment and sludge...
October 5, 2018: Journal of Hazardous Materials
Xiaotian Tan, Anu David, James Day, Haoyue Tang, Emily Rose Dixon, Hongbo Zhu, Yu-Cheng Chen, Maung Kyaw Khaing Oo, Ariella Shikanov, Xudong Fan
Follicle stimulating hormone (FSH) plays a critical role in female reproductive development and homeostasis. The blood/serum concentration of FSH is an important marker for reporting multiple endocrinal functions. Standardized method for mouse FSH (mFSH) quantification based on radioimmunoassay (RIA) suffers from long assay time (~2 days), relatively low sensitivity, larger sample volume (60 μL), and small dynamic range (2-60 ng/mL), thus is insufficient for monitoring fast developing events with relatively small mFSH fluctuations (e...
October 18, 2018: ACS Sensors
Soroor Sadegh Malvajerd, Amir Azadi, Zhila Izadi, Masoumeh Kurd, Tahereh Dara, Maryam Dibaei, Mohammad Sharif Zadeh, Hamid Akbari-Javar, Mehrdad Hamidi
Curcumin is a multi-therapeutic agent with great therapeutic potential in central nervous system (CNS) diseases. In the current study curcumin was encapsulated in solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for the purpose of increasing the brain accumulation. The preparation processes have been optimized using experimental design and multi-objective optimization method. Entrapment efficiency of curcumin in SLNs and NLCs was found to be 82% ± 0.49 and 94% ± 0.74, respectively...
October 17, 2018: ACS Chemical Neuroscience
Yueyuan Li, Wenjuan Zhu, Qing Kang, Lei Yang, Yong Zhang, Yaoguang Wang, Qin Wei
The detection of insulin by electrochemical (EC) immunoassay is desirable but highly challenged due to the obstacle of improving accuracy, especially in single response system. In this work, based on Cu7S4-Au as a dual signal indicator, we fabricated a dual mode electrochemical immunoassay for insulin. Especially, Cu7S4 presents a strong differential pulse voltammetry (DPV) signal for the electron transfer between the Cu2+ and Cu+, without the addition of K3[Fe(CN)6] or other electron transfer mediators. Furthermore, Cu7S4 displays high sensitivity and high electrocatalytic activity towards the reduction of H2O2 through chronoamperometry (CA)...
October 18, 2018: ACS Applied Materials & Interfaces
Manyando Simbotwe, Daisuke Fujikura, Miyuki Ohnuma, Ryosuke Omori, Yoshikazu Furuta, Geoffrey Munkombwe Muuka, Bernard Mudenda Hang'ombe, Hideaki Higashi
In Zambia, anthrax outbreaks among cattle are reported on nearly an annual basis. Presently, there is a lack of serological assays and information to develop an anthrax management and control strategy. In this study, an indirect enzyme-linked immunosorbent assay (ELISA) based on recombinant protective antigen domain 1 (rPA-D1) of Bacillus anthracis was developed and used to detect anti-PA antibodies in cattle in Zambia. An antigen coating of 10 ng/well and a serum dilution of 1:100 were determined to be the optimal rPA-D1 ELISA titration conditions...
2018: PloS One
Qianyu Li, Jinglu Wu, Zhonghua Zhao
Concentrations of polycyclic aromatic hydrocarbons (PAHs) were measured in 22 surface sediment samples and an approximately 100-year scale sediment core collected from Poyang Lake. This valuable sediments enable analysis of spatial and temporal distribution patterns of PAH sources, and determine the anthropogenic impacts on Poyang Lake. Total PAH concentrations in the surface sediments ranged from 73.2 to 367.2 ng/g dw, and higher residues were encountered in regions with high-density populations and intensive human activities...
2018: PloS One
Yoon Sun Ree, Hyun-Moon Back, Hwi-Yeol Yun, Ji Hyun Ahn, Eun Sun Son, Jung Woo Han, Chuhl Joo Lyu, Sandy Jeong Rhie
PURPOSE: Retinoblastoma is a childhood malignancy of the retina. To increase the exposures of systemic chemotherapy, high-dose cyclosporine, as a P-glycoprotein modulating agent, has been combined with a standard chemotherapy. However, the effective and safe dose of cyclosporine has not been well evaluated. This study is to optimize cyclosporine dose using population pharmacokinetic modeling. METHODS: Clinical data were obtained from 161 systemic chemotherapy cycles of 34 pediatric retinoblastoma patients between December 2006 and April 2015...
October 18, 2018: Journal of Ocular Pharmacology and Therapeutics
Jennifer R Seal, Michael R Robinson, James Burke, Marina Bejanian, Michael Coote, Mayssa Attar
PURPOSE: To explore the ocular distribution of bimatoprost after intracameral administration of a biodegradable sustained-release bimatoprost implant (Bimatoprost SR) versus repeated topical administration of bimatoprost 0.03% ophthalmic solution in dogs. Bimatoprost SR and topical bimatoprost 0.03% previously were shown to have similar intraocular pressure-lowering effects in humans in a phase 1/2 clinical trial. METHODS: Twenty-four beagle dogs received either once-daily topical bimatoprost 0...
October 18, 2018: Journal of Ocular Pharmacology and Therapeutics
Li Li, Jia Liu, Shuang Qin, Ruiman Li
Present study was aimed to detect the influence of cytotoxic T-lymphocyte associated protein 4 (CTLA4) gene polymorphisms for the risk of recurrent spontaneous abortion (RSA), as well as the serum level of CTLA4 protein in RSA patients.One hundred thirty-three RSA patients and 146 healthy persons were recruited in this case-control study. PCR-RFLP was used to genotype the CTLA4 gene polymorphisms both in case and control groups. Serum level of CTLA4 was detected by ELISA kit. Quantitative variables were compared by t test or Mann-Whitney U test between groups...
October 2018: Medicine (Baltimore)
Pooja Dewan, Anupriya Dixit, Sunil Gomber, Mrinalini Kotru, Basu D Banerjee, Vipin Tyagi, Rajeev K Malhotra
Bone marrow iron estimation remains the gold standard for diagnosing iron-deficiency anemia (IDA); serum ferritin, total iron-binding capacity, and transferrin saturation are routinely used as surrogate markers of IDA. However, these tests are marred by problems like poor specificity and sensitivity. Recently, hepcidin, a protein hormone synthesized in the liver and excreted in urine, has been shown to be related to iron status. We estimated the serum and urinary hepcidin levels in healthy children aged 6 to 60 months with (n=30) and without IDA (n=30)...
October 16, 2018: Journal of Pediatric Hematology/oncology
Burcin Erkal, Aysel Kalayci Yigin, Sukru Palanduz, Selcuk Dasdemir, Mehmet Seven
Klinefelter syndrome (KS) is a common sex chromosome-related abnormality seen among men. KS negatively affects spermatogenesis and testosterone production. It increases the risk of thrombosis but its molecular mechanism has not been well described yet. Elevated PAI-1 is a risk factor for thrombosis. The rs1799889 polymorphism located in the promoter region of the PAI-1 gene was detected in patients with deep venous thrombosis. In this study, the PAI-1 gene variant and its plasma levels in KS patients were examined...
November 2018: American Journal of Men's Health
Enrico Miceli, Benno Kuropka, Christine Rosenauer, Ernesto R Osorio Blanco, Loryn E Theune, Mrityunjoy Kar, Christoph Weise, Svenja Morsbach, Christian Freund, Marcelo Calderón
AIM: We analyzed the protein corona of thermoresponsive, poly(N-isopropylacrylamide)- or poly(N-isopropylmethacrylamide)-based nanogels. MATERIALS & METHODS: Traces of protein corona detected after incubation in human serum were characterized by proteomics and dynamic light scattering in undiluted serum. RESULTS: Apolipoprotein B-100 and albumin were the main components of the protein coronae. For dendritic polyglycerol-poly(N-isopropylacrylamide) nanogels at 37°C, an increase in adsorbed immunoglobulin light chains was detected, followed by partially reversible nanogel aggregation...
October 18, 2018: Nanomedicine
Rohit Abraham John, Natalia Yantara, Yan Fong Ng, Govind Narasimman, Edoardo Mosconi, Daniele Meggiolaro, Mohit R Kulkarni, Pradeep Kumar Gopalakrishnan, Chien A Nguyen, Filippo De Angelis, Subodh G Mhaisalkar, Arindam Basu, Nripan Mathews
Emulation of brain-like signal processing is the foundation for development of efficient learning circuitry, but few devices offer the tunable conductance range necessary for mimicking spatiotemporal plasticity in biological synapses. An ionic semiconductor which couples electronic transitions with drift-diffusive ionic kinetics would enable energy-efficient analog-like switching of metastable conductance states. Here, ionic-electronic coupling in halide perovskite semiconductors is utilized to create memristive synapses with a dynamic continuous transition of conductance states...
October 17, 2018: Advanced Materials
Chen Men, Chun Hong Li, Xue Mei Wei, Jia Jun Liu, Yu Xin Liu, Cheng Zhi Huang, Shu Jun Zhen
Ricin is an extremely potent ribosome-inactivating protein and serves as a likely food biocontaminant or biological weapon. Thus, simple, sensitive and accurate analytical assays capable of detecting ricin are urgently needed to be established. Herein, we present a novel method for ricin B-chain (RTB) detection by using two materials: (a) a highly efficient hybrid probe that was formed by linking a glucose oxidase (GOD)-encapsulated liposome (GOD-L) to magnetic beads (MBs) through hybridization between an aptamer and a blocker and (b) a new low-background g-C3N4-MnO2 sandwich nanocomposite that exhibits fluorescence resonance energy transfer (FRET) between the g-C3N4 nanosheet and MnO2...
October 18, 2018: Analyst
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Yasuhide Kofunato, Teruhide Ishigame, Ryo Okada, Naoya Sato, Takashi Kimura, Akira Kenjo, Shigeru Marubashi
The identification of novel biomarkers for hepatocellular carcinoma (HCC) is of great importance in improving the outcome of patients with HCC. The present study aimed to determine the prognostic significance of the soluble intercellular adhesion molecule (sICAM)-1 in patients with HCC. The present study prospectively collected clinicopathological data from 36 patients with HCC who had undergone successful hepatectomy. An analysis using a receiver operating characteristic (ROC) curve was performed to determine the cut-off value for predicting prognosis...
November 2018: Oncology Letters
Xavier Charest-Morin, Jacques Hébert, Georges-Étienne Rivard, Arnaud Bonnefoy, Eric Wagner, François Marceau
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation. An enzyme immunoassay for BK was applied to extracts of citrated blood incubated at 37°C under gentle agitation for 0-2 h in the presence of activators and/or inhibitory agents. Biologically active kinins in extracts were corroborated by c-Fos accumulation in HEK 293a cells that express either recombinant human B2 or B1 receptors (B2 R, B1 R)...
2018: Frontiers in Immunology
Tamio Okimoto, Yukari Tsubata, Takamasa Hotta, Megumi Hamaguchi, Mika Nakao, Shun-Ichi Hamaguchi, Akinobu Hamada, Takeshi Isobe
The central nervous system is a common site of relapse in patients receiving crizotinib, which is presumed to be associated with the low concentration of crizotinib in the cerebrospinal fluid (CSF). Our patient received surgical treatment for anaplastic lymphoma kinase-positive stage IIA lung adenocarcinoma. His cancer recurred with brain metastases and carcinomatous meningitis. We started whole-brain radiation therapy (WBRT) and subsequently administered crizotinib. The concentration of crizotinib on day 15 in the plasma was 158 ng/mL, and that in the spinal fluid was 4...
October 17, 2018: Internal Medicine
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