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https://www.readbyqxmd.com/read/30110719/erythropoietic-effects-of-low-dose-cobalt-application
#1
Torben Hoffmeister, Dirk Schwenke, Nadine Wachsmuth, Oliver Krug, Mario Thevis, William Byrnes, Walter Schmidt
Cobaltous ions (Co2+ ) stabilize HIFα, increase endogenous erythropoietin (EPO) production, and may, therefore, be used as performance-enhancing substance. To date, the dosage necessary to stimulate erythropoiesis is unknown. The aim of this study was, therefore, to determine the minimum dosage necessary to increase erythropoietic processes. In a first double-blind placebo-controlled study (n=5), single oral Co2+ dosages of 5 mg (n=6) and 10 mg (n=7) were administered to healthy young men. Cubital venous blood and urine samples were collected before and up to 24 h after Co2+ administration...
August 15, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/30110704/fetal-goitrous-hypothyroidism-and-polyhydramnios-in-a-patient-with-compound-heterozygous-duoxa2-mutations
#2
Kanako Tanase-Nakao, Ichiro Miyata, Ayako Terauchi, Maki Saito, Seiji Wada, Tomonobu Hasegawa, Satoshi Narumi
BACKGROUND: Fetal goiter is only rarely observed in pregnant women without autoimmune thyroid disorders, and there is no epidemiological data on its pathophysiology. Dual oxidase maturation factor 2 (DUOXA2), together with dual oxidase 2, serves pivotal roles in thyroid hormone biosynthesis. To date, all reported patients with DUOXA2 mutations were diagnosed postnatally through newborn screening for congenital hypothyroidism. CASE REPORT: The mother of a male fetus presented at 33 + 4 gestational weeks (GW) with a fetal goiter and polyhydramnios...
August 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/30110608/ultrasensitive-quantification-of-cardiac-troponin-i-by-a-single-molecule-counting-method-analytical-validation-and-biological-features
#3
Alvaro Garcia-Osuna, David Gaze, Margarita Grau-Agramunt, Thomas Morris, Catarina Telha, Amelita Bartolome, Jeffrey J Bishop, Luis Monsalve, Richard Livingston, Joel Estis, Niamh Nolan, Johanna Sandlund, Jordi Ordonez-Llanos
AIM: To evaluate analytical and biological characteristics of the Singulex Clarity® cTnI assay, based upon Single Molecule Counting technology. METHODS: Assay's analytical sensitivity, precision, linearity, hook effect, cross-reactivity or interference by endogenous and exogenous substances, stability, 99th reference percentile [p99th] in EDTA plasma were evaluated in single or multi-site studies. RESULTS: Detection limit was 0.12 ng/L...
August 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30110546/noble-gas-inserted-metal-acetylides-metal-cu-ag-au
#4
Gourhari Jana, Sudip Pan, Gabriel Merino, Pratim Kumar Chattaraj
Metal acetylides (MCCH, M = Cu, Ag, Au) were already reported to be experimentally detected in molecular form. Herein, we investigate the possibility of noble gas (Ng) insertion within C-H bond of MCCH and their stability is compared with those of the reported MNgCCH and HCCNgH molecules. Our coupled-cluster computations show that MCCNgH (Ng = Kr, Xe, Rn) systems corresponds to minima on the potential energy surfaces, whereas their lighter analogues do not remain in the chemically bound form. Further, their stability is analyzed with respect to all possible dissociation channels...
August 15, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/30110513/unified-strategy-for-hplc-ms-evaluation-of-bioactive-compounds-for-quality-control-of-herbal-products
#5
Polina Turova, Elena Stekolshchikova, Timur Baygildiev, Oleg Shpigun, Igor Rodin, Andrey Stavrianidi
Evaluation of safety, quality and composition of herbal products and food supplements based on botanical ingredients is a matter of serious concern. For screening of botanicals in herbal products multi-targeted and group-targeted approaches may be applied. In the group-targeted approach botanicals are characterized by means of appropriate group of structurally related biomarkers instead of multi-targeted approach where the number of selected analytes are monitored based on multiple reaction monitoring survey...
August 15, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/30110425/a-lateral-flow-strip-based-on-gold-nanoparticles-to-detect-6-monoacetylmorphine-in-oral-fluid
#6
Jia Liu, Xiaolong Hu, Fangqi Cao, Yurong Zhang, Jianzhong Lu, Libo Zeng
We used lateral flow strips based on gold nanoparticles to detect 6-monoacetylmorphine (6-MAM; heroin's unique metabolite) in oral fluid samples. In this competitive lateral chromatographic immunoassay, the 6-MAM was chemically synthesized and conjugated to bovine serum albumin. The results were qualitatively detected via the colour change of the test line. By using a proper sample pad, a suitable nitrocellulose membrane and a customized sponge device adsorbed the oral fluid directly from the mouth; the total test time was 3 min...
June 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30110347/optimization-of-fluorophores-for-chemical-tagging-and-immunohistochemistry-of-drosophila-neurons
#7
Geoffrey W Meissner, Jonathan B Grimm, Rebecca M Johnston, Ben Sutcliffe, Julian Ng, Gregory S X E Jefferis, Sebastian Cachero, Luke D Lavis, Oz Malkesman
The use of genetically encoded 'self-labeling tags' with chemical fluorophore ligands enables rapid labeling of specific cells in neural tissue. To improve the chemical tagging of neurons, we synthesized and evaluated new fluorophore ligands based on Cy, Janelia Fluor, Alexa Fluor, and ATTO dyes and tested these with recently improved Drosophila melanogaster transgenes. We found that tissue clearing and mounting in DPX substantially improves signal quality when combined with specific non-cyanine fluorophores...
2018: PloS One
https://www.readbyqxmd.com/read/30109787/anemia-management-among-hemodialysis-patients-with-high-ferritin-levels
#8
Yael Einbinder, Timna Agur, Kirill Davidov, Tali Zitman-Gal, Eliezer Golan, Sydney Benchetrit
BACKGROUND: Anemia management strategies among chronic hemodialysis patients with high ferritin levels remains challenging for nephrologists. OBJECTIVES: To compare anemia management in stable hemodialysis patients with high (≥ 500 ng/ml) vs. low (< 500 ng/ml) ferritin levels. METHODS: In a single center, record review, cohort study of stable hemodialysis patients who were followed for 24 months, an anemia management policy was amended to discontinue intravenous (IV) iron therapy for stable hemodialysis patients with hemoglobin > 10 g/dl and ferritin ≥ 500 ng/ml...
July 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/30109775/detection-of-the-designer-benzodiazepine-flunitrazolam-in-urine-and-preliminary-data-on-its-metabolism
#9
Alice Ameline, Camille Richeval, Jean-Michel Gaulier, Jean-Sébastien Raul, Pascal Kintz
Designer benzodiazepines emerged as recreational drugs and are available via the Internet without control and are found in the form of falsified (fake) medicines. For some of them, limited information concerning their effects, their toxicity and their detection in bio fluids are available in the literature. For others, nothing has been published, as in the case for flunitrazolam (FNTZ). In order to gain preliminary data on its elimination parameters in urine and to investigate its metabolism, one of the authors ingested one pink tablet bought on the Internet, after confirming the absence of other compounds and agreement with the labeled dosage (0...
August 14, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/30109716/simultaneous-ultraperformance-liquid-chromatography-tandem-mass-spectrometry-determination-of-four-antihypertensive-drugs-in-human-plasma-using-hydrophilic-lipophilic-balanced-reversed-phase-sorbents-sample-preparation-protocol
#10
Marianne A Mahrouse
Therapeutic drug monitoring of angiotensin converting enzyme inhibitors (ACEI) has a great impact in blood pressure control in patient with heart failure, hepatic and renal impairment. To provide an efficient tool for drug assessment in plasma, UPLC-MS/MS method was developed for simultaneous determination of benazepril hydrochloride (BNZ), fosinopril sodium (FOS), captopril (CAP) and hydrochlorothiazide (HCT) in human plasma samples. Solid phase extraction was applied for sample preparation using OASIS® hydrophilic-lipophilic balanced reversed phase sorbents cartridges...
August 14, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/30109590/aflatoxin-m-1-levels-in-different-marketed-milk-products-in-nairobi-kenya
#11
Johanna Frida Lindahl, I N Kagera, D Grace
Milk is an important source of energy and nutrients, especially for children, and in Kenya, milk consumption is higher than other countries in the region. One major concern with milk is the risks of chemical contaminants, and reports of high levels of aflatoxin M1 (AFM1 ) in milk in Kenya has been causing public health concerns. This study collected marketed milk products every month during 1 year, just as a consumer would purchase them from retailers and traders in a low-income area, and a major supermarket in a middle/high-income area...
August 14, 2018: Mycotoxin Research
https://www.readbyqxmd.com/read/30109442/nephrotoxicity-and-kidney-transport-assessment-on-3d-perfused-proximal-tubules
#12
Marianne K Vormann, Linda Gijzen, Simon Hutter, Lisette Boot, Arnaud Nicolas, Angelique van den Heuvel, Jelle Vriend, Chee Ping Ng, Tom T G Nieskens, Vincent van Duinen, Bjorn de Wagenaar, Rosalinde Masereeuw, Laura Suter-Dick, Sebastiaan J Trietsch, Martijn Wilmer, Jos Joore, Paul Vulto, Henriette L Lanz
Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates from the body into the urine, leading to high local concentrations of xenobiotics. This makes the proximal tubule a major target for drug toxicity that needs to be evaluated during the drug development process. Here, we describe an advanced in vitro model consisting of fully polarized renal proximal tubular epithelial cells cultured in a microfluidic system. Up to 40 leak-tight tubules were cultured on this platform that provides access to the basolateral as well as the apical side of the epithelial cells...
August 14, 2018: AAPS Journal
https://www.readbyqxmd.com/read/30109430/physico-chemical-parameters-and-levels-of-polycyclic-aromatic-hydrocarbons-in-water-sediments-and-soil-in-river-nzoia-kakamega-county-kenya
#13
J K Basweti, M P Nawiri, H N Nyambaka
The River Nzoia basin is the main source of water for domestic, agricultural, and industrial activities. The levels of the priority polycyclic aromatic hydrocarbons (PAHs) in water, soil, and sediments of River Nzoia during two seasons are reported. The physico-chemical parameters gave levels that were within the maximum allowable limit but with significant differences between the wet and dry seasons (p < 0.005). In water (max: 0.092 ± 0.003 ng/L) and soils (max 9.74 ± 1.97 ng/g), levels were significantly higher in the wet season unlike in sediment (8...
August 14, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/30109145/selection-and-evaluation-of-an-efficient-method-for-the-recovery-of-viral-nucleic-acid-extraction-from-complex-biologicals
#14
Sarmitha Sathiamoorthy, Rebecca J Malott, Lucy Gisonni-Lex, Siemon H S Ng
There is a need for a broad and efficient testing strategy for the detection of both known and novel viral adventitious agents in vaccines and biologicals. High-throughput sequencing (HTS) is an approach for such testing; however, an optimized testing method is one with a sample-processing pipeline that can help detect any viral adventitious agent that may be present. In this study, 11 commercial methods were assessed for efficient extraction of nucleic acids from a panel of viruses. An extraction strategy with two parallel arms, consisting of both the Invitrogen PureLink™ Virus RNA/DNA kit for total nucleic acid extraction and the Wako DNA Extractor® kit with an RNase A digestion for enrichment of double-stranded nucleic acid, was selected as the strategy for the extraction of all viral nucleic acid types (ssRNA, dsRNA, and dsDNA)...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/30109037/new-sporopollenin-based-%C3%AE-cyclodextrin-functionalized-magnetic-hybrid-adsorbent-for-magnetic-solid-phase-extraction-of-nonsteroidal-anti-inflammatory-drugs-from-water-samples
#15
Syed Fariq Fathullah Syed Yaacob, Muhammad Afzal Kamboh, Wan Aini Wan Ibrahim, Sharifah Mohamad
A magnetic solid-phase extraction (MSPE) procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI) as a linker and further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD), was developed for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs), namely, indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP) and fenoprofen (FNP) from water samples prior to their HPLC-DAD determination. The newly synthesized MSp-TDI-βCD was comprehensibly characterized using FT-IR, XRD, SEM-EDX, BET and VSM analyses...
July 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30108644/the-bioavailability-and-pharmacokinetics-of-silymarin-smedds-formulation-study-in-healthy-thai-volunteers
#16
Chuleegone Sornsuvit, Darunee Hongwiset, Songwut Yotsawimonwat, Manatchaya Toonkum, Satawat Thongsawat, Wandee Taesotikul
The present study aimed to determine the pharmacokinetic parameters and bioavailability of silymarin 140 mg SMEDDS formulation. An open-label, single-dose pharmacokinetic study was conducted. Twelve healthy volunteers were included in the study. After the volunteers had fasted overnight for 10 h, a single-dose generic silymarin 140 mg SMEDDS soft capsule was administered. Then 10 ml blood samples were taken at 0.0, 0.25, 0.50, 0.75, 1.0, 1.33, 1.67, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10.0, and 12.0 h. The plasma silybin concentrations were analyzed using validated LC-MS/MS...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30108431/irisin-protects-macrophages-from-oxidized-low-density-lipoprotein-induced-apoptosis-by-inhibiting-the-endoplasmic-reticulum-stress-pathway
#17
Guanlin Zheng, Haizhen Li, Tie Zhang, Libo Yang, Shutong Yao, Shihong Chen, Maochuan Zheng, Qin Zhao, Hua Tian
Irisin is a newly discovered myokine which can relieve metabolic disorders and resist atherosclerosis. The effects of irisin on ox-LDL-induced macrophage apoptosis and endoplasmic reticulum stress-related pathways were observed in vitro . RAW264.7 macrophages were cultured in vitro and pretreated with irisin at 20, 40 and 80 ng/ml for 30 min, followed by culture with 100 mg/L ox-LDL and 5 mg/L tunicamycin (TM) for 12 h. The cell viability and apoptosis were detected by MTT assay and annexin V-FITC double staining...
July 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/30108392/role-of-melatonin-in-management-of-hypoxic-ischaemic-encephalopathy-in-newborns-a-randomized-control-trial
#18
Qazi Mumtaz Ahmad, Akmal Laeeq Chishti, Nayyab Waseem
OBJECTIVE: To find out the effect of melatonin as adjunct therapy on outcome of admitted newborns presenting with hypoxic ischaemic encephalopathy. METHODS: This randomized controlled trial was conducted at King Edward Medical University, Lahore, Pakistan, from October 2016 to March 2017, and comprised newborns with gestational age of 34 weeks or higher who fulfilled the definition of hypoxic ischaemic encephalopathy and presented within 12 hours of birth. The severity of hypoxic ischaemic encephalopathy was assessed by Thompson score...
August 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30108375/role-of-the-4kscore-test-as-a-predictor-of-reclassification-in-prostate-cancer-active-surveillance
#19
Ángel Borque-Fernando, José Rubio-Briones, Luis M Esteban, Yan Dong, Ana Calatrava, Álvaro Gómez-Ferrer, Enrique Gómez-Gómez, Jesús M Gil Fabra, Nuria Rodríguez-García, Pedro Á López González, Jorge García-Rodríguez, Miguel Rodrigo-Aliaga, Bernardo Herrera-Imbroda, Juan Soto-Villalba, Sara Martínez-Breijo, Virginia Hernández-Cañas, Ana M Soto-Poveda, Carlos Sánchez-Rodríguez, Carlos Carrillo-George, Yumaira E Hernández-Martínez, David Okrongly
BACKGROUND: Management of active surveillance (AS) in low-risk prostate cancer (PCa) patients could be improved with new biomarkers, such as the 4Kscore test. We analyze its ability to predict tumor reclassification by upgrading at the confirmatory biopsy at 6 months. METHODS: Observational, prospective, blinded, and non-randomized study, within the Spanish National Registry on AS (AEU/PIEM/2014/0001; NCT02865330) with 181 patients included after initial Bx and inclusion criteria: PSA ≤10 ng/mL, cT1c-T2a, Grade group 1, ≤2 cores, and ≤5 mm/50% length core involved...
August 14, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/30108343/vitamin-d-and-associated-perinatal-neonatal-outcomes-among-extremely-low-birth-weight-infants
#20
Birju A Shah, James F Padbury, Michael P Anderson, Michael F Holick, Edgardo Szyld, Catherine M Gordon
OBJECTIVE: To evaluate vitamin D inadequacy among extremely low-birth-weight (ELBW, <1000 g) infants and the association between circulating vitamin D concentrations and perinatal-neonatal outcomes. STUDY DESIGN: Prospective cohort study of ELBW infants in the neonatal ICU. Blood was collected within the first 3 days after birth after obtaining informed consent. Circulating 25-hydroxyvitamin D concentrations (25(OH)D) were quantified using liquid chromatography-tandem mass spectroscopy and classified as vitamin D deficient, insufficient, or adequate ( < 20, 20-30, or > 30 ng/mL, respectively)...
August 14, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
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