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Martin Ruste, Laurent Bitker, Hodane Yonis, Zakaria Riad, Aurore Louf-Durier, Floriane Lissonde, Sophie Perinel-Ragey, Claude Guerin, Jean-Christophe Richard
BACKGROUND: Hemodynamic response to prone position (PP) has never been studied in a large series of patients with acute respiratory distress syndrome (ARDS). The primary aim of this study was to estimate the rate of PP sessions associated with cardiac index improvement. Secondary objective was to describe hemodynamic response to PP and during the shift from PP to supine position. METHODS: The study was a single-center retrospective observational study, performed on ARDS patients, undergoing at least one PP session under monitoring by transpulmonary thermodilution...
December 7, 2018: Annals of Intensive Care
Phillipp Schwarzfischer, Dariusz Gruszfeld, Piotr Socha, Veronica Luque, Ricardo Closa-Monasterolo, Déborah Rousseaux, Melissa Moretti, Benedetta Mariani, Elvira Verduci, Berthold Koletzko, Veit Grote
BACKGROUND/OBJECTIVES: The aim of this study was to examine the effect of physical activity (PA) and sedentary behaviour (SB) on body mass index (BMI) and fat mass index (FMI) in children over the course of five years and identify potential bi-directional associations. SUBJECTS/METHODS: Data were drawn from the EU Childhood Obesity Project (CHOP). PA and SB were measured with the SenseWear Armband 2 at the ages of 6 (T1), 8 (T2) and 11 (T3) years. Height and weight were measured and BMI was calculated at each time point, resulting in 1254 complete observations from 600 children...
December 7, 2018: International Journal of Behavioral Nutrition and Physical Activity
Caroline Solda, Fernando Branco Barletta, José Roberto Vanni, Paula Lambert, Marcus Vinícius Reis Só, Carlos Estrela
The present study assessed oxygen saturation (SaO2) levels before, during, and after at-home bleaching treatment in the pulps of healthy maxillary central incisors. SaO2 levels were measured in 136 healthy maxillary central incisors using a pulse oximeter. The bleaching protocol consisted of 10% carbamide peroxide gel placed in individual trays and used for four hours daily for 14 days. SaO2 levels were assessed before bleaching (T0), immediately after the first session (T1), on the 7th day of treatment (T2), on the 15th day (the day following the last session) (T3), and 30 days after completion of the bleaching protocol (T4)...
November 2018: Brazilian Dental Journal
Selvihan Beysel, Nilnur Eyerci, Ferda Alparslan Pinarli, Mahmut Apaydin, Muhammed Kizilgul, Mustafa Caliskan, Ozgur Ozcelik, Seyfullah Kan, Erman Cakal
This is the first study to investigate the effect of vitamin D receptor ( VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case-control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. VDR gene polymorphisms BsmI, ApaI, and TaqI did not differ between the papillary thyroid cancer group and control group (p > 0...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Rebecca L Lambach, Nicole E Stafford, Julie A Kolesar, B Jenny Kiratli, Graham H Creasey, Robin S Gibbons, Brian J Andrews, Gary S Beaupre
OBJECTIVE: To determine the effect of a functional electrical stimulation (FES) rowing program on bone mineral density (BMD) when implemented within two years after SCI. DESIGN: Prospective. SETTING: Health Care Facility. PARTICIPANTS: Convenience sample; four adults with recent (<2 years) traumatic, motor complete SCI (C7-T12 AIS A-B). INTERVENTION: A 90-session FES rowing exercise program; participants attended 30-minute FES training sessions approximately three times each week for the duration of their participation...
November 26, 2018: Journal of Spinal Cord Medicine
Rieko Ohta, Ayako Demachi-Okamura, Yoshiki Akatsuka, Hiroshi Fujiwara, Kiyotaka Kuzushima
This study presents an efficient method to improve TCR affinity, comprising 1) CDR-directed saturation mutation of TCR cDNA, 2) transient TCR display on CD3-expressing HEK293T (CD3-293 T) cells by simple plasmid transfection, 3) staining with HLA-tetramers, and 4) multi-round sorting of cells with CD8-independent tetramer binding on a flow cytometer. Using these procedures, we successfully identified mutant TCRs with enhanced binding from an HLA-A*24:02-restricted, human telomerase reverse transcriptase (hTERT)-specific TCR...
November 22, 2018: Journal of Immunological Methods
Sogand Assarnia, Sima Ardalan Khales, Mohammad Mahdi Forghanifard
SALL4, as a stemness marker, plays a key role in the maintenance of pluripotency and self-renewal of cancer stem cells. To elucidate probable linkage between SALL4 stemness marker and bone morphogenetic protein (BMP) cell signaling pathway, we aimed to analyze the expression levels of the related genes in esophageal squamous cell carcinoma (ESCC) patients. Tumoral and corresponding margin normal tissues from 50 treatment-naive ESCC patients were subjected for expression analysis using relative comparative real-time reverse transcription polymerase chain reaction...
November 15, 2018: Journal of Biochemical and Molecular Toxicology
Lisa Beatty, Emma Kemp, Joseph R Coll, Jane Turner, Phyllis Butow, Donna Milne, Patsy Yates, Sylvie Lambert, Addie Wootten, Desmond Yip, Bogda Koczwara
PURPOSE: This multicentre randomised controlled trial examined the efficacy of Finding My Way (FMW), a 6-week/6-module online self-guided psychotherapeutic intervention for newly diagnosed curatively treated cancer survivors, in reducing cancer-related distress and improving quality of life compared to an online attention control. METHODS: Participants were randomised on a 1:1 ratio using a gender-stratified block design to intervention (n = 94) or attention control (n = 97), and were blinded to condition...
November 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Li Zhang, Fengxiang Zhang, Yanxin Li, Xiangjun Qi, Yaming Guo
Breast cancer (BC) severely threatens women's life, and Triiodothyronine (T3) shows a positive role on BC cell proliferation, while the potential mechanism underlying it is still unclear. T3 was used to stimulate BC cell lines MCF-7 and T47-D. Real-time PCR was performed to determine the expression of miRNAs, while western blot was used to measure protein expression of Amphiregulin (AREG), AKT and p-AKT. The interaction between miR-204 and AREG was determined using luciferase reporter assay. MTT was performed to detect cell viability...
November 8, 2018: Pathology Oncology Research: POR
Deguo Wang, Yong Wu, Yueyun Chen, Ancai Wang, Kun Lv, Xiang Kong, Yang He, Nengwei Hu
Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. The present study determined the effects of intrathecal RTX administration on transverse aortic constriction (TAC)-induced cardiac dysfunction and cardiac remodeling in rats. Five days before TAC, RTX (2 μg/10 μl) was injected intrathecally into the T2/T3 interspace of rats. Cardiac sympathetic nerve activities (CSNAs) and cardiac structure and function were determined eight weeks after TAC...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Qing Tu, Zhou Yang, Jianhui Gan, Jian Zhang, Bin Que, Qiaofeng Song, Yan Wang
The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS...
January 1, 2018: Technology in Cancer Research & Treatment
Monica Rocco, P Pelaia, P Di Benedetto, G Conte, L Maggi, S Fiorelli, M Mercieri, C Balestra, R A De Blasi
PURPOSE: Underwater divers face several potential neurological hazards when breathing compressed gas mixtures including nitrogen narcosis which can impact diver's safety. Various human studies have clearly demonstrated brain impairment due to nitrogen narcosis in divers at 4 ATA using critical flicker fusion frequency (CFFF) as a cortical performance indicator. However, recently some authors have proposed a probable adaptive phenomenon during repetitive exposure to high nitrogen pressure in rats, where they found a reversal effect on dopamine release...
October 22, 2018: European Journal of Applied Physiology
Heidi Hautajärvi, Janne Hukkanen, Miia Turpeinen, Sampo Mattila, Ari Tolonen
Cholesterol oxidation product 4β‑hydroxycholesterol (4β‑OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A activity by 4β‑OHC plasma or serum levels, may be of clinical significance. The plasma and serum concentrations of 4α‑hydroxycholesterol (4α‑OHC), an isomer of 4β‑OHC, increase during uncontrolled storage conditions and therefore serve as an indicator of proper handling of samples...
October 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Craig Sykes, Kimberly Blake, Nicole White, Amanda P Schauer, Bryan B Guzman, Mackenzie L Cottrell, Bani Tamraz, Angela D M Kashuba
Measurement of drug concentrations in hair provides a non-invasive approach to assess drug adherence. Here, we report on the development and validation of a method for the quantification of the antiretroviral dolutegravir (DTG) extracted from human hair. DTG is extracted from hair samples by sonication and incubation in 50:50 methanol:acetonitrile with 2% formic acid overnight at 40 °C. Following extraction, samples are analyzed by reverse-phase chromatography on a Waters Atlantis T3 (50 × 2.1 mm, 3-μm particle size) column with subsequent detection by electrospray ionization in positive ion mode on an AB Sciex API-5000 triple quadrupole mass spectrometer...
October 2, 2018: Analytical and Bioanalytical Chemistry
Chien-Chun Li, Chih-Ching Yen, Ciou-Ting Fan, Wei-Ting Chuang, Chin-Shiu Huang, Haw-Wen Chen, Chong-Kuei Lii
Obesity is highly correlated with several metabolic disorders. Adipocyte differentiation is a key process in determining obesogenesis. 14-Deoxy-11,12-didehydroandrographolide (deAND) is a diterpenoid rich in Andrographis paniculata (Burm.f.) Nees., a herbal medicine commonly used to treat colds, infections, and liver diseases. We investigated whether deAND inhibits the adipogenesis of 3T3-L1 cells and the underlying mechanisms. We found that deAND (0-15 μM) dose-dependently inhibits the mRNA and protein expression of peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein 1c, fatty acid synthase, and stearoyl-CoA desaturase-1...
September 21, 2018: Toxicology and Applied Pharmacology
Leonidas H Duntas, Gabriela Brenta
Thyroid dysfunction, manifesting as either overt or subclinical hypothyroidism, negatively affects lipid metabolism: this leads to hypercholesterolemia which progressively increases the risk for cardiovascular disease and, potentially, mortality. Hypercholesterolemia in hypothyroidism is mainly due to a reduction in low-density lipoprotein (LDL) receptor activity, this accompanied by concomitant diminishing control by triiodothyronine (T3) of sterol regulatory element-binding protein 2 (SREBP-2), which modulates cholesterol biosynthesis by regulating rate-limit degrading enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) activity...
2018: Frontiers in Endocrinology
Ioannis Kyrou, Olu Adesanya, Nicholas Hedley, Sarah Wayte, Dimitris Grammatopoulos, Claire L Thomas, Andrew Weedall, Subash Sivaraman, Lavanya Pelluri, Thomas M Barber, Vinod Menon, Harpal S Randeva, Miroslav Tedla, Martin O Weickert
Background: Obesity may affect both biochemical thyroid function tests; and thyroid morphology, as assessed using ultrasound scans (US). The aim of the present pilot study was to explore whether weight loss achieved by bariatric surgery alters thyroid US morphology including gray-scale measurements; and/or function in euthyroid adults with severe obesity. Methods: Euthyroid adults (>18 years) with body mass index (BMI) ≥40 kg/m2 and negative thyroid peroxidase antibodies were assessed at baseline (pre-surgery) and after achieving at least 5% weight loss of their baseline body weight following bariatric surgery...
2018: Frontiers in Endocrinology
Giuseppe Carrà, Cristina Crocamo, Matthias Angermeyer, Traolach Brugha, Mondher Toumi, Paul Bebbington
BACKGROUND: Recent network models of schizophrenia propose it is the consequence of mutual interaction between its symptoms. While cross-sectional associations between negative and positive symptoms are consistent with this idea, they may merely reflect their involvement in the diagnostic process. Longitudinal analyses however may allow the identification of possible causal relationships. The European Schizophrenia Cohort (EuroSC) provides data suitable for this purpose. METHODS: EuroSC includes 1208 patients randomly sampled from outpatient services in France, Germany and the UK...
August 31, 2018: Schizophrenia Research
Feiby L Nassan, Tim I M Korevaar, Brent A Coull, Niels E Skakkebæk, Stephen A Krawetz, Molly Estill, Elizabeth J Hait, Joshua R Korzenik, Jennifer B Ford, Ralph A De Poortere, Maarten A Broeren, Alan C Moss, Thomas R Zoeller, Russ Hauser
BACKGROUND: Dibutyl phthalate (DBP) is an endocrine disruptor and used in some medication coatings, such as mesalamine for treatment inflammatory bowel disease (IBD). OBJECTIVES: To determine whether high-DBP from some mesalamine medications alters thyroid function. METHODS: Seventy men with IBD, without thyroid disease or any radiation history participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback)...
January 2019: International Journal of Hygiene and Environmental Health
Xiaogang Zhang, Xia Wang, Chunfeng Dai, Meilian Chen
A simple, rapid and sensitive method for the simultaneous determination of six cephalosporin (cephalexin, cephapirin, cefotaxime, cefazolin, cefalonium and cefquinome) residues in milk was developed by QuEChERS coupled with ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).The milk samples were extracted with 10 mL acetonitrile containing 1%(v/v) acetic acid, and then centrifuged for 10 min.The supernatant was cleaned up with 100 mg C18 adsorbent powder.The analytes were separated on a reversed phase HSS T3 column (100 mm×2...
April 8, 2018: Se Pu, Chinese Journal of Chromatography
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