Read by QxMD icon Read

Phrenic nerve

J Ricoy, N Rodríguez-Núñez, J M Álvarez-Dobaño, M E Toubes, V Riveiro, L Valdés
The diaphragm is the main breathing muscle and contraction of the diaphragm is vital for ventilation so any disease that interferes with diaphragmatic innervation, contractile muscle function, or mechanical coupling to the chest wall can cause diaphragm dysfunction. Diaphragm dysfunction is associated with dyspnoea, intolerance to exercise, sleep disturbances, hypersomnia, with a potential impact on survival. Diagnosis of diaphragm dysfunction is based on static and dynamic imaging tests (especially ultrasound) and pulmonary function and phrenic nerve stimulation tests...
November 30, 2018: Pulmonology
Takuro Nishimura, Kaoru Okishige, Yasuteru Yamauchi, Hideshi Aoyagi, Naruhiko Ito, Yusuke Tsuchiya, Takatoshi Shigeta, Rena Nakamura, Mitsutoshi Asano, Mitsumi Yamashita, Tomofumi Nakamura, Hidetoshi Suzuki, Tsukasa Shimura, Manabu Kurabayashi, Takehiko Keida, Tetsuo Sasano, Kenzo Hirao
Background: Complete occlusion of the pulmonary veins (PVs) with the cryoballoon (CB) is considered to be the crucial factor for a successful PV isolation (PVI). We investigated whether a complete occlusion was indispensable for a successful CB based PVI of every PV. Methods and Results: Atrial fibrillation patients (n=123, 97; paroxysmal) undergoing a de novo PVI were enrolled. A total of 477 PVs were analyzed. The occlusion grade (OG) was scored as follows: OG3 (complete occlusion), OG2 (incomplete occlusion with slight leakage), OG1 (poor occlusion with massive leakage)...
August 2018: Journal of Atrial Fibrillation
E T Karlin, J E Rush, E A Nobrega
A 3-year-old, 20-kg, spayed female, mix-breed dog received a dual-chamber pacemaker for management of symptomatic 3rd-degree atrioventricular block. Synchronous diaphragmatic contraction was documented to occur with atrial pacing. Various methods to reduce the occurrence of pacemaker-related phrenic nerve stimulation are discussed.
November 28, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Giuseppe Ciconte, Žarko Ćalović, Luke C McSpadden, Kyungmoo Ryu, Jan Mangual, Igor Caporaso, Mario Baldi, Massimo Saviano, Amarild Cuko, Raffaele Vitale, Manuel Conti, Luigi Giannelli, Gabriele Vicedomini, Vincenzo Santinelli, Carlo Pappone
PURPOSE: Cardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP]) improves long-term LV reverse remodeling, though questions persist about how to program LV pacing vectors and delays. We evaluated if an empirical method of programming MPP vectors and delays between pacing pulses improved CRT response similar to pressure-volume loop (PVL) optimized MPP programming. METHODS: Patients undergoing CRT implant (Quadra Assura MP™ CRT-D and Quartet™ LV lead) received MPP with programmed settings optimized either by PVL measurements at implant (PVL-OPT group) or empirically determined by maximizing the spatial separation between the two cathodes and minimal delays between the three ventricular pacing pulses (MAX-SEP group)...
November 27, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Serge Boveda, Andreas Metzner, Dinh Q Nguyen, K R Julian Chun, Konrad Goehl, Georg Noelker, Jean-Claude Deharo, George Andrikopoulos, Tillman Dahme, Nicolas Lellouche, Pascal Defaye
OBJECTIVES: The CRYO4PERSISTENT AF (Cryoballoon Ablation for Early Persistent Atrial Fibrillation) trial aims to report long-term outcomes after a single pulmonary vein isolation (PVI)-only ablation procedure using the second-generation cryoballoon in persistent atrial fibrillation (PerAF) patients. BACKGROUND: Pulmonary vein isolation is recognized as the cornerstone of atrial fibrillation (AF) ablation, including ablation of PerAF. METHODS: The CRYO4PERSISTENT AF trial (NCT02213731) is a prospective, multicenter, single-arm trial designed to assess single-procedure outcomes of PVI using the cryoballoon...
November 2018: JACC. Clinical Electrophysiology
Kanchai Malungpaishope, Somsak Leechavengvongs, Patamaporn Ratchawatana, Akaradech Pitakveerakul, Sarun Jindahara, Chairoj Uerpairojkit, Dechporn Putthiwara, Navapong Anantavorasakul, Valerie Huali Tan
BACKGROUND: To report the results of restoring the elbow flexion and extension in patients with total brachial root avulsion injuries by simultaneous transfer of the phrenic nerve to the nerve to the biceps and three intercostal nerves to the nerve of the long head of the triceps. METHODS: Ten patients with total brachial root avulsion injuries underwent the spinal accessory nerve transfer to the suprascapular nerve for shoulder reconstruction. Simultaneous transfer of the phrenic nerve to the nerve to the biceps via the sural nerve graft and three intercostal nerves to the nerve of the long head of the triceps was done for restoration of the elbow flexion and extension...
December 2018: Journal of Hand Surgery Asian-Pacific Volume
Luke M Alvey, James F X Jones, Cathal Tobin-O'Brien, Mark Pickering
The precise cause of the bands of Fontana, striations on peripheral nerves visible to the naked eye, has been the subject of debate for hundreds of years. Some researchers have described them as reflecting the sinuous course of nerve fibres passing through nerves, and others have proposed that endoneurial collagen and sheaths surrounding nerves play a role in their appearance. We hypothesised that the bands are caused exclusively by reflection of light from the surfaces of nerve fibres travelling in phase in sinusoidal waveforms through peripheral nerves...
November 13, 2018: Journal of Anatomy
Ramanan Kumareswaran, Francis E Marchlinski
Epicardial ablation is needed to eliminate ventricular tachycardia (VT) in some patients with nonischaemic cardiomyopathy. The 12-lead electrocardiogram of VT, pre-procedural imaging and endocardial unipolar voltage maps can predict a high likelihood of epicardial substrate and VT. A septal VT substrate may preclude the need for epicardial access and mapping and can be identified with imaging, pacing and voltage mapping. Pericardial access is usually obtained prior to systemic anticoagulation or after reversal of systemic anticoagulation...
August 2018: Arrhythmia & Electrophysiology Review
Carlos B Mantilla, Wen-Zhi Zhan, Heather M Gransee, Y S Prakash, Gary C Sieck
Structural plasticity in motoneurons may be influenced by activation history and motoneuron-muscle fiber interactions. The goal of this study was to examine the morphological adaptations of phrenic motoneurons following imposed motoneuron inactivity while controlling for diaphragm muscle inactivity. Well-characterized rat models were used including unilateral C2 spinal hemisection (SH; ipsilateral phrenic motoneurons and diaphragm muscle are inactive) and tetrodotoxin phrenic nerve blockade (TTX; ipsilateral diaphragm muscle is paralyzed while phrenic motoneuron activity is preserved)...
November 8, 2018: Journal of Comparative Neurology
Keiko Hashimoto, Yoichiro Sugiyama, Shinya Fuse, Toshiro Umezaki, Yoshitaka Oku, Mathias Dutschmann, Shigeru Hirano
OBJECTIVES/HYPOTHESIS: We aimed to investigate and validate the cellular activity patterns and the potential topographical organization of neurons of the medullary swallowing pattern generator (Sw-CPG). We used the perfused brainstem preparation as an innovative experimental model that allows for stable neuronal recording in the brainstem. STUDY DESIGN: Animal model. METHODS: Experiments were conducted in 14 juvenile Wistar rats. The activities of the phrenic, vagus, and hypoglossal nerves were recorded at baseline, and fictive swallowing was elicited by stimulation of the superior laryngeal nerve...
November 8, 2018: Laryngoscope
Robert Da Costa, Pezad Doctor, Kaustubh Mahajan, Vidyadhara G Lakkappan
Neuropathy is one of the major reasons of morbidity in diabetes mellitus (DM). We presented a 64-year-old male who was a case of type 2 DM for >6 years. He presented with orthopnea and respiratory failure secondary to bilateral phrenic neuropathy and resultant diaphragmatic palsy. Clinical examination, ultrasound, and nerve conduction studies confirmed the bilateral involvement of the phrenic nerves. Phrenic neuropathy may be an important, albeit a rare complication of diabetes, and hence, diaphragmatic dysfunction associated with diabetic phrenic neuropathy should be considered in any patient with unexplained breathlessness, orthopnea, and respiratory failure...
October 2018: Indian Journal of Critical Care Medicine
Satyakam Baruah, Sudhir Dubey, Utkarsh Ghavgave, A N Jha
BACKGROUND: Neurological complications are increasingly being reported in dengue epidemics. Intra-spinal hematomas are rare and those associated with dengue fever are still rarer with only one being reported in literature. CASE DESCRIPTION: We report a case of dengue fever presenting with acute onset quadriparesis (upper limbs MRC 4/5 and lower limbs 0/5) and urinary incontinence. Patient was radiologically diagnosed with cervicodorsal acute to subacute anterior epidural hematoma...
November 4, 2018: World Neurosurgery
Yoonjin Kang, Eung Rae Kim, Jae Gun Kwak, Woong-Han Kim
One of the complications of permanent pacemaker implantation is unintended phrenic nerve stimulation. A 15-year-old boy with a permanent pacemaker presented with chest discomfort due to synchronous chest wall contraction with pacing beats. Even after reprogramming of the pacemaker, diaphragmatic stimulation persisted. Therefore, we performed thoracoscopic phrenic nerve insulation using a Gore-Tex patch to insulate the phrenic nerve from the wire. A minimally invasive approach using a thoracoscope is a feasible option for retractable phrenic nerve stimulation after pacemaker implantation...
October 2018: Korean Journal of Thoracic and Cardiovascular Surgery
Kruti B Patel, Shuowei Cai, Michael Adler, Brajendra K Singh, Virinder S Parmar, Bal Ram Singh
Botulinum neurotoxins (BoNTs), the most poisonous proteins known to mankind, are a family of seven (A-G) immunologically distinct proteins synthesized primarily by different strains of the anaerobic bacteria, Clostridium botulinum Being the causative agents of botulism, the toxins block neurotransmitter release by specifically cleaving one of the three SNARE proteins thereby inducing flaccid paralysis. Developing countermeasures and therapeutics against BoNTs are high priority research areas for public health because of their extreme toxicity and potential as bio-warfare agents...
November 2, 2018: Applied and Environmental Microbiology
Ashwin Bhaskaran, Roderick Tung, William G Stevenson, Saurabh Kumar
Non-ischaemic cardiomyopathy (NICM) encompasses a heterogeneous group of disorders that includes genetic, idiopathic, post viral and inflammatory cardiomyopathies. NICM is associated with an increased risk of ventricular arrhythmias (VAs), namely in the form of ventricular tachycardia (VT). Although implanted cardiac defibrillators (ICD) may prevent sudden death from VA, NICM patients may suffer from recurrent symptoms and ICD therapies, and anti-arrhythmic drug side effects. Catheter ablation is highly efficacious in NICM, however poses unique challenges when compared to post myocardial infarction substrates...
October 19, 2018: Heart, Lung & Circulation
Ebru Biricik, Ersel Güleç, Işıl Öcal, Mehmet Bertan Yılmaz, Feride Karacaer, Dilek Özcengiz
Background/aim: We aimed to investigate the effect of long-term use of dexamethasone and prednisolone on the reversal effect of sugammadex. Materials and methods: TTwenty-four male Wistar albino rats were divided into three groups. Dexamethasone (600 µg/kg) was given to group D, prednisolone (10 mg/kg) was given to group P, and an equivalent volume of saline per day was administered intraperitoneally to group S for 14 days, respectively. The left hemidiaphragm with attached phrenic nerve was maintained in Krebs solution...
October 31, 2018: Turkish Journal of Medical Sciences
Luigi Di Biase, Andrea Natale, Jorge Romero
Understanding the anatomy, physiology, and arrhythmogenic and thrombogenic roles of the left atrial appendage (LAA) has become very important. The potential deleterious effects of this chamber in patients with atrial fibrillation have led to the development of specific treatments for this structure. It has been established that the LAA is the area where the vast majority of thrombi in nonvalvular atrial fibrillation are formed and that some LAA morphologies may actually facilitate thrombi formation and risk stratification for thromboembolic events in patients with low CHA2 DS2 -VASc scores...
October 30, 2018: Circulation
Elaine Fernanda da Silva, Mirian Bassi, José Vanderlei Menani, Débora Simões Almeida Colombari, Daniel Breseghello Zoccal, Gustavo Rodrigues Pedrino, Eduardo Colombari
NEW FINDINGS: What is the central question of this study? Does carotid body input contribute to the hyperosmotic responses? What is the main finding and its importance? The response to NaCl overload is sympathorespiratory excitation. Eliminating the carotid body input reduced sympathoexcitation but did not affect the increase in phrenic burst frequency, whereas eliminating the hypothalamus prevented the tachypnoea and sympathoexcitation. We conclude that the carotid body inputs are essential for the full expression of the sympathetic activity during acute NaCl overload, whereas the tachypnoea depends on hypothalamic mechanisms...
October 29, 2018: Experimental Physiology
Elliot Le, Lenhanh Tran
A 16-month old female was referred to our practice for laryngotracheal reconstruction (LTR) for acquired subglottic stenosis (SGS) diagnosed at 4 weeks of age due to prolonged intubation. She has a history of open thoracic repair of congenital tracheoesophageal fistula that was complicated by a pneumothorax and phrenic nerve paralysis. We performed a variation of an anterior and posterior cricoid split LTR with tracheal stenting in order to avoid risks of pulmonary morbidity from costochondral cartilage harvesting...
December 2018: International Journal of Pediatric Otorhinolaryngology
Daryl P Fields, Brandon M Roberts, Alec K Simon, Andrew R Judge, David D Fuller, Gordon S Mitchell
BACKGROUND: Cancer cachexia is an insidious process characterized by muscle atrophy with associated motor deficits, including diaphragm weakness and respiratory insufficiency. Although neuropathology contributes to muscle wasting and motor deficits in many clinical disorders, neural involvement in cachexia-linked respiratory insufficiency has not been explored. METHODS: We first used whole-body plethysmography to assess ventilatory responses to hypoxic and hypercapnic chemoreflex activation in mice inoculated with the C26 colon adenocarcinoma cell line...
October 25, 2018: Journal of Cachexia, Sarcopenia and Muscle
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"