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https://www.readbyqxmd.com/read/29755192/efficacy-and-pharmacokinetics-of-bupivacaine-with-epinephrine-or-dexmedetomidine-after-intraperitoneal-administration-in-cats-undergoing-ovariohysterectomy
#1
RANDOMIZED CONTROLLED TRIAL
Javier Benito, Beatriz Monteiro, Francis Beaudry, Paulo Steagall
The aim of this study was to determine the efficacy and pharmacokinetics of bupivacaine in combination with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy. Sixteen healthy adult cats (3.3 ± 0.6 kg) were included in a prospective, randomized, masked clinical trial after obtaining owners' consent. Anesthetic protocol included buprenorphine-propofol-isoflurane. Meloxicam [0.2 mg/kg body weight (BW)] was administered subcutaneously before surgery. Cats were randomly divided into 2 groups to receive 1 of 2 treatments...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29680394/the-clinical-effects-of-a-low-dose-dexmedetomidine-constant-rate-infusion-in-isoflurane-anesthetized-cats
#2
B T Simon, E M Scallan, C D Coursey, W M Kiehl, E J Moore
The aim of this study was to evaluate the effects of a low dose dexmedetomidine constant rate infusion (CRI) on cardiopulmonary function, inhalant anesthetic concentration and recovery in isoflurane anesthetized cats. In a prospective, randomized, blinded, controlled design, 12 cats undergoing anesthesia for ovariohysterectomy were administered hydromorphone (0.1mg/kg) intramuscularly, propofol (4.3-7.8mg/kg) intravenously and maintained with isoflurane. During isoflurane anesthesia, the cats were administered either a dexmedetomidine loading dose (0...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29627201/perioperative-analgesic-effects-of-an-ultrasound-guided-transversus-abdominis-plane-block-with-a-mixture-of-bupivacaine-and-lidocaine-in-cats-undergoing-ovariectomy
#3
RANDOMIZED CONTROLLED TRIAL
Despoina Skouropoulou, Luca Lacitignola, Paola Centonze, Angela Simone, Alberto M Crovace, Francesco Staffieri
OBJECTIVE: To evaluate the perioperative analgesic effects of a transversus abdominis plane (TAP) block with a mixture of lidocaine and bupivacaine administered to cats undergoing ovariectomy. STUDY DESIGN: Controlled, randomized, prospective, blinded clinical study. ANIMALS: A group of 20 healthy cats. METHODS: Robenacoxib (2 mg kg-1 ) was administered subcutaneously 0.5 hour before intramuscular (IM) administration of ketamine (5 mg kg-1 ), methadone (0...
May 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29606730/effect-of-different-analgesic-techniques-on-hemodynamic-variables-recorded-with-an-esophageal-doppler-monitor-during-ovariohysterectomy-in-dogs
#4
Ignacio Sández, María Soto, Daniel Torralbo, Eva Rioja
This study compared the efficacy of intravenous (IV) fentanyl and ketamine with lumbosacral epidural lidocaine in dogs undergoing ovariohysterectomy. Dogs with esophageal Doppler monitoring ( n = 112) were included in this retrospective study. All dogs were premedicated with dexmedetomidine and methadone, induced with IV propofol or alfaxalone and maintained using isoflurane and IV fentanyl, IV ketamine, or epidural lidocaine. Heart rate (HR), mean arterial pressure (MAP), expired fraction of isoflurane (ETIso), stroke distance (SD), minute distance (MD), peak velocity (PV) and mean acceleration (MA) were recorded before and after ligation of the ovarian pedicle (OvP)...
April 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29551921/effect-of-dexmedetomidine-induced-anesthesia-on-the-postoperative-cognitive-function-of-elder-patients-after-laparoscopic-ovarian-cystectomy
#5
Hui-Ying Xu, Guang-Hua Fu, Gui-Sheng Wu
Objective: To investigate the effect of dexmedetomidine at maintenance dose on the postoperative function of elder patients after general anesthesia for laparoscopic ovarian cystectomy. Methods: We enrolled a total of 96 elder patients who were admitted to this hospital for laparoscopic ovarian cystectomy under general anesthesia between March 2015 and March 2017, and divided them into two groups, Group A (n = 48) and B (n = 48). Patients in both groups received the same methods for anesthesia induction and maintenance drugs...
December 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29150087/dexmedetomidine-methadone-ketamine-versus-dexmedetomidine-methadone-alfaxalone-for-cats-undergoing-ovariectomy
#6
RANDOMIZED CONTROLLED TRIAL
Rocio Fernandez-Parra, Chiara Adami, Thomas Dresco, Thomas M Donnelly, Luca Zilberstein
OBJECTIVE: To compare the duration, quality of anaesthesia and analgesia, and quality of recovery of dexmedetomidine and methadone combined with either ketamine or alfaxalone. STUDY DESIGN: Randomized, prospective clinical trial. ANIMALS: A group of 44 healthy client-owned cats presenting for ovariectomy. METHODS: Cats were randomly assigned to one of the two treatment groups: DAM (n=22), which was administered intramuscularly (IM) dexmedetomidine (15 μg kg-1 ), methadone (0...
November 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28968927/in-vivo-effects-of-dexmedetomidine-on-immune-function-and-tumor-growth-in-rats-with-ovarian-cancer-through-inhibiting-the-p38mapk-nf-%C3%AE%C2%BAb-signaling-pathway
#7
Qi-Hang Cai, Yao Tang, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
OBJECTIVES: During this study, we aimed to analyze the correlation between dosages of dexmedetomidine (DEX) and the p38MAPK/NF-κB signaling pathway, and their effects on immune function and tumor growth in rats with ovarian cancer (OC). METHODS: A total of 100 rats were selected for the purposes of the study. The normal group consisted of 20 rats, while the remaining 80 rats were utilized for OC model establishment purposes, and further assigned into the model, 0...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28190788/a-comparison-of-cardiopulmonary-effects-and-anaesthetic-requirements-of-two-dexmedetomidine-continuous-rate-infusions-in-alfaxalone-anaesthetized-greyhounds
#8
RANDOMIZED CONTROLLED TRIAL
Setefilla Quirós-Carmona, Rocío Navarrete, Juan M Domínguez, María Del Mar Granados, Rafael J Gómez-Villamandos, Pilar Muñoz-Rascón, Daniel Aguilar, Francisco J Funes, Juan Morgaz
OBJECTIVE: To determine the effects of two dexmedetomidine continuous rate infusions on the minimum infusion rate of alfaxalone for total intravenous anaesthesia (TIVA), and subsequent haemodynamic and recovery effects in Greyhounds undergoing laparoscopic ovariohysterectomy. STUDY DESIGN: Prospective, randomized and blinded clinical study. ANIMALS: Twenty-four female Greyhounds. METHODS: Dogs were premedicated with dexmedetomidine 3 μg kg-1 and methadone 0...
March 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28186425/influence-of-two-administration-rates-of-propofol-at-induction-of-anaesthesia-on-its-relative-potency-in-cats-a-pilot-study
#9
RANDOMIZED CONTROLLED TRIAL
Sébastien H Bauquier, Wendy Bayldon, Leon N Warne, Jennifer E Carter, Thierry Beths
Objectives This was a randomised, blinded trial to investigate the influence of administration rate on the dose of propofol required for the orotracheal intubation of cats. Methods Twenty-four female domestic cats undergoing ovariohysterectomy were premedicated with oral tramadol (6 mg/kg) or intramuscular tramadol (4 mg/kg), and intramuscular dexmedetomidine (0.007 mg/kg). Oral or intramuscular (IM) tramadol was administered 60 or 30 mins prior to induction of anaesthesia, respectively. Dexmedetomidine was administered 30 mins prior to anaesthetic induction...
December 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27610299/successful-management-of-dexmedetomidine-for-postoperative-intensive-care-sedation-in-a-patient-with-anti-nmda-receptor-encephalitis-a-case-report-and-animal-experiment
#10
Daiki Yamanaka, Takashi Kawano, Hiroki Tateiwa, Hideki Iwata, Fabricio M Locatelli, Masataka Yokoyama
BACKGROUND: Anti-N-methyl-d-aspartate receptor (NMDA-R) encephalitis is a recently identified but increasingly recognized autoimmune paraneoplastic disease. Because these patients present complex neuropsychiatric symptoms due to NMDA-R dysfunction, the optimal methods of sedation/anesthesia remain controversial. Here, we present animal experiment data, along with a related case report, implying the safe and effective use of dexmedetomidine in patients with anti-NMDA-R encephalitis. FINDINGS: (1) Animal experiment: in order to investigate whether dexmedetomidine may interfere with NMDA-R activity, an NMDA antagonist (MK-801) model in rats was used to simulate anti-NMDA-R encephalitis...
2016: SpringerPlus
https://www.readbyqxmd.com/read/25719847/application-of-fast-track-surgery-principles-to-evaluate-effects-of-atipamezole-on-recovery-and-analgesia-following-ovariohysterectomy-in-cats-anesthetized-with-dexmedetomidine-ketamine-hydromorphone
#11
Michelle M M Hasiuk, Dean Brown, Claire Cooney, Marta Gunn, Daniel S J Pang
OBJECTIVE: To evaluate the effects of atipamezole hydrochloride on recovery and analgesia following ovariohysterectomy in cats anesthetized with a dexmedetomidine hydrochloride, ketamine hydrochloride, and hydromorphone hydrochloride combination, in accordance with fast-track surgery principles. DESIGN: Prospective, randomized, clinical trial. ANIMALS: 44 cats. PROCEDURES: Cats were anesthetized with a combination of dexmedetomidine (15 μg/kg [6...
March 15, 2015: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/25170033/prepubertal-gonadectomy-in-cats-different-injectable-anaesthetic-combinations-and-comparison-with-gonadectomy-at-traditional-age
#12
COMPARATIVE STUDY
Nathalie Porters, Hilde de Rooster, Christel P H Moons, Luc Duchateau, Klara Goethals, Tim Bosmans, Ingeborgh Polis
Anaesthetic and analgesic effects of three different injectable anaesthetic combinations for prepubertal gonadectomy (PPG) in cats were studied. One anaesthetic protocol was compared with a similar one for gonadectomy at traditional age (TAG). Kittens were randomly assigned to PPG or TAG. For PPG, three different protocols were compared: (1) intramuscular (IM) administration of 60 μg/kg dexmedetomidine plus 20 μg/kg buprenorphine followed by an IM injection of the anaesthetic agent (20 mg/kg ketamine) (DB-IM protocol); (2) oral transmucosal (OTM) administration of 80 μg/kg dexmedetomidine plus 20 μg/kg buprenorphine followed by an IM injection of 20 mg/kg ketamine combined with 20 µg/kg dexmedetomidine (DB-OTM protocol); (3) IM injection of a 40 μg/kg medetomidine-20 μg/kg buprenorphine-20 mg/kg ketamine combination (MBK-IM protocol)...
June 2015: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/25039918/postoperative-analgesic-effects-of-either-a-constant-rate-infusion-of-fentanyl-lidocaine-ketamine-dexmedetomidine-or-the-combination-lidocaine-ketamine-dexmedetomidine-after-ovariohysterectomy-in-dogs
#13
RANDOMIZED CONTROLLED TRIAL
Eduardo Gutierrez-Blanco, José M Victoria-Mora, José A Ibancovichi-Camarillo, Carlos H Sauri-Arceo, Manuel E Bolio-González, Carlos M Acevedo-Arcique, Gabriela Marin-Cano, Paulo Vm Steagall
OBJECTIVE: To evaluate the postoperative analgesic effects of a constant rate infusion (CRI) of either fentanyl (FENT), lidocaine (LIDO), ketamine (KET), dexmedetomidine (DEX), or the combination lidocaine-ketamine-dexmedetomidine (LKD) in dogs. STUDY DESIGN: Randomized, prospective, blinded, clinical study. ANIMALS: Fifty-four dogs. METHODS: Anesthesia was induced with propofol and maintained with isoflurane. Treatments were intravenous (IV) administration of a bolus at start of anesthesia, followed by an IV CRI until the end of anesthesia, then a CRI at a decreased dose for a further 4 hours: CONTROL/BUT (butorphanol 0...
May 2015: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/23910822/evaluation-of-the-isoflurane-sparing-effects-of-fentanyl-lidocaine-ketamine-dexmedetomidine-or-the-combination-lidocaine-ketamine-dexmedetomidine-during-ovariohysterectomy-in-dogs
#14
RANDOMIZED CONTROLLED TRIAL
Eduardo Gutierrez-Blanco, José M Victoria-Mora, Jose A Ibancovichi-Camarillo, Carlos H Sauri-Arceo, Manuel E Bolio-González, Carlos M Acevedo-Arcique, Gabriela Marin-Cano, Paulo V M Steagall
OBJECTIVE: To evaluate the isoflurane-sparing effects of an intravenous (IV) constant rate infusion (CRI) of fentanyl, lidocaine, ketamine, dexmedetomidine, or lidocaine-ketamine-dexmedetomidine (LKD) in dogs undergoing ovariohysterectomy. STUDY DESIGN: Randomized, prospective, blinded, clinical study. ANIMALS: Fifty four dogs. METHODS: Anesthesia was induced with propofol and maintained with isoflurane with one of the following IV treatments: butorphanol/saline (butorphanol 0...
November 2013: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/23601417/protective-effects-of-dexmedetomidine-in-pneumoperitoneum-related-ischaemia-reperfusion-injury-in-rat-ovarian-tissue
#15
B Cekic, A Besir, E Yulug, S Geze, M Alkanat
OBJECTIVES: To determine the effects of dexmedetomidine on pneuomoperitoneum-related ischaemia-reperfusion (I/R) injury in rat ovarian tissue. STUDY DESIGN: Animals were randomized into three groups: Group S (n=8), no pneumoperitoneum; Group C (n=8), pneumoperitoneum; and Group D (n=8), 100μg intraperitoneal dexmedetomidine 30min before pneumoperitoneum. Ovarian tissue was collected from all rats 30min after desufflation, and fresh frozen for histological and biochemical evaluation...
July 2013: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/23277701/epidural-anesthesia-and-postoperatory-analgesia-with-alpha-2-adrenergic-agonists-and-lidocaine-for-ovariohysterectomy-in-bitches
#16
RANDOMIZED CONTROLLED TRIAL
Virgínia H Pohl, Adriano B Carregaro, Carlize Lopes, Martielo I Gehrcke, Daniel C M Muller, Clarissa D Garlet
The aim of this study was to determine the viability and cardiorespiratory effects of the association of epidural alpha-2 adrenergic agonists and lidocaine for ovariohysterectomy (OH) in bitches. Forty-two bitches were spayed under epidural anesthesia with 2.5 mg/kg body weight (BW) of 1% lidocaine with adrenaline (CON) or in association with 0.25 mg/kg BW of xylazine (XYL), 10 μg/kg BW of romifidine (ROM), 30 μg/kg BW of detomidine (DET), 2 μg/kg BW of dexmedetomidine (DEX), or 5 μg/kg BW of clonidine (CLO)...
July 2012: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/23230861/an-investigation-about-the-inhibition-of-acute-ischemia-reperfusion-damage-by-dexmedetomidine-in-rat-ovarian-tissue
#17
Ali Kurt, Metin Ingec, Unal Isaoglu, Mehmet Yilmaz, Nihal Cetin, Muhammet Calik, Beyzagul Polat, Fatih Akcay, Cemal Gundogdu, Halis Suleyman
Reperfusion has always been "the emergency intervention" to ischemic tissue. For a given period of time, tissue injury due to ischemia and reperfusion is more serious than injury due to ischemia only. Groups were as: Group 1: 25 µg/kg dexmedetomidine + ischemia/reperfusion group. Group 2: 10 mg/kg yohimbine +25 µg/kg dexmedetomidine + ischemia/reperfusion group. Group 3: Ischemia/reperfusion (control) group. Group 4: Healthy rats. Rat ovaries were exposed to a 3-hour ischemia and then reperfusion ensured for 2 hours...
March 2013: Gynecological Endocrinology
https://www.readbyqxmd.com/read/23113522/evaluation-of-a-ketamine-propofol-drug-combination-with-or-without-dexmedetomidine-for-intravenous-anesthesia-in-cats-undergoing-ovariectomy
#18
RANDOMIZED CONTROLLED TRIAL
Giuliano Ravasio, Martina Gallo, Michela Beccaglia, Stefano Comazzi, Maria Elena Gelain, Diego Fonda, Valerio Bronzo, Annalisa Zonca
OBJECTIVE: To evaluate the use of a ketamine-propofol combination, with or without dexmedetomidine, in cats undergoing ovariectomy and to assess Heinz body formation following administration of these drugs. DESIGN: Randomized clinical trial. ANIMALS: 15 client-owned female cats. PROCEDURES: Anesthesia was induced with a ketamine (2.0 mg/kg [0.91 mg/lb])-propofol (2.0 mg/kg) combination with (n = 7) or without (8) dexmedetomidine (0...
November 15, 2012: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/22788217/alfaxalone-for-total-intravenous-anaesthesia-in-dogs-undergoing-ovariohysterectomy-a-comparison-of-premedication-with-acepromazine-or-dexmedetomidine
#19
RANDOMIZED CONTROLLED TRIAL
Georgina L Herbert, Kelly L Bowlt, Vicky Ford-Fennah, Gwen L Covey-Crump, Joanna C Murrell
OBJECTIVE: To describe alfaxalone total intravenous anaesthesia (TIVA) following premedication with buprenorphine and either acepromazine (ACP) or dexmedetomidine (DEX) in bitches undergoing ovariohysterectomy. STUDY DESIGN: Prospective, randomised, clinical study. ANIMALS: Thirty-eight healthy female dogs. METHODS: Following intramuscular buprenorphine (20 μg kg(-1) ) and acepromazine (0.05 mg kg(-1) ) or dexmedetomidine (approximately 10 μg kg(-1) , adjusted for body surface area), anaesthesia was induced and maintained with intravenous alfaxalone...
March 2013: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/20305886/hemodynamics-and-bispectral-index-bis-of-dogs-anesthetized-with-midazolam-and-ketamine-associated-with-medetomidine-or-dexmedetomidine-and-submitted-to-ovariohysterectomy
#20
Fernando do Carmo Silva, Eduardo Hatschbach, Yuri Karaccas de Carvalho, Bruno Watanabe Minto, Flávio Massone, Paulo do Nascimento Junior
PURPOSE: To evaluate hemodynamics and bispectral index (BIS) in bitches anesthetized with ketamine and midazolam in combination with dexmedetomidine or medetomidine and submitted to ovariohysterectomy. METHODS: Twenty bitches pretreated with levomedetomidine and buprenorphine were anesthetized with 5 mg*kg(-1) ketamine and 0.2 mg*kg(-1) midazolam i.v. Continuous infusion of 0.4 mg*kg(-1)*h(-1) midazolam and 20 mg*kg(-1)*h(-1) ketamine was initiated in combination with DEX (n=10): 20 microg*kg(-1)*h(-1) dexmedetomidine or MED (n=10): 30 microg*kg(-1)*h(-1) medetomidine over 30 minutes...
April 2010: Acta Cirúrgica Brasileira
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