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Unsaturated fatty acids

Haizea Ziarrusta, Leire Mijangos, Sergio Picart-Armada, Mireia Irazola, Alexandre Perera-Lluna, Aresatz Usobiaga, Ailette Prieto, Nestor Etxebarria, Maitane Olivares, Olatz Zuloaga
The extensive use of the organic UV filter oxybenzone has led to its ubiquitous occurrence in the aquatic environment, causing an ecotoxicological risk to biota. Although some studies reported adverse effects, such as reproductive toxicity, further research needs to be done in order to assess its molecular effects and mechanism of action. Therefore, in the present work, we investigated metabolic perturbations in juvenile gilt-head bream (Sparus aurata) exposed over 14 days via the water to oxybenzone (50 mg/L)...
August 4, 2018: Chemosphere
Min Gao, Xuan Meng, Xuliang Guo, Jundong Zhu, Aiping Fan, Zheng Wang, Yanjun Zhao
Traditional antitumor nanomedicines have been suffering from the poor tumor targeting (ca. 1%) by the enhanced permeability and retention (EPR) effect, and the low drug loading (<5%). It was postulated that engineering all-active nanoplatform could increase the therapeutic efficacy to enable the nanocarrier function as both vehicle and active ingredient. To achieve this, a photosensitizer, Ce6 was encapsulated within polymeric micelles with unsaturated fatty acids as the building blocks. Upon light irradiation, the singlet oxygen produced by Ce6 induced lipid peroxidation, resulting in the generation of both active free radicals and aldehydes...
August 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yancun Yin, Maolei Xu, Ju Gao, Minjing Li
OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. Alkaline ceramidase 3 (Acer3) hydrolyzed long-chain unsaturated ceramide to produce free fatty acids and sphingosine. However, whether and how Acer3 modulates progression of HCC remains largely unknown. METHODS: Acer3 mRNA levels in different types of human HCC samples or normal tissues were determined from Gene Expression across Normal and Tumor tissue (GENT) database...
July 27, 2018: Pathology, Research and Practice
Wenbo Cao, Xiaoxiao Ma, Zishuai Li, Xiaoyu Zhou, Zheng Ouyang
The presence of carbon-carbon double bonds (C=Cs) in unsaturated phospholipids is closely related to lipid overall confor-mations and physiochemical activities. Previously, we have demonstrated that epoxidation reaction facilitated by low-temperature plasma (LTP) enabled the structural analysis of unsaturated fatty acids (FAs). Epoxidation of the C=C leads to the production of an epoxide, which can be easily cleaved via collision induced dissociation (CID) to produce diagnostic ions indic-ative of the C=C bond locations in FAs...
August 10, 2018: Analytical Chemistry
Aline F O Ramos, Stephanie A Terry, Devin B Holman, Gerhard Breves, Luiz G R Pereira, André G M Silva, Alexandre V Chaves
Tucumã oil is sourced from the fruit pulp of the tucumã tree and contains high concentrations of unsaturated fatty acids and carotenoids. Due to these properties it may have the potential to decrease enteric methane (CH4 ) from ruminants when included in the diet. The objective of this study was to determine the effect of oil mechanically extracted from the fruit pulp of tucumã on fermentation characteristics, CH4 production and the microbial community using the rumen stimulation technique. Treatments consisted of a control diet (forage:concentrate; 70:30), and tucumã oil included at 0...
2018: Frontiers in Microbiology
V Ananthi, G Siva Prakash, K Mohan Rasu, K Gangadevi, T Boobalan, Rathinam Raja, K Anand, M Sudhakar, Anil Chuturgoon, A Arun
Microalgal isolates (Chlorella sp. and Spirulina sp.) and yeast isolates (Candida albicans and Saccharomyces sp.) were employed as the resources of biodiesel production and silver nanoparticle synthesis. The prominent peaks of the FTIR spectrum accustomed the efficient lipid property. The developed profile containing fatty acid methyl ester (FAME) displayed the elevated amount of both saturated (C15:0, C17:0, C21:0) and unsaturated (C17:1, C18:2, C20:4) fatty acids. The physicochemical properties analyzed by using Biodiesel analyzer V1...
July 24, 2018: Journal of Photochemistry and Photobiology. B, Biology
A M Oberbauer, R Daniels, K Levy, T R Famula, P Mundell, R Kelley
Unsaturated omega-3 fatty acids, especially docosahexaenoic acid (DHA), when fed to dogs improves cognitive and neurological development. Supplementation with omega-3 fatty acids such as DHA and eicosapentaenoic acid (EPA) has also been associated with lipid peroxidation, which in turn has been implicated in reduced body weight and altered bone formation. To assess the impact of omega-3 fatty acid supplementation on skeletal growth, diets containing three levels of DHA and EPA (0.01 and 0.01%, 0.14 and 0.12%, and 0...
2018: PloS One
Yu Sawada, Tetsuya Honda, Satoshi Nakamizo, Atsushi Otsuka, Narihito Ogawa, Yuichi Kobayashi, Motonobu Nakamura, Kenji Kabashima
The potential of omega-3 poly-unsaturated fatty acids (PUFAs) as a therapeutic target for psoriasis, a chronic inflammatory skin disease of IL-23/IL-17 axis, is a long-disputed question, since various epidemiological studies have suggested the association between high-intake of omega-3 PUFAs and the reduced frequency and severity of psoriasis. However, their actual significance and the molecular mechanisms remain largely unknown. To address these issues, we focused on resolvin E1 (RvE1), an omega-3 PUFAs-derived metabolite, and examined its effects on psoriatic dermatitis, using an imiquimod-induced mouse psoriasis model...
August 8, 2018: Scientific Reports
Mengya Wang, Kuili Fang, Sung Min Choi Hong, Inwha Kim, Ik-Soon Jang, Seok Hoon Hong
Persisters represent a small bacterial population that is dormant and that survives under antibiotic treatment without experiencing genetic adaptation. Persisters are also considered one of the major reasons for recalcitrant chronic bacterial infections. Although several mechanisms of persister formation have been proposed, it is not clear how cells enter the dormant state in the presence of antibiotics or how persister cell formation can be effectively controlled. A fatty acid compound, cis-2-decenoic acid, was reported to decrease persister formation as well as revert the dormant cells to a metabolically active state...
August 7, 2018: Applied Microbiology and Biotechnology
Zhiwei Huang, Yuanyuan Yu, Zhijia Fang, Yunxia Deng, Yuhu Shen, Ping Shi
Cadmium has been shown to be an important environmental pollutant. Our previous studies have shown that the regulation of OLE1 in the synthesis of unsaturated fatty acids may act as a positive feedback mechanism to help yeast cells counter the lipid peroxidation and cytoplasmic membrane damage induced by cadmium. However, the involvement of OLE1 in cadmium-induced oxidative stress is still unclear. In this study, we explored the effects of OLE1 on cadmium induced oxidative stress in yeast. Different from ascorbic acid, the overexpression of OLE1 did not affect the activities of superoxide dismutase, catalase and glutathione peroxidase...
August 6, 2018: FEMS Microbiology Letters
Dan-Dan Yin, Wen-Zhong Xu, Qing-Yan Shu, Shan-Shan Li, Qian Wu, Cheng-Yong Feng, Zhao-Yu Gu, Liang-Sheng Wang
α-linolenic acid (ALA) deficiency and a skewed ω6: ω3 fatty acid ratio in the diet are thought to be a major cause for the high incidence of cardiovascular, inflammatory, and autoimmune diseases. Recent years, tree peony (Paeonia suffruticosa Andr.) with the high proportion of ALA (more than 45% in seed oil) is widely concerned. However, the underlying accumulation mechanism of the ALA in tree peony seeds remains unknown. In this study, comparative transcriptome analysis was performed between two cultivars ('Saiguifei' and 'Jingshenhuanfa') with different ALA contents...
September 2018: Plant Science: An International Journal of Experimental Plant Biology
Hae Lim Kim, Dae-Keun Kim, Seung Wan Kang, Yoo Kyoung Park
This study attempted to investigate whether nutrient and food intake were related with mild cognitive impairment (MCI) in adults and elderly over 50 years of age in Korea. Questionnaires and anthropometric measurements were conducted on general aspects of the research, and food frequency questionnaires (FFQs) were conducted to determine nutritional status. The relative theta power (RTP) through electroencephalography (EEG) measurements, neurocognitive function test (NFT; CNS Vital Signs), and cognitive function was measured...
July 2018: Clinical Nutrition Research
Aleksandr Voskoboinik, Sandeep Prabhu, Hariharan Sugumar, Peter M Kistler
The interaction between arrhythmias and certain lifestyle factors such as obesity and alcohol consumption is well-established. There is significant public and professional interest in the role of various diets, vitamins, and minerals in cardiovascular health. However, many widely held beliefs are not supported by the literature. There is limited evidence for routine magnesium and omega-3 poly-unsaturated fatty acids supplementation, while coffee, tea, nuts, antioxidant vitamins, and even chocolate may have some antiarrhythmic properties...
July 4, 2018: American Journal of Cardiology
Roberto Covino, Gerhard Hummer, Robert Ernst
Eukaryotic cells face the challenge of maintaining the complex composition of several coexisting organelles. The molecular mechanisms underlying the homeostasis of subcellular membranes and their adaptation during stress are only now starting to emerge. Here, we discuss three membrane property sensors of the endoplasmic reticulum (ER), namely OPI1, MGA2, and IRE1, each controlling a large cellular program impacting the lipid metabolic network. OPI1 coordinates the production of membrane and storage lipids, MGA2 regulates the production of unsaturated fatty acids required for membrane biogenesis, and IRE1 controls the unfolded protein response (UPR) to adjust ER size, protein folding, and the secretory capacity of the cell...
August 2, 2018: Molecular Cell
Sook Chin Chew, Chin Ping Tan, Kar Lin Nyam
Kenaf seed oil is prone to undergo oxidation due to its high content of unsaturated fatty acids, thus microencapsulation stands as an alternative to protect kenaf seed oil from the adverse environment. This study primarily aimed to evaluate the oxidative stability of microencapsulated refined kenaf seed oil (MRKSO) by the use of gum arabic, β-cyclodextrin, and sodium caseinate as the wall materials by spray drying. Bulk refined kenaf seed oil (BRKSO) and MRKSO were kept at 65 °C for 24 days to evaluate its oxidative stability, changes of tocopherol and tocotrienol contents, phytosterol content, and fatty acid profile...
August 3, 2018: Journal of Food Science
Vivek Kumar Chaturvedi, Sonam Agarwal, Krishna Kumar Gupta, Pramod W Ramteke, M P Singh
Medicinal mushrooms are higher fungi with additional nutraceutical attributes having low fat content and a trans-isomer of unsaturated fatty acids along with high fibre content, triterpenes, phenolic compounds, sterols, eritadenine and chitosan. They are considered as the unmatched source of healthy foods and drugs. They have outstanding attractive taste, aroma and nutritional value, so are considered as functional food, which means they are beneficial to the body not only in terms of nutrition but also for improved health...
August 2018: 3 Biotech
Mahdi Ebrahimi, Mohamed Ali Rajion, Saeid Jafari, Mohammad Faseleh Jahromi, Ehsan Oskoueian, Awis Qurni Sazili, Yong Meng Goh, Morteza Hosseini Ghaffari
The present study was conducted to investigate the effects of altering the ratio of n-6 to n-3 fatty acids in the diet on meat quality, fatty acid composition of muscle, and expression of lipogenic genes in the muscle of Boer goats. A total of twenty-one Boer goats (5 months old; 31.66±1.07 kg body weight) were randomly assigned to three dietary treatments with n-6:n-3 fatty acid ratios of 2.27:1 (LR), 5.01:1 (MR) and 10.38:1 (HR), fed at 3.7% of body weight. After 100 days of feeding, all goats were slaughtered and the longissimus dorsi muscle was sampled for analysis of fatty acids and gene expression...
2018: PloS One
María I Palacio, Analía I Etcheverría, Guillermo D Manrique
Gluten-free muffins with squash seed flour (SSF) were developed for contribute to reduce nutritional deficiencies and improving the health of the celiac population. Physicochemical and sensory properties of muffins were evaluated. SSF was incorporated at two levels (10 and 20% w/w) in commercial gluten-free premix (control). Incorporation of SSF increased total dietary fiber content, protein and unsaturated fatty acids. The addition of SSF at 10% resulted in a muffin that did not differ significantly from the control muffin; and also that formulations with SSF at 20% caused an increase in the browning index...
August 2018: Journal of Food Science and Technology
Yuxiao Yao, Shaoyang Sun, Jingjing Wang, Fei Fei, Zhaoru Dong, Ai-Wu Ke, Ruoyu He, Lei Wang, Lili Zhang, Min-Biao Ji, Qiang Li, Min Yu, Guo-Ming Shi, Jia Fan, Zhiyuan Gong, Xu Wang
There is limited understanding of the effects of major oncogenic pathways and their combinatorial actions on lipid composition and transformation during hepatic tumorigenesis. Here we report a negative correlation of Wnt/Myc activity with steatosis in human hepatocellular carcinoma (HCC) and perform in vivo functional studies using three conditional transgenic zebrafish models. Double-transgenic zebrafish larvae conditionally expressing human CTNNB1mt and zebrafish tcf7l2 or murine Myc together with krasv12 in hepatocytes led to severe hepatomegaly and significantly attenuated accumulation of lipid droplets and cell senescence triggered by krasv12 expression alone...
July 31, 2018: Cancer Research
Apramita Devi, K A Anu-Appaiah
Understanding the mechanisms of combating phenolic stress in wine is important for optimization of starter culture for improved competitiveness. The cellular membrane adaptations, as well as metabolic transformations driven by malo-lactic starter cultures, i.e. Lactobacillus plantarum (Lp2565) and Oenococcus oeni (Oo2219) with response to wine phenolic compounds were studied. The morphological changes based on scanning electron microscopy indicated the higher tolerance of Oo2219 to phenolic stress than Lp2565...
December 1, 2018: Food Chemistry
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