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Clear cell Adenocarcinoma of the vagina

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https://www.readbyqxmd.com/read/29888186/clear-cell-adenocarcinoma-of-female-urethra-a-case-report
#1
Kasondra Hartman, Jinghong Li, Tullika Garg
Primary malignancies of the female urethra are rare, accounting for less than 1% of genitourinary malignancies. Clear cell adenocarcinoma of the urethra (CCAU) occurs more infrequently, accounting for 0.003% of malignancies of the female urogenital tract. Definitive clinical diagnosis of CCAU is difficult and must be differentiated from tumors of the vagina. Currently, there is limited understanding of the causes of CCAU and there is no established standard of care for treatment. Immunohistochemistry and pathologic analysis can be used to identify the origin of the tumor...
July 2018: Urology Case Reports
https://www.readbyqxmd.com/read/28889719/-two-cases-of-urethral-clear-cell-adenocarcinoma-with-suspected-recurrence-of-uterine-cancer
#2
Masato Okuno, Yuji Kusuda, Isao Taguchi, Gaku Kawabata
Herein, we report two cases of urethral clear cell carcinoma in two patients who had previously undergone radical hysterectomyfor utetine cancer. Case 1 presented with bloodyvaginal discharge and case 2 presented with acute urinaryretention. Magnetic resonance imaging revealed a periurethral tumor in both cases. Both cases were suspected to be recurrence at first. However, pathological findings of the transurethral resection-biopsyshowed clear cell adenocarcinoma in both cases. Subsequentlyradical cystourethrectomy and pelvic lymphadenectomy were performed in both cases...
August 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28689666/incidence-rates-and-risks-of-diethylstilbestrol-related-clear-cell-adenocarcinoma-of-the-vagina-and-cervix-update-after-40-year-follow-up
#3
Dezheng Huo, Diane Anderson, Julie R Palmer, Arthur L Herbst
OBJECTIVE: Women exposed to diethylstilbestrol (DES) in utero are at increased risk for the development of vaginal and cervical clear cell adenocarcinoma (CCA) at younger age. It is unknown if a second peak will occur in later life, the ages when CCA developed spontaneously in the pre-DES era. The complete epidemiologic curve of CCA has not been reported, yet. METHODS: We reviewed 720 cases of CCA from the CCA registry at the University of Chicago through 2014. Incidence rates and cumulative risks for CCA were calculated based on white women born in the U...
September 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28029590/a-new-short-daily-brachytherapy-schedule-in-postoperative-endometrial-carcinoma-preliminary-results
#4
Ángeles Rovirosa, Carlos Ascaso, Antonio Herreros, Joan Sánchez, Katarzyna Holub, Albert Camarasa, Sebastià Sabater, Gabriela Oses, Julia García-Miguel, Yamile Rivera, Meritxell Arenas
PURPOSE: To evaluate the preliminary results of vaginal-cuff relapses (VCR) and complications of a short brachytherapy (BT) schedule in postoperative endometrial carcinoma. METHODS AND MATERIALS: From September 2011 to December 2014, 102 patients were treated with postoperative BT for endometrial carcinoma. Seventy-four patients received a single 7 Gy dose after external beam irradiation (Group 1), and 28 intermediate-risk patients received three daily fractions of 6 Gy (Group 2)...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/27939984/risk-of-cervical-intra-epithelial-neoplasia-and-invasive-cancer-of-the-cervix-in-des-daughters
#5
J Verloop, F E van Leeuwen, Th J M Helmerhorst, I M C M de Kok, E J M van Erp, H H van Boven, M A Rookus
OBJECTIVE: Women exposed to diethylstilbestrol in utero (DES) have an increased risk of clear cell adenocarcinoma (CCA) of the vagina and cervix, while their risk of non-CCA invasive cervical cancer is still unclear. METHODS: We studied the risk of pre-cancerous (CIN) lesions and non-CCA invasive cervical cancer in a prospective cohort of 12,182 women with self-reported DES exposure followed from 2000 till 2008. We took screening behavior carefully into account...
February 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27631522/yolk-sac-tumor-in-extragonadal-pelvic-sites-still-a-diagnostic-challenge
#6
Sanjita Ravishankar, Anais Malpica, Preetha Ramalingam, Elizabeth D Euscher
We present the clinicopathologic features of 15 cases of extragonadal yolk sac tumor (EGYST) detected in female patients and reviewed at our institution from 1988 to 2016. We recorded: patient age, clinical presentation, tumor location, FIGO stage (where applicable), histologic patterns including presence/absence of Schiller-Duval bodies, other germ cell or somatic components, immunoperoxidase results, treatment, and outcome. Patients' ages ranged from 17 to 87 (median, 62) years and presentation included: abnormal uterine bleeding, 12; hematuria, 1; labial mass, 1; abdominal pain, 1...
January 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27527897/long-term-outcomes-using-adjuvant-pelvic-intensity-modulated-radiation-therapy-imrt-for-endometrial-carcinoma
#7
Siping He, Beant S Gill, Dwight E Heron, Joseph L Kelley, Paniti Sukumvanich, Alexander B Olawaiye, Robert P Edwards, John Comerci, Sushil Beriwal
PURPOSE: We evaluated the long-term outcome and toxicity of adjuvant intensity modulated radiation therapy (IMRT) for high-risk endometrial carcinoma via a retrospective institutional review of patients treated in this setting with extended follow-up. METHODS AND MATERIALS: Patients with endometrial cancer who underwent comprehensive surgical staging followed by adjuvant IMRT with or without sequential chemotherapy between 1999 and 2010 were reviewed. Median doses delivered with IMRT and brachytherapy were 45 Gy in 25 fractions and 10 Gy in 2 fractions; 10...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27001869/robotic-assisted-radical-parametrectomy-in-patients-with-malignant-gynecological-tumors
#8
Grigor A Gorchev, Slavcho T Tomov, Zdravka V Radionova, Lachezar S Tanchev
We describe the operative technique of robotic-assisted laparoscopic radical parametrectomy and analyze perioperative data including adequacy of resections, pathology, and complications in our initial cases. A retrospective study was performed of seven patients with gynecological cancers involving the cervix who had previously been treated with simple hysterectomies and then underwent robotic-assisted radical parametrectomies. Pathology from the initial hysterectomies and the radical parametrectomies was reviewed...
December 2013: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/26979629/prenatal-diethylstilbestrol-exposure-and-high-grade-squamous-cell-neoplasia-of-the-lower-genital-tract
#9
Rebecca Troisi, Elizabeth E Hatch, Julie R Palmer, Linda Titus, Stanley J Robboy, William C Strohsnitter, Arthur L Herbst, Ervin Adam, Marianne Hyer, Robert N Hoover
BACKGROUND: Prenatal diethylstilbestrol (DES) exposure is associated with an excess risk of clear-cell adenocarcinoma of the vagina and cervix, and of high-grade squamous neoplasia. OBJECTIVE: We explored whether neoplasia risk remains elevated among DES-exposed women as they age. STUDY DESIGN: In all, 4062 DES-exposed and 1837 unexposed daughters were followed for approximately 30 years (1982 through 2013) for pathology-confirmed diagnoses of cervical intraepithelial neoplasia grade ≥2 (CIN2+) of the lower genital tract (n = 178)...
September 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26645463/recent-developments-in-non-hpv-related-adenocarcinomas-of-the-lower-female-genital-tract-and-their-precursors
#10
REVIEW
W Glenn McCluggage
Most adenocarcinomas in the lower female genital tract (cervix, vagina, vulva) arise in the cervix and are associated with high-risk human papillomavirus (HPV) infection. However, there is an emerging spectrum of non-HPV-related cervical adenocarcinomas, the most common of which is so-called gastric type. In this review, the concept of gastric-type cervical adenocarcinomas and their possible precursor lesions is covered, the precursor lesions still being poorly understood. Other non-HPV-related cervical adenocarcinomas are also discussed, including new information regarding molecular events in mesonephric adenocarcinoma...
January 2016: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/26630224/an-isolated-metastasis-from-clear-cell-renal-cell-carcinoma-to-the-uterus-a-case-report-and-review-of-literature
#11
REVIEW
Kamaljeet Singh, Paul A DiSilvestro, W Dwayne Lawrence, M Ruhul Quddus
Ovaries are a favored site for metastatic tumors arising in the female genital tract. Other organs of the mullerian system, that is, the uterine corpus as well as the fallopian tubes, cervix, and the vagina are less commonly involved by metastases. If there is no clinical history of a known extramullerian primary tumor, suspicion that a uterine mass represents metastatic disease is low. We report the case of a renal clear cell carcinoma presenting as an isolated uterine mass and morphologically mimicking a primary endometrial clear cell adenocarcinoma...
September 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25768943/factors-associated-with-a-lack-of-pap-smear-utilization-in-women-exposed-in-utero-to-diethylstilbestrol
#12
Elizabeth A Camp, Angela W Prehn, Ji Shen, Arthur L Herbst, William C Strohsnitter, Christopher D Hobday, Stanley J Robboy, Ervin Adam
BACKGROUND: Women in the 1940s-1960s were prescribed diethylstilbestrol (DES), a nonsteroidal estrogen, to prevent miscarriages, but the practice was terminated after it was discovered that the daughters so exposed in utero were at increased risk for developing clear cell adenocarcinoma (CCA) of the vagina or cervix at early ages. Pap smear screening is one of the principal methods used to identify tumor development and is necessary in this group of women to maintain their health. Currently, little is known about the factors associated with nonutilization of this screening tool in this high-risk population of women...
April 2015: Journal of Women's Health
https://www.readbyqxmd.com/read/25768078/the-use-of-transvaginal-ultrasound-in-type-ii-endometrial-cancer
#13
Caroline C Billingsley, Kimberly A Kenne, Catherine D Cansino, Floor J Backes, David E Cohn, David M O'Malley, Larry J Copeland, Jeffrey M Fowler, Ritu Salani
OBJECTIVE: To determine the use of the transvaginal ultrasound (TVUS) in postmenopausal women with type II endometrial cancer. METHODS/MATERIALS: A retrospective review was conducted for 173 women with pathology proven type II endometrial cancer at a single institution. Those who underwent preoperative TVUS were included, and the following data were obtained: endometrial stripe (EMS) measurement, uterine and/or adnexal findings, and uterine size/volume. Clinicopathologic factors were abstracted...
June 2015: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/25594143/clinical-characteristics-of-non-squamous-cell-carcinoma-of-the-vagina
#14
Hidetaka Nomura, Maki Matoda, Sanshiro Okamoto, Kohei Omatsu, Eiji Kondo, Kazuyoshi Kato, Kenji Umayahara, Nobuhiro Takeshima
OBJECTIVE: The prognosis and vaginal disease control rate after treatment with radiotherapy or concurrent chemoradiotherapy (CCRT) are reported to be worse for primary non-squamous cell carcinoma (non-SCC) of the vagina than for squamous cell carcinoma (SCC) of the vagina. Our objective was to examine the clinicopathological characteristics of primary non-SCC of the vagina and suggest an appropriate treatment strategy. MATERIALS AND METHODS: In a retrospective chart review, we identified patients with primary vaginal cancer who were treated in our hospital between 1990 and 2013...
February 2015: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/24850989/non-diethylstilbestrol-associated-primary-clear-cell-carcinoma-of-the-vagina-two-case-reports-with-immunohistochemical-studies-and-literature-review
#15
Shagufta T Mufti, Hiba Hassan Ali
Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina from the archives of the Anatomical Pathology Department at King Abdulaziz University in order to improve our understanding of its biological behavior...
May 2014: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/24819657/treatment-failure-in-endometrial-carcinoma
#16
Huei-Jean Huang, Yun-Hsin Tang, Hung-Hsueh Chou, Lan-Yan Yang, Angel Chao, Yi-Ting Huang, Gigin Lin, Feng-Yuan Liu, Ting-Chang Chang, Chyong-Huey Lai
OBJECTIVE: Our aim was to investigate the outcomes and prognostic factors after treatment failure of endometrial cancer. METHODS: A total of 923 endometrial cancer patients were treated between 2000 and 2010, of which 109 experienced treatment failure. Treatment failure was defined as relapse after complete removal of all cancerous lesions or persistent/progressive disease despite treatment. Variables including clinicopathological features at initial treatment, type of primary treatment, failure pattern, salvage treatment, and outcomes were analyzed...
June 2014: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/24698194/-diethylstilbestrol-story
#17
Michel Tournaire, Sylvie Epelboin, Emmanuel Devouche
This story, that has been going on for 75 years begins with an infatuation for a "miraculous" drug supposed to, according to a theory and without scientific proof of effectiveness, reduce the pregnancy complications, especially the number of miscarriages. The next steps are painful with the discovery during the seventies, for the in utero exposed daughters, of particular cancers (clear cells adenocarcinoma) of the uterus cervix or the vagina, then during the eighties infertility and pregnancy accidents. This story is exemplary because it involves the different society actors whose roles will be analysed: health professionals, health authorities, patients associations, media and pharmaceutical companies...
January 2014: Thérapie
https://www.readbyqxmd.com/read/24690973/primary-non-clear-cell-adenocarcinoma-of-the-vagina-in-a-diethylstilbestrol-exposed-woman
#18
Samit A Patel, Jan Sunde
A 54-year-old woman with a history of in-utero diethylstilbestrol (DES) exposure, who had a prior hysterectomy for symptomatic leiomyomata and dysmenorrhea, presented for vaginal bleeding. Vaginal biopsies showed a non-clear-cell adenocarcinoma, and the patient was subsequently treated with radiation therapy. We present a case of primary vaginal non-clear-cell adenocarcinoma in a patient with in-utero DES exposure. Continued monitoring of older DES-exposed women for vaginal lesions is warranted because of reported cases of non-clear-cell adenocarcinoma and persistent risk of clear cell adenocarcinoma...
April 2014: Military Medicine
https://www.readbyqxmd.com/read/24382040/-des-daughter-expertise-remains-necessary
#19
René H M Verheijen, Janneke Verloop, Theo J M Helmerhorst
As early as the 1950s there were warnings about the toxicity of the synthetic oestrogen diethylstilbestrol (DES), but in the Netherlands this drug continued to be prescribed to pregnant women up to the late 1970s. Until recently the periodic check-ups of children born from these pregnancies - the so-called DES Daughters - was mainly focused on genital abnormalities and the sporadically occurring clear cell adenocarcinoma of the vagina. As they grow older, the risk of this and similar types of carcinoma decreases and the nature of the periodic check-ups changes...
2013: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/24118204/endodermal-sinus-tumor-of-vagina-posing-a-diagnostic-challenge-and-managed-by-chemotherapy-and-novel-posterior-sagittal-surgical-approach-lessons-learned
#20
Surbhi Goyal, Archana Puri, Kiran Mishra, Satish Kumar Aggarwal, Manisha Kumar, Pitamber Sonaker
Vaginal germ cell tumor (GCT) is a rare gynecological malignancy with no more than 100 reported cases in the international medical literature. It is an unusual, but an important, cause of premenarchal vaginal bleeding in a child. This article describes a 2-year-old child with vaginal GCT, initially misdiagnosed as rhabdomyosarcoma (on imprint smear cytology) and then as clear cell adenocarcinoma. The authors highlight the salient differentiating clinical, radiological and histological features to prevent misdiagnosis in future...
February 2014: Journal of Obstetrics and Gynaecology Research
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