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Risperidone schizoaffective disorder

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https://www.readbyqxmd.com/read/30344996/real-world-effectiveness-of-long-acting-antipsychotic-treatments-in-a-nationwide-cohort-of-3957-patients-with-schizophrenia-schizoaffective-disorder-and-other-diagnoses-in-quebec
#1
Emmanuel Stip, Jean Lachaine
Background: Long-acting injectable antipsychotics (LAI-AP) for patients with schizophrenia (SCZ) have saved significant healthcare costs. However, the cost effectiveness of LAI-AP for patients with other mental disorders has yet to be established. The goal of this study was to evaluate the impact of early initiation of LAI-AP medications on healthcare resource utilization (HRU). Drawing on the Quebecois universal healthcare program (RAMQ), we conducted a nationwide prospective cohort study of LAI-AP under real-world conditions...
November 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/30036457/acute-blood-pressure-changes-associated-with-antipsychotic-administration-to-psychiatric-inpatients
#2
Kristin A Parks, Clayton G Parks, Johnathon P Yost, Jeffrey I Bennett, Obiora E Onwuameze
Objective: To investigate blood pressure (BP) changes within the first 3 days after initiating antipsychotic medication in psychiatric inpatients. Methods: Through retrospective chart review using a repeated measures design, vital signs data were collected on 60 adult psychiatric inpatients who were psychiatrically hospitalized May 26, 2011, through September 4, 2012, at 9 time points within 3 days of initiation of 1 of 6 different antipsychotic medications. The random sample included patients with the following DSM-IV-TR diagnoses: schizophrenia (n = 25), schizoaffective disorder (either type; n = 19), and bipolar I disorder (n = 16)...
July 19, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29920116/predictors-and-moderators-of-antipsychotic-related-weight-gain-in-the-treatment-of-early-onset-schizophrenia-spectrum-disorders-study
#3
Jerome H Taylor, Ewgeni Jakubovski, Daniel Gabriel, Michael H Bloch
BACKGROUND: Antipsychotic-related weight gain is a common clinically relevant side effect when treating psychotic disorders in pediatric populations, yet few predictors and no moderators of antipsychotic-related weight gain are known. METHODS: The Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study randomized 119 youths (age 8-19 years) with schizophrenia or schizoaffective disorder to 8 weeks of antipsychotic treatment with molindone, risperidone, or olanzapine and assessed treatment response and side effects...
September 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29713100/do-long-acting-injectable-antipsychotics-prevent-or-delay-hospital-readmission
#4
Thomas J Maestri, Lisa M Mican, Heather Rozea, Jamie C Barner
Introduction: Long-acting injectable (LAI) antipsychotics were developed as a way to decrease pill burden and simplify medication regimens by allowing less frequent administration to assist with medication adherence. Methods: The purpose of this study was to determine whether LAI antipsychotics prevent or delay hospital readmission in patients with a known history of medication non-adherence. The study is a retrospective evaluation of 240 men and women 18-65 years of age diagnosed with bipolar disorder, schizophrenia, or schizoaffective disorder discharged from an inpatient state hospital over a 2 year period of time on a LAI antipsychotic (fluphenazine LAI, haloperidol LAI, risperidone LAI or paliperidone LAI) or oral antipsychotic...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29534691/a-case-report-of-schizoaffective-disorder-with-ritualistic-behaviors-and-catatonic-stupor-successful-treatment-by-risperidone-and-modified-electroconvulsive-therapy
#5
Yuanhan Bai, Xi Yang, Zhiqiang Zeng, Haichen Yang
BACKGROUND: Ritualistic behaviors are common in obsessive compulsive disorder (OCD), while catatonic stupor occasionally occurs in psychotic or mood disorders. Schizoaffective disorder is a specific mental disorder involving both psychotic and affective symptoms. The syndrome usually represents a specific diagnosis, as in the case of the 10th edition of the International Classification of Diseases (ICD-10) or the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)...
March 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29175720/t-4-and-waist-hip-ratio-as-biomarkers-of-antipsychotic-induced-weight-gain-in-han-chinese-inpatients-with-schizophrenia
#6
Shen Li, Ying Gao, Hao Lv, Miaomiao Zhang, Lili Wang, Rui Jiang, Chengai Xu, Xueshi Wang, Ming Gao, Yukun He, Jie Li, Wei-Dong Li
Second-generation antipsychotic agents (SGAs) cause serious metabolic side effects, including weight gain, dyslipidemia, and glucose metabolism abnormalities, which occur by unknown mechanisms. Therefore, the search for prospective markers for antipsychotic-induced weight gain (AIWG) has been of major interest. So far, predictive factors predisposing patients to the develop obesity and related metabolic disturbances induced by SGAs have been relatively less studied among large samples of Chinese schizophrenic patients...
February 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29092658/an-unexpected-circumstance-acute-dystonic-reaction-in-the-setting-of-clozapine-administration
#7
Alexander Morris Kaplan, William Bradly Pitts, Iqbal Ahmed
Clozapine is a second-generation antipsychotic typically reserved for refractory psychotic disorders due to its high-risk side effect profile to include agranulocytosis, with its attendant need for regular blood draws. While reports of extrapyramidal symptoms (EPS), including acute dystonic reactions, are exceedingly rare, we present the case of a 44-year-old male with a long-standing history of treatment-resistant schizoaffective disorder and no history of EPS who experienced an acute buccal dystonic reaction in the setting of clozapine initiation and discontinuation of depot and oral risperidone...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29045304/effect-of-clozapine-vs-other-second-generation-antipsychotics-on-hospitalization-and-seclusion-a-retrospective-mirror-image-study-in-a-japanese-public-psychiatric-hospital
#8
COMPARATIVE STUDY
Fuminari Misawa, Takefumi Suzuki, Yasuo Fujii
BACKGROUND: Clozapine has been regarded as the gold standard for patients with treatment-resistant schizophrenia, but a recent network meta-analysis has questioned its relative superiority over other second-generation antipsychotics (SGAs) such as olanzapine and risperidone. PURPOSE: We conducted a retrospective mirror-image study of clozapine vs other SGAs to evaluate real-world effectiveness of clozapine in terms of the duration of hospitalization and seclusion, both of which represent a critical outcome...
December 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28806390/combination-antipsychotic-therapies-an-analysis-from-a-longitudinal-pragmatic-trial
#9
Adriana Foster, Peter Buckley, John Lauriello, Stephen Looney, Nina Schooler
BACKGROUND: Combination antipsychotics (CAs) are prescribed in schizophrenia despite limited evidence of efficacy. To explore the effect of switching from CA to monotherapy, we performed an exploratory analysis of the PROACTIVE (Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared with Injectables: Evaluating Efficacy) study data, in which 305 patients with schizophrenia and schizoaffective disorder were followed for 30 months after randomization to long-acting injectable (LAI) risperidone or second-generation oral antipsychotic (OA)...
October 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28675307/pharmacokinetic-drug-evaluation-of-paliperidone-in-the-treatment-of-schizoaffective-disorder
#10
REVIEW
Matthew Macaluso, Hannah Oliver, Zohaib Sohail
This paper reviews the pharmacokinetics, receptor binding, clinical efficacy and safety of paliperidone in the treatment of patients with schizoaffective disorder. Areas covered: We reviewed the literature using keywords 'paliperidone', 'schizoaffective disorder' and 'clinical trials' with a focus on seminal data papers and information that is clinically relevant to the treatment of schizoaffective disorder. The purpose of this paper is to provide a clinically oriented review of the pharmacokinetic and pharmacodynamic properties of paliperidone including receptor binding, clinical efficacy, safety and tolerability...
August 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28595147/predictors-of-treatment-response-and-drop-out-in-the-treatment-of-early-onset-schizophrenia-spectrum-disorders-teoss-study
#11
RANDOMIZED CONTROLLED TRIAL
Daniel Gabriel, Ewgeni Jakubovski, Jerome H Taylor, Bekir B Artukoglu, Michael H Bloch
The Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) compared the efficacy of risperidone, olanzapine, and molindone over 8 weeks in 119 youths age 8-19 years with early-onset schizophrenia or schizoaffective disorder. From this large dataset, we examined predictors of treatment response and drop out using stepwise regression and receiver operating characteristics curve (ROC) analysis. Treatment response was defined as having both a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) score and a Clinical Global Impression-Improvement (CGI-I) score < 3...
September 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28571548/intermittent-transient-motor-aphasia-associated-with-acute-lithium-toxicity-a-case-report-and-brief-review
#12
REVIEW
Subramoniam Madhusoodanan, Varudhini Reddy, Sonya Mohan
BACKGROUND: Lithium is known to cause certain neurological deficits. However, reports of aphasia secondary to lithium toxicity are scant. We report the case of a 70 year old African American woman with a history of schizoaffective disorder and mild dementia who developed transient intermittent aphasia secondary to lithium toxicity. METHODS: Patient was admitted because of agitation, delusional behavior, and pressured speech. Her previous medications included divalproex sodium 500 mg po bid, valproic acid 250 mg po qd, risperidone 3...
2017: Current Drug Safety
https://www.readbyqxmd.com/read/28353490/accuracy-of-clinician-assessments-of-medication-status-in-the-emergency-setting-a-comparison-of-clinician-assessment-of-antipsychotic-usage-and-plasma-level-determination
#13
COMPARATIVE STUDY
Leonardo V Lopez, Atef Shaikh, Jonathan Merson, Jessica Greenberg, Raymond F Suckow, John M Kane
PURPOSE: The present study aimed to assess the level of agreement between clinicians' routine assessments of medication status and plasma levels of commonly prescribed antipsychotic medications in patients presenting to an emergency room with an exacerbation of psychosis. METHODS: We studied 105 patients presenting to an emergency room and admitted to an inpatient psychiatric unit with a diagnosis of schizophrenia, schizoaffective disorder, bipolar I disorder, or psychotic disorder not otherwise specified and a prior outpatient medication regimen including risperidone, olanzapine, quetiapine, aripiprazole, or paliperidone...
June 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28140680/paliperidone-for-the-treatment-of-schizophrenia-and-schizoaffective-disorders-a-drug-safety-evaluation
#14
REVIEW
M C Mauri, A Reggiori, S Paletta, C Di Pace, A C Altamura
Paliperidone, the major active metabolite of risperidone, is a second-generation antipsychotic that has been developed as an extended-release (ER) oral formulation and a long-acting injectable paliperidone palmitate (PP) formulation. Paliperidone has demonstrated efficacy in the reduction of acute schizophrenia symptoms and clinical benefits were maintained also in the long-term treatments. Paliperidone ER and PP are generally well tolerated with a predictable adverse event profile. Areas covered: Data from studies evaluating safety and tolerability in the acute and maintenance treatment of schizophrenia with paliperidone are reviewed...
March 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27964751/neurotoxicity-and-nephrotoxicity-caused-by-combined-use-of-lithium-and-risperidone-a-case-report-and-literature-review
#15
REVIEW
Chih-Wei Hsu, Yu Lee, Chun-Yi Lee, Pao-Yen Lin
BACKGROUND: Combination lithium, a mood stabilizer, and risperidone, an atypical antipsychotic drug, is widely used for treatment of psychotic disorders. Rare reports concern severe adverse drug reaction in multiple organic systems with their combined use. We report two episodes of neurotoxicity and nephrotoxicity in a patient following the combined use of lithium and risperidone. CASE PRESENTATION: A 55-year-old male had a diagnosis of schizoaffective disorder at the age of 51...
December 14, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27745822/cognition-and-dopamine-d-2-receptor-availability-in-the-striatum-in-older-patients-with-schizophrenia
#16
Tarek K Rajji, Benoit H Mulsant, Shinichiro Nakajima, Fernando Caravaggio, Takefumi Suzuki, Hiroyuki Uchida, Philip Gerretsen, Wanna Mar, Bruce G Pollock, David C Mamo, Ariel Graff-Guerrero
OBJECTIVES: To assess the impact of reducing the dose of antipsychotics on cognition and dopaminergic D2 receptor availability in the whole striatum, and identify their relationship in patients with schizophrenia aged 50 years or older. DESIGN: Open-label prospective PET [11 C]-raclopride study. SETTING: A tertiary care center outpatient setting. PARTICIPANTS: Thirty-seven clinically stable participants with schizophrenia or schizoaffective disorder, aged 50 years or greater, and having been treated with olanzapine or risperidone monotherapy at the same dose for at least 6 months...
January 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27721999/paliperidone-inducing-concomitantly-syndrome-of-inappropriate-antidiuretic-hormone-neuroleptic-malignant-syndrome-and-rhabdomyolysis
#17
Jaspinder Kaur, Dileep Kumar, Mostafa Alfishawy, Ricardo Lopez, Issac Sachmechi
Paliperidone, an active metabolite of risperidone, is a new atypical antipsychotic agent. Syndrome of inappropriate antidiuretic hormone (SIADH), neuroleptic malignant syndrome (NMS), and rhabdomyolysis are the uncommon side effects of psychotropic drugs. We report a case of 35-year-old male with schizoaffective disorder who was admitted for acute-on-chronic exacerbation of his psychotic disorder for which intramuscular paliperidone 234 mg injection was given. Two days later, the patient developed hyponatremic seizures secondary to SIADH which was treated with hypertonic saline...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27525965/treatment-patterns-and-antipsychotic-medication-adherence-among-commercially-insured-patients-with-schizoaffective-disorder-in-the-united-states
#18
Kruti Joshi, Jay Lin, Melissa Lingohr-Smith, Dong-Jing Fu, Erik Muser
This study assessed real-world treatment patterns and antipsychotic (AP) medication adherence among commercially insured US patients with schizoaffective disorder (SCA). Continuously insured adults aged 18 years or older with a diagnosis of SCA from January 1, 2009, to December 31, 2012, were identified from the Clinformatics Data Mart database. Patients were categorized into 2 cohorts: incident or prevalent SCA. Demographics and clinical characteristics were evaluated during the baseline period. Use of psychiatric medications and adherence to AP medications were evaluated during a 12-month follow-up period after index diagnosis of SCA...
October 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27416102/phase-i-open-label-randomized-parallel-study-to-evaluate-the-pharmacokinetics-safety-and-tolerability-of-one-intramuscular-injection-of-risperidone-ism-at-different-dose-strengths-in-patients-with-schizophrenia-or-schizoaffective-disorder-prisma-1
#19
RANDOMIZED CONTROLLED TRIAL
Jordi Llaudó, Lourdes Anta, Ignacio Ayani, Javier Martínez, Juan Schronen, Margarita Morozova, Mikhail Ivanov, Ibón Gutierro
The aim of this study was to characterize the pharmacokinetics and to evaluate the safety of risperidone ISM in patients with schizophrenia or schizoaffective disorder after a single gluteal intramuscular injection at three different dose strengths (50, 75, and 100 mg). A total of 36 patients were randomized and blood samples were collected to measure the plasma concentrations. The pharmacokinetic of the active moiety was biphasic for all three dose groups, and the mean plasma concentration was 21.45, 24...
November 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27159603/clinical-case-of-the-month-a-48-year-old-man-with-fever-and-abdominal-pain-of-one-day-duration
#20
REVIEW
Mary Yu, David Tadin, Erich J Conrad, Fred A Lopez
A 48-year-old man residing in a mental health department inpatient program with a history of schizoaffective disorder presented to the emergency department with a chief complaint of fever and intense abdominal pain for one day. The patient stated he initially fell in the shower and afterwards experienced back pain. He was transferred to an acute care unit within the facility for further evaluation. The facility physician noted that the patient had a mild temperature elevation and abdominal rigidity on exam...
September 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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