Juan Blanco-Heredia, Carla Anjos Souza, Juan L Trincado, Maria Gonzalez-Cao, Samuel Gonçalves-Ribeiro, Sara Ruiz Gil, Dmytro Pravdyvets, Samandhy Cedeño, Maurizio Callari, Antonio Marra, Andrea M Gazzo, Britta Weigelt, Fresia Pareja, Theodore Vougiouklakis, Achim A Jungbluth, Rafael Rosell, Christian Brander, Francesc Tresserra, Jorge S Reis-Filho, Daniel Guimarães Tiezzi, Nuria de la Iglesia, Holger Heyn, Leticia De Mattos-Arruda
The interactions between tumor and immune cells along the course of breast cancer progression remain largely unknown. Here, we extensively characterize multiple sequential and parallel multiregion tumor and blood specimens of an index patient and a cohort of metastatic triple-negative breast cancers. We demonstrate that a continuous increase in tumor genomic heterogeneity and distinct molecular clocks correlated with resistance to treatment, eventually allowing tumors to escape from immune control. TCR repertoire loses diversity over time, leading to convergent evolution as breast cancer progresses...
February 21, 2024: Nature Communications