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https://www.readbyqxmd.com/read/29708939/outcomes-of-thermal-pulsation-treatment-for-dry-eye-syndrome-in-patients-with-sjogren-disease
#1
Morgan R Godin, Sandra S Stinnett, Preeya K Gupta
PURPOSE: To evaluate the clinical outcomes of thermal pulsation treatment in patients with meibomian gland dysfunction (MGD) and dry eye secondary to Sjogren disease. METHODS: Twenty-four eyes from 13 patients with previously diagnosed Sjogren disease who presented to our institution with dry eye symptoms and had thermal pulsation treatment were prospectively followed up. Patients underwent comprehensive slit-lamp examination, including MGD grading, gland oil flow, corneal and conjunctival staining scores, and tear break-up time (TBUT)...
April 26, 2018: Cornea
https://www.readbyqxmd.com/read/29705184/homogeneous-vs-patient-specific-breast-models-for-monte-carlo-evaluation-of-mean-glandular-dose-in-mammography
#2
A Sarno, G Mettivier, F Di Lillo, K Bliznakova, I Sechopoulos, P Russo
PURPOSE: To compare, via Monte Carlo simulations, homogeneous and non-homogenous breast models adopted for mean glandular dose (MGD) estimates in mammography vs. patient specific digital breast phantoms. METHODS: We developed a GEANT4 Monte Carlo code simulating four homogenous cylindrical breast models featured as follows: (1) semi-cylindrical section enveloped in a 5-mm adipose layer; (2) semi-elliptical section with a 4-mm thick skin; (3) semi-cylindrical section with a 1...
April 25, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29688838/intense-pulsed-light-applied-directly-on-eyelids-combined-with-meibomian-gland-expression-to-treat-meibomian-gland-dysfunction
#3
Bei Rong, Yun Tang, Ping Tu, Ruixing Liu, Jing Qiao, Wenjing Song, Rolando Toyos, Xiaoming Yan
OBJECTIVE: To determine the efficacy and safety of intense pulsed light (IPL) applied directly on the eyelids and meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD). BACKGROUND: IPL application on the periocular skin effectively improves meibomian gland secretion and tear film break-up time (TBUT) in patients with MGD/dry eye. METHODS: This prospective, randomized, double-masked, controlled study involved 44 patients...
April 24, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29675376/clinical-efficacy-of-combined-topical-0-05-cyclosporine-a-and-0-1-sodium-hyaluronate-in-the-dry-eyes-with-meibomian-gland-dysfunction
#4
Ho-Yun Kim, Ji-Eun Lee, Ha-Na Oh, Ju-Whan Song, Sang-Youp Han, Jong-Soo Lee
AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis® , Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD). METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675375/the-association-between-demodex-infestation-and-ocular-surface-manifestations-in-meibomian-gland-dysfunction
#5
Xiao-Bo Zhang, Ying-Hui Ding, Wei He
AIM: To investigate the association between ocular demodex folliculorum infestation and ocular surface manifestations in meibomian gland dysfunction (MGD). METHODS: Eight-six patients with MGD were enrolled. All enrolled subjects were tested in the following sequence: ocular surface disease index (OSDI), slit-lamp biomicroscope examination, corneal surface regularity index (SRI) and surface asymmetry index (SAI), tear fluid collection, fluorescein tear film break-up time (F-BUT), corneal fluorescein staining (CFS), Schirmer I test (SIT) and demodex folliculorum counting...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29673742/skin-models-and-their-impact-on-mean-glandular-dose-in-mammography
#6
Rodrigo Trevisan Massera, Alessandra Tomal
PURPOSE: To quantify the influence of different skin models on mammographic breast dosimetry, based on dosimetric protocols and recent breast skin thickness findings. METHODS: By using an adapted PENELOPE (v. 2014) + PenEasy (v. 2015) Monte Carlo (MC) code, simulations were performed in order to obtain the mean glandular dose (MGD), the normalized MGD by incident air Kerma (DgN), and the glandular depth dose (GDD(z)). The geometry was based on a cranio-caudal mammographic examination...
April 16, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29656524/the-prevalence-of-meibomian-gland-dysfunction-tear-film-and-ocular-surface-parameters-in-an-austrian-dry-eye-clinic-population
#7
Dieter Franz Rabensteiner, Haleh Aminfar, Ingrid Boldin, Gerold Schwantzer, Jutta Horwath-Winter
PURPOSE: The purpose of this study was to assess the prevalence of meibomian gland dysfunction (MGD) and its association with tear film and ocular surface parameters in an Austrian clinical population of dry eye patients. METHODS: The records of 1372 consecutive patients from a dry eye unit were analysed retrospectively. Symptoms and objective tear film and ocular surface parameters were evaluated. Patients were classified into pure MGD, pure aqueous tear deficiency (ATD), MGD combined with ATD, pure anterior blepharitis (AB), Sjogren's syndrome (SS) without MGD and SS together with MGD...
April 15, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29649988/the-function-and-morphology-of-meibomian-glands-in-patients-with-thyroid-eye-disease-a-preliminary-study
#8
Chia-Yu Wang, Ren-Wen Ho, Po-Chiung Fang, Hun-Ju Yu, Chun-Chih Chien, Chang-Chun Hsiao, Ming-Tse Kuo
BACKGROUND: To investigate function and morphology of the meibomian gland (MG) in patients with thyroid eye disease (TED). METHODS: In this prospective case series study, patients with unilateral or bilateral TED were consecutively enrolled. The diagnosis of TED was based on the typical orbital findings and/or radiographic evidence. The disease activity of TED was classified according to the clinical activity score (CAS). Degrees of lagophthalmos and exophthalmos, blinking rates, and results of the Schirmer test 1 were also recorded...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29627826/meibomian-gland-dysfunction-in-primary-and-secondary-sj%C3%A3-gren-syndrome
#9
David A Sullivan, Reza Dana, Rose M Sullivan, Kathleen L Krenzer, Afsun Sahin, Beril Arica, Yang Liu, Wendy R Kam, Athena S Papas, Jennifer M Cermak
PURPOSE: We hypothesized that women with primary (pSS) and secondary Sjögren syndrome (sSS; with systemic lupus erythematosus [SLE] or rheumatoid arthritis [RA]) have meibomian gland dysfunction (MGD). We sought to test our hypothesis. METHODS: Subjects with pSS, sSS + SLE, sSS + RA, and non-SS-related MGD were recruited from the Sjögren's Syndrome Foundation or outpatient clinics at Tufts University School of Dental Medicine or Brigham and Women's Hospital. The control population was recruited from the Greater Boston area...
April 6, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29601143/synthetic-%C3%AE-mangostin-dilaurate-strongly-suppresses-wide-spectrum-organ-metastasis-in-a-mouse-model-of-mammary-cancer
#10
Masa-Aki Shibata, Hitomi Hamaoka, Junji Morimoto, Tadashi Kanayama, Kentaro Maemura, Yuko Ito, Munekazu Iinuma, Yoichi Kondo
We previously reported that, in a mouse model of mammary cancer, α-mangostin alone exhibits anti-metastatic properties. To enhance this anti-metastatic effect, we examined the efficacy of synthetic α-mangostin dilaurate (MGD), prepared by adding lauric acid to α-mangostin, in the same experimental system wherein mice bearing mammary tumors are exposed to dietary MGD at 0, 2000, and 4000 ppm. Lauric acid has a high propensity for lymphatic absorbtion, which is the most common pathway of initial dissemination of many solid malignancies...
March 30, 2018: Cancer Science
https://www.readbyqxmd.com/read/29599081/improvement-of-early-detection-of-breast-cancer-through-collaborative-multi-country-efforts-medical-physics-component
#11
Patricia Mora, Keith Faulkner, Ahmed M Mahmoud, Vesna Gershan, Aruna Kausik, Urban Zdesar, María-Ester Brandan, Serap Kurt, Jasna Davidović, Dina H Salama, Erkin Aribal, Clara Odio, Arvind K Chaturvedi, Zahida Sabih, Saša Vujnović, Diana Paez, Harry Delis
PURPOSE: The International Atomic Energy Agency (IAEA) through a Coordinated Research Project on "Enhancing Capacity for Early Detection and Diagnosis of Breast Cancer through Imaging", brought together a group of mammography radiologists, medical physicists and radiographers; to investigate current practices and improve procedures for the early detection of breast cancer by strengthening both the clinical and medical physics components. This paper addresses the medical physics component...
March 26, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29590633/disease-ontology-improving-and-unifying-disease-annotations-across-species
#12
Susan M Bello, Mary Shimoyama, Elvira Mitraka, Stanley J F Laulederkind, Cynthia L Smith, Janan T Eppig, Lynn M Schriml
Model organisms are vital to uncovering the mechanisms of human disease and developing new therapeutic tools. Researchers collecting and integrating relevant model organism and/or human data often apply disparate terminologies (vocabularies and ontologies), making comparisons and inferences difficult. A unified disease ontology is required that connects data annotated using diverse disease terminologies, and in which the terminology relationships are continuously maintained. The Mouse Genome Database (MGD, http://www...
March 12, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29543662/perioperative-ocular-parameters-associated-with-persistent-dry-eye-symptoms-after-cataract-surgery
#13
Young Joon Choi, Si Yoon Park, Ikhyun Jun, Moonjung Choi, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
PURPOSE: To evaluate perioperative dry eye (DE) syndrome and meibomian gland dysfunction (MGD) parameters associated with persistent DE symptoms after cataract surgery. METHODS: We enrolled patients who underwent uncomplicated cataract surgery without previous ocular comorbidities and previous use of ophthalmic treatment except for artificial tears at a single tertiary hospital. Lipid layer thickness, meibomian gland (MG) dropout, tear breakup time, Oxford staining score, lid margin abnormality, meibum quality, meibum expressibility, MG orifice obstruction, MGD stage, Ocular Surface Disease Index (OSDI), and Schirmer test score were prospectively assessed in order at baseline and 1 and 3 months postoperative...
June 2018: Cornea
https://www.readbyqxmd.com/read/29514152/investigation-of-exposure-factors-for-various-breast-composition-and-thicknesses-in-digital-screening-mammography-related-to-breast-dose
#14
Khaled Alkhalifah, Ajit Brindhaban
OBJECTIVE: To investigate the effect of exposure factors used in digital screening mammography on images quality of different breast compositions. MATERIAL AND METHODS: A digital mammographic unit, with Tungsten (W) as target, Rhodium (Rh) and Silver (Ag) as filters and amorphous selenium (a-Se) detectors, was used to image Computerized Imaging Reference Systems (CIRS) Model 12A phantoms of thickness 4, 5 and 6 cm. Images of each phantom were obtained using target-filter combinations of W/Rh and W/Ag, at 28, 30, and 32 kVp...
March 7, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29483942/optimization-of-cellulolytic-enzyme-components-through-engineering-trichoderma-reesei-and-on-site-fermentation-using-the-soluble-inducer-for-cellulosic-ethanol-production-from-corn-stover
#15
Yong-Hao Li, Xiao-Yue Zhang, Fei Zhang, Liang-Cai Peng, Da-Bing Zhang, Akihiko Kondo, Feng-Wu Bai, Xin-Qing Zhao
Background: Cellulolytic enzymes produced by Trichoderma reesei are widely studied for biomass bioconversion, and enzymatic components vary depending on different inducers. In our previous studies, a mixture of glucose and disaccharide (MGD) was developed and used to induce cellulase production. However, the enzymatic profile induced by MGD is still not defined, and further optimization of the enzyme cocktail is also required for efficient ethanol production from lignocellulosic biomass...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29483649/structural-basis-for-gtp-hydrolysis-and-conformational-change-of-mfn1-in-mediating-membrane-fusion
#16
Liming Yan, Yuanbo Qi, Xiaofang Huang, Caiting Yu, Lan Lan, Xiangyang Guo, Zihe Rao, Junjie Hu, Zhiyong Lou
Fusion of the outer mitochondrial membrane is mediated by the dynamin-like GTPase mitofusin (MFN). Here, we determined the structure of the minimal GTPase domain (MGD) of human MFN1 in complex with GDP-BeF3 - . The MGD folds into a canonical GTPase fold with an associating four-helix bundle, HB1, and forms a dimer. A potassium ion in the catalytic core engages GDP and BeF3 - (GDP-BeF3 - ). Enzymatic analysis has confirmed that efficient GTP hydrolysis by MFN1 requires potassium. Compared to previously reported MGD structures, the HB1 structure undergoes a major conformational change relative to the GTPase domains, as they move from pointing in opposite directions to point in the same direction, suggesting that a swing of the four-helix bundle can pull tethered membranes closer to achieve fusion...
March 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29472943/do-galactolipid-synthases-play-a-key-role-in-the-biogenesis-of-chloroplast-membranes-of-higher-plants
#17
REVIEW
Joana Rocha, Milène Nitenberg, Agnès Girard-Egrot, Juliette Jouhet, Eric Maréchal, Maryse A Block, Christelle Breton
A unique feature of chloroplasts is their high content of the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), which constitute up to 80% of their lipids. These galactolipids are synthesized in the chloroplast envelope membrane through the concerted action of galactosyltransferases, the so-called 'MGDG synthases (MGDs)' and 'DGDG synthases (DGDs),' which use uridine diphosphate (UDP)-galactose as donor. In Arabidopsis leaves, under standard conditions, the enzymes MGD1 and DGD1 provide the bulk of galactolipids, necessary for the massive expansion of thylakoid membranes...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29459039/influence-of-meibomian-gland-dysfunction-and-friction-related-disease-on-the-severity-of-dry-eye
#18
Chi Hoang Viet Vu, Motoko Kawashima, Masakazu Yamada, Kazuhisa Suwaki, Miki Uchino, Chika Shigeyasu, Yoshimune Hiratsuka, Norihiko Yokoi, Kazuo Tsubota
PURPOSE: To evaluate the effect of meibomian gland dysfunction (MGD) and friction-related disease (FRD) on the severity of dry eye disease (DED). DESIGN: Cross-sectional observational study. PARTICIPANTS: This study enrolled 449 patients with DED (63 men and 386 women; mean age, 62.6±15.7 years [range, 21-90 years]) for analysis. METHODS: Subjective symptoms, the ocular surface, tear function, and the presence of MGD and FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy) were investigated...
February 16, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29438509/dose-distribution-in-a-breast-undergoing-mammography-based-on-a-3d-detailed-breast-model-for-chinese-women
#19
Wenjing Wang, Rui Qiu, Li Ren, Zechen Feng, Zhen Wu, Chunyan Li, Yantao Niu, Junli Li
Not only the mean glandular dose (MGD) but also the glandular dose distribution is important in describing the radiation exposure to breast in mammography. For a more precise knowledge of the absorbed dose distribution in the breast, experimental measurements with thermoluminescence dosemeter and Monte Carlo simulations with Geant4 were performed in this study. The experimental measurements with homogeneous physical breast phantoms were used to validate Monte Carlo simulations of homogeneous mathematical breast models undergoing mammography...
February 9, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29430473/dose-and-diagnostic-performance-comparison-between-phase-contrast-mammography-with-synchrotron-radiation-and-digital-mammography-a-clinical-study-report
#20
Christian Fedon, Luigi Rigon, Fulvia Arfelli, Diego Dreossi, Elisa Quai, Maura Tonutti, Giuliana Tromba, Maria Assunta Cova, Renata Longo
Two dosimetric quantities [mean glandular dose (MGD) and entrance surface air kerma (ESAK)] and the diagnostic performance of phase-contrast mammography with synchrotron radiation (MSR) are compared to conventional digital mammography (DM). Seventy-one patients (age range, 41 to 82 years) underwent MSR after a DM examination if questionable or suspicious breast abnormalities were not clarified by ultrasonography. The MGD and the ESAK delivered in both examinations were evaluated and compared. Two on-site radiologists rated the images in consensus according to the Breast Imaging Reporting and Data System assessment categories, which were then correlated with the final diagnoses by means of statistical generalized linear models (GLMs)...
January 2018: Journal of Medical Imaging
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