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https://www.readbyqxmd.com/read/27920125/structures-of-human-mitofusin-1-provide-insight-into-mitochondrial-tethering
#1
Yuanbo Qi, Liming Yan, Caiting Yu, Xiangyang Guo, Xin Zhou, Xiaoyu Hu, Xiaofang Huang, Zihe Rao, Zhiyong Lou, Junjie Hu
Mitochondria undergo fusion and fission. The merging of outer mitochondrial membranes requires mitofusin (MFN), a dynamin-like GTPase. How exactly MFN mediates membrane fusion is poorly understood. Here, we determined crystal structures of a minimal GTPase domain (MGD) of human MFN1, including the predicted GTPase and the distal part of the C-terminal tail (CT). The structures revealed that a helix bundle (HB) formed by three helices extending from the GTPase and one extending from the CT closely attaches to the GTPase domain, resembling the configuration of bacterial dynamin-like protein...
December 5, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27911432/-eye-lid-hygiene-in-chronic-allergic-blepharoconjunctivitis-patients-before-laser-refractive-surgery
#2
S V Yanchenko, A V Malyshev, S N Sakhnov, N V Fedotova, O Yu Orekhova
AIM: To evaluate the effectiveness of eyelid hygiene in patients with chronic allergic blepharoconjunctivitis (ABC) as a part of their preparation for laser refractive surgery. MATERIAL AND METHODS: The study involved 32 patients (12 males and 20 females aged 25-42 years) with refractive errors, namely, compound myopic astigmatism (23 patients) and hyperopic astigmatism (9 patients) suffering from chronic ABC and secondary dry eye syndrome (DES). All the patients initially received a standard treatment for ABC and DES, that is olopatodin hydrochloride instillations - 1 mg/ml 2 times daily, preservative-free hyaluronic acid preparation - 1 mg/ml 3 times daily, and polyacrylic acid and dexpanthenol gel at night for one month...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27908421/low-magnesium-diet-alters-distribution-of-macroelements-and-trace-elements-in-tissues-and-organs-of-female-rats
#3
Anastasia A Zheltova, Maria V Kharitonova, Igor N Iezhitsa, Eugeny P Serebryansky, Oleg Y Evsyukov, Alexander A Spasov, Anatoly V Skalny
The aim of the present study was to assess whether dietary magnesium deficiency can alter distribution of macroelements and trace elements in different organs and tissues. Experiments were carried out on 12 adult female Wistar rats, which were fed either a diet with low Mg content (≤20mgkg(-1) of diet) (LMgD) or a diet with daily recommended Mg content (≈500mgkg(-1)) as control group (CG) for 70 days. On the 70th day of the experiment heart, aorta, femoral skeletal muscle, forebrain, cerebellum, pituitary gland, thyroid gland, ovaries, uterus, liver, kidneys, and spleen were taken for analysis of mineral content...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27899570/mouse-genome-database-mgd-2017-community-knowledge-resource-for-the-laboratory-mouse
#4
Judith A Blake, Janan T Eppig, James A Kadin, Joel E Richardson, Cynthia L Smith, Carol J Bult
The Mouse Genome Database (MGD: http://www.informatics.jax.org) is the primary community data resource for the laboratory mouse. It provides a highly integrated and highly curated system offering a comprehensive view of current knowledge about mouse genes, genetic markers and genomic features as well as the associations of those features with sequence, phenotypes, functional and comparative information, and their relationships to human diseases. MGD continues to enhance access to these data, to extend the scope of data content and visualizations, and to provide infrastructure and user support that ensures effective and efficient use of MGD in the advancement of scientific knowledge...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27895876/assessment-of-mean-glandular-dose-in-mammography-system-with-different-anode-filter-combinations-using-mcnp-code
#5
Lida Gholamkar, Ali Asghar Mowlavi, Mahdi Sadeghi, Mitra Athari
BACKGROUND: X-ray mammography is one of the general methods for early detection of breast cancer. Since glandular tissue in the breast is sensitive to radiation and it increases the risk of cancer, the given dose to the patient is very important in mammography. OBJECTIVES: The aim of this study was to determine the average absorbed dose of X-ray radiation in the glandular tissue of the breast during mammography examinations as well as investigating factors that influence the mean glandular dose (MGD)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27854048/magnesium-deficiency-and-oxidative-stress-an-update
#6
Anastasia A Zheltova, Maria V Kharitonova, Igor N Iezhitsa, Alexander A Spasov
Magnesium deficiency (MgD) has been shown to impact numerous biological processes at the cellular and molecular levels. In the present review, we discuss the relationship between MgD and oxidative stress (OS). MgD is accompanied by increased levels of OS markers such as lipid, protein and DNA oxidative modification products. Additionally, a relationship was detected between MgD and a weakened antioxidant defence. Different mechanisms associated with MgD are involved in the development and maintenance of OS...
December 2016: BioMedicine
https://www.readbyqxmd.com/read/27853352/tear-lipid-layer-thickness-with-eye-drops-in-meibomian-gland-dysfunction
#7
Jennifer S Fogt, Matthew J Kowalski, P Ewen King-Smith, Alice T Epitropolous, Andrew J Hendershot, Carrie Lembach, John Paul Maszczak, Lisa A Jones-Jordan, Joseph T Barr
PURPOSE: The aim of this study was to evaluate the efficacy of a lipid containing emollient eye drop, Soothe XP, which was reformulated in 2014 with a more stable preservative and buffer system, compared to a control, non-emollient, eye drop (Systane Ultra) in improving lipid layer thickness (LLT) in subjects with dry eye due to meibomian gland dysfunction (MGD). PATIENTS AND METHODS: This prospective single-center, open-label, cross-over, examiner masked-study enrolled subjects aged 30-75 years with lipid-deficient dry eye and a clinical diagnosis of MGD as determined by a slit lamp examination, an evaluation of meibomian gland drop out with meibography, and a standard patient evaluation of eye dryness questionnaire of >5...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27837409/need-for-animal-models-of-meibomian-gland-dysfunction
#8
Louis Tong, Preeya K Gupta
Evaporative dry eye has gained increasing interest in recent years in academia, pharmaceutical, and medical device industries. The main cause of this type of dry eye is attributed to meibomian gland dysfunction (MGD). MGD is a diffuse abnormality of the meibomian glands characterised by terminal duct obstruction and eventually leading to signs and symptoms of dry eye. There have been only a few reported animal models of MGD, but recent advances are likely to lead to new models and better ways to assess the pathology in these animals...
November 11, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27817990/infrared-thermography-in-the-evaluation-of-meibomian-gland-dysfunction
#9
Tai-Yuan Su, Wei-Ting Ho, Shu-Chiung Chiang, Chien-Yi Lu, Huihua Kenny Chiang, Shu-Wen Chang
BACKGROUND/PURPOSE: To evaluate meibomian gland dysfunction (MGD) by infrared thermography. METHODS: An observational study was conducted at the Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan. Participants included 89 MGD patients (30 in Grade 1, 49 in Grade 2, and 10 in Grade 3) and 65 controls. The close-eye thermographic images of the eyelid were obtained noninvasively by infrared thermography. Temperatures at 8 regions of interest (ROIs) of the eyelid margin and a reference temperature at the center of the upper eyelid were measured...
November 3, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27816570/examination-of-gland-dropout-detected-on-infrared-meibography-by-using-optical-coherence-tomography-meibography
#10
Young-Sik Yoo, Kyung-Sun Na, Yong-Soo Byun, Jun Geun Shin, Byeong Ha Lee, Geunyoung Yoon, Tae Joong Eom, Choun-Ki Joo
PURPOSE: To elucidate the anatomic details of gland dropout detected on two-dimensional infrared (IR) meibography in cases of dry eye associated with meibomian gland dysfunction (MGD) by using three-dimensional optical coherence tomography (OCT) meibography. METHODS: In this cross-sectional, observational case series, we enrolled gland dropout detected on IR meibography; the condition was then examined using a real-time swept-source OCT system. Accordingly, a series of 500 raster B-scan OCT images, with the gland dropout site (observed on IR imaging) at the center, were obtained and rendered as three-dimensional volume images...
November 2, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27798696/a-simple-novel-technique-of-infrared-meibography-by-means-of-spectral-domain-optical-coherence-tomography-a-cross-sectional-clinical-study
#11
Pietro Emanuele Napoli, Franco Coronella, Giovanni Maria Satta, Claudio Iovino, Raffaele Sanna, Maurizio Fossarello
PURPOSE: To compare a novel spectral-domain optical coherence tomography (SD-OCT) technique with traditional lid transillumination for evaluation of meibomian glands (MGs) and to assess the relation of MG morphologic changes to the glandular atrophy. DESIGN: Evaluation of diagnostic technology. PARTICIPANTS: Sixty-one patients with obstructive MGD (30 men, 31 women; age [mean ± standard deviation] 45.1 ± 12.1 years), and 75 control subjects (32 men, 43 women; 44...
2016: PloS One
https://www.readbyqxmd.com/read/27791408/evaluation-of-meibomian-gland-dysfunction-in-polycystic-ovary-syndrome-and-obesity
#12
Gonen Baser, Nurdan Yildiz, Mehmet Calan
: Purpose/Aim of the study: The purpose of this study was to evaluate the interaction between Polycystic ovary syndrome (PCOS) and Meibomian gland dysfunction (MGD) and obesity, to reveal whether there is a correlation between the testosterone levels and body-mass index (BMI) levels and the dry-eye complaints of these patients. MATERIAL AND METHODS: The study included 92 patients with PCOS and 52 healthy patients from March 2013 to March 2014. All patients underwent a physical examination, pelvic ultrasound, and clinical and biochemical tests, including free testosterone levels to confirm the diagnosis of PCOS...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27779170/in-vivo-confocal-microscopy-evaluation-of-meibomian-gland-dysfunction-in-dry-eye-patients-with-different-symptoms
#13
Hui Zhao, Jing-Yao Chen, Yu-Qian Wang, Zhi-Rong Lin, Shen Wang
BACKGROUND: Dry eye patients suffer from all kinds of symptoms. Sometimes, the clinical signs evaluation does not disclose any obvious difference in routine examination; in vivo confocal microscopy (IVCM) is a powerful tool for ocular surface disease. This study aimed to clarify meibomian gland (MG) alterations in dry eye patients with different symptoms and to compare the findings using IVCM. METHODS: A total of sixty patients were recruited, all subjected to Ocular Surface Disease Index (OSDI) and Salisbury Eye Evaluation Questionnaire (SEEQ), and questionnaires for the assessment of dry eye symptoms before clinical sign examinations were given to the patients...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27755288/the-relationship-between-morphology-and-function-of-the-meibomian-glands
#14
Hyo Myung Kim, Youngsub Eom, Jong Suk Song
Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease (DED). Meibomian gland dysfunction is divided into two major categories based on meibomian gland secretion: low delivery and high delivery. The low-delivery states are further classified as either hyposecretory or obstructive subtype, and the high-delivery state is termed "hypersecretory MGD." Two parameters are commonly used to evaluate meibomian gland function: lipid layer thickness and meibum quality and expressibility. To evaluate the morphology of meibomian glands, meibography is used to detect meibomian gland dropout...
October 13, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27755193/reversibility-of-gland-dropout-and-significance-of-eyelid-hygiene-treatment-in-meibomian-gland-dysfunction
#15
Yue Yin, Lan Gong
PURPOSE: To observe reversibility of meibomian gland (MG) dropout and analyze correlated factors and to compare the treatment efficiency with and without eyelid hygiene in patients with meibomian gland dysfunction (MGD). METHODS: Consecutive 78 eyes of 78 MGD (stage 2-3) patients who finished follow-up examination after 1-month of treatment were recruited in this retrospective study. All patients were treated with artificial lubricant and eyelid hygiene. Related ocular surface evaluation and meibomian gland assessment were examined...
October 14, 2016: Cornea
https://www.readbyqxmd.com/read/27749453/assessment-of-the-tear-meniscus-by-strip-meniscometry-and-keratograph-in-patients-with-dry-eye-disease-according-to-the-presence-of-meibomian-gland-dysfunction
#16
Kang Won Lee, Jung Yong Kim, Hee Seung Chin, Kyoung Yul Seo, Tae-Im Kim, Ji Won Jung
PURPOSE: We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects. METHODS: We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27729924/conditions-promoting-mycorrhizal-parasitism-are-of-minor-importance-for-competitive-interactions-in-two-differentially-mycotrophic-species
#17
Martina Friede, Stephan Unger, Christine Hellmann, Wolfram Beyschlag
Interactions of plants with arbuscular mycorrhizal fungi (AMF) may range along a broad continuum from strong mutualism to parasitism, with mycorrhizal benefits received by the plant being determined by climatic and edaphic conditions affecting the balance between carbon costs vs. nutritional benefits. Thus, environmental conditions promoting either parasitism or mutualism can influence the mycorrhizal growth dependency (MGD) of a plant and in consequence may play an important role in plant-plant interactions...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27714925/diagnostic-reference-levels-for-digital-mammography-in-new-south-wales
#18
Moayyad E Suleiman, Mark F McEntee, Lucy Cartwright, Jennifer Diffey, Patrick C Brennan
INTRODUCTION: This work aims to explore radiation doses delivered in screening mammography in Australia, with a focus on whether compressed breast thickness should be used as a guide when determining patient derived diagnostic reference levels (DRLs). METHODS: Anonymized mammograms (52,405) were retrieved from a central database, and DICOM headers were extracted using third party software. Women with breast implants, breast thicknesses outside 20-110 mm and images with incomplete exposure or quality assurance (QA) data were excluded...
October 6, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27699522/eyelid-cleansing-with-ointment-for-obstructive-meibomian-gland-dysfunction
#19
Minako Kaido, Osama M A Ibrahim, Motoko Kawashima, Reiko Ishida, Enrique A Sato, Kazuo Tsubota
PURPOSE: To investigate the efficacy of eyelid margin cleansing with ofloxacin ophthalmic ointment in obstructive meibomian gland dysfunction (MGD) patients. METHODS: Thirty-one eyes of 31 patients diagnosed with obstructive MGD were enrolled. All subjects were instructed to rub the eyelid edge with ofloxacin eye ointment once daily prior to bathing. Lid margin abnormalities, meibum properties, and tear stability were observed before and 3 months after ointment treatment...
October 3, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27695207/scrotal-abscess-varied-etiology-associations-and-management
#20
Raghu S Ramareddy, Anand Alladi
AIM: To report a series of scrotal abscess, a rare problem, their etiology, and management. MATERIALS AND METHODS: A retrospective study of children who presented with scrotal abscess between January 2010 and March 2015, analyzed with respect to clinical features, pathophysiology of spread and management. RESULTS: Eight infants and a 3-year-old phenotypically male child presented with scrotal abscess as a result of abdominal pathologies which included mixed gonadal dysgenesis (MGD) [1]; three anorectal malformations with ectopic ureter [1], urethral stricture [1], and neurogenic bladder [1]; meconium peritonitis with meconium periorchitis [2], ileal atresia [1], and intra-abdominal abscess [1]; posturethroplasty for Y urethral duplication with metal stenosis [1] and idiopathic pyocele [1]...
October 2016: Journal of Indian Association of Pediatric Surgeons
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