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https://www.readbyqxmd.com/read/29334455/modulating-the-molybdenum-coordination-sphere-of-escherichia-coli-trimethylamine-n-oxide-reductase
#1
Paul Kaufmann, Benjamin R Duffus, Biljana Mitrova, Chantal Iobbi-Nivol, Christian Teutloff, Manfred Nimtz, Lothar Jänsch, Ulla Wollenberger, Silke Leimkühler
The well-studied enterobacterium Escherichia coli present in the human gut is able to reduce TMAO to trimethylamine (TMA) during anaerobic respiration. The TMAO reductase TorA is a monomeric, bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor-containing enzyme belonging to the dimethylsulfoxide (DMSO) reductase family of molybdoenzymes. We report on a system for the in vitro reconstitution of TorA with molybdenum cofactors (Moco) from different sources. Higher TMAO reductase activities for TorA were obtained when using Moco-sources containing a sulfido ligand at the molybdenum atom...
January 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29317053/fear-of-movement-modulates-the-feedforward-motor-control-of-the-affected-limb-in-complex-regional-pain-syndrome-crps-a-single-case-study
#2
Michihiro Osumi, Masahiko Sumitani, Yuko Otake, Shu Morioka
Pain-related fear can exacerbate physical disability and pathological pain in complex regional pain syndrome (CRPS) patients. We conducted a kinematic analysis of grasping movements with a pediatric patient suffering from CRPS in an upper limb to investigate how pain-related fear affects motor control. Using a three-dimensional measurement system, we recorded the patient's movement while grasping three vertical bars of different diameters (thin, middle, thick) with the affected and intact hands. We analyzed the maximum grasp distance between the thumb and the index finger (MGD), the peak velocity of the grasp movement (PV), and the time required for the finger opening phase (TOP) and closing phase (TCP)...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29300267/ocular-surface-workup-with-automated-noninvasive-measurements-for-the-diagnosis-of-meibomian-gland-dysfunction
#3
Giuseppe Giannaccare, Luca Vigo, Marco Pellegrini, Stefano Sebastiani, Francesco Carones
PURPOSE: To analyze diagnostic performance of an ocular surface workup based on automated noninvasive measurements in the diagnosis of meibomian gland dysfunction (MGD). METHODS: Two hundred ninety-eight eyes of 149 patients with MGD and 54 eyes of 27 control patients were analyzed. Ocular Surface Disease Index (OSDI), noninvasive breakup time (BUT), lipid layer thickness, meibomian gland loss, and tear osmolarity were calculated. The correlations among variables in the MGD group were analyzed...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29234088/tear-proteome-analysis-in-ocular-surface-diseases-using-label-free-lc-ms-ms-and-multiplexed-microarray-biomarker-validation
#4
Javier Soria, Arantxa Acera, Jesús Merayo-LLoves, Juan A Durán, Nerea González, Sandra Rodriguez, Nikitas Bistolas, Soeren Schumacher, Frank F Bier, Harald Peter, Walter Stöcklein, Tatiana Suárez
We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals. Of these, 37 samples were analyzed using spectral-counting-based LC-MS/MS label-free quantitation, and 33 samples were evaluated in the validation of candidate biomarkers employing customized antibody microarray assays. Comparative analysis of tear protein profiles revealed differences in the expression levels of 26 proteins, including protein S100A6, annexin A1, cystatin-S, thioredoxin, phospholipase A2, antileukoproteinase, and lactoperoxidase...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227342/eyelid-changes-related-to-meibomian-gland-dysfunction-in-early-middle-aged-patients-using-topical-glaucoma-medications
#5
Ji Hong Kim, Yong Un Shin, Mincheol Seong, Hee Yoon Cho, Min Ho Kang
PURPOSE: To investigate the relationship between topical glaucoma medications and meibomian gland dysfunction (MGD) in early middle-aged patients with glaucoma. METHODS: In this cross-sectional study, 50 patients with glaucoma younger than 50 years who had used topical glaucoma medications for more than 6 months and 40 normal controls of similar age were included. Patients in each group were graded for MGD (0-4) using slit-lamp microscopy. Tear film breakup time (BUT), ocular surface staining, and Marx line scores were also evaluated...
December 8, 2017: Cornea
https://www.readbyqxmd.com/read/29199865/changes-in-the-meibomian-gland-after-exposure-to-intense-pulsed-light-in-meibomian-gland-dysfunction-mgd-patients
#6
Yue Yin, Ninghua Liu, Lan Gong, Nan Song
PURPOSE: To observe (1) changes in meibomian gland (MG) after exposure to intense pulsed light (IPL) and (2) to understand the mechanism by which IPL treats meibomian gland dysfunction (MGD) in patients. METHODS: A cohort study, including 35 MGD patients, was conducted. IPL treatment was administered in one group (IPL group; n = 18), and eyelid hygiene in another (control group; n = 17) for 3 months. All patients were given artificial tears during the treatment period...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29174058/intraoperative-pth-spikes-during-parathyroidectomy-may-be-associated-with-multiglandular-disease
#7
Richard Teo, Josefina C Farrá, Zahra F Khan, Andrea R Marcadis, John I Lew
BACKGROUND: The importance of intraoperative parathormone (ioPTH) "spikes" during parathyroidectomy (PTX) remains unclear. This study compared patients with and without ioPTH spikes during PTX using the criterion of a > 50% PTH, and determined the effect of ioPTH spikes on operative outcome. METHODS: We performed a retrospective review of prospectively collected data of 683 patients who underwent PTX guided by ioPTH monitoring. An ioPTH "spike value' (SV) was calculated by subtracting the pre-incision ioPTH value (PI) from pre-excision ioPTH value (PE) (SV = PE - PI)...
November 21, 2017: Surgery
https://www.readbyqxmd.com/read/29169367/image-based-quantitative-analysis-of-tear-film-lipid-layer-thickness-for-meibomian-gland-evaluation
#8
Hyeonha Hwang, Hee-Jae Jeon, Kin Choong Yow, Ho Sik Hwang, EuiHeon Chung
BACKGROUND: Dry eye syndrome is one of the most common ocular diseases, and meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye syndrome. When the tear film lipid layer becomes thin due to obstructive or hyposecretory meibomian gland dysfunction, the excessive evaporation of the aqueous layer can occur, and this causes evaporative dry eye syndrome. Thus, measuring the lipid layer thickness (LLT) is essential for accurate diagnosis and proper treatment of evaporative dry eye syndrome...
November 23, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29163230/physiological-levels-of-nitric-oxide-diminish-mitochondrial-superoxide-potential-role-of-mitochondrial-dinitrosyl-iron-complexes-and-nitrosothiols
#9
Sergey I Dikalov, Vladimir I Mayorov, Alexander V Panov
Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that physiological production of nitric oxide reduces oxidative stress and inflammation, however, the precise mechanism of "antioxidant" effect of nitric oxide is not clear. In this work we tested the hypothesis that physiological levels of nitric oxide diminish mitochondrial superoxide production without inhibition of mitochondrial respiration...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29152172/a-quadratic-correlation-between-long-term-mean-group-size-and-group-density-in-a-cooperatively-breeding-passerine
#10
Dian-Hua Ke, Yan-Hui Deng, Wei-Bin Guo, Zu-Hao Huang
Both mean group size (MGS) and mean group density (MGD) are critical indices to characterize a population of cooperatively breeding birds. When a population reaches its carrying capacity, both long-term MGS and long-term MGD will remain relatively stable. However, there has been little study of how these two variables relate. The Masked laughingthrush Garrulax perspicillatus is a cooperatively breeding bird living in fragmented habitats. During 2010 and 2012-2016, we used song playback to observe and confirm the group sizes and territory ranges of the birds and the data of bird presence to determine habitat suitability...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29103483/mathematical-modelling-of-radiation-induced-cancer-risk-from-breast-screening-by-mammography
#11
Raed M K M Ali, Andrew England, Claire Mercer, Andrew Tootell, Lucy Walton, Wouter Schaake, Peter Hogg
OBJECTIVES: Establish a method to determine and convey lifetime radiation risk from FFDM screening. METHODS: Radiation risk from screening mammography was quantified using effective risk (number of radiation-induced cancer cases/million). For effective risk calculations, organ doses and examined breast MGD were used. Screening mammography was simulated by exposing a breast phantom for cranio-caudal and medio-lateral oblique for each breast using 16 FFDM machines...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29103124/features-and-influencing-factors-of-nitrogen-and-phosphorus-diffusive-fluxes-at-the-sediment-water-interface-of-erhai-lake
#12
Haichao Zhao, Li Zhang, Shengrui Wang, Lixin Jiao
Nitrogen and phosphorus diffusion at the sediment-water interface is vital to the water quality of lakes. In this paper, N and P diffusive fluxes at the sediment-water interface in Erhai Lake were studied using the sediment-pore water diffusive flux method. Characteristics of temporal and spatial variation of N and P diffusive fluxes were analyzed. Effects of the physicochemical properties of sediments and overlying water were discussed. Results showed that (1) the total N and P diffusive fluxes at the sediment-water interface of Erhai Lake are relatively low...
November 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29092072/mouse-genome-database-mgd-2018-knowledgebase-for-the-laboratory-mouse
#13
Cynthia L Smith, Judith A Blake, James A Kadin, Joel E Richardson, Carol J Bult
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the key community mouse database which supports basic, translational and computational research by providing integrated data on the genetics, genomics, and biology of the laboratory mouse. MGD serves as the source for biological reference data sets related to mouse genes, gene functions, phenotypes and disease models with an increasing emphasis on the association of these data to human biology and disease. We report here on recent enhancements to this resource, including improved access to mouse disease model and human phenotype data and enhanced relationships of mouse models to human disease...
October 30, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29090572/air-emission-reduction-benefits-of-biogas-electricity-generation-at-municipal-wastewater-treatment-plants
#14
Daniel Beryl Gingerich, Meagan S Mauter
Conventional processes for municipal wastewater treatment facilities are energy and materially intensive. This work quantifies the air emission implications of energy consumption, chemical use, and direct pollutant release at municipal wastewater treatment facilities across the US and assesses the potential to avoid these damages by generating electricity and heat from the combustion of biogas produced during anaerobic sludge digestion. We find that embedded and on-site air emissions from municipal wastewater treatment imposed human health, environmental, and climate (HEC) damages on the order of $1...
November 1, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29078878/machine-learning-to-identify-multigland-disease-in-primary-hyperparathyroidism
#15
Joseph R Imbus, Reese W Randle, Susan C Pitt, Rebecca S Sippel, David F Schneider
BACKGROUND: 20%-25% of patients with primary hyperparathyroidism will have multigland disease (MGD). Preoperatative imaging can be inaccurate or unnecessary in MGD. Identification of MGD could direct the need for imaging and inform operative approach. The purpose of this study is to use machine learning (ML) methods to predict MGD. METHODS: Retrospective review of a prospective database. The ML platform, Waikato Environment for Knowledge Analysis, was used, and we selected models for (1) overall accuracy and (2) preferential identification of MGD...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29075094/effect-of-topical-3-diquafosol-sodium-on-eyes-with-dry-eye-disease-and-meibomian-gland-dysfunction
#16
Shiro Amano, Kenji Inoue
PURPOSE: To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD). PATIENTS AND METHODS: The subjects were consecutive patients diagnosed with both DED and MGD at Inouye Eye Hospital between March and September of 2016. The subjects were administered topical 3% diquafosol sodium ophthalmic solution six times a day for 3 months. At each study visit, subjects underwent slit-lamp examination and completed MGD symptoms and dry eye-related quality of life score (DEQS) questionnaires...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29055903/significant-correlation-between-meibomian-gland-dysfunction-and-keratitis-in-young-patients-with-demodex-brevis-infestation
#17
Lingyi Liang, Yan Liu, Xiaohu Ding, Hongmin Ke, Chuan Chen, Scheffer C G Tseng
AIMS: To report the clinical characteristics and correlation between meibomian gland dysfunction (MGD) and keratitis in young patients with ocular demodicosis. METHODS: Observational case series of 60 patients younger than 35 years with ocular demodicosis, of which the diagnosis was based on microscopic counting of Demodex folliculorum and D. brevis of epilated lashes. Severity of keratitis and MGD was graded by photography and meibography, respectively, in a masked fashion...
October 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29055358/meibomian-gland-disease-the-role-of-gland-dysfunction-in-dry-eye-disease
#18
REVIEW
Priyanka Chhadva, Raquel Goldhardt, Anat Galor
TOPIC: To discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationship to dry eye. CLINICAL RELEVANCE: MGD is a common disorder with various contributing mechanisms and clinical manifestations. Understanding MGD pathophysiology and its relationship to dry eye is important in order to optimize diagnosis and treatment algorithms. METHODS: A review of current literature was performed to discern MGD in terms of pathophysiology, risk factors, and ocular surface impact, and the relationship to dry eye...
November 2017: Ophthalmology
https://www.readbyqxmd.com/read/29052604/effect-of-topical-loteprednol-etabonate-with-lid-hygiene-on-tear-cytokines-and-meibomian-gland-dysfunction-in-prosthetic-eye-wearers
#19
J S Ko, Y Seo, M K Chae, S Y Jang, J S Yoon
PurposeTo assess tear cytokine levels and clinical outcomes in meibomian gland dysfunction (MGD) in the blind eye of patients wearing an ocular prosthesis after 2 months of treatment with topical loteprednol etabonate and eyelid scrubs with warm compresses.Patients and methodsThis study included patients with MGD wearing a unilateral ocular prosthesis for more than 1 year. All patients topically received 0.5% loteprednol etabonate and were instructed to scrub their eyelids with warm compresses on the prosthetic eye for 2 months...
October 20, 2017: Eye
https://www.readbyqxmd.com/read/29033270/a-survey-of-contact-lens-related-complications-in-a-tertiary-hospital-in-china
#20
Weiwei Li, Xuguang Sun, Zhiqun Wang, Yang Zhang
PURPOSE: To describe the type of complications related to contact lens (CL) wear in a tertiary hospital in XX, China. METHODS: A retrospective study of 141 patients who complained discomfort after wearing contact lens on an outpatient basis of XX Hospital were conducted from the January 2012 to December 2015. The data included patients' demographics, lens type, history, slit-lamp examination, reports of corneal scrapings, culture, and examination of in vivo confocal microscopy...
October 12, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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