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https://www.readbyqxmd.com/read/28099212/dysfunctional-tear-syndrome-dry-eye-disease-and-associated-tear-film-disorders-new-strategies-for-diagnosis-and-treatment
#1
Mark S Milner, Kenneth A Beckman, Jodi I Luchs, Quentin B Allen, Richard M Awdeh, John Berdahl, Thomas S Boland, Carlos Buznego, Joseph P Gira, Damien F Goldberg, David Goldman, Raj K Goyal, Mitchell A Jackson, James Katz, Terry Kim, Parag A Majmudar, Ranjan P Malhotra, Marguerite B McDonald, Rajesh K Rajpal, Tal Raviv, Sheri Rowen, Neda Shamie, Jonathan D Solomon, Karl Stonecipher, Shachar Tauber, William Trattler, Keith A Walter, George O Waring, Robert J Weinstock, William F Wiley, Elizabeth Yeu
Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of diagnosis and treatment guidelines pertaining to disorders resulting in DTS, including the Delphi panel treatment recommendations for DTS (2006), the International Dry Eye Workshop (DEWS) (2007), the Meibomian Gland Dysfunction (MGD) Workshop (2011), and the updated Preferred Practice Pattern guidelines from the American Academy of Ophthalmology pertaining to dry eye and blepharitis (2013)...
January 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28093340/bacteriological-profile-of-ocular-surface-flora-in-meibomian-gland-dysfunction
#2
Shao Dan Zhang, Jing Na He, Tong Tong Niu, Chiu Yeung Chan, Chun Yang Ren, Shan Shan Liu, Yang Qu, Kam Lung Chong, Hai Lin Wang, Jun Tao, Chi Pui Pang
PURPOSE: To compare the bacteriological profile of meibomian gland secretion and conjunctival cul-de-sac in subjects with and without meibomian gland dysfunction (MGD). METHODS: This hospital-based study enrolled 201 eyes from 201 MGD patients and 84 eyes from 84 age- and gender-matched controls. Samples from the conjunctivae and meibomian gland secretion were obtained. Both aerobic and anaerobic cultures were performed. Differences in the culture-positivity and bacterial strains between two groups were compared...
January 13, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28075335/towards-standardization-of-x-ray-beam-filters-in-digital-mammography-and-digital-breast-tomosynthesis-monte-carlo-simulations-and-analytical-modelling
#3
Suman Shrestha, Srinivasan Vedantham, Andrew Karellas
In digital breast tomosynthesis and digital mammography, the x-ray beam filter material and thickness vary between systems. Replacing K-edge filters with Al was investigated with the intent to reduce exposure duration and to simplify system design. Tungsten target x-ray spectra were simulated with K-edge filters (50��m Rh; 50��m Ag) and Al filters of varying thickness. Monte Carlo simulations were conducted to quantify the x-ray scatter from various filters alone, scatter-to-primary ratio (SPR) with compressed breasts, and to determine the radiation dose to the breast...
January 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28064087/modelling-the-link-amongst-fine-pore-diffuser-fouling-oxygen-transfer-efficiency-and-aeration-energy-intensity
#4
Manel Garrido-Baserba, Reza Sobhani, Pitiporn Asvapathanagul, Graham W McCarthy, Betty H Olson, Victory Odize, Ahmed Al-Omari, Sudhir Murthy, Andrea Nifong, Johnnie Godwin, Charles B Bott, Michael K Stenstrom, Andrew R Shaw, Diego Rosso
This research systematically studied the behavior of aeration diffuser efficiency over time, and its relation to the energy usage per diffuser. Twelve diffusers were selected for a one year fouling study. Comprehensive aeration efficiency projections were carried out in two WRRFs with different influent rates, and the influence of operating conditions on aeration diffusers' performance was demonstrated. This study showed that the initial energy use, during the first year of operation, of those aeration diffusers located in high rate systems (with solids retention time - SRT-less than 2 days) increased more than 20% in comparison to the conventional systems (2 > SRT)...
December 19, 2016: Water Research
https://www.readbyqxmd.com/read/28060066/assessment-of-the-tear-meniscus-by-strip-meniscometry-and-keratograph-in-patients-with-dry-eye-disease-according-to-the-presence-of-meibomian-gland-dysfunction
#5
Kang Won Lee, Jung Yong Kim, Hee Seung Chin, Kyoung Yul Seo, Tae-Im Kim, Ji Won Jung
PURPOSE: We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects. METHODS: We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060064/automated-measurement-of-tear-film-dynamics-and-lipid-layer-thickness-for-assessment-of-non-sj%C3%A3-gren-dry-eye-syndrome-with-meibomian-gland-dysfunction
#6
Yong Woo Ji, Jeihoon Lee, Hun Lee, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
PURPOSE: To investigate automated values from an advanced corneal topographer with a built-in real keratometer, color camera, and ocular surface interferometer for the evaluation of non-Sjögren dry eye syndrome (NSDES) with meibomian gland dysfunction (MGD). METHODS: Sixty-four patients (64 eyes) diagnosed with NSDES with MGD were enrolled. All eyes were evaluated using the Ocular Surface Disease Index (OSDI), fluorescence staining score, tear film breakup time (TBUT), Schirmer test, and MGD grade...
February 2017: Cornea
https://www.readbyqxmd.com/read/28048420/su-f-r-27-use-local-shape-descriptor-based-on-geodesic-distance-to-predict-survival-in-non-small-cell-lung-cancer-after-radiotherapy
#7
H Zhang, L Yan, K Huang, F Kong, J Jin
PURPOSE: The shape of the Positron Emission Tomography (PET) image represents the heterogeneity of tumor growth in various directions, and thus could be associated with tumor malignancy. We have proposed a median geodesic distance (MGD) to represent the local complexity of the shape and use a normalized MGD (NMGD) to quantify the shape, and found a potential correlation of NMGD to survival in a 20-patient pilot study. This study was to verify the finding in a larger patient cohort. METHODS: Geodesic distance of two vertices on a surface is defined as the shortest path on the surface connecting the two vertices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048364/we-fg-207a-01-introduction-to-dedicated-breast-ct-early-studies
#8
S Vedantham
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047717/we-fg-207a-02-why-we-need-breast-ct-clinical-perspective
#9
A O'Connell
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047520/we-fg-207a-05-dedicated-breast-ct-as-a-diagnostic-imaging-tool-physics-and-clinical-feasibility
#10
A Karellas
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047068/we-fg-207a-03-low-dose-cone-beam-breast-ct-physics-and-technology-development
#11
J Boone
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046981/we-de-207b-01-optimization-for-contrast-enhanced-spectral-mammography-based-on-photon-counting-detectors
#12
H Ding, S Molloi
PURPOSE: To investigate the feasibility of optimizing the imaging parameters for contrast-enhanced spectral mammography based on Si strip photon-counting detectors. METHODS: A computer simulation model using polyenergetic spectra from a tungsten anode x-ray tube and a Si-based photon-counting detector was evaluated for contrast-enhanced spectral mammography. The simulation traces the emission of photons from the x-ray source, attenuation through the breast and subsequent absorption in the detector...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046408/we-fg-207a-04-performance-characteristics-of-photon-counting-breast-ct
#13
W Kalender
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046291/we-fg-207a-00-advances-in-dedicated-breast-ct
#14
Srinivasan Vedantham, Sabee Molloi
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28030610/impact-of-chronic-smoking-on-meibomian-gland-dysfunction
#15
Shen Wang, Hui Zhao, Caihong Huang, Zhengri Li, Wei Li, Xiaobo Zhang, Zuguo Liu
PURPOSE: The aim of this study was to explore the relationship between chronic cigarette smoking and meibomian gland dysfunction (MGD). METHODS: This study enrolled 322 smokers with MGD and 2067 non-smokers with MGD. All enrolled subjects were tested in the following sequence: Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), corneal fluorescein staining (CFS), Schirmer I test (SIT)and finally slit-lamp microscope examination of lid margin abnormalities, meibomian gland expression as well as meibum...
2016: PloS One
https://www.readbyqxmd.com/read/28002224/meibomian-gland-dysfunction-and-contact-lens-discomfort
#16
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
Meibomian glands are located in the eyelids and secrete meibum, which gives rise to the lipid layer of the tear film. Changes to these glands can lead to the development of meibomian gland dysfunction (MGD), which is associated with various ocular symptoms such as fatigue, dryness, burning sensation, and heavy sensation. The diagnosis of MGD thus relies on evaluation of ocular symptoms, meibum condition, and lid margin abnormalities. The recent development of noninvasive meibography and tear interferometry has provided important insight into meibomian gland structure and function, respectively...
January 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28002092/treatment-practices-and-outcomes-of-meibomian-gland-dysfunction-at-a-tertiary-center-in-southern-india
#17
Ling Lee, Qian Garrett, Judith L Flanagan, Pravin K Vaddavalli, Eric B Papas
OBJECTIVE: To describe the current treatment practices for meibomian gland dysfunction (MGD) at a tertiary eye center, together with the subjective outcomes and compliance behaviors of patients. METHODS: This retrospective cohort study reviewed medical records for MGD severity grading, treatment prescribed, and follow-up schedule. In addition, participants were surveyed to gauge subjective outcomes and treatment adherence. RESULTS: Eight hundred ten patients were diagnosed with "MGD" or "meibomitis" and had a total of 14 different treatment combinations prescribed...
December 19, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27989818/the-binuclear-form-of-dinitrosyl-iron-complexes-with-thiol-containing-ligands-in-animal-tissues
#18
Vasak D Mikoyan, Evgeniya N Burgova, Rostislav R Borodulin, Anatoly F Vanin
It has been established that treatment of mice with sodium nitrite, S-nitrosoglutathione and the water-soluble nitroglycerine derivative isosorbide dinitrate (ISDN) as NO donors initiates in vivo synthesis of significant amounts of EPR-silent binuclear dinitrosyl iron complexes (B-DNIC) with thiol-containing ligands in the liver and other tissues of experimental mice. This effect is especially apparent if NO donors are administered to mice simultaneously with the Fe(2+)-citrate complex. Similar results were obtained in experiments on isolated liver and other mouse tissues treated with gaseous NО in vitro and during stimulation of endogenous NO synthesis in the presence of inducible NO synthase...
January 30, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27959779/brevundimonas-canariensis-sp-nov-isolated-from-roots-of-triticum-aestivum-in-lanzarote-island
#19
Esther Menéndez, Juan Pérez-Yepes, Lorena Carro, Mercedes Fernández-Pascual, Martha-Helena Ramírez-Bahena, Hans-Peter Klenk, Milagros León Barrios, Alvaro Peix, Encarna Velázquez
A bacterial strain designated GTAE24T was isolated from a root of wheat growing in a soil from Canary Islands in Spain. Phylogenetic analyses based on 16S rRNA gene sequence placed the isolate into the genus Brevundimonas being its closest relative Brevundimonas abyssalis TAR.001T with 99.4 % similarity. DNA-DNA hybridization studies showed an average of 38% between the strain GTAE24T and the type strain of B. abyssalis. The isolate is Gram-stain negative and motile by polar flagella. Oxidase is positive and catalase is weakly produced...
December 12, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27941381/automated-measurement-of-tear-film-dynamics-and-lipid-layer-thickness-for-assessment-of-non-sj%C3%A3-gren-dry-eye-syndrome-with-meibomian-gland-dysfunction
#20
Yong Woo Ji, Jeihoon Lee, Hun Lee, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
PURPOSE: To investigate automated values from an advanced corneal topographer with a built-in real keratometer, color camera, and ocular surface interferometer for the evaluation of non-Sjögren dry eye syndrome (NSDES) with meibomian gland dysfunction (MGD). METHODS: Sixty-four patients (64 eyes) diagnosed with NSDES with MGD were enrolled. All eyes were evaluated using the Ocular Surface Disease Index (OSDI), fluorescence staining score, tear film breakup time (TBUT), Schirmer test, and MGD grade...
December 8, 2016: Cornea
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