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https://www.readbyqxmd.com/read/29453956/frequent-mutations-of-retnet-genes-in-eohm-further-confirmation-in-325-probands-and-comparison-with-late-onset-high-myopia-based-on-exome-sequencing
#1
Lin Zhou, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Qingjiong Zhang
In our previous study, potential pathological mutations of RetNet genes were detected in 23.8% (71/298) of probands with early-onset high myopia (eoHM), based on whole exome sequencing (WES). The current study aimed to confirm this finding in an additional 325 probands with eoHM and to clarify its specificity by comparison of 195 probands with late-onset high myopia (loHM). Variants in the 234 RetNet genes were selected from whole-exome sequencing data and were filtered using multistep bioinformatics analyses...
February 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29453727/floating-flap-of-internal-limiting-membrane-in-myopic-macular-hole-surgery
#2
Kenji Yamashiro, Eri Kinoshita-Nakano, Toru Ota, Yoko Jingami, Isao Nakata, Hisako Hayashi
PURPOSE: To evaluate the surgical results of macular hole (MH) in patients with high myopia treated with pars plana vitrectomy (PPV) leaving the internal limiting membrane (ILM) flap floating in vitreous fluid at the edge of the MH. METHODS: Nine highly myopic eyes with MH of nine consecutive patients who underwent PPV were retrospectively evaluated. Three eyes were accompanied by retinal detachment (RD). ILM peeling was performed around the MH and some part of the ILM flap was left attached to the edge of the MH...
February 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29449654/analysis-combining-correlated-glaucoma-traits-identifies-five-new-risk-loci-for-open-angle-glaucoma
#3
Puya Gharahkhani, Kathryn P Burdon, Jessica N Cooke Bailey, Alex W Hewitt, Matthew H Law, Louis R Pasquale, Jae H Kang, Jonathan L Haines, Emmanuelle Souzeau, Tiger Zhou, Owen M Siggs, John Landers, Mona Awadalla, Shiwani Sharma, Richard A Mills, Bronwyn Ridge, David Lynn, Robert Casson, Stuart L Graham, Ivan Goldberg, Andrew White, Paul R Healey, John Grigg, Mitchell Lawlor, Paul Mitchell, Jonathan Ruddle, Michael Coote, Mark Walland, Stephen Best, Andrea Vincent, Jesse Gale, Graham RadfordSmith, David C Whiteman, Grant W Montgomery, Nicholas G Martin, David A Mackey, Janey L Wiggs, Stuart MacGregor, Jamie E Craig
Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways - "response to fluid shear stress" and "abnormal retina morphology" - in pathway-based tests...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29446816/atrophic-tear-retinal-detachment-clinical-characteristics-and-surgical-treatment-results-at-long-term
#4
Imen Ammous, Imène Zhioua Braham, Majdi Boukari, Ilhem Mili Boussen, Khalil Errais, Raja Zhioua
AIM: to analyse clinical and epidemiological characteristics of atrophic tear retinal detachment (ATRD) and evaluate anatomical and functional results. METHODS: Retrospective study of 48 cases underwent primary scleral buckling for ATRD. Mean follow up was 80,52 months. RESULTS: ATRD represented 7% of all reghmatogenous RD. Mean age of patients was 38 years and 7 months. Age was less than 40 years in 62,5% of patients. Male predominance was noted...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29443802/full-thickness-macular-hole-with-macular-intrachoroidal-cavitation-in-a-patient-with-pathologic-myopia
#5
Nurgül Örnek, Kemal Örnek
PURPOSE: To describe a full-thickness macular hole (MH) opening to macular intrachoroidal cavitation in a patient with pathologic myopia. METHODS: Full ophthalmologic examination, fundus camera (Topcon TRC; Topcon Co, Tokyo, Japan), optical coherence tomography (RetinaScan Advanced RS-3000; NIDEK, Gamagori, Japan) imaging, and cataract surgery. RESULTS: A 61-year-old woman admitted with decreased vision in the left eye. Visual acuity was counting fingers from 30 cm...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29443795/posterior-precortical-vitreous-pockets-in-high-myopia-observed-by-enhanced-vitreous-imaging-of-spectral-domain-optical-coherence-tomography
#6
Xiaohan Wang, Mengxi Shen, Ruoshi Wang, Yanping Zhou, Tong Li, Meichun Xiao, Minlu Song, Xiaodong Sun, Fenghua Wang
PURPOSE: To observe the vitreous in highly myopic eyes with posterior precortical vitreous pockets (PPVPs) using enhanced vitreous imaging of spectral domain optical coherence tomography. METHODS: Fifty-two highly myopic eyes with PPVPs of 36 patients were included in this study. All subjects underwent enhanced vitreous imaging optical coherence tomography. The size of PPVPs was measured, and the frequency of imaging features was recorded. RESULTS: Nine imaging features of the vitreous in highly myopic eyes with PPVPs were found...
February 13, 2018: Retina
https://www.readbyqxmd.com/read/29438120/misight-assessment-study-spain-adverse-events-tear-film-osmolarity-and-discontinuations
#7
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Francisco L Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: To assess the relative clinical success of MiSight contact lenses (CLs) (study group) and distance single-vision (SV) spectacles (control group) in children in terms of adverse events (AEs), discontinuations, and tear film osmolarity over a 2-year period. METHODS: Seventy-four subjects aged 8 to 12 with myopia of -0.75 to -4.00 D and astigmatism less than 1.00 D were randomly assigned to MiSight CLs or SV groups. Subjects were monitored at 6-month intervals over the course of 24 months and advised to report to the clinic immediately should AEs occur...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29437727/unique-case-of-gyrate-atrophy-with-a-well-preserved-electroretinogram-erg
#8
Kirti M Jasani, Neil R A Parry, Graeme Black, Simon P Kelly
Gyrate atrophy is a rare autosomal recessive disorder caused by a mutation in the ornithine-δ-amino transferase gene. We present an interesting case of a 33-year-old woman who presented with increasing myopia, nyctalopia and failing vision. Examination revealed posterior subscapsular cataracts, narrowed peripheral visual fields and scalloped atrophic peripheral chorioretinal lesions. Blood investigations showed a raised plasma ornithine level at 917 μmol/L (normal range: 32-88 μmol/L) confirming the diagnosis of gyrate atrophy...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437571/impact-of-varying-the-definition-of-myopia-on-estimates-of-prevalence-and-associations-with-risk-factors-time-for-an-approach-that-serves-research-practice-and-policy
#9
Phillippa M Cumberland, Vasiliki Bountziouka, Jugnoo S Rahi
BACKGROUND: Refractive error is an increasing global public health concern that requires robust and reliable research to identify modifiable risk factors and provide accurate estimates of population burden. We investigated the impact of reclassification of individuals when using different threshold values of spherical equivalent (SE) to define myopia, on estimates of frequency, distribution and associations with risk factors, to inform current international initiatives to standardise definitions...
February 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29437569/myopia-its-historical-contexts
#10
REVIEW
Paulus T V M de Jong
Worldwide, and especially in Asia, myopia is a major vision-threatening disorder. From AD 1600 on, to prevent myopia, authors warned against near work without sufficient pauses. There was an abundance of theories about the causes of myopia, the most common one being the necessity of extra convergence on nearby work with thickened extraocular muscles and elevated intraocular pressure. Ocular tenotomies against myopia were in vogue for a while. Axial lengthening of the eye in myopia was mentioned around 1700, but it took 150 years to become accepted as the most prevalent sign of high myopia...
February 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436656/early-quantitative-profiling-of-differential-retinal-protein-expression-in-lens-induced-myopia-in-guinea-pig-using-fluorescence-difference-two-dimensional-gel-electrophoresis
#11
Yi Wu, Carly Siu-Yin Lam, Dennis Yan-Yin Tse, Chi Ho To, Quan Liu, Sally A McFadden, Rachel Ka-Man Chun, King Kit Li, Jianfang Bian, Chuen Lam
The current study aimed to investigate the differential protein expression in guinea pig retinas in response to lens-induced myopia (LIM) before fully compensated eye growth. Four days old guinea pigs (n=5) were subjected to ‑4D LIM for 8 days. Refractive errors were measured before and at the end of the lens wear period. Ocular dimensions were also recorded using high‑frequency A‑scan ultrasonography. After the LIM treatment, retinas of both eyes were harvested and soluble proteins were extracted. Paired retinal protein expressions in each animal were profiled and compared using a sensitive fluorescence difference two‑dimensional gel electrophoresis...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29429286/-study-on-the-change-of-optical-zone-after-femtosecond-laser-assisted-laser-in-situ-keratomileusis
#12
H Li, M Chen, L Tian, D W Li, Y S Peng, F F Zhang
Objective: To explore the change of optical zone after femtosecond laser assisted laser in sitn keratomileusis(FS-LASIK) so as to provide the reference for measurement and design of clinical optical zone. Methods: This retrospective case series study covers 41 eyes of 24 patients (7 males and 17 females, aged from 18 to 42 years old) with myopia and myopic astigmatism who have received FS-LASIK surgery at Corneal Refractive Department of Qingdao Eye Hospital and completed over 6 months of clinical follow-up...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429284/-clinical-observation-on-corneal-transparency-after-small-incision-lenticule-extraction-surgery
#13
L Zhang, Y Wang, T Cui, W Zhao, W B Cheng
Objective: To evaluate the changes of corneal transparency over the 1-year period after small incision lenticule extraction (SMILE) according to corneal Scheimpflug densitometry. Methods: Prospective cohort study. Fifty-five patients (100 eyes) with myopia (19 male and 36 female, aged 18 to 39 years with average of 24) who underwent SMILE and regular follow-up for at least 1 year at Tianjin Eye Hospital were enrolled. Examinations took place before SMILE and postoperatively at 1 day, 1 week, and 1, 3, 6, and 12 months...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429282/-problems-and-challenges-in-the-development-of-corneal-refractive-surgery
#14
Y Wang, J Li
Corneal refractive surgery, as one of the common visual correction methods, has been increasingly accepted in China. There are a large number of people in China who undergo the corneal refractive surgery due to the high incidence of myopia in the country. It is essential that the safest and most effective surgery should be used to correct refractive errors in the cases involved with relatively normal eyes and corneas. In recent years, corneal refractive surgery has been rapidly developing with new technologies and techniques emerging all the time, such as SMILE (small incision lenticule extraction) surgery, which has been extensively applied in China since five years ago when it was approved by FDA...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423510/low-dose-atropine-for-myopia-control-reply
#15
Qianwen Gong, Miroslaw Janowski, Longqian Liu
No abstract text is available yet for this article.
February 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29423500/low-dose-atropine-for-myopia-control-considering-all-the-data
#16
Mark A Bullimore, David A Berntsen
No abstract text is available yet for this article.
February 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29422769/a-genome-wide-association-study-of-corneal-astigmatism-the-cream-consortium
#17
Rupal L Shah, Qing Li, Wanting Zhao, Milly S Tedja, J Willem L Tideman, Anthony P Khawaja, Qiao Fan, Seyhan Yazar, Katie M Williams, Virginie J M Verhoeven, Jing Xie, Ya Xing Wang, Moritz Hess, Stefan Nickels, Karl J Lackner, Olavi Pärssinen, Juho Wedenoja, Ginevra Biino, Maria Pina Concas, André Uitterlinden, Fernando Rivadeneira, Vincent W V Jaddoe, Pirro G Hysi, Xueling Sim, Nicholas Tan, Yih-Chung Tham, Sonoko Sensaki, Albert Hofman, Johannes R Vingerling, Jost B Jonas, Paul Mitchell, Christopher J Hammond, René Höhn, Paul N Baird, Tien-Yin Wong, Chinfsg-Yu Cheng, Yik Ying Teo, David A Mackey, Cathy Williams, Seang-Mei Saw, Caroline C W Klaver, Jeremy A Guggenheim, Joan E Bailey-Wilson
Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29422753/investigating-the-visual-status-of-preschool-children-in-riyadh-saudi-arabia
#18
Ali M Alsaqr, Ghayda'a Ibrahim, Ali Abu Sharha, Raied Fagehi
PURPOSE: The purpose of the study was to explore the vision status of preschool children aged 3-6 years in Al Riyadh and to identify children at risk of amblyopia. MATERIALS AND METHODS: This was a cross-sectional population-based study. Visual acuity (VA) was measured using 15-line Lea symbols, refractive error was assessed using the Mohindra near retinoscopy technique, and peak contrast sensitivity (CS) was measured with the aid of the numerical CS test. We recruited 335 children, with their parents' written consent, from 14 kindergartens...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29421295/association-between-optic-nerve-head-deformation-and-retinal-microvasculature-in-high-myopia
#19
Mi Sun Sung, Tae Hee Lee, Hwan Heo, Sang Woo Park
PURPOSE: To evaluate the retinal microvasculature of peripapillary and macular regions in highly myopic eyes and investigate the association between the vascular parameters and optic nerve head (ONH) deformation. DESIGN: Cross-sectional study METHODS: Seventy-one subjects with highly myopic eyes and 26 subjects with emmetropic eyes were included. Horizontal B-scan images of the ONH were obtained using optical coherence tomography (OCT) and horizontal tilt angles were measured...
February 5, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29417005/refractive-errors-among-patients-attending-the-ophthalmology-department-of-a-medical-college-in-north-east-india
#20
Tanie Natung, Trishna Taye, Laura Amanda Lyngdoh, Begonia Dkhar, Ranendra Hajong
Purpose: To determine the magnitude and pattern of refractive errors among patients attending the ophthalmology department of a new medical college in North-East India. Materials and Methods: A prospective study of the new patients (age ≥5 years), who were phakic and whose unaided visual acuities were worse than 20/20 but improved with pinhole, was done. Complete ophthalmic examination and refraction with appropriate cycloplegia for age were done for the 4582 eligible patients...
July 2017: Journal of Family Medicine and Primary Care
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