keyword
https://read.qxmd.com/read/38427378/technological-advances-of-wearable-device-for-continuous-monitoring-of-in-vivo-glucose
#21
REVIEW
Xinshuo Huang, Chuanjie Yao, Shuang Huang, Shantao Zheng, Zhengjie Liu, Jing Liu, Ji Wang, Hui-Jiuan Chen, Xi Xie
Managing diabetes is a chronic challenge today, requiring monitoring and timely insulin injections to maintain stable blood glucose levels. Traditional clinical testing relies on fingertip or venous blood collection, which has facilitated the emergence of continuous glucose monitoring (CGM) technology to address data limitations. Continuous glucose monitoring technology is recognized for tracking long-term blood glucose fluctuations, and its development, particularly in wearable devices, has given rise to compact and portable continuous glucose monitoring devices, which facilitates the measurement of blood glucose and adjustment of medication...
March 1, 2024: ACS Sensors
https://read.qxmd.com/read/38423754/encephalitis-associated-with-anti-mglur5-antibodies
#22
JOURNAL ARTICLE
Denison Alves Pedrosa, João Henrique Fregadolli Ferreira, Rene Gleizer, Rafael Bernhart Carra, Rachel Marin de Carvalho, Verena Endmayr, Romana Hoftberger, Lívia Almeida Dutra
A 30-year-old woman had 5 days of visual hallucinations, nystagmus, memory impairment and mutism. On examination, she was disorientated with reduced attention span, gaze-evoked nystagmus, paratonia and abnormal frontal reflexes. Cerebrospinal fluid (CSF) showed 80 cells, protein 0.41 g/L and glucose 3.2 mmol/L (plasma glucose 5.0 mmol/L). MR scan of the brain showed involvement of limbic and extra-limbic regions and brainstem. Commercial cell-based assays were negative, but tissue-based assays showed neuropil staining, and cell-based assays for anti-metabotropic glutamate receptor 5 (mGluR5) antibodies were positive in serum and CSF...
February 29, 2024: Practical Neurology
https://read.qxmd.com/read/38422498/matrix-metalloproteinase-9-testing-of-golden-rice-cookies-with-piper-crocatum-active-extract-for-preventing-foot-ulcers-in-patients-with-diabetes-protocol-for-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Andina Setyawati, Ariyanti Saleh, Takdir Tahir, Saldy Yusuf, Syahrul Syahrul, Aminuddin Aminuddin, Muhammad Raihan, Nuurhidayat Jafar, Hasyrul Hamzah, Nur Arfian
BACKGROUND: Diabetic foot ulcers (DFUs) present a formidable challenge to both patients and health care systems. DFUs significantly reduce the quality of life for patients, prolong hospital stays, and are the cause of approximately 70,000 lower limb amputations across the globe annually. Prevention of DFUs primarily involves the optimization of blood sugar levels and the effective management of complications, particularly peripheral neuropathy. Golden Rice has been proven to lower blood sugar levels due to its beta-carotene content, and Piper crocatum (P...
February 29, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38417016/online-classification-of-unstructured-free-living-exercise-sessions-in-people-with-type-1-diabetes
#24
JOURNAL ARTICLE
Emilia Fushimi, Eleonora Maria Aiello, Sunghyun Cho, Michael C Riddell, Robin Gal, Corby Martin, Susana R Patton, Michael Rickels, Francis J Doyle Iii
BACKGROUND: Managing exercise in type 1 diabetes (T1D) is challenging, in part because different types of exercise can have diverging effects on glycemia. The aim of this work was to develop a classification model that can classify an exercise event (structured or unstructured) as aerobic, interval or resistance for the purpose of incorporation into an automated insulin delivery (AID) system. METHODS: A long short-term memory (LSTM) network model was developed with real world data from 30-minute structured sessions of at-home exercise (aerobic, resistance, or mixed) using tri-axial accelerometer, heart rate and activity duration information...
February 28, 2024: Diabetes Technology & Therapeutics
https://read.qxmd.com/read/38411371/machine-learning-identifies-fatigue-as-a-key-symptom-of-fibromyalgia-reflected-in-tyrosine-purine-pyrimidine-and-glutaminergic-metabolism
#25
JOURNAL ARTICLE
Teemu Zetterman, Anni I Nieminen, Ritva Markkula, Eija Kalso, Jörn Lötsch
Fibromyalgia patients vary in clinical phenotype and treatment can be challenging. The pathophysiology of fibromyalgia is incompletely understood but appears to involve metabolic changes at rest or in response to stress. We enrolled 54 fibromyalgia patients and 31 healthy controls to this prospective study. Symptoms were assessed using the Fibromyalgia Impact Questionnaire (FIQ) and blood samples were collected for metabolomics analysis at baseline and after an oral glucose tolerance test and a cardiopulmonary exercise test...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38411173/new-therapies-for-immunoglobulin-a-nephropathy-what-s-the-standard-of-care-in-2023
#26
REVIEW
Bryce Barr, Sean Barbour
PURPOSE OF REVIEW: As the most common primary glomerulonephritis, immunoglobulin A (IgA) nephropathy (IgAN) is an important cause of kidney failure and mortality. Until recently, therapeutic options were limited. Fortunately, there have been numerous recent clinical trials demonstrating efficacy of new therapies in slowing chronic kidney disease (CKD) progression at varying stages of disease. RECENT FINDINGS: The TESTING trial has provided high-quality evidence for slowing estimated glomerular filtration rate (eGFR) decline with a reduced-dose glucocorticoid regimen, while demonstrating an improved safety profile...
May 1, 2024: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/38402868/semaglutide-a-long-acting-glp-1-analogue-for-the-management-of-early-onset-obesity-due-to-mc4r-defect-a-case-report
#27
Pon Ramya Gokul, Louise Apperley, Jennifer Parkinson, Kate Clark, Kim Lund, Megan Owens, Senthil Senniappan
INTRODUCTION: Childhood obesity is a global concern and has both nutritional and genetic causative factors. One of the most common monogenic causes of obesity is heterozygous mutations in the Melanocortin 4 receptor (MC4R), which are found in 5.7% to 8.6% of individuals with early-onset obesity. We report, the effect of Semaglutide, a long-acting Glucagon like peptide (GLP1) analogue, in the treatment of severe obesity in an adolescent boy with a heterozygous mutation in MC4R. CASE PRESENTATION: A 13-year-old boy with a history of excessive weight gain since infancy was referred to the specialised weight management team...
February 23, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38401771/the-presence-of-white-cell-jordan-s-anomaly-in-multiple-acyl-coa-dehydrogenase-deficiency-a-case-report-and-implications-for-clinical-practice
#28
Ji Liu, Wenpeng Ni, Kunyi Deng, Yanhui Chen, Guanghong Gu
BACKGROUND: Multiple Acyl-CoA Dehydrogenase Deficiency (MADD), also known as Glutaric Aciduria Type II, is an exceptionally rare autosomal recessive genetic disorder that disrupts the metabolism of fatty acids, amino acids, and choline. It presents with a wide range of clinical manifestations, from severe neonatal-onset forms to milder late-onset cases, with symptoms including metabolic disturbances and muscle weakness. Jordan's anomaly is a distinctive morphological feature found in peripheral blood white cells and is typically associated with Neutral Lipid Storage Disease (NLSD)...
February 22, 2024: Clinical Biochemistry
https://read.qxmd.com/read/38396755/resveratrol-alleviates-the-early-challenges-of-implant-based-drug-delivery-in-a-human-glial-cell-model
#29
JOURNAL ARTICLE
Luise Schlotterose, François Cossais, Ralph Lucius, Kirsten Hattermann
Brain diseases are oftentimes life-threatening and difficult to treat. The local administration of drug substances using brain implants can increase on-site concentrations and decrease systemic side effects. However, the biocompatibility of potential brain implant materials needs to be evaluated carefully as implants can trigger foreign body reactions, particularly by increasing the microglia and astrocyte reactivity. To date, these tests have been frequently conducted in very simple in vitro models, in particular not respecting the key players in glial cell reactions and the challenges of surgical implantation characterized by the disruption of oxygen and nutrient supply...
February 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38394910/copper-regulation-of-ptrhrucu-nanozyme-targeted-boosting-peroxidase-like-activity-for-ultrasensitive-smartphone-assisted-colorimetric-sensing-of-glucose
#30
JOURNAL ARTICLE
Xinpeng Zhi, Qi Yang, Xinghao Zhang, Hanbo Zhang, Ya Gao, Lulu Zhang, Yuping Tong, Weiwei He
Point-of-care testing (POCT) is promising for biodetection in home healthcare due to advantages of simplicity, rapidity, low cost, portability, high sensitivity and accuracy, and object-oriented POCT platform can be developed by nanozyme-based biosensing. However, designing high-performance nanozymes with targeted regulated catalytic activity remains challenging. Herein, advanced PtRhRuCu quaternary alloy nanozymes (QANs) were rationally designed and successfully synthesized. Cu atoms induced mechanisms of hydrogen peroxide (H2 O2 ) activation and d-band center regulation, achieving high enhancement of peroxide (POD)-like activity and inhibition of oxidase (OXD)-like activity...
February 17, 2024: Food Chemistry
https://read.qxmd.com/read/38388706/enteric-and-systemic-postprandial-lactate-shuttle-phases-and-dietary-carbohydrate-carbon-flow-in-humans
#31
JOURNAL ARTICLE
Robert G Leija, Casey C Curl, Jose A Arevalo, Adam D Osmond, Justin J Duong, Melvin J Huie, Umesh Masharani, George A Brooks
Dietary glucose in excess is stored in the liver in the form of glycogen. As opposed to direct conversion of glucose into glycogen, the hypothesis of the postprandial lactate shuttle (PLS) proposes that dietary glucose uptake is metabolized to lactate in the gut, thereby being transferred to the liver for glycogen storage. In the present study, we provide evidence of a PLS in young healthy men and women. Overnight fasted participants underwent an oral glucose tolerance test, and arterialized lactate concentration and rate of appearance were determined...
February 22, 2024: Nature metabolism
https://read.qxmd.com/read/38387038/cystic-fibrosis-related-diabetes-screening-at-a-large-pediatric-center
#32
JOURNAL ARTICLE
Anil K Chokkalla, Pamela Tuley, Miray Kurtca, Herda Ona, Fadel E Ruiz, Sridevi Devaraj
OBJECTIVE: Cystic Fibrosis Foundation guidelines recommend annual diabetes screening by oral glucose tolerance test (OGTT) in pediatric patients with cystic fibrosis (CF) starting at the age of 10 years. Adherence to these guidelines proves to be challenging, and the nationwide screening rates are still considered suboptimal. The aim of this study was to assess and improve the screening rates at our large pediatric center. METHODS: A 4-year retrospective audit of OGTT completion among pediatric patients with CF of age ≥10 years who are not yet diagnosed with diabetes was conducted...
February 22, 2024: Laboratory Medicine
https://read.qxmd.com/read/38382776/latest-advances-in-glucose-responsive-microneedle-based-systems-for-transdermal-insulin-delivery
#33
REVIEW
Miquel Martínez-Navarrete, Alexandre Pérez-López, Antonio José Guillot, Ana Sara Cordeiro, Ana Melero, Juan Aparicio-Blanco
The development of a self-regulated minimally invasive system for insulin delivery can be considered as the holy grail in the field of diabetes mellitus. A delivery system capable of releasing insulin in response to blood glucose levels would significantly improve the quality of life of diabetic patients, eliminating the need for frequent finger-prick tests and providing better glycaemic control with lower risk of hypoglycaemia. In this context, the latest advances in glucose-responsive microneedle-based transdermal insulin delivery are here compiled with a thorough analysis of the delivery mechanisms and challenges lying ahead in their clinical translation...
February 19, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38378043/light-stimulation-of-mitochondria-reduces-blood-glucose-levels
#34
JOURNAL ARTICLE
Michael B Powner, Glen Jeffery
Mitochondria regulate metabolism, but solar light influences its rate. Photobiomodulation (PBM) with red light (670 nm) increases mitochondrial membrane potentials and adenosine triphosphate production and may increase glucose demand. Here we show, with a glucose tolerance test, that PBM of normal subjects significantly reduces blood sugar levels. A 15 min exposure to 670 nm light reduced the degree of blood glucose elevation following glucose intake by 27.7%, integrated over 2 h after the glucose challenge...
February 20, 2024: Journal of Biophotonics
https://read.qxmd.com/read/38375486/development-and-validation-of-a-multiplexed-lc-ms-ms-ketone-body-assay-for-clinical-diagnostics
#35
JOURNAL ARTICLE
Robin H J Kemperman, Rebecca D Ganetzky, Stephen R Master
OBJECTIVES: Ketone bodies (KBs) serve as important energy sources that spare glucose, providing the primary energy for cardiac muscle, skeletal muscle during aerobic exercise, and the brain during periods of catabolism. The levels and relationships between the KBs are critical indicators of metabolic health and disease. However, challenges in separating isomeric KBs and concerns about sample stability have previously limited their clinical measurement. METHODS: A novel 6...
January 2024: Journal of mass spectrometry and advances in the clinical lab
https://read.qxmd.com/read/38372780/genome-wide-association-and-mendelian-randomisation-analysis-among-30-699-chinese-pregnant-women-identifies-novel-genetic-and-molecular-risk-factors-for-gestational-diabetes-and-glycaemic-traits
#36
JOURNAL ARTICLE
Jianxin Zhen, Yuqin Gu, Piao Wang, Weihong Wang, Shengzhe Bian, Shujia Huang, Hui Liang, Mingxi Huang, Yan Yu, Qing Chen, Guozhi Jiang, Xiu Qiu, Likuan Xiong, Siyang Liu
AIMS/HYPOTHESIS: Gestational diabetes mellitus (GDM) is the most common disorder in pregnancy; however, its underlying causes remain obscure. This study aimed to investigate the genetic and molecular risk factors contributing to GDM and glycaemic traits. METHODS: We collected non-invasive prenatal test (NIPT) sequencing data along with four glycaemic and 55 biochemical measurements from 30,699 pregnant women during a 2 year period at Shenzhen Baoan Women's and Children's Hospital in China...
February 19, 2024: Diabetologia
https://read.qxmd.com/read/38372235/the-development-and-potential-applications-of-an-automated-method-for-detecting-and-classifying-continuous-glucose-monitoring-patterns
#37
JOURNAL ARTICLE
Mansur Shomali, Shiping Liu, Abhimanyu Kumbara, Anand Iyer, Guodong Gordon Gao
INTRODUCTION: Continuous glucose monitoring (CGM) is emerging as a transformative tool for helping people with diabetes self-manage their glucose and supporting clinicians in effective treatment. Unfortunately, many CGM users, and clinicians, find interpreting the large volume of CGM data to be overwhelming and complex. To address this challenge, an efficient, intelligent method for detecting and classifying discernable patterns in CGM data was desired. METHODS: We developed an automated artificial intelligence (AI)-driven method to detect and classify different discernable CGM patterns which called "CGM events...
February 19, 2024: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/38371387/prevalence-of-diabetes-and-associated-factors-among-government-employees-of-mizan-aman-town-and-zonal-sector-office-bench-sheko-zone-southwest-ethiopia-region-2022
#38
JOURNAL ARTICLE
Mesfin Yimam Zegeye, Tewodros Yosef, Abyot Asres
INTRODUCTION: Diabetes mellitus (DM) is a serious non-communicable disease (NCD) that represents a major health and development challenge of the 21st century. Ethiopia is the leading country among the top five high-burden African countries for the number of people with diabetes. To address problems within the population, it is important to assess the prevalence of diabetes and identify the risk factors associated with its diagnosis. OBJECTIVE: The study aims to determine the prevalence of diabetes and identify its associated factors among office workers of Mizan-Aman Town administration and Bench Sheko Zone Sector Office...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38370705/differential-mitochondrial-bioenergetics-and-cellular-resilience-in-astrocytes-hepatocytes-and-fibroblasts-from-aging-baboons
#39
Daniel A Adekunbi, Hillary F Huber, Cun Li, Peter W Nathanielsz, Laura A Cox, Adam B Salmon
Biological resilience, broadly defined as ability to recover from acute challenge and return to homeostasis, is of growing importance to the biology of aging. At the cellular level, there is variability across tissue types in resilience and these differences likely to contribute to tissue aging rate disparities. However, there are challenges in addressing these cell-type differences at regional, tissue and subject level. To address this question, we established primary cells from aged male and female baboons between 13...
February 9, 2024: bioRxiv
https://read.qxmd.com/read/38370356/proposed-treatment-strategy-for-reactive-hypoglycaemia
#40
JOURNAL ARTICLE
Younes R Younes, Nicholas Cron, Benjamin C T Field, Vidhu Nayyar, James Clark, Sunil Zachariah, Kavitha Lakshmipathy, Jimboy O Isuga, Negar Maghsoodi, Julian Emmanuel
BACKGROUND/AIM: Managing reactive hypoglycaemia (RH) poses challenges due to limited and often ineffective treatment options. We report a case series and draw on this to propose a stepwise treatment approach consisting of lifestyle modifications, metformin, GLP-1 analogues, and the use of flash glucose monitoring technology. METHOD: A retrospective review was conducted to analyse the management of 11 cases presenting with recurrent RH symptoms. RESULT: Two patients experienced successful resolution of symptoms through lifestyle modifications...
2024: Frontiers in Endocrinology
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