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glucose challenge test

Chia-Po Fu, Wayne H-H Sheu, Wen-Lieng Lee, Wen-Jane Lee, Jun-Sing Wang, Shih-Yi Lin, I-Te Lee
INTRODUCTION: Postprandial hyperglycemia plays a pivotal role in cardiovascular disease. However, few studies have investigated associations between the severity of coronary artery disease (CAD) and postprandial glucose levels in angina patients without known diabetes before coronary angiography. METHODS: Subjects who were admitted for coronary angiography due to angina and were in stable condition after discharge were recruited. A standard 75-g oral glucose tolerance test (OGTT) was performed at outpatient visits approximately 2-4 weeks after hospital discharge, and fasting and post-challenge blood glucose were measured...
2018: PloS One
Rudolf A Werner, Hiroshi Wakabayashi, Jochen Bauer, Claudia Schütz, Christina Zechmeister, Nobuyuki Hayakawa, Mehrbod S Javadi, Constantin Lapa, Roland Jahns, Süleyman Ergün, Valerie Jahns, Takahiro Higuchi
Aims: Although mortality rate is very high, diagnosis of acute myocarditis remains challenging with conventional tests. We aimed to elucidate the potential role of longitudinal 2-Deoxy-2-18F-fluoro-D-glucose (18F-FDG) positron emission tomography (PET) inflammation monitoring in a rat model of experimental autoimmune myocarditis. Methods and results: Autoimmune myocarditis was induced in Lewis rats by immunizing with porcine cardiac myosin emulsified in complete Freund's adjuvant...
August 8, 2018: European Heart Journal Cardiovascular Imaging
Melanie Heinrich, Nicole Maison, Peter Achenbach, Robin Assfalg, Sonja Braig, Dominik Böcker, Desiree Dunstheimer, Uwe Ermer, Antonia Gavazzeni, Eva-Maria Gerstl, Sandra Hummel, Kerstin Kick, Herbert Müller, Nicole Nellen-Hellmuth, Christian Ockert, Marina Sindichakis, Stefanie Tretter, Katharina Warncke, Anette-Gabriele Ziegler, Andreas Beyerlein
AIMS: In children with presymptomatic type 1 diabetes, intermittent hyperglycemia and rising HbA1c levels are a known signal of progression towards insulin-dependency. Episodes of hypoglycemia, however, have also been reported in one published case. We investigated the prevalence of hypoglycemia and its association with disease progression in children with presymptomatic type 1 diabetes. METHODS: We compared the frequency of hypoglycemic fasting blood glucose levels (<60 mg/dl) in 48 autoantibody negative and 167 multiple beta-cell autoantibody positive children aged 2-5 years...
August 11, 2018: Pediatric Diabetes
Mehmet Şükrü Budak, Eşref Araç
OBJECTIVES: To discuss obstetric and neonatal outcomes of maternal hypoglycaemia observed after the 50 g oral glucose challenge test. MATERIAL AND METHODS: A retrospective evaluation was made of the results of patients at 24-28 weeks gestation of a live singleton pregnancy who underwent a 50 g OGCT at the Health Sciences University Gazi Yaşargil Training and Research Hos-pital, between September 2016 and August 2017. In the 50 g OGCT, 1-hour blood glucose results were divided into Low OGCT (< 90 mg/dL) and Normal OGCT (90-139 mg/dL)...
2018: Ginekologia Polska
David C Ensminger, Tracy Langkilde, Dustin A S Owen, Kirsty J MacLeod, Michael J Sheriff
1.While biomedical researchers have long appreciated the influence of maternally-derived glucocorticoids on offspring phenotype, ecologists have only recently begun exploring its impact in wild animals. Interpreting biomedical findings within an ecological context has posited that maternal stress, mediated by elevations of maternal glucocorticoids, may play an adaptive role preparing offspring for a stressful or rigorous environment. Yet, the influence of maternal stress on offspring phenotype has been little studied in wild animals...
August 3, 2018: Journal of Animal Ecology
Emma Louise Klatman, Alicia Josephine Jenkins, Muhammad Yakoob Ahmedani, Graham David Ogle
Blood glucose meters and test strips for self-monitoring of blood glucose (SMBG) are often inaccessible to, and infrequently used by, people with diabetes in countries with limited resources for health care. Supplies for measuring blood glucose can also be scarce in health facilities, despite being needed in a myriad of clinical settings at all levels of the health system. Numerous studies and international guidelines emphasise the value of SMBG in diabetes care, particularly in people with type 1 diabetes...
July 30, 2018: Lancet Diabetes & Endocrinology
Getasew Shitaye, Endalamaw Gadisa, Lynn Grignard, Girma Shumie, Wakweya Chali, Temesgen Menberu, Mulualem Belachew, Getaneh Tegegn, Sagni Challi, Jonathan Curry, Laleta Mahey, Tsegaye Hailu, Hassen Mamo, Menakath Menon, Taye Balcha, Abraham Aseffa, Chris Drakeley, Teun Bousema, Fitsum G Tadesse
BACKGROUND: 8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but challenged by the widespread prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) in endemic countries since primaquine in G6PDd individuals may lead to acute haemolysis...
August 2, 2018: Malaria Journal
Celeste Alexander, Tzu-Wen L Cross, Saravanan Devendran, Franka Neumer, Stephan Theis, Jason M Ridlon, Jan S Suchodolski, Maria R C de Godoy, Kelly S Swanson
Because obesity is associated with many co-morbidities, including diabetes mellitus, this study evaluated the second-meal effect of a commercial prebiotic, inulin-type fructans, and the effects of the prebiotic on faecal microbiota, metabolites and bile acids (BA). Nine overweight beagles were used in a replicated 3×3 Latin square design to test a non-prebiotic control (cellulose) against a low (equivalent to 0·5 % diet) and high dose (equivalent to 1·0 % diet) of prebiotic over 14-d treatments. All dogs were fed the same diet twice daily, with treatments provided orally via gelatin capsules before meals...
August 1, 2018: British Journal of Nutrition
Siddhartha S Ghosh, Hongliang He, Jing Wang, William Korzun, Paul J Yannie, Shobha Ghosh
Intestinal epithelial cell derived alkaline phosphatase (IAP) dephosphorylates/detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen. We have earlier demonstrated that consumption of high-fat high-cholesterol containing western type-diet (WD) significantly reduces IAP activity, increases intestinal permeability leading to increased plasma levels of LPS and glucose intolerance. Furthermore, oral supplementation with curcumin that increased IAP activity improved intestinal barrier function as well as glucose tolerance...
July 2018: Physiological Reports
Gang Liu, Zhangying Ye, Dezhao Liu, Jian Zhao, Elayaraja Sivaramasamy, Yale Deng, Songming Zhu
A 120-day feeding trial was conducted to evaluate the effect of different stocking densities on growth, the non-specific immunities, antioxidant status and digestive enzyme activities of Oreochromis niloticus fingerlings under a zero-water exchange biofloc system. Tilapias (0.51 ± 0.05 g) were randomly distributed in twelve tanks, each with 300 L water. The experimental design was completely randomized using three replications with four treatments 166 orgs m-3 (LD, low density), 333 orgs m-3 (MD, middle density) and 600 orgs m-3 (HD, high density) with glucose added as biofloc groups, and a clear water group without glucose added as a control 333 orgs m-3 ...
July 26, 2018: Fish & Shellfish Immunology
Natascha Wosnick, Fabiano Bendhack, Renata D Leite, Rosana N Morais, Carolina A Freire
The use of anesthetic in fish farming is a traditional practice which aims to reduce the stress caused by transport and handling. However, anesthesia-induction protocols are commonly established and implemented without proper physiological/behavioral evaluation. Additionally, concentration and time of exposure to the anesthetic are often set without considering species-specific responses. The fat snook (Centropomus parallelus) is a fish with great potential for aquaculture. Given its remarkable euryhalinity, it can grow in fresh- or seawater...
July 26, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Peter Panjan, Vesa Virtanen, Adama Marie Sesay
Bioprocessing is of crucial importance in pharmaceutical, biofuel, food and other industries. Miniaturization of bioprocesses into microbioreactors allows multiplexing of experiments as well as reduction of reagent consumption and labour-intensity. A crucial part of the research within microbioreactors is biochemical analysis of product, byproduct and substrate concentrations that currently heavily relies on large analytical equipment. Biosensors are a promising analytical tool, however, integration into a microbioreactor is associated with challenges in ensuring sterility, appropriate sensing range, control of matrix effects and stability...
August 6, 2018: Analyst
Uilson Pereira Dos Santos, Georgina S Tolentino, Jorge Sá Morais, Kely de Picoli Souza, Leticia M Estevinho, Edson Lucas Dos Santos
Hancornia speciosa Gomes is a fruit tree, commonly known as the mangaba tree, which is widespread throughout Brazil. The leaves of this plant are used in traditional medicine for medicinal purposes. Thus, the objective of this study was to perform a physicochemical characterization, identify the lipophilic antioxidants and fatty acids, and determine the microbiological quality and safety of H. speciosa leaves. In addition, the antioxidant, antimutagenic, and inhibitory activities of the ethanolic extract of H...
2018: Oxidative Medicine and Cellular Longevity
Grazia Aleppo, Kimberly M Webb
OBJECTIVE: Intensive glucose management with insulin pump and continuous glucose monitoring therapy in insulin-treated patients with diabetes poses many challenges in all aspects of daily life. Automated insulin delivery (AID) is the ultimate goal of insulin replacement therapy to reduce the burden of managing this condition. Many systems are being tested in the clinical research setting, and one hybrid closed-loop (HCL) system has received Food and Drug Administration (FDA) approval for use in type 1 diabetes patients above the age of 14 years...
July 2018: Endocrine Practice
Viviana Lo Martire, Alice Valli, Mark J Bingaman, Giovanna Zoccoli, Alessandro Silvani, Steven J Swoap
Many small mammals, such as the laboratory mouse, utilize the hypometabolic state of torpor in response to caloric restriction. The signals that relay the lack of fuel to initiate a bout of torpor are not known. Because the mouse will only enter a torpid state when calorically challenged, it may be that one of the inputs for initiation into a bout of torpor is the lack of the primary fuel (glucose) used to power brain metabolism in the mouse. Using telemetry in mice, we tested the hypotheses that: 1) circulating glucose (GLC), core body temperature (Tb ), and activity are significantly interrelated, and 2) that the level of GLC at the onset of torpor differs from both GLC during arousal from torpor, and during feeding when there is no torpor...
July 24, 2018: American Journal of Physiology. Endocrinology and Metabolism
Suzanne J Bakewell, Daisy F Rangel, Dat P Ha, Jyothi Sethuraman, Richard Crouse, Emma Hadley, Tara L Costich, Xingliang Zhou, Peter Nichols, Amy S Lee
In many cancers, combination therapy regimens are successfully improving response and survival rates, but the challenges of toxicity remain. GRP78, the master regulator of the unfolded protein response, is emerging as a target that is upregulated in tumors, specifically following treatment, and one that impacts tumor cell survival and disease recurrence. Here, we show IT-139, an antitumor small molecule inhibitor, suppresses induction of GRP78 from different types of endoplasmic reticulum (ER) stress in a variety of cancer cell lines, including those that have acquired therapeutic resistance, but not in the non-cancer cells being tested...
July 3, 2018: Oncotarget
Asli F Ceylan, Shuyi Wang, Machender R Kandadi, Jie Chen, Yinan Hua, Zhaohui Pei, Sreejayan Nair, Jun Ren
Endothelin (ET)-1 is implicated in the pathophysiology of cardiovascular diseases although its role in obesity anomalies has not been fully elucidated. This study was designed to examine the impact of ET-1 receptor A (ETA ) ablation on obesity-induced changes in cardiac geometry and contractile function, as well as the mechanisms involved with a focus on autophagy. Cardiomyocyte-specific ETA receptor knockout (ETAKO) and WT mice were fed either low-fat (10% calorie from fat) or high-fat (45% calorie from fat) diet for 24 weeks...
July 18, 2018: Biochimica et Biophysica Acta
Xiang Ren, Peng Lu, Rui Feng, Tong Zhang, Yong Zhang, Dan Wu, Qin Wei
The accurate and rapid ochratoxin A (OTA) detection at early stage can prevent people from getting cancer to a great extent due to its strong liver toxicity and renal toxicity. The development of an efficient strategy to detect OTA without sophisticated instruments is highly desired, but still remains a severe challenge. In this communication, a sandwich type point-of-care testing (POCT) immunoassay is developed for OTA detection. The 3-aminopropyltrimethoxysilane-glutaraldehyde (APTMS-GA) is used as color matrix and Au-N-TiO2 as labels for loading more captured antibodies and glucose oxidases (GOD)...
October 1, 2018: Talanta
Lahiru N Jayakody, Timothy Lee Turner, Eun Ju Yun, In Iok Kong, Jing-Jing Liu, Yong-Su Jin
Engineered S. cerevisiae employing the xylose reductase pathway enables efficient xylose valorization to fuels and chemicals. However, toxicity of thermochemically pretreated biomass hydrolysate on S. cerevisiae is one of the key technical challenges to upgrade biomass-derived sugars including xylose and glucose into high-value products. We investigated the effect of glycolaldehyde, one of the biomass-derived highly toxic aldehyde compounds, and its combinatorial inhibitory effect with other major fermentation inhibitors commonly found in plant hydrolysate such as methylglyoxal, 5-HMF, furfural, vanillin, and acetic acid on engineered xylose-fermenting S...
July 19, 2018: Applied Microbiology and Biotechnology
Sérgio Luiz Pinheiro, Bruna Segatti, Daniel Sartorelli Pucca, Priscila Tessaro Dutra
The study aims to assess the utility of dental acid etchant containing 37% phosphoric acid and methylene blue dye (DAE) as a sensitizing agent for photodynamic therapy (PDT) to reduce Streptococci mutans in dentinal caries. Forty-five permanent third molars were sectioned and the coronal dentin exposed. A cariogenic challenge was performed using brain-heart infusion (BHI) supplemented with 0.5% yeast extract, 1% glucose, 1% sucrose, and S. mutans ATCC 25175 standardized to 0.5 McFarland turbidity. Specimens were incubated in anaerobic jars at 37 °C for 15 days...
July 19, 2018: Lasers in Medical Science
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