keyword
MENU ▼
Read by QxMD icon Read
search

Cyanide poisoning

keyword
https://www.readbyqxmd.com/read/30094773/monitoring-dose-response-of-cyanide-antidote-dimethyl-trisulfide-in-rabbits-using-diffuse-optical-spectroscopy
#1
Jangwoen Lee, Gary Rockwood, Brian Logue, Erica Manandhar, Ilona Petrikovics, Changhoon Han, Vik Bebarta, Sari B Mahon, Tanya Burney, Matthew Brenner
INTRODUCTION: Cyanide (CN) poisoning is a serious chemical threat from accidental or intentional exposures. Current CN exposure treatments, including direct binding agents, methemoglobin donors, and sulfur donors, have several limitations. Dimethyl trisulfide (DMTS) is capable of reacting with CN to form the less toxic thiocyanate with high efficiency, even without the sulfurtransferase rhodanese. We investigated a soluble DMTS formulation with the potential to provide a continuous supply of substrate for CN detoxification which could be delivered via intramuscular (IM) injection in a mass casualty situation...
August 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/30046915/animal-mortality-and-illegal-poison-bait-use-in-greece
#2
K Ntemiri, V Saravia, C Angelidis, K Baxevani, M Probonas, E Kret, Y Mertzanis, Y Iliopoulos, L Georgiadis, D Skartsi, D Vavylis, A Manolopoulos, P Michalopoulou, S M Xirouchakis
The present study describes the use of poison baits against so-called pest species in Greece and explores various aspects of this illegal practice. Data were collected from 2000 to 2016, and a total of 1015 poisoning incidents in rural areas causing the death of 3248 animals were examined. In 58.7% of investigated cases, the motives remained unknown; in the remaining cases, human-wildlife conflicts and retaliatory actions among stakeholders (e.g., hunters vs. livestock breeders) were found to be the main reasons for poison bait use...
July 25, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/30028920/neuronal-nitric-oxide-inhibition-attenuates-the-protective-effect-of-hbo2-during-cyanide-poisoning
#3
Morten Hedetoft, Peter Polzik, Niels Vidiendal Olsen, Ole Hyldegaard
Purpose: Experiments have shown that hyperbaric oxygen (HBO2) therapy reduces cyanide-induced cerebral distress. The exact mechanism behind HBO2's neuroprotective effect is unknown, but has been proposed to be mediated by an increased neuronal nitric oxide (NO) bioavailability, which may compete with cyanide for the active site of cytochrome oxidase in the mitochondrial respiratory chain. We hypothesized that the ameliorating effect of HBO2 is caused by an increased bioavailability of NO, which can be attenuated by injection of the selective neuronal NO synthase inhibitor, 7-nitroindazole, preceding the HBO2 procedure...
May 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/30007331/determination-of-cyanide-by-microdiffusion-technique-coupled-to-spectrophotometry-and-gc-npd-and-propofol-by-fast-gc-ms-tof-in-a-case-of-poisoning
#4
Gabriella Roda, Sebastiano Arnoldi, Michele Dei Cas, Valeria Ottaviano, Eleonora Casagni, Fausto Tregambe, Giacomo Luca Visconti, Fiorenza Farè, Rino Froldi, Veniero Gambaro
A man was found dead in a hotel located near Rome (Italy). The man was still holding a syringe attached to a butterfly needle inserted in his left forearm vein. The syringe contained a cloudy pinkish fluid. In the hotel room the Police found a broken propofol glass vial plus four sealed ones, an opened NaCl plastic vial and six more still sealed, and a number of packed smaller disposable syringes and needles. An opened plastic bottle containing a white crystalline powder labeled as potassium cyanide was also found...
July 1, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29981837/konzo-a-distinct-neurological-disease-associated-with-food-cassava-cyanogenic-poisoning
#5
REVIEW
Espérance Kashala-Abotnes, Daniel Okitundu, Dieudonne Mumba, Michael J Boivin, Thorkild Tylleskär, Desire Tshala-Katumbay
Epidemics of neurodegenerative diseases putatively caused by food toxins have been reported in the tropics with no clear understanding of their pathogenetic mechanisms. These diseases include the disease named Konzo that has been well documented in sub-Sahara Africa, mostly among children and women of childbearing age. Outbreaks of Konzo have occurred in the Democratic Republic of Congo, Mozambique, Tanzania, Central African Republic, Angola, Cameroun, and most recently in Zambia. The main clinical picture consists of a symmetrical, permanent and irreversible spastic paraparesis (motor neuron disease) with no signs of sensory or genitourinary impairments...
July 5, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29951043/growth-and-product-formation-of-clostridium-ljungdahlii-in-presence-of-cyanide
#6
Florian Oswald, Michaela Zwick, Ola Omar, Ernst N Hotz, Anke Neumann
Cyanide is a minor constituent of crude syngas whose content depends on the feedstock and gasification procedure. It is a known poison to metal catalysts and inhibits iron-containing enzymes like carbon monoxide dehydrogenase of acetogenic organisms. Therefore, it is considered a component that has to be removed from the gas stream prior to use in chemical synthesis or syngas fermentation. We show that the growth rate and maximum biomass concentration of Clostridium ljungdahlii are unaffected by cyanide at concentrations of up to 1...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29879736/identification-of-specific-metabolic-pathways-as-druggable-targets-regulating-the-sensitivity-to-cyanide-poisoning
#7
Patrick Y Sips, Xu Shi, Gabriel Musso, Anjali K Nath, Yanbin Zhao, Jason Nielson, Jordan Morningstar, Amy E Kelly, Brittney Mikell, Eva Buys, Vikhyat Bebarta, Jared Rutter, V Jo Davisson, Sari Mahon, Matthew Brenner, Gerry R Boss, Randall T Peterson, Robert E Gerszten, Calum A MacRae
Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures. We have created a pipeline that combines high-throughput screening in zebrafish with subsequent validation in two mammalian small animal models as well as a porcine large animal model. We found that zebrafish embryos in the first 3 days post fertilization (dpf) are highly resistant to cyanide, becoming progressively more sensitive thereafter...
2018: PloS One
https://www.readbyqxmd.com/read/29872744/effects-of-the-gut-microbiota-on-amygdalin-and-its-use-as-an-anti-cancer-therapy-substantial-review-on-the-key-components-involved-in-altering-dose-efficacy-and-toxicity
#8
REVIEW
Vani Jaswal, Jeyanthi Palanivelu, Ramalingam C
Conventional and Alternative Medicine (CAM) is popularly used due to side-effects and failure of approved methods, for diseases like Epilepsy and Cancer. Amygdalin, a cyanogenic diglycoside is commonly administered for cancer with other CAM therapies like vitamins and seeds of fruits like apricots and bitter almonds, due to its ability to hydrolyse to hydrogen cyanide (HCN), benzaldehyde and glucose. Over the years, several cases of cyanide toxicity on ingestion have been documented. In-vitro and in-vivo studies using various doses and modes of administration, like IV administration studies that showed no HCN formation, point to the role played by the gut microbiota for the commonly seen poisoning on consumption...
July 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29806005/on-chip-in-situ-monitoring-of-competitive-interfacial-anionic-chemisorption-as-a-descriptor-for-oxygen-reduction-kinetics
#9
Mengning Ding, Guangyan Zhong, Zipeng Zhao, Zhihong Huang, Mufan Li, Hui-Ying Shiu, Yuan Liu, Imran Shakir, Yu Huang, Xiangfeng Duan
The development of future sustainable energy technologies relies critically on our understanding of electrocatalytic reactions occurring at the electrode-electrolyte interfaces, and the identification of key reaction promoters and inhibitors. Here we present a systematic in situ nanoelectronic measurement of anionic surface adsorptions (sulfates, halides, and cyanides) on ultrathin platinum nanowires during active electrochemical processes, probing their competitive adsorption behavior with oxygenated species and correlating them to the electrokinetics of the oxygen reduction reaction (ORR)...
May 23, 2018: ACS Central Science
https://www.readbyqxmd.com/read/29797369/instant-detection-of-hydrogen-cyanide-gas-and-cyanide-salts-in-solid-matrices-and-water-by-using-cu-ii-and-ni-ii-complexes-of-intramolecularly-hydrogen-bonded-zwitterions
#10
Ratish R Nair, M Raju, Kalyanashis Jana, Dhrubajyoti Mondal, E Suresh, Bishwajit Ganguly, Pabitra B Chatterjee
A series of intramolecularly hydrogen-bonded zwitterionic compartmental ligands HL1-HL4, containing a pendent diamine arm that is monoprotonated and an aldehyde functionality at two different ortho-positions of a 4-halophenoxide, is reported herein. Single-crystal X-ray diffraction (SXRD) provides persuasive evidence for the identification of this class of proton-transferred zwitterions at room temperature. The solid-state photoluminescent nature of these zwitterions remains intact in aqueous and organic solutions...
May 23, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29644580/on-the-efficacy-of-cardio-pulmonary-resuscitation-and-epinephrine-following-cyanide-and-h-2-s-intoxication-induced-cardiac-asystole
#11
Annick Judenherc-HaouzI, Takashi Sonobe, Vikhyat S Bebarta, Philippe Haouzi
This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2 S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to either intravenous KCN (n = 27) or H2 S solutions (n = 12), at a rate that led to a PEA within less than 10 min. In the group intoxicated by CN, 20 rats were mechanically ventilated and received either epinephrine (0...
April 11, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29543597/determinants-of-lactic-acidosis-in-acute-cyanide-poisonings
#12
Frédéric J Baud, Mohamad K Haidar, Romain Jouffroy, Jean-Herlé Raphalen, Lionel Lamhaut, Pierre Carli
OBJECTIVES: To investigate the magnitude of lactic acidosis in response to cyanide poisoning compared with the secondary response caused by cardiovascular shock. DESIGN: Retrospective case-control observational study. SETTING: University Hospital of Assistance Publique - Hôpitaux de Paris. SUBJECTS: Patients admitted for suspicion of cyanide poisoning or drug overdose. Medical charts provided by Assistance Publique - Hôpitaux de Paris of patients between January 1988 and December 2015...
June 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29536431/translational-application-of-measuring-mitochondrial-functions-in-blood-cells-obtained-from-patients-with-acute-poisoning
#13
David H Jang, Utsha G Khatri, Anita Mudan, Jennifer S Love, Shawn Owiredu, David M Eckmann
It is conservatively estimated that 5,000 deaths per year and 20,000 injuries in the USA are due to poisonings caused by chemical exposures (e.g., carbon monoxide, cyanide, hydrogen sulfide, phosphides) that are cellular inhibitors. These chemical agents result in mitochondrial inhibition resulting in cardiac arrest and/or shock. These cellular inhibitors have multi-organ effects, but cardiovascular collapse is the primary cause of death marked by hypotension, lactic acidosis, and cardiac arrest. The mitochondria play a central role in cellular metabolism where oxygen consumption through the electron transport system is tightly coupled to ATP production and regulated by metabolic demands...
June 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29506505/pathology-of-carbon-monoxide-poisoning-in-two-cats
#14
Arya Sobhakumari, Robert H Poppenga, J Brad Pesavento, Francisco A Uzal
BACKGROUND: Carbon monoxide (CO), a common cause of poisoning in human beings has also been implicated in the death of animals. Though there are multiple studies on CO poisoning and relevant lethal blood COHb concentrations in humans, there are no reliable reports of diagnostic lethal carboxyhemoglobin percentage of saturation (COHb%) in cats. Additionally, due to shared housing environments, exposures to companion animals can be a surrogate for lethal exposures in human beings and provide valuable information in concurrent forensic investigations...
March 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29495184/-a-case-report-of-acute-severe-hydrogen-cyanide-poisoning
#15
Z P Dong, M G Shi, H Y Shao
No abstract text is available yet for this article.
January 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29489307/emergency-department-management-of-smoke-inhalation-injury-in-adults-digest
#16
Karalynn Otterness, Christine Ahn, Jeffrey Nusbaum, Nachi Gupta
Smoke inhalation injury portends increased morbidity and mortality in fire-exposed patients. Upper airway thermal burns, inflammation from lower airway irritants, and systemic effects of carbon monoxide and cyanide can contribute to injury. A standardized diagnostic protocol for inhalation injury is lacking, and management remains mostly supportive. Clinicians should maintain a high index of suspicion for concomitant traumatic injuries. Diagnosis is mostly clinical, aided by bronchoscopy and other supplementary tests...
March 1, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29489306/emergency-department-management-of-smoke-inhalation-injury-in-adults
#17
Karalynn Otterness, Christine Ahn
Smoke inhalation injury portends increased morbidity and mortality in fire-exposed patients. Upper airway thermal burns, inflammation from lower airway irritants, and systemic effects of carbon monoxide and cyanide can contribute to injury. A standardized diagnostic protocol for inhalation injury is lacking, and management remains mostly supportive. Clinicians should maintain a high index of suspicion for concomitant traumatic injuries. Diagnosis is mostly clinical, aided by bronchoscopy and other supplementary tests...
March 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29471072/neuroreflex-control-of-cardiovascular-function-is-impaired-after-acute-poisoning-with-chlorpyrifos-an-organophosphorus-insecticide-possible-short-and-long-term-clinical-implications
#18
Alexandre F Cunha, Igor S A Felippe, Nilson C Ferreira-Junior, Leonardo B M Resstel, Daniela A M Guimarães, Vanessa Beijamini, Julian F R Paton, Karla N Sampaio
Although it is well-established that severe poisoning by organophosphorus (OP) compounds strongly affects the cardiorespiratory system, the effects of sub-lethal exposure to these compounds on the neural control of cardiovascular function are poorly explored. The aim of this study was to evaluate the effects of acute sub-lethal exposure to chlorpyrifos (CPF), a commonly used OP insecticide, on three basic reflex mechanisms involved in blood pressure regulation, the peripheral chemoreflex, the baroreflex and the Bezold-Jarisch reflex...
April 1, 2018: Toxicology
https://www.readbyqxmd.com/read/29461292/inhalation-injury-in-the-burned-patient
#19
Guillermo Foncerrada, Derek M Culnan, Karel D Capek, Sagrario González-Trejo, Janos Cambiaso-Daniel, Lee C Woodson, David N Herndon, Celeste C Finnerty, Jong O Lee
Inhalation injury causes a heterogeneous cascade of insults that increase morbidity and mortality among the burn population. Despite major advancements in burn care for the past several decades, there remains a significant burden of disease attributable to inhalation injury. For this reason, effort has been devoted to finding new therapeutic approaches to improve outcomes for patients who sustain inhalation injuries.The three major injury classes are the following: supraglottic, subglottic, and systemic. Treatment options for these three subtypes differ based on the pathophysiologic changes that each one elicits...
March 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29461288/carbon-monoxide-and-cyanide-poisoning-in-the-burned-pregnant-patient-an-indication-for-hyperbaric-oxygen-therapy
#20
Derek M Culnan, Beretta Craft-Coffman, Genevieve H Bitz, Karel D Capek, Yiji Tu, William C Lineaweaver, Maggie J Kuhlmann-Capek
Carbon monoxide (CO) is a small molecule poison released as a product of incomplete combustion. Carbon monoxide binds hemoglobin, reducing oxygen delivery. This effect is exacerbated in the burned pregnant patient by fetal hemoglobin that binds CO 2.5- to 3-fold stronger than maternal hemoglobin. With no signature clinical symptom, diagnosis depends on patient injury history, elevated carboxyhemoglobin levels, and alterations in mental status. The standard of care for treatment of CO intoxication is 100% normobaric oxygen, which decreases the half-life of CO in the bloodstream from 5 hours to 1 hour...
March 2018: Annals of Plastic Surgery
keyword
keyword
158630
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"