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clinical laboratory diagnose

Revital Kariv, Dan Turner, Joseph Rosenblum, Vered Morad, Nir Zigman, Mira Friedman, Gili Focht, Oren Leder, Malka Avitzour, Iris Goren
INTRODUCTION: Inflammatory bowel diseases (IBD) are becoming a significant cause for chronic long term complex morbidity, particularly among adolescents and young adults. IBD patients require multidisciplinary management and considerable health resources. Recent advances and developments in the diagnostics and therapeutic options require identification and tight monitoring of these patients at both hospital and community level for better management and care. AIMS: To establish at Maccabi Healthcare Services (MHS) a dedicated registry for inflammatory bowel disease patients for long term monitoring in order to optimize care, better use of health resources and to promote high quality research...
October 2018: Harefuah
Alfred O Ankrah, Lambert F R Span, Hans C Klein, Pim A de Jong, Rudi A J O Dierckx, Thomas C Kwee, Mike M Sathekge, Andor W J M Glaudemans
INTRODUCTION: Invasive fungal infections (IFIs) occur mostly in immunosuppressed patients and can be life-threatening. Inadequate treatment is associated with high morbidity and mortality. We examined the role of 2-fluorodeoxyglucose positron emission tomography integrated with CT (FDG-PET/CT) in monitoring IFIs and therapy decision-making, and evaluated the role of baseline metabolic parameters in predicting the metabolic response. METHODS: All patients between October 2009 and March 2018, diagnosed with IFIs, treated with antifungal drugs, and who underwent FDG-PET/CT at baseline and at one or more timepoints during treatment were retrospectively included...
October 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Man-Li Tong, Yu-Yan Chen, Xiao-Zhen Zhu, Kun Gao, Hui-Lin Zhang, Wei-Hong Zheng, Hui-Rong Wang, Li-Li Liu, Yong Lin, Li-Rong Lin, Tian-Ci Yang
BACKGROUND: The differential diagnosis of general paresis (GP) and non-neurosyphilis (NS) dementia is not clearly defined. The present study examined the differences in clinical and laboratory features of GP and non-NS dementia. MATERIALS AND METHODS: We retrospectively examined clinical and laboratory features of 85 GP patients and 196 non-NS dementia patients. Data were collected from Zhongshan Hospital between June 2005 and June 2014. RESULTS: The GP group had a higher percentage of males (83...
October 19, 2018: European Neurology
Arun Agarwal, Amit Sanghi, Manisha Agarwal, Mamta Agarwal
Autoimmune disease (AD) may well start off as a single diagnosis and over the years develop into polyautoimmunity and even multiple autoimmune syndromes (MAS) seen in the same patient, as new clinical symptoms and laboratory finding show up in the course of disease. We present a case of MAS who was initially diagnosed to have autoimmune thyroid disease (AITD) - hypothyroidism. She was then evaluated for persistent mild to moderate iron deficiency anemia, unintentional weight loss along with skin rash and diagnosed to have celiac disease and undifferentiated connective tissue disease (uCTD)...
January 2018: Journal of the Association of Physicians of India
Archana Aher, Madhuri Paithankar, Baliram Bhurke
Aims and Objective: To assess the clinical features, complications and outcome in patients with central nervous system tuberculosis (CNS TB) and to correlate the clinical, laboratory and radiological findings of CNS TB. Materials and Methods: In a cross sectional study, total 50 diagnosed cases of CNS TB (either TB meningitis or tuberculoma) were studied. The data on demographic factors, clinical features, complications and laboratory findings, details of treatment and outcome were recorded and analyzed...
January 2018: Journal of the Association of Physicians of India
Haiyi Li, Ruolan Bai, Zhenyu Zhao, Lvyan Tao, Mingbiao Ma, Zhenhua Ji, Miaomiao Jian, Zhe Ding, Xitin Dai, Fukai Bao, Aihua Liu
Polymerase chain reaction (PCR) is a molecular biology technique used to multiply certain deoxyribonucleic acid (DNA) fragments. It is a common and indispensable technique that has been applied in many areas, especially in clinical laboratories. The third generation of polymerase chain reaction, droplet digital polymerase chain reaction (ddPCR), is a biotechnological refinement of conventional polymerase chain reaction methods that can be used to directly quantify and clonally amplify DNA. Droplet digital polymerase chain reaction is now widely used in low-abundance nucleic acid detection and is useful in diagnose infectious diseases...
October 19, 2018: Bioscience Reports
Jian Wang, Wei Cheng, Shaoji Zhang, Yousheng Li, Jieshou Li
OBJECTIVES: Intestinal tuberculosis (ITB) remains prevalent and a big health hazard in China. The aim of this study was to retrospectively analyze its clinico-pathological features. METHODS: Retrospective study of 85 consecutive ITB patients in two tertiary hospitals in East China. Relevant clinical, laboratory examination, radiological, endoscopic and histopathological features of ITB were recorded. RESULTS: The mean age was 37.3±16.0 years; 56 patients (65...
October 18, 2018: Tropical Medicine & International Health: TM & IH
L F Ni, H Wang, H Li, Z G Zhang, X M Liu
OBJECTIVE: To improve the understanding of the clinical features of pulmonary cryptococcosis in non-human immunodeficiency virus (non-HIV) infection patients and reduce delay in diagnosis, or misdiagnosis. METHODS: The clinical features, imaging characteristics, laboratory examinations, treatment and prognosis of 34 cases of pulmonary cryptococcosis were retrospectively analyzed. The data were collected from Peking University First Hospital from June 1997 to June 2016...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Chuanyin Sun, Guanhua Xu, Jin Lin
BACKGROUND: It can be difficult to distinguish between IgG4-related lymphadenopathy and multicentric Castleman's disease (MCD) because these conditions cannot be differentially diagnosed using immunohistochemical staining alone. In this study, we analyzed the clinical features of IgG4-related lymphadenopathy and MCD patients. METHODS: We retrospectively analyzed 27 patients with MCD, including 20 with plasma cell-type (PC-type) and 7 with hyaline vascular (HV) features (mixed-type)...
October 1, 2018: Clinical Laboratory
Maryla Kuczyńska, Ewa Piasek, Łukasz Światłowski, Ewa Kuklik, Jan Sobstyl, Anna Drelich-Zbroja, Tomasz Słomka, Krzysztof Pyra, Olga Furmaga, Małgorzata Szczerbo-Trojanowska
AIM OF THE STUDY: The aim of this study is to assess the prevalence and evolution of perirenal fluid collections in a group of 488 patients who have undergone kidney transplantation. MATERIAL AND METHODS: Sonographic documentation of 488 deceased-donor kidney recipients was evaluated for the prevalence of perirenal fluid collections and their evolution in time, depending on selected demographic features of the patients, time of detection, initial dimensions and precise position of the collection relative to the kidney and the location of the transplanted organ in the right or left iliac fossa...
2018: Journal of Ultrasonography
Mohamed Elshazzly, Ani Mnatsakanian, Ryan Machiele, Roxana Aghili, Yen-Ping Kuo, Amy Hinkelman
Context: Uninsured patients living in rural areas of North Carolina have been inordinately affected by the increasing prevalence of sexually transmitted diseases (STDs) in the midst of severe budget cuts to treatment programs and a shortage of rural primary care physicians. The Campbell University Community Care Clinic, a self-funded, student-run clinic, provides free health care to uninsured residents of rural Harnett County. As a relatively new clinic serving a unique population, epidemiologic research is paramount to the clinic's continued efficacy...
October 1, 2018: Journal of the American Osteopathic Association
Jennifer A Brown, Rex Allman, Barbara L Herwaldt, Elizabeth Gray, Hilda N Rivera, Yvonne Qvarnstrom, Natalie Kwit, Martin E Schriefer, Alison Hinckley, Pamela Pontones
No abstract text is available yet for this article.
October 19, 2018: MMWR. Morbidity and Mortality Weekly Report
Katherine Carroll, Jessica Mesman, Heidi McLeod, Judy Boughey, Gary Keeney, Elizabeth Habermann
Utilising frozen section technologies, Mayo Clinic has one of the lowest reoperation rates for breast lumpectomy in the United States. The research reported on sought to understand the successful teamwork between the Breast Surgery Team and the Frozen Section Laboratory at Mayo Clinic. Researchers worked collaboratively with healthcare staff from breast surgery and the frozen section pathology laboratory to identify communication styles and strategies that contribute to the timely and accurate intraoperative evaluation of breast cancer specimens...
October 18, 2018: Journal of Interprofessional Care
Wan Syamimee Wan Ghazali, Saidatul Manera Mohd Daud, Nurashikin Mohammad, Kah Keng Wong
The aims of this study were to determine damage index in systemic lupus erythematosus (SLE) patients based on Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) and to determine the laboratory and clinico-demographic factors affecting SDI.This is a retrospective cohort study of 94 SLE patients attending rheumatology clinics in 2 local hospitals in Kelantan, Malaysia. The patients were divided into 2 groups based on SDI score assigned by the attending physician, 0 (without damage) or ≥1 (with damage)...
October 2018: Medicine (Baltimore)
Guilherme Gozzoli Podolsky-Gondim, Luciano Lopes Furlanetti, Dinark Conceição Viana, Matheus Fernando Manzolli Ballestero, Ricardo Santos de Oliveira
INTRODUCTION: Head injury is a significant economic, social, and medical problem in developing countries and remains one of the leading causes of pediatric morbidity and mortality. The association of traumatic brain injury and coagulopathy in children is linked with an increase in mortality and poor functional outcomes. However, its impact on long-term outcome has not been discussed in the literature so far. OBJECTIVES: The aim of this paper was to investigate the effect of coagulopathy diagnosed by routine laboratory tests on neurological outcome following traumatic brain injury in children...
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Michael P Reichel, Lloyd C Wahl, Fraser I Hill
Infectious causes of reproductive failure in cattle are important in Australia and New Zealand, where strict biosecurity protocols are in place to prevent the introduction and spread of new diseases. Neospora caninum ranks highly as an important cause of reproductive wastage along with fungal and bacterial infections. Brucella , a leading cause of abortion elsewhere in the world, is foreign, following successful programs to control and eradicate the disease. Leptospirosis in cattle is largely controlled by vaccination, while Campylobacter and Tritrichomonas infections occur at low rates...
2018: Frontiers in Veterinary Science
Parviz K Kavoussi, Melissa S Gilkey, Caitlin Hunn, G Luke Machen, Shu-Hung Chen, J David Wininger, Keikhosrow M Kavoussi, Shahryar K Kavoussi
PURPOSE: A recent study suggested that ibuprofen may alter testicular physiology in a state of compensated hypogonadism, but only evaluated spermatogenic cells in a laboratory ex-vivo model with no significant effect, and found no significant change in follicle stimulating hormone (FSH) in men treated with ibuprofen. The study did not evaluate the impact of ibuprofen use on clinical semen parameters, which has not been assessed to date. The purpose of this study was to evaluate the impact of ibuprofen on semen parameters...
October 17, 2018: Journal of Assisted Reproduction and Genetics
Sana Khochtali, Salma Gargouri, Sourour Zina, Imen Ksiaa, Nesrine Abroug, Sonia Zaouali, Bechir Jelliti, Sonia Attia, Moncef Khairallah
BACKGROUND: Acute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis. RESULTS: This study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Patients with three or more retinal lesions in at least one eye, with at least one lesion of less than 500 μm in size were included. All patients had complete ophthalmological examination, fundus photography, and fluorescein angiography...
October 17, 2018: Journal of Ophthalmic Inflammation and Infection
Anat Cohen, Rajkumar Agarwal, Ahmad Farooqi, Nirupama Kannikeswaran
BACKGROUND: Seizures are a common presenting symptom to the emergency department (ED) in children with intraventricular shunts (IVS). The incidence of shunt malfunction and the yield of imaging studies in children with IVS presenting with seizures is unknown. OBJECTIVES: Weassessed the utility and diagnostic yield of evaluation for shunt malfunction in patients with IVS with seizure and identified clinical predictors for shunt malfunction in these children. METHODS: We performed a retrospective review of children aged zero to 21years with IVS who presented to the ED with seizure between 2011 and 2015...
August 10, 2018: Pediatric Neurology
Petra Anheuser, Sandra Mühlstädt, Jennifer Kranz, Laila Schneidewind, Joachim Steffens, Paolo Fornara
INTRODUCTION: Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems to be a key treatment point for Fournier's gangrene. The aim of this study was to investigate the influence of HBO therapy on the outcome and prognosis of Fournier's gangrene. PATIENTS AND METHODS: In the present multicenter, retrospective observational study, we evaluated the data of approximately 62 patients diagnosed with Fournier's gangrene between 2007 and 2017...
October 16, 2018: Urologia Internationalis
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