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clinical laboratory diagnose

Seda Sirin Kose, Gizem Atakul, Suna Asilsoy, Ozkan Karaman, Nevin Uzuner, Ozden Anal
PROPOSE: Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last two decades, the efficiency of barrier-enforcing measures in AR has been investigated. In this study, we aimed to evaluate the effect of allergen-blocker mechanical barrier gel (MBG) (AlerjiSTOP® ) treatment on symptoms and quality of life score (QoLS) in patients with seasonal and perennial allergic rhinitis. METHODS: A single-center, prospective study was conducted between January 2017 and May 2018...
December 15, 2018: European Archives of Oto-rhino-laryngology
Ravi Uniyal, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Amita Jain, Neera Kohli, Sukriti Kumar, Shweta Pandey, Imran Rizvi
OBJECTIVE: Computed tomography (CT) of the thorax is the imaging modality of choice to detect or demonstrate lesions suggestive of active pulmonary tuberculosis. We aimed to evaluate the imaging abnormalities detected on CT of the thorax in patients with tuberculous meningitis (TBM). METHODS: In this prospective study, we enrolled consecutive newly-diagnosed patients with TBM. Patients were subjected to detailed clinical evaluation and laboratory investigations including MRI of brain and thoracic CT...
December 7, 2018: Journal of the Neurological Sciences
Tereza Rojko, Petra Bogovič, Stanka Lotrič-Furlan, Katarina Ogrinc, Tjaša Cerar-Kišek, Urška Glinšek Biškup, Miroslav Petrovec, Eva Ružić-Sabljić, Andrej Kastrin, Franc Strle
The aims of the study were to determine the frequency of borrelial infection in patients with peripheral facial palsy (PFP) and to compare clinical and laboratory characteristics of patients with borrelial PFP and patients with PFP of unknown etiology. Adult patients with PFP who presented at our department between January 2006 and December 2013 qualified for the study if they had undergone lumbar puncture and also been tested for the presence of borrelial IgM and IgG antibodies in serum and cerebrospinal fluid (CSF) in indirect chemiluminescence immunoassay...
December 6, 2018: Ticks and Tick-borne Diseases
Tuba Dal, Soner Sertan Kara, Aytekin Cikman, Cigdem Eda Balkan, Ziya Cibali Acıkgoz, Hasan Zeybek, Hakan Uslu, Rıza Durmaz
OBJECTIVE: Brucellosis is a zoonotic disease with various clinical presentations and early diagnosis is crucial to avoid severe complications. Due to limitations of conventional diagnostic methods, polymerase chain reaction (PCR) based approaches have gained importance in diagnosis.We aimed to evaluate diagnostic value of multiplex real time-PCR (mRT-PCR) in serum samples collected from brucellosis suspected patients by comparision sensitivity of mRT-PCR with those of conventional diagnostic methods...
December 12, 2018: Journal of Infection and Public Health
Rory O'Sullivan, Khalid Munir, Louise Keating
BACKGROUND: Toe-walking is a normal variant in children up to 3 years of age but beyond this a diagnosis of idiopathic toe-walking (ITW) must be considered. ITW is an umbrella term that covers all cases of toe-walking without any diagnosed underlying medical condition and before assigning these diagnosis potential differential diagnoses such as cerebral palsy, peripheral neuropathy, spinal dysraphism and myopathy must be ruled out. Gait laboratory assessment (GLA) is thought to be useful in the evaluation of ITW, and kinematic, kinetic and electromyography features associated with ITW have been described...
December 6, 2018: Gait & Posture
Fermin Person, Markus M Rinschen, Silke R Brix, Sonia Wulf, Maria de Las Mercedes Noriega, Wilfried Fehrle, Jessica Schmitz, Anke Schwarz, Philipp Ivanyi, Oliver M Steinmetz, Linda Reinhard, Elion Hoxha, Peter F Zipfel, Jan Hinrich Bräsen, Thorsten Wiech
Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. We observed a distinctive histopathological pseudothrombotic pattern different from the previously reported thrombotic microangiopathy...
December 14, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Ai-Wu Shi, Xiao-Feng Shen, Hong-Juan Ding, Yao-Qiu Liu, Li Meng, Bill Kalionis
BACKGROUND: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Pancreatic adenocarcinoma is one of the most common malignancies associated with thromboembolic events. A clinical study showed that thromboembolic events were detected in 36% of patients diagnosed as having pancreatic cancer...
December 15, 2018: Journal of Medical Case Reports
Minh Tu Van Hoang, To Anh Nguyen, Tan Thanh Tran, Thi Ty Hang Vu, Nguyen Truc Nhu Le, Thi Han Ny Nguyen, Thanh Hoang Nhat Le, Thi Thu Hong Nguyen, Thanh Hung Nguyen, Nguyen Thanh Nhan Le, Huu Khanh Truong, Tuan Quy Du, Manh Tuan Ha, Lu Viet Ho, Chau Viet Do, Tran Nam Nguyen, Thi My Thanh Nguyen, Saraswathy Sabanathan, Tu Qui Phan, Vinh Chau Nguyen Van, Guy E Thwaites, Bridget Wills, C Louise Thwaites, Van Tan Le, H Rogier van Doorn
BACKGROUND: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200.000 hospitalised cases and over 200 deaths in 2011-12, the large majority occurring in southern Vietnam. METHODS: We conducted a prospective observational study in outpatient clinics, infectious diseases wards and paediatric intensive care units in the three main referral centres for treatment of HFMD in southern Vietnam...
December 11, 2018: International Journal of Infectious Diseases: IJID
L I Zhukova, O I Kovalevskaya, V N Gorodin, Yu G Shakhverdyan
The purpose of study is the clinical laboratory characteristic of acquired acute cytomegalovirus infection in nonimmunocompromised adult patients. The sampling included 75 patients with acquired acute cytomegalovirus infection admitted to the specialized clinical infection hospital of the Minzdrav of the Krasnodar kraii. The verifcation of diagnosis was implemented using serological tests and polymerase chain reaction. It is demonstrated that males of younger age are most often infected with acute cytomegalovirus infection in the Krasnodar kraii...
2018: Klinicheskaia Laboratornaia Diagnostika
Tzvika Porges, Tali Shafat, Iftach Sagy, Lior Zeller, Carmi Bartal, Tamara Khutarniuk, Alan Jotkowitz, Leonid Barski
BACKGROUND: Erythema nodosum (EN) is the most common type of panniculitis, commonly secondary to infectious diseases. OBJECTIVES: To elucidate the causative factors and the clinical presentation of patients with EN (2004-2014) and to compare their data to those reported in a previous study. METHODS: A retrospective study was conducted of all patients diagnosed with EN who were hospitalized at Soroka University Medical Center (2004-2014). The clinical, demographic, and laboratory characteristics of the patients were compared to those in a cohort of patients diagnosed with EN from 1973-1982...
December 2018: Israel Medical Association Journal: IMAJ
Tarush Kothari, Kendal Jensen, Debbie Mallon, Gerard Brogan, James Crawford
Acute kidney injury, especially early-stage disease, is a common hospital comorbidity requiring timely recognition and treatment. We investigated the effect of daily laboratory alerting of patients at risk for acute kidney injury as measured by documented International Classification of Diseases diagnoses. A quasi-experimental study was conducted at 8 New York hospitals between January 1, 2014, and June 30, 2017. Education of clinical documentation improvement specialists, physicians, and nurses was conducted from July 1, 2014, to December 31, 2014, prior to initiating daily hospital-wide laboratory acute kidney injury alerting on January 1, 2015...
January 2018: Academic pathology
Claudia Sengler, Julian Zink, Jens Klotsche, Martina Niewerth, Ina Liedmann, Gerd Horneff, Christoph Kessel, Gerd Ganser, Angelika Thon, Johannes-Peter Haas, Anton Hospach, Frank Weller-Heinemann, Arnd Heiligenhaus, Dirk Foell, Angela Zink, Kirsten Minden
OBJECTIVE: The objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the course of JIA. METHODS: Patients ≤ 16 years of age with recently diagnosed JIA (< 12 months) were enrolled in the inception cohort of patients with newly diagnosed JIA (ICON), an ongoing prospective observational, controlled multicenter study started in 2010...
December 13, 2018: Arthritis Research & Therapy
Song Guo, Hongtao Lv, Li Yan, Fengnian Rong
RATIONALE: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor. PATIENT CONCERNS: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. On physical examination, she showed abdominal distention and tenderness, with rebound pain. Laboratory evaluation showed significantly elevated serum amylase levels. Computed tomography (CT) revealed a solid mass with uneven density in the pelvis...
December 2018: Medicine (Baltimore)
Min Ho Kim, Ho Ra
RATIONALE: For the treatment of primary canaliculitis, 1,2,3-snip punctoplasty and canalicular curettage are commonly used; however, a recurrence rate of 6.6% to 22% has been reported. Herein, we describe a case of recurrent primary canaliculitis that was completely cured by 4-snip punctoplasty and canalicular curettage. PATIENT CONCERNS: A 53-year-old woman was admitted to our hospital with chief complaints of epiphora, discharge, eyelid flare up, and swelling near the inferior lacrimal punctum in the left eye, which initially presented 6 months earlier...
December 2018: Medicine (Baltimore)
Howe Mao, Tony G E Milne, Gregory O'Grady, Ryash Vather, Richard Edlin, Ian Bissett
BACKGROUND: Prolonged postoperative ileus is a common major complication after abdominal surgery. Retrospective data suggest that ileus doubles the cost of inpatient stay. However, current economic impact data are based on retrospective studies that rely on clinical coding to diagnose ileus. OBJECTIVE: The aim of this study was to determine the economic burden of ileus for patients undergoing elective colorectal surgery. DESIGN: Economic data were audited from a prospective database of patients who underwent surgery at Auckland City Hospital between September 2012 and June 2014...
December 12, 2018: Diseases of the Colon and Rectum
Chris Wincup, Yiannis Ioannou
Antiphospholipid syndrome (APS) is a rare autoimmune disease of unknown etiology that represents a leading cause of acquired thromboembolism and recurrent miscarriage. It is characterized by the persistent elevated presence of pathogenic antiphospholipid auto-antibodies directed against cardiolipin, ß2-glycoprotein-I, and/or a positive lupus anticoagulant test. As with many autoimmune disorders, the pathogenesis of APS is believed to be the result of a complex interaction between environmental triggers and genetic predisposition...
2018: Frontiers in Pediatrics
Angelique K Luabeya, Rachel C Wood, Justin Shenje, Elizabeth Filander, Cynthia Ontong, Simbarashe Mabwe, Hadn Africa, Felicia K Nguyen, Alaina Olson, Kris M Weigel, Lisa Jones-Engel, Mark Hatherill, Gerard A Cangelosi
Diagnostic tests for tuberculosis (TB) usually require collection of sputum, a viscous material derived from human airways. Sputum can be difficult and hazardous to collect and challenging to process in the laboratory. Oral swabs have been proposed as alternative sample types that are non-invasive and easy to collect. This study evaluated the biological feasibility of oral swab analysis (OSA) for diagnosis of TB. Swabs were tested from South African adult subjects including sputum GeneXpert® MTB/RIF (GeneXpert)-confirmed TB patients (N=138), sputum GeneXpert-negative but culture-positive TB patients (N=10), ill non-TB patients (N=37), and Quantiferon-negative controls (N=34)...
December 12, 2018: Journal of Clinical Microbiology
Takanori Noto, Hiroki Seto, Junji Fukuhara, Masao Murabayashi, Akihiro Yachie, Mamoru Ayusawa, Ichiro Morioka
BACKGROUND: The clinical features and laboratory parameters of patients with Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) occasionally overlap. Therefore, serum levels of cytokine and ferritin are used as markers to distinguish between KD and sJIA. KD patients have a high level of interleukin (IL)-6, low level of IL-18, and no elevation of the level of serum ferritin. Conversely, sJIA patients have a low level of IL-6 and high levels of IL-18 and ferritin in the serum...
December 12, 2018: BMC Pediatrics
Lulu Yang, Chenhui Zhang, Wei Wang, Junqi Wang, Yuan Xiao, Wenli Lu, Xiaoyu Ma, Lifen Chen, Jihong Ni, Defen Wang, Jinxiu Shi, Zhiya Dong
BACKGROUND: Dwarfism is a common severe growth disorder, but the etiology is unclear in the majority of cases. Recombinant human growth hormone may be a treatment option, but it has limited efficacy. The currently known laboratory assays do not meet the precision requirements for clinical diagnosis. Here, we have constructed a targeted next-generation sequencing (NGS) panel of selected genes that are suspected to be associated with dwarfism for genetic screening. METHODS: Genetic screening of 91 children with short stature of unknown etiology was performed with the help of the NGS panel...
December 12, 2018: BMC Medical Genetics
Stefanie Völk, Uwe Koedel, Hans-Walter Pfister, Roland Schwankhart, Mark Op den Winkel, Konstanze Mühlbauer, Matthias Klein
BACKGROUND: The approach to unconscious patients in the emergency department (ED) is difficult, often depends on local resources and interests, and workup strategies often lack standardization. One reason for this is that data on causes, management, and outcome of patients who present to the ED with sudden onset unconsciousness of unknown cause is limited. OBJECTIVES: This study was performed to analyze the causes of acute impaired consciousness in patients in an interdisciplinary ED...
December 12, 2018: European Neurology
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