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https://www.readbyqxmd.com/read/30517979/sox11-regulates-apoptosis-and-cell-cycle-in-hepatocellular-carcinoma-via-wnt-%C3%AE-catenin-signaling-pathway
#1
Zhi Liu, Yang Zhong, Yu Jian Chen, Hui Chen
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging to group C of Sry-related HMG box family whose abnormal expression is frequently seen in many kinds of human cancers. Here, we reported that the expression of SOX11 was decreased in human HCC tumors than that in matched normal tissues. Overexpression of SOX11 promoted growth inhibition and apoptosis in HCC cell line HuH-7...
December 5, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/30517974/simultaneous-quantitation-of-metformin-and-dapagliflozin-in-human-plasma-by-lc-ms-ms-application-to-a-pharmacokinetic-study
#2
Priyanka A Shah, Pranav S Shrivastav, Jaivik V Shah, Archana George
A single LC-MS/MS assay is developed and validated for simultaneous determination of metformin and dapagliflozin in human plasma using ion-pair solid phase extraction. Chromatographic separation of the analytes and their internal standards was carried out on a reversed-phase ACE 5CN (150 × 4.6 mm, 5 μm) column using acetonitrile-15 mM ammonium acetate, pH 4.5 (70:30, v/v) as the mobile phase. To achieve higher sensitivity and selectivity for the analytes, mass spectrometric analysis was performed using polarity switching approach...
December 5, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/30517967/-the-mini-audio-test-mat-a-screening-method-on-hearing-impairment-to-be-used-by-general-practitioners-and-specialized-physicians
#3
Jan Löhler, Martin Lehmann, Veronika Segler, Stefan Volkenstein, Rolf-Dieter Battmer, Arneborg Ernst, Frederike Gräbner, Peter Schlattmann, Rainer Schönweiler, Barbara Wollenberg, Stefan Dazert
BACKGROUND: In Germany, about 15 million people are suffering from hearing loss (HL), whereas only 16 % are using hearing aids. Untreated hearing loss may lead to severe complications (e. g. social isolation, depression, progress of dementia). An early and widespread screening, beginning at the age of 50, is meant to improve this shortage in medical care. By this study, the Mini-Audio-Test (MAT), a six-question and three-step answers containing questionnaire on subjective HL, should be verified on a normal collective of subjects (sensitivity (Se), specificity (Sp), positive predictive value (Ppv))...
December 5, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/30517936/serum-neuroendocrine-markers-predict-therapy-outcome-of-patients-with-metastatic-castration-resistant-prostate-cancer-a-meta-analysis
#4
REVIEW
Yangzhou Liu, Shankun Zhao, Jiamin Wang, Zhiguo Zhu, Lianmin Luo, Ermao Li, Fucai Tang, Zhigang Zhao
PURPOSE: To evaluate whether serum neuroendocrine markers could effectively predict treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: The PubMed, Cochrane Library and Embase databases were sought to identify eligible studies concerning serum neuroendocrine markers and the prognosis of post-treatment mCRPC from inception to April 2018. The association between serum neuroendocrine markers, that is, chromogranin A (CgA) and neurone-specific enolase (NSE), levels and the prognosis of post-treatment mCRPC were summarized using a random-effects model and hazard ratio (HR) with 95% CI Sensitivity analyses were conducted to assess potential bias...
December 5, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30517932/correlation-of-ultrasound-findings-and-fine-needle-aspiration-cytology-for-the-diagnosis-of-axillary-lymph-node-metastasis-in-patients-with-breast-carcinoma
#5
Kusum Kapila, Preetha Alath, Govind H Hebbar, Mohammed Jaragh, Sara S George, Ayesha AlJassar
OBJECTIVE: Ultrasound-guided fine-needle aspiration cytology (USG-FNAC) is used for the detection of axillary lymph node (ALN) metastasis in patients with breast carcinoma (BC). US findings have a good diagnostic accuracy with high sensitivity and specificity. The aim of this study is to correlate the detection of ALN metastases on US with FNAC in BC patients. STUDY DESIGN: In 75 BC patients, over a period of 9 months (January to September 2017), the size, cortical thickness (CT), presence or absence of hilar fat, and length/width ratio of ALN on US were reviewed and correlated with FNAC findings...
December 5, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/30517919/a-systematic-review-and-meta-analysis-of-molecular-biomarkers-associated-with-early-neurological-deterioration-following-acute-stroke
#6
REVIEW
Alexander J Martin, Christopher I Price
BACKGROUND: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END. SUMMARY: Electronic searches from January 1990 to March 2017 identified studies reporting a blood/cerebrospinal fluid (CSF)/urine biomarker measurement within 24 h of acute stroke and at least 2 serial assessments of clinical neurological status (< 24 h and < 7 days)...
December 5, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/30517887/neuronal-snare-complex-a-protein-folding-system-with-intricate-protein-protein-interactions-and-its-common-neuropathological-hallmark-snap25
#7
REVIEW
Srijeeb Karmakar, Laipubam Gayatri Sharma, Abhishek Roy, Anjali Patel, Lalit Mohan Pandey
SNARE (Soluble NSF(N-ethylmaleimide-sensitive factor) Attachment Receptor) complex is a trimeric supramolecular organization of SNAP25, syntaxin, and VAMP which mediates fusion of synaptic vesicles with the presynaptic plasma membrane. The functioning of this entire protein assembly is dependent on its tetrahelical coiled coil structure alongside its interaction with a large spectrum of regulatory proteins like synaptotagmin, complexin, intersectin, etc. Defects arising in SNARE complex assembly due to mutations or faulty post-translational modifications are associated to severe synaptopathies like Schizophrenia and also proteopathies like Alzheimer's disease...
December 2, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/30517878/cervical-cancer-cell-lines-are-sensitive-to-sub-erythemal-uv-exposure
#8
Wenyi Gu, Surong Sun, Andrew Kahn, Dalton Dacus, Sebastian O Wendel, Nigel McMillan, Nicholas A Wallace
High risk human papillomavirus (HPV) infections are the causative agent in virtually every cervical cancer as well as a host of other anogenital and oropharyngeal malignancies. These viruses must activate DNA repair pathways to facilitate their replication, while avoiding the cell cycle arrest and apoptosis that can accompany DNA damage. HPV oncoproteins facilitate each of these goals, but also reduce genome stability. Our data dissect the cytotoxic and cytoprotective characteristics of HPV oncogenes in cervical cancer cells...
December 2, 2018: Gene
https://www.readbyqxmd.com/read/30517866/isre-reporter-mouse-reveals-high-basal-and-induced-type-i-ifn-responses-in-inflammatory-monocytes
#9
Melissa B Uccellini, Adolfo García-Sastre
Type I and type III interferons (IFNs) are critical for controlling viral infections. However, the precise dynamics of the IFN response have been difficult to define in vivo. Signaling through type I IFN receptors leads to interferon-stimulated response element (ISRE)-dependent gene expression and an antiviral state. As an alternative to tracking IFN, we used an ISRE-dependent reporter mouse to define the cell types, localization, and kinetics of IFN responding cells during influenza virus infection. We find that measurable IFN responses are largely limited to hematopoietic cells, which show a high sensitivity to IFN...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30517864/cmv-primes-functional-alternative-signaling-in-adaptive-%C3%AE-g-nk-cells-but-is-subverted-by-lentivirus-infection-in-rhesus-macaques
#10
Spandan V Shah, Cordelia Manickam, Daniel R Ram, Kyle Kroll, Hannah Itell, Sallie R Permar, Dan H Barouch, Nichole R Klatt, R Keith Reeves
Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid killing, and mobilization to sites of virus exposure. Using the rhesus macaque model, we demonstrate the systemic distribution of Δg NK cells expressing memory features, including downregulated Helios and Eomes...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30517849/a-light-initiated-chemiluminescent-assay-for-rapid-quantitation-of-allergen-specific-igg-4-in-clinical-samples
#11
Junpu Li, Shaoshen Li, Lunhui Huang, Yaqiong Cui, Tiantian She, Ying Bian, Huiqiang Li
BACKGROUND: An increase in allergen-specific IgG4 (sIgG4 ), which serves as a blocking antibody, is associated with acquisition of immune tolerance after immunotherapy. In this study, we developed a rapid, sensitive, and homogeneous immunoassay based on the light-initiated chemiluminescent assay (LICA) technology for quantifying allergen sIgG4 in serum samples. METHODS: Allergen sIgG4 was measured in vitro by incubating the sample with biotinylated allergens and chemiluminescent beads coated with anti-human IgG4 antibody, followed by the addition of streptavidin-coated sensitizer beads...
December 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30517846/candidate-early-predictive-plasma-protein-markers-of-doxorubicin-induced-chronic-cardiotoxicity-in-b6c3f-1-mice
#12
Varsha G Desai, Taewon Lee, Carrie L Moland, Vikrant Vijay, Tao Han, Sherry M Lewis, Eugene H Herman, James C Fuscoe
Cardiotoxicity is a serious adverse effect of doxorubicin (DOX) treatment in cancer patients. Currently, there is a lack of sensitive biomarkers to predict the risk of DOX-induced cardiotoxicity. Using SOMAmer-based proteomic technology, 1129 proteins were profiled to identify potential early biomarkers of cardiotoxicity in plasma from male B6C3F1 mice given a weekly intravenous dose of 3 mg/kg DOX or saline (SAL) for 2, 3, 4, 6, or 8 weeks (6, 9, 12, 18, or 24 mg/kg cumulative DOX doses, respectively)...
December 2, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30517825/colorimetric-detection-of-the-%C3%AE-agonist-ractopamine-in-animal-feed-tissue-and-urine-samples-using-gold-silver-alloy-nanoparticles-modified-with-sulfanilic-acid
#13
Xing Hu, Jiawei Du, Junhui Pan, Fengfeng Wang, Deming Gong, Guowen Zhang
A highly sensitive, selective and simple method was proposed for colorimetric detection of ractopamine on the basis of the interaction between ractopamine and sulfanilic acid-modified gold-silver alloy nanoparticles (AuAgNPs). The AuAgNPs were prepared by the reduction of HAuCl4 and AgNO3 with sodium citrate in aqueous medium and further modified by sulfanilic acid. The interaction of ractopamine with sulfanilic acid induced rapid aggregation of sulfanilic acid-modified AuAgNPs along with an optical colour change, leading to precise quantification which could be detected by absorptiometry...
December 5, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/30517810/avoided-crossing-and-sub-fourier-sensitivity-in-driven-quantum-systems
#14
David Cubero, Gordon R M Robb, Ferruccio Renzoni
The response of a linear system to an external perturbation is governed by the Fourier limit, with the inverse of the interaction time constituting a lower limit for the system bandwidth. This does not hold for nonlinear systems, which can thus exhibit sub-Fourier-behavior. The present Letter identifies a mechanism for sub-Fourier-sensitivity in driven quantum systems, which relies on avoided crossing between Floquet states. Features up to three orders of magnitude finer than the Fourier limit are presented...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517809/disentangling-genuine-from-matter-induced-cp-violation-in-neutrino-oscillations
#15
José Bernabéu, Alejandro Segarra
We prove that, in any flavor transition, neutrino oscillation CP-violating asymmetries in matter have two disentangled components: (i) a CPT-odd T-invariant term, non-vanishing iff there are interactions with matter, and (ii) a T-odd CPT-invariant term, non-vanishing iff there is genuine CP violation. As function of the baseline, these two terms are distinct L-even and L-odd observables to separately test (i) matter effects sensitive to the neutrino hierarchy and (ii) genuine CP violation in the neutrino sector...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517806/nuclear-charge-radii-of-229-th-from-isotope-and-isomer-shifts
#16
M S Safronova, S G Porsev, M G Kozlov, J Thielking, M V Okhapkin, P Głowacki, D M Meier, E Peik
The isotope ^{229}Th is unique in that it possesses an isomeric state of only a few electron volts above the ground state, suitable for nuclear laser excitation. An optical clock based on this transition is expected to be a very sensitive probe for variations of fundamental constants, but the nuclear properties of both states have to be determined precisely to derive the actual sensitivity. We carry out isotope shift calculations in Th^{+} and Th^{2+} including the specific mass shift, using a combination of configuration interaction and all-order linearized coupled-cluster methods and estimate the uncertainty of this approach...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517791/missing-satellites-problem-completeness-corrections-to-the-number-of-satellite-galaxies-in-the-milky-way-are-consistent-with-cold-dark-matter-predictions
#17
Stacy Y Kim, Annika H G Peter, Jonathan R Hargis
A critical challenge to the cold dark matter (CDM) paradigm is that there are fewer satellites observed around the Milky Way than found in simulations of dark matter substructure. We show that there is a match between the observed satellite counts corrected by the detection efficiency of the Sloan Digital Sky Survey (for luminosities L≳340  L_{⊙}) and the number of luminous satellites predicted by CDM, assuming an empirical relation between stellar mass and halo mass. The "missing satellites problem," cast in terms of number counts, is thus solved...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517790/understanding-the-air-exposure-degradation-chemistry-at-nanoscale-of-layered-oxide-cathodes-for-sodium-ion-batteries
#18
Ya You, Andrei Dolocan, Wangda Li, Arumugam Manthiram
Undesired reactions between layered sodium transition-metal oxide cathodes and air impede their utilization in practical sodium-ion batteries. Consequently, a fundamental understanding of how layered oxide cathodes degrade in air is of paramount importance, but it has not been fully understood yet. Here a comprehensive study on a model material NaNi0.7Mn0.15Co0.15O2 reveals its reaction chemistry with air and the dynamic evolution of the degradation species upon air exposure. We find that besides the extraction of Na+ ions from the crystal lattice to form NaOH, Na2CO3, and Na2CO3•H2O in contact with air, nickel ions gradually dissolve from the bulk to form NiO and accumulate on the particle surface as revealed by sub-nanometer surface sensitive time-of-flight secondary ion mass spectroscopy...
December 5, 2018: Nano Letters
https://www.readbyqxmd.com/read/30517763/itch-nuclear-translocation-and-h1-2-polyubiquitination-negatively-regulate-the-dna-damage-response
#19
Lufen Chang, Lei Shen, Hu Zhou, Jing Gao, Hangyi Pan, Li Zheng, Brian Armstrong, Yang Peng, Guang Peng, Binhua P Zhou, Steven T Rosen, Binghui Shen
The downregulation of the DNA damage response (DDR) enables aggressive tumors to achieve uncontrolled proliferation against replication stress, but the mechanisms underlying this process in tumors are relatively complex. Here, we demonstrate a mechanism through which a distinct E3 ubiquitin ligase, ITCH, modulates DDR machinery in triple-negative breast cancer (TNBC). We found that expression of a nuclear form of ITCH was significantly increased in human TNBC cell lines and tumor specimens. Phosphorylation of ITCH at Ser257 by AKT led to the nuclear localization of ITCH and ubiquitination of H1...
December 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30517735/increases-in-absolute-temperature-stimulate-free-calcium-concentration-elevations-in-the-chloroplast
#20
Gioia Lenzoni, Marc R Knight
Plants need to sense increases in temperature to be able to adapt their physiology and development to survive; however, the mechanisms of heat perception are currently relatively poorly understood. Here we demonstrate that in response to elevated temperature the free calcium concentration of the stroma of chloroplasts increases. This response is specific to the chloroplast, as no corresponding increase in calcium is seen in the cytosol. The chloroplast calcium response is dose-dependent above a threshold. The magnitude of this calcium response is dependent upon absolute temperature, not rate of heating...
December 4, 2018: Plant & Cell Physiology
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