Qingqing Sun, Xiao Han, Lingtong Meng, Hongru Li, Yijia Chen, Lizheng Yin, Chang Wang, Jiachao Wang, Miao Li, Xue Gao, Wenjian Li, Lin Wei, Cuiqing Ma
Innate immune response is the first line of defense for the host against virus invasion. One important response is the synthesis and secretion of type I interferon (IFN-I) in the virus-infected host cells. Here, we found that respiratory syncytial virus (RSV) infection induced high expression of TRIM25, which belongs to the tripartite motif-containing (TRIM) family of proteins. TRIM25 bound and activated retinoic acid-inducible gene I (RIG-I) by K63-linked ubiquitination. Accordingly, RIG-I mediated the production of IFN-I mainly through the nuclear factor kappa-B (NF-κB) pathway in respiratory epithelial cells...
April 17, 2024: Inflammation