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https://www.readbyqxmd.com/read/30445960/production-of-mannosylglycerate-in-saccharomyces-cerevisiae-by-metabolic-engineering-and-bioprocess-optimization
#1
Cristiana Faria, Nuno Borges, Isabel Rocha, Helena Santos
BACKGROUND: Mannosylglycerate (MG) is one of the most widespread compatible solutes among marine microorganisms adapted to hot environments. This ionic solute holds excellent ability to protect proteins against thermal denaturation, hence a large number of biotechnological and clinical applications have been put forward. However, the current prohibitive production costs impose severe constraints towards large-scale applications. All known microbial producers synthesize MG from GDP-mannose and 3-phosphoglycerate via a two-step pathway in which mannosyl-3-phosphoglycerate is the intermediate metabolite...
November 16, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/30387984/conversion-reactions-of-atomically-precise-semiconductor-clusters
#2
Max R Friedfeld, Jennifer L Stein, Andrew Ritchhart, Brandi M Cossairt
Clusters are unique molecular species that can be viewed as a bridge between phases of matter and thus between disciplines of chemistry. The structural and compositional complexity observed in cluster chemistry serves as an inspiration to the material science community and motivates our search for new phases of matter. Moreover, the formation of kinetically persistent cluster molecules as intermediates in the nucleation of crystals makes these materials of great interest for determining and controlling mechanisms of crystal growth...
November 2, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30366224/a-literature-review-and-meta-ethnography-of-fathers-psychological-health-and-received-social-support-during-unpredictable-complicated-childbirths
#3
REVIEW
Emmeli Vallin, Hanna Nestander, Michael B Wells
BACKGROUND: Fathers' attendance during pregnancy and childbirth has increased in recent decades. During childbirth, complications may occur that may put the woman and/or child in danger. To experience such situations may be traumatic for the father, as well as may increase his risk of childbirth-related mental illness during the postpartum period. AIM: The aim of this literature review was to describe expectant fathers' experiences of complications during childbirth...
October 18, 2018: Midwifery
https://www.readbyqxmd.com/read/30279401/possible-emergence-of-sequence-specific-rna-aminoacylation-via-peptide-intermediary-to-initiate-darwinian-evolution-and-code-through-origin-of-life
#4
Dimiter Kunnev, Anastas Gospodinov
One of the most intriguing questions in biological science is how life originated on Earth. A large number of hypotheses have been proposed to explain it, each putting an emphasis on different events leading to functional translation and self-sustained system. Here, we propose a set of interactions that could have taken place in the prebiotic environment. According to our hypothesis, hybridization-induced proximity of short aminoacylated RNAs led to the synthesis of peptides of random sequence. We postulate that among these emerged a type of peptide(s) capable of stimulating the interaction between specific RNAs and specific amino acids, which we call "bridge peptide" (BP)...
October 2, 2018: Life
https://www.readbyqxmd.com/read/30217162/intraventricular-infusion-of-quinolinic-acid-impairs-spatial-learning-and-memory-in-young-rats-a-novel-mechanism-of-lead-induced-neurotoxicity
#5
Abdur Rahman, Muddanna S Rao, Khalid M Khan
BACKGROUND: Lead (Pb), a heavy metal, and quinolinic acid (QA), a metabolite of the kynurenine pathway of tryptophan metabolism, are known neurotoxicants. Both Pb and QA impair spatial learning and memory. Pb activates astrocytes and microglia, which in turn induce the synthesis of QA. We hypothesized increased QA production in response to Pb exposure as a novel mechanism of Pb-neurotoxicity. METHODS: Two experimental paradigms were used. In experiment one, Wistar rat pups were exposed to Pb via their dams' drinking water from postnatal day 1 to 21...
September 14, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/30194299/stereoselective-oxidative-glycosylation-of-anomeric-nucleophiles-with-alcohols-and-carboxylic-acids
#6
Tianyi Yang, Feng Zhu, Maciej A Walczak
Oligosaccharides, one of the most abundant biopolymers, are involved in numerous biological processes. Although many efforts have been put in preparative carbohydrate chemistry, achieving optimal anomeric and regioselectivities remains challenging. Herein we describe an oxidative glycosylation method between anomeric stannanes and oxygen nucleophiles resulting in the formation of a C-O bond with consistently high anomeric control for glycosyl donors bearing a free C2-hydroxyl group. These reactions are promoted by hypervalent iodine reagents with catalytic or stoichiometric amounts of Cu or Zn salts...
September 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/30152675/pathways-to-new-applications-for-quantum-control
#7
Daniel Keefer, Regina de Vivie-Riedle
In 1998, the first successful quantum control experiment with application to a molecular framework was conducted with a shaped laser pulse, optimizing the branching ratio between different organometallic reaction channels. This work induced a vast activity in quantum control during the next 10 years, and different optimization aims were achieved in the gas phase, liquid phase, and even in biologically relevant molecules like light-harvesting complexes. Accompanying and preceding this development were important advances in theoretical quantum control simulations...
September 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30132962/a-cancer-specific-middle-range-theory-of-symptom-self-care-management-a-theory-synthesis
#8
Mohamad Baydoun, Debra L Barton, Cynthia Arslanian-Engoren
AIM: This article describes the development of a middle-range theory of symptom self-care management for adults with cancer. BACKGROUND: Current evidence indicates that people with cancer may benefit from engagement in self-care management behaviours, one of which is symptom management. A middle-range theory that explains and guides symptom self-care management in people with cancer is lacking. DESIGN: This paper combines and expands prior work related to symptom management and self-care management to introduce a newly synthesized theory of symptom self-care management for adult people with cancer...
August 21, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/30019439/synthesis-of-cyclic-compounds-via-photoinduced-radical-cyclization-cascade-of-c-c-bonds
#9
REVIEW
Yating Zhao, Yanwen Lv, Wujiong Xia
Cyclic compounds constitute a great important class of substances in the science of medicine and biology, which renders the research on facile and efficient construction of such complex scaffolds from simple starting materials to be hot and appealing. Recently, the radical cascade reaction involving multiple bond formation/cleavage has emerged as an ideal and powerful route to give high-value cyclic products, along with diminished cost and waste. As a simple and benign methodology, photoredox catalysis offers a readily available access to the generation of radical species...
July 18, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29946977/the-chemical-biology-and-coordination-chemistry-of-putrebactin-avaroferrin-bisucaberin-and-alcaligin
#10
REVIEW
Rachel Codd, Cho Zin Soe, Amalie A H Pakchung, Athavan Sresutharsan, Christopher J M Brown, William Tieu
Dihydroxamic acid macrocyclic siderophores comprise four members: putrebactin (putH2 ), avaroferrin (avaH2 ), bisucaberin (bisH2 ), and alcaligin (alcH2 ). This mini-review collates studies of the chemical biology and coordination chemistry of these macrocycles, with an emphasis on putH2 . These Fe(III)-binding macrocycles are produced by selected bacteria to acquire insoluble Fe(III) from the local environment. The macrocycles are optimally pre-configured for Fe(III) binding, as established from the X-ray crystal structure of dinuclear [Fe2 (alc)3 ] at neutral pH...
October 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29875637/input-convergence-synaptic-plasticity-and-functional-coupling-across-hippocampal-prefrontal-thalamic-circuits
#11
REVIEW
Lezio S Bueno-Junior, Joao P Leite
Executive functions and working memory are long known to involve the prefrontal cortex (PFC), and two PFC-projecting areas: midline/paramidline thalamus (MLT) and cornus ammonis 1 (CA1)/subiculum of the hippocampal formation (HF). An increasing number of rodent electrophysiology studies are examining these substrates together, thus providing circuit-level perspectives on input convergence, synaptic plasticity and functional coupling, as well as insights into cognition mechanisms and brain disorders. Our review article puts this literature into a method-oriented narrative...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29755542/design-synthesis-and-antitubercular-evaluation-of-novel-series-of-pyrazinecarboxamide-metal-complexes
#12
Mohsin Ali, Mansoor Ahmed, Saleem Hafiz, Mustafa Kamal, Majid Mumtaz, Seyed Abdulmajid Ayatollahi
The interest in the synthesis of metallic complexes of different drugs to make them more efficient in biological environment of the human body is seen for the last few decades. Wide range of metal complexes are already used in clinical practice which encourages additional research for innovating new metal based drugs, such as metal-mediated antibiotics, anti-parasitic, antiviral, antibacterial, and anticancer compounds. Tuberculosis has been known as one of the most disastrous disease putting burden on health system worldwide...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29740396/redox-dependent-inflammation-in-islet-transplantation-rejection
#13
REVIEW
Jessie M Barra, Hubert M Tse
Type 1 diabetes is an autoimmune disease that results in the progressive destruction of insulin-producing pancreatic β-cells inside the islets of Langerhans. The loss of this vital population leaves patients with a lifelong dependency on exogenous insulin and puts them at risk for life-threatening complications. One method being investigated to help restore insulin independence in these patients is islet cell transplantation. However, challenges associated with transplant rejection and islet viability have prevented long-term β-cell function...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29736706/nutrient-stress-small-molecule-screening-platform-for-escherichia-coli
#14
Sara S El Zahed, Garima Kumar, Madeline Tong, Eric D Brown
Clinically approved antibiotics target a narrow spectrum of cellular processes, namely cell wall synthesis, DNA replication, and protein synthesis. Numerous screens have been designed to identify inhibitors that target one of these cellular processes. Indeed, this narrow range of drug mechanisms and a reliance on chemical classes discovered many decades ago are thought to be principally responsible for the current crisis of antibiotic drug resistance. Seeking to expand the target base of antibacterial drug discovery, we developed a nutrient stress screening platform that identifies inhibitors of the growth of in Escherichia coli under nutrient limitation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29716144/all-optical-transistor-based-on-rydberg-atom-assisted-optomechanical-system
#15
Yi-Mou Liu, Xue-Dong Tian, Jing Wang, Chu-Hui Fan, Feng Gao, Qian-Qian Bao
We study the optical response of a double optomechanical cavity system assisted by two Rydberg atoms. The target atom is only coupled with one side cavity by a single cavity mode, and gate one is outside the cavities. It has been realized that a long-range manipulation of optical properties of a hybrid system, by controlling the Rydberg atom decoupled with the optomechanical cavity. Switching on the coupling between atoms and cavity mode, the original spatial inversion symmetry of the double cavity structure has been broken...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29697250/effects-of-nanofiber-architecture-and-antimony-doping-on-the-performance-of-lithium-rich-layered-oxides-enhancing-lithium-diffusivity-and-lattice-oxygen-stability
#16
Ruizhi Yu, Zhijuan Zhang, Sidra Jamil, Jiancheng Chen, Xiaohui Zhang, Xianyou Wang, Zhenhua Yang, Hongbo Shu, Xiukang Yang
Li-rich layered oxides (LLOs) with high specific capacities are favorable cathode materials with high-energy density. Unfortunately, the drawbacks of LLOs such as oxygen release, low conductivity, and depressed kinetics for lithium ion transport during cycling can affect the safety and rate capability. Moreover, they suffer severe capacity and voltage fading, which are major challenges for the commercializing development. To cure these issues, herein, the synthesis of high-performance antimony-doped LLO nanofibers by an electrospinning process is put forward...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29694014/indigoid-photoswitches-visible-light-responsive-molecular-tools
#17
Christian Petermayer, Henry Dube
Indigoid photoswitches comprise a class of chromophores that are derived from the parent and well-known indigo dye. Different from most photoswitches their core structures absorb in the visible region of the spectrum in both isomeric states even without substitutions, which makes them especially interesting for applications not tolerant of high-energy UV light. Also different from most current photoswitching systems, they provide highly rigid structures that undergo large yet precisely controllable geometry changes upon photoisomerization...
May 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29625876/recycling-of-polyurethanes-from-laboratory-to-industry-a-journey-towards-the-sustainability
#18
REVIEW
D Simón, A M Borreguero, A de Lucas, J F Rodríguez
The recycling of any kind of plastic to convert it in valuable products is one of the main challenges of today's society. Besides, if the recycling process is itself green, then it would be a great achievement. This paper reviews the way covered from the first attempts of reusing the polyurethane (PU) scraps as a filler for cushions to the last chemical routes employing green recycling agents. Polyurethane is the 6th most used polymer all over the world with a production of 18 millions tons per year, which means a daily production of PU specialties greater than 1 million of cubic meters, equivalent to the volume of the Empire State Building...
June 2018: Waste Management
https://www.readbyqxmd.com/read/29589019/synthesis-properties-and-formation-mechanism-of-mn-doped-zn-2-sio-4-nanowires-and-associated-heterostructures
#19
Haiqing Liu, Dominic Moronta, Luyao Li, Shiyu Yue, Stanislaus S Wong
In this work, we have put forth a facile hydrothermal approach to synthesize an array of one-dimensional (1D) Mn-doped Zn2SiO4 nanostructures. Specifically, we have probed and correlated the effects of controllable reaction parameters such as the pH and Mn dopant concentrations with the resulting crystal structures and morphologies of the products obtained. Based upon our results, we find that careful tuning of the pH versus the Mn dopant level gives rise to opposite trends with respect to the overall size of the resulting one-dimensional nanostructures...
April 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29562514/amyloid-%C3%AE-and-tau-in-alzheimer-s-disease-novel-pathomechanisms-and-non-pharmacological-treatment-strategies
#20
Rebecca M Nisbet, Jürgen Götz
Accumulation of the peptide amyloid-β (Aβ) and the protein tau in Alzheimer's disease (AD) brains is a gradual process that involves the post-translational modification and assembly of monomeric forms into larger structures that eventually form fibrillar inclusions. This process is thought to both drive and initiate AD. However, why the axonally enriched tau in the course of AD accumulates in the somatodendritic domain is not fully understood. We discuss new data that provide a possible explanation that involves de novo protein synthesis, induced by Aβ and mediated through the kinase Fyn...
2018: Journal of Alzheimer's Disease: JAD
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