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Kevin H Choe, Jared W Coburn, Pablo B Costa, Derek N Pamukoff
Choe, KH, Coburn, JW, Costa, PB, and Pamukoff, DN. Hip and knee kinetics during a back-squat and deadlift. J Strength Cond Res XX(X): 000-000, 2018-The back-squat and deadlift are performed to improve hip and knee extensor function. The purpose of this study was to compare lower extremity joint kinetics (peak net joint moments [NJMs] and positive joint work [PJW]) between the back-squat and deadlift. Twenty-eight resistance-trained subjects (17 men: 23.7 ± 4.3 years, 1.76 ± 0.09 m, 78.11 ± 10.91 kg; 11 women: 23...
October 17, 2018: Journal of Strength and Conditioning Research
Cong Cao, Ling Zhu, Ye Chen, Cheng-Hui Wang, Jian-Zhong ShenTu, Yun-Liang Zheng
Physalin B (PB) is one of the major constituents of Physalis alkekengi var. franchetii, a well-known Chinese traditional herb. In this study, we demonstrated for the first time that PB exhibits significant antiproliferative and apoptotic activity in A549 human lung cancer cells in a concentration-dependent and time-dependent manner. Flow cytometric analyses indicated that PB-induced G2/M arrest through down-regulation of cyclin B1 and cell division control protein cyclin-dependent kinase 1, and up-regulation of p21...
October 17, 2018: Anti-cancer Drugs
Qucheng Deng, Lijuan Chen, Yongping Wei, Yonghua Li, Xuerong Han, Wei Liang, Yinjun Zhao, Xiaofei Wang, Juan Yin
The aging population is a big challenge all over the world. However, there are few studies to date investigating the effects of trace element and mineral levels in drinking water and soil (especially in karst areas) on longevity. This study aims to examine temporal and spatial variations in longevity in Hechi (which is recognized as a longevity city) and to investigate relationships between longevity and trace element and mineral levels in drinking water and soils in this city (the karst landscape). Population data were collected from relevant literature and four national population censuses in 1982, 1990, 2000 and 2010...
October 16, 2018: International Journal of Environmental Research and Public Health
Zhe Wang, Xuwen Wang, Youyong Li, Tailong Lei, Ercheng Wang, Dan Li, Yu Kang, Feng Zhu, Tingjun Hou
Summary: Protein-protein interactions (PPIs) have been regarded as an attractive emerging class of therapeutic targets for the development of new treatments. Computational approaches, especially molecular docking, have been extensively employed to predict the binding structures of PPI-inhibitors or discover novel small molecule PPI inhibitors. However, due to the relatively 'undruggable' features of PPI interfaces, accurate predictions of the binding structures for ligands towards PPI targets are quite challenging for most docking algorithms...
October 17, 2018: Bioinformatics
Sonia J Moisá, Sharif S Aly, Terry W Lehenbauer, William J Love, Paul V Rossitto, Alison L Van Eenennaam, Sophia C Trombetta, Eduarda M Bortoluzzi, Lindsey E Hulbert
We conducted a nested, case-control study of pre-weaned dairy calves ( n = 477; 4 California dairy farms) to assess the association between bovine respiratory disease (BRD) and hematologic biomarkers, including plasma haptoglobin (Hp) and plasma bactericide (PB). At each location, heifer or bull dairy calves were observed 2-4 times per week until confirmed as BRD-positive using parallel interpretation of thoracic ultrasound examination and auscultation. In addition, control calves were enrolled after being confirmed as BRD-negative using ultrasound and auscultation...
October 17, 2018: Journal of Veterinary Diagnostic Investigation
Megha A Deshmukh, Gajanan A Bodkhe, Sumedh Shirsat, Arunas Ramanavicius, Mahendra D Shirsat
Heavy metal ions are considered as one of the major water pollutants, revealing health hazards as well as threat to the ecosystem. Therefore, investigation of most versatile materials for the sensitive and selective detection of heavy metal ions is need of the hour. Proposed work emphasizes the synthesis of conducting polymer and carbon nanotube nanocomposite modified with chelating ligand for the detection of heavy metal ions. Carbon nanotubes are having well known features such as tuneable conductivity, low density, good charge transport ability, and current carrying capacity...
2018: Frontiers in Chemistry
Maria Luisa Astolfi, Elisabetta Marconi, Carmela Protano, Matteo Vitali, Elisa Schiavi, Paola Mastromarino, Silvia Canepari
Breast milk guarantees all the nutrients required by infants during their first few months of life and remains the most important food source for their health and growth. However, the mother may transfer potentially toxic chemicals to the suckling infant through breastfeeding. The aim of this study was to optimize and validate a fast method for the determination of a total content of 34 elements (Al, As, B, Ba, Be, Bi, Ca, Cd, Co, Cr, Cs, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, P, Pb, Rb, Sb, Se, Si, Sn, Sr, Te, Ti, Tl, U, V, and Zn) in liquid and lyophilized breast milk...
December 21, 2018: Analytica Chimica Acta
Neha Rai, Viktor Sjöberg, Göran Forsberg, Stefan Karlsson, Per-Erik Olsson, Jana Jass
The present study evaluated the toxicity of metal contamination in soils from an art glass factory in Småland Sweden using a Caenorhabditis elegans nematode model. The aim of the study was to chemically analyze the soil samples and study the biological effects of water-soluble leachates on the nematodes using different physiological endpoints. The total metal content showed that As, Cd and Pb were at levels above the guideline values for soils in areas around the factory. Less than 10% of the total metal content in the soil was found in the water-soluble leachates, however, Al, As, Fe and Pb remained higher than the guideline values for safe drinking water...
October 6, 2018: Science of the Total Environment
Carol V Tadros, Pauline C Treble, Andy Baker, Stuart Hankin, Regina Roach
Constraining sources and site-specific processes of trace elements in speleothem geochemical records is key to an informed interpretation. This paper examines a 10-year data set of drip water solutes from Harrie Wood Cave, south-eastern Australia, and identifies the processes that control their response to El Niño-Southern Oscillation events which varies the site water balance. The contributions of aerosol and bedrock end-members are quantified via hydrochemical mass balance modelling. The parent bedrock is the main source for the drip water solutes: Mg, Sr, K and trace elements (Ba, Al, V, Cr, Mn, Ni, Co, Cu, Pb and U), while atmospheric aerosol inputs also contribute significantly to drip water trace elements and Na, K and Zn...
October 4, 2018: Science of the Total Environment
Mingyue Li, Liheng Ren, Jiachao Zhang, Lin Luo, Pufeng Qin, Yaoyu Zhou, Chao Huang, Jiayi Tang, Hongli Huang, Anwei Chen
Sixteen treatments of soil contaminated by Cu, Pb, and Zn by the addition of a different percentage of biochar and compost were incubated for 120 days. The abundance of denitrifying genes such as narG, nirK, nirS and nosZ and the ammonia-oxidizing amoA genes of ammonia-oxidizing archaea/bacteria (AOA/AOB), soil nitrite reductase activity (S-NiR) and their shaping factors were also determined. The relationships between functional genes, S-NiR, and physico-chemical parameters were analyzed using the Pearson correlation method...
October 11, 2018: Science of the Total Environment
Henning Schroeder, Anne-Lena Fabricius, Dennis Ecker, Thomas A Ternes, Lars Duester
The impact of mechanical disturbance and oxygen induced acidification on the concentration and size fractionation of the 12 metal(loid)s As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Sb, Tl, V and the polyatomic nonmetals C, P and S in the pore water was studied. Using the meso profiling and sampling system (messy) 12 pore water depth profiles were sampled from two incubation experiments undertaken in parallel, which were both mechanically disturbed in the lab and subsequently exposed to a different air supply. In parallel to the low invasive, automated sampling process the redox potential, the pH value and the O2 concentration were detected...
October 2, 2018: Science of the Total Environment
Liyun Yang, Tingting Wen, Liping Wang, Takahiro Miki, Hao Bai, Xin Lu, Huafang Yu, Tetsuya Nagasaka
The potential feasibility of steel slag as a low cost removal agent for heavy metal ions Pb(II), Cu(II) and Cd(II) in acidic conditions was investigated in this study. The initial pH effect on heavy metal ion removal efficiency, the compounds formed after heavy metal ion removal, and the binding force of metals with the compounds were determined. The results showed that the efficiency of removing heavy metal ions by steel slag was low at low initial pH levels, yet it sharply increased and then became stable as the initial pH increased...
October 13, 2018: Journal of Environmental Management
Yanan Cai, Yuwei Yin, Longtao Wang, Dongze Leng, Chenxia Ge, Abedin Abdallah, Yuehong Li
Lead (Pb), a heavy metal and an environmental stressor, may affect many physiological processes, including the serum index and the immune response. The aim of this study was to explore the toxic effects of Pb on the serum index and the immune response of Carassius auratus gibelio (C. gibelio) fed 0, 120, or 240 mg/kg Pb, and 109  cfu/g Bacillus subtilis (B. subtilis). After 15 and 30 days of dietary exposure, the serum indices and the immune responses of the fish were assessed. Dietary Pb exposure significantly affected various components of the serum index, including calcium, magnesium, glucose, cholesterol, total protein, glutamic-pyruvic transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH)...
October 15, 2018: Biological Trace Element Research
Pía Simonetti, Sandra Elizabeth Botté, Jorge Eduardo Marcovecchio
An extensive population of the burrowing crab, Neohelice granulata, inhabits the intertidal areas of the Bahía Blanca estuary, a moderately polluted temperate ecosystem located to the southwest of the province of Buenos Aires, Argentina. In order to determine the metal-accumulating ability of this species, concentrations of Cd, Cu, Pb, Ni, Zn, Mn, Cr, and Fe in soft tissues of adult specimens were measured. Subsequently, the bioconcentration factors (BCFs) of all heavy metals were determined using levels of concentrations previously obtained in intertidal sediments...
October 15, 2018: Environmental Science and Pollution Research International
Thitiya Sae-Jung, Panjana Sengprasert, Jirun Apinun, Srihatach Ngarmukos, Pongsak Yuktanandana, Aree Tanavalee, Rangsima Reantragoon
OBJECTIVE: Osteoarthritis (OA) is a condition that features inflammation and immune responses of innate and adaptive immunity. The role of T cells in knee OA pathogenesis is still unclear. Our aim was to characterize T cell functions and their clonality in patients with knee OA in peripheral blood (PB) and infrapatellar fat pads (IPFP). METHODS: We isolated T cells from PB and IPFP of patients with knee OA and PB of healthy individuals and determined soluble mediators produced from these cells...
October 15, 2018: Journal of Rheumatology
Kristine B Pedersen, Pernille E Jensen, Lisbeth M Ottosen, John Barlindhaug
Multivariate analysis was applied to simultaneously evaluate the influence of soil properties and experimental variables on electrodialytic removal of Cu and Pb from three shooting range soils. Both stationary and stirred set-ups in laboratory scale were tested, representing in-situ and ex-situ remediation conditions, respectively. Within the same experimental space, higher removal of the targeted metals, Cu and Pb, were observed in the stirred set-up (9-81%) compared to the stationary set-up (0-41%). Multivariate analysis (projections onto latent structures) revealed that the influence of soil type on the remediation efficiency was dependent on the metal and varied in the stationary and stirred set-ups...
October 5, 2018: Journal of Hazardous Materials
Wei Liu, Dan Hu, Ce Gu, Yan Zhou, Wen-Song Tan
A packed-bed (PB) bioreactor for bioartificial liver (BAL) was fabricated based on an optimum two-stage culture strategy and evaluated in vitro in this research. Human induced hepatocytes (hiHeps) were first expanded using Cytodex 3 microcarriers and the choice of microcarrier concentration and fetal bovine serum (FBS) content was optimized. Then, the cells expanded under the optimum expansion condition were perfused into a perfusion system containing Fibra-Cel (FC) disks to fabricate a PB bioreactor. Operating parameters including flow rate and seeding density for perfusion culture were optimized, respectively...
October 12, 2018: Journal of Bioscience and Bioengineering
Yongsheng Hong, Ruili Shen, Hang Cheng, Yiyun Chen, Yong Zhang, Yaolin Liu, Min Zhou, Lei Yu, Yi Liu, Yanfang Liu
Heavy metal contamination of peri-urban agricultural soil is detrimental to soil environmental quality and human health. A rapid assessment of soil pollution status is fundamental for soil remediation. Heavy metals can be monitored by visible and near-infrared spectroscopy coupled with chemometric models. First and second derivatives are two commonly used spectral preprocessing methods for resolving overlapping peaks. However, these methods may lose the detailed spectral information of heavy metals. Here, we proposed a fractional-order derivative (FOD) algorithm for preprocessing reflectance spectra...
October 1, 2018: Science of the Total Environment
Jianshu Lv
Absolute principal component score/multiple linear regression (APCS/MLR) and positive matrix factorization (PMF) were applied to a dataset consisting of 10 heavy metals in 300 surface soils samples. Robust geostatistics were used to delineate and compare the factors derived from these two receptor models. Both APCS/MLR and PMF afforded three similar source factors with comparable contributions, but APCS/MLR had some negative and unidentified contributions; thus, PMF, with its optimal non-negativity results, was adopted for source apportionment...
October 8, 2018: Environmental Pollution
Connor J Welty, Matthew L Sousa, Frank M Dunnivant, Paul H Yancey
Anthropogenic use of high density, toxic elements results in marine pollution which is bio-accumulating throughout marine food webs. While there have been several studies in various locations analyzing such elements in fish, few have investigated patterns in these elements and their isotopes in terms of ocean depth, and none have studied the greatest depth zones. We used a flame atomic absorption spectrophotometer-hydride system and an inductively coupled plasma-mass spectrometer to determine concentrations of the high-density elements arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), lead (Pb), mercury (Hg), nickel (Ni), selenium (Se), plus the light-metal barium (Ba), in fish ranging from bathyal (1000 m in Monterey Bay) to upper hadal zones (6500-7626 m in the Kermadec and Mariana Trenches) in the Pacific Ocean...
October 2018: Heliyon
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