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Weijun Xu, Junmin Qian, Guanghui Hou, Yaping Wang, Jinlei Wang, Tiantian Sun, Lijie Ji, Aili Suo, Yu Yao
Integration of multimodal therapies into one nanoplatform holds great promise to overcome the drawbacks of conventional single-modal therapy and pursues enhanced anticancer efficacy. Herein, we developed a PEGylated gold nanorods (GNRs)-based nanoplatform (GNRs-MPH-ALA/DOX -PEG) with pH-responsive drug release property for triple-combined chemotherapy (CT), photodynamic therapy (PDT) and photothermal therapy (PTT) of breast cancer. GNRs were first decorated with mercaptopropionylhydrazide (MPH) and thiol-terminated monomethoxyl poly(ethylene glycol) (mPEG-SH) via Au-thiol linkage, and subsequently conjugated with chemotherapeutant doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (ALA) through acid-liable hydrazone bonds between drugs and MPH molecules...
October 15, 2018: Acta Biomaterialia
Hainan Yang, Zaijia Liu, Xufeng Li, Zhenfeng Zhang, Deji Chen, Hui Lian
Herein, a tumor-targeted multifunctional theranostic agent was synthetized using a facile method, combining four clinically approved materials: artesunate (Arte), human serum albumin (HSA), folic acid (FA), and indocyanine green (ICG). The obtained nanocomposites (FA-IHA NPs) showed an excellent photo- and physiological stability. The ICG in the FA-IHA NPs was used not only for near infrared (NIR) fluorescence imaging, but also for photothermal and photodynamic (PTT-PDT) therapy under a single NIR irradiation...
October 11, 2018: Nanoscale Research Letters
Xuwu Zhang, Liyao Luo, Lei Li, Yuchu He, Weiwei Cao, Huan Liu, Kang Niu, Dawei Gao
A multifunctional antitumor drug delivery system was synthesized based on graphene oxide (GO) for near-infrared (NIR) light controlling chemotherapeutic/photothermal (PTT) /photodynamic (PDT) trimodal synergistic therapy. The system named ICG-Wed-GO was formed by co-loading wedelolactone (Wed) and indocyanine green (ICG) on the surface of GO through π-π stacking interaction. Under NIR laser irradiation, ICG-Wed-GO could effectively absorb and transform optical energy to heat, generate reactive oxygen species (ROS) to ablating and damage tumor cells...
October 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Yudi Ruan, Xiaodai Jia, Chao Wang, Wenyao Zhen, Xiue Jiang
Iron-manganese layered double hydroxide nanosheets were developed as an effective photothermal nanocarrier for loading a photosensitizer. The catalase-like activity enables the nanosheets to decompose H2 O2 into O2 , overcoming tumor hypoxia and enhancing O2 -dependent photodynamic therapy (PDT). The combination of PDT and photothermal therapy (PTT) can almost completely eliminate tumor tissues.
October 25, 2018: Chemical Communications: Chem Comm
Peng Xue, Mengmeng Hou, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Yuejun Kang
Indocyanine green (ICG) is an efficient photosensitizer that can facilitate producing cytotoxic reactive oxygen species (ROS). At the same time, ICG also has characteristic absorption of near infrared light and thus can induce a strong photothermal effect. Both of these important features of ICG may be applied for noninvasive light-induced tumor ablation. On the other hand, ICG is lack of stability in blood circulation and susceptible to aggregation or premature clearance from the body. These issues need to be effectively addressed before antitumor application of ICG becomes possible...
September 26, 2018: Acta Biomaterialia
Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu
The common existence of hypoxia in solid tumors has been heavily researched because it renders tumors more resistant to most standard therapeutic methods, such as radiotherapy (RT), chemotherapy, and photodynamic therapy (PDT), and is associated with a more malignant phenotype and poor survival in patients with tumors. The development of hypoxia modulation methods for advanced therapeutic activity is therefore of great interest but remains a considerable challenge. Since the significant development of nanotechnology and nanomedicine, functionalized nanomaterials can be exploited as adjuvant "drugs" for these oxygen-dependent standard therapies or as hypoxia initiators for advanced new therapies to solid tumors...
September 20, 2018: Accounts of Chemical Research
Huaqin Zuo, Junxian Tao, Hua Shi, Jian He, Zhengyang Zhou, Chao Zhang
W18 O49 -mediated photodynamic therapy (PDT) and photothermal therapy (PTT) are limited by the easily oxidized property and tumor hypoxia. Here, we report the development of platelet membranes as nanocarriers to co-load W18 O49 nanoparticles (NPs) and metformin (PM-W18 O49 -Met NPs). Platelet membranes can protect W18 O49 from oxidation and immune evasion, and increase the accumulation of W18 O49 in tumor sites via the passive EPR effect and active adhesion between platelets and cancer cells. The introduction of metformin (Met), a typical anti-diabetic drug, can alleviate the tumor hypoxia through reducing oxygen consumption...
September 15, 2018: Acta Biomaterialia
Alberto Marcos Heredia-Rizo, Kristian Kjær Petersen, Pascal Madeleine, Lars Arendt-Nielsen
OBJECTIVES: The effects of eccentric exercises on clinical outcomes and central pain mechanisms are unclear in neck/shoulder pain (NSP). The aims were to (1) evaluate the clinical impact of unilateral eccentric training in female computer users with chronic NSP, (2) compare pressure pain sensitivity, temporal summation of pain (TSP), and conditioned pain modulation (CPM) in female office workers with and without NSP, and (3) assess sensitization and central pain responses after training...
September 15, 2018: Clinical Journal of Pain
Lihong Sun, Qian Li, Mengmeng Hou, Ya Gao, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Multiple therapeutic modalities, such as photodynamic (PDT) and photothermal (PTT) therapies, have been jointly applied to produce a synergistic effect for tumor eradication based on the hyperthermia and generation of reactive oxygen species (ROS) mediated by photoactive agents. Effective delivery of highly efficient photosensitizers and photothermal agents is the key for combination of PDT/PTT. Herein, we propose a strategy to functionalize Prussian blue (PB) nanoparticles (NPs) with Chlorin e6 (Ce6)-imbedded erythrocyte membrane vesicles...
September 7, 2018: Biomaterials Science
Wei Zhao, Aihua Li, Aitang Zhang, Yiwei Zheng, Jingquan Liu
In this review, we focus on recent advances in the synthesis of polymer-functionalized transition-metal-based nanomaterials and follow this up by discussing their applications in bioimaging diagnosis and cancer therapy. Transition-metal-based nanomaterials show great potential in cancer therapy owing to their intensive near-IR absorption, excellent photothermal conversion efficiency, strong X-ray attenuation, and magnetic properties. Functional polymers are usually introduced by a one-step or multistep method to further endow these nanomaterials with great biocompatibility and physiological stability...
August 28, 2018: ChemMedChem
Rachel S Riley, Rachel K O'Sullivan, Andrea M Potocny, Joel Rosenthal, Emily S Day
Light-activated therapies are ideal for treating cancer because they are non-invasive and highly specific to the area of light application. Photothermal therapy (PTT) and photodynamic therapy (PDT) are two types of light-activated therapies that show great promise for treating solid tumors. In PTT, nanoparticles embedded within tumors emit heat in response to laser light that induces cancer cell death. In PDT, photosensitizers introduced to the diseased tissue transfer the absorbed light energy to nearby ground state molecular oxygen to produce singlet oxygen, which is a potent reactive oxygen species (ROS) that is toxic to cancer cells...
August 25, 2018: Nanomaterials
Liang Zhang, Dong Wang, Ke Yang, Danli Sheng, Bin Tan, Zhigang Wang, Haitao Ran, Hengjing Yi, Yixin Zhong, Han Lin, Yu Chen
Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low therapeutic efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic efficacy by constructing a near-infrared (NIR)-responsive multifunctional nanoplatform for synergistic cancer phototherapy by a single NIR irradiation, which can concurrently achieve mitochondria-targeting phototherapy, synergistic photothermal therapy (PTT)/photodynamic therapy (PDT), self-sufficient oxygen-augmented PDT, and multiple-imaging guidance/monitoring...
August 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Bo Li, Xiaoya Wang, Lei Chen, Yanling Zhou, Wentao Dang, Jiang Chang, Chengtie Wu
Nanostructures based on metal-organic frameworks (MOFs) have promising potential as theragnostic nanoplatforms for phototherapy of cancer cells. However, the MOFs alone are seldom reported to be used as photothermal agents mainly due to their poor near-infrared (NIR) light absorption. Methods: Ultrathin copper-tetrakis (4-carboxyphenyl) porphyrin (Cu-TCPP) MOF nanosheets were prepared by a facile solvothermal route. The photothermal therapy (PTT), photodynamic therapy (PDT), and T1 -weighted magnetic resonance (MR) imaging capabilities and the high biocompatibility of these composite nanosheets were evaluated in vitro as well as in vivo in a mouse tumor model...
2018: Theranostics
Jing Bai, Xiaodan Jia, Yudi Ruan, Chao Wang, Xiue Jiang
Phototherapy, including photothermal therapy (PTT)/photodynamic therapy (PDT), is usually considered as a promising strategy for cancer treatment due to its noninvasive and selective therapeutic effect by laser irradiation. A light-activatable nanoplatform based on bovine serum albumin (BSA)-coated Bi2 Te3 nanosheets conjugated with methylene blue (MB) was successfully designed and constructed for bimodal PTT/PDT combination therapy. The resultant nanoconstruct (BSA-Bi2 Te3 /MB) exhibited high stability in various physiological solutions and excellent biocompatibility...
August 20, 2018: Inorganic Chemistry
Ying Wang, Feng Zhang, Qian Wang, Piaoping Yang, Huiming Lin, Fengyu Qu
The construction of nanoplatforms that integrate multiple therapies has attracted much attention in the field of cancer treatment. Herein, selenide molybdenum (MoSe2) nanoflowers were synthesized as nanocarriers capable of delivering NIR-mediated synergetic photothermal therapy (PTT), photodynamic therapy (PDT), and drug release. All of the MoSe2 nanoflowers (150-180 nm) are made up of many thin nanosheets of about 3-4 layers of MoSe2. With the novel hierarchical nanostructure and small band gap (1.24 eV), the as-synthesized MoSe2 nanoflowers possess strong near-infrared (NIR) absorption and high photothermal conversion efficiency (61...
August 2, 2018: Nanoscale
Farzaneh Ghorbani, Armin Imanparast, Fatemeh Hataminia, Ameneh Sazgarnia
BACKGROUND: In this study, iron oxide nanoparticles (SPIONs) were synthesized and coated by GA (SG) and then SG was encapsulated by ICG (SGI). After identifying specifications and cytotoxicity of the agents, the potential of SGI for photodynamic therapy (PDT) and photothermal therapy (PTT) was studied. METHODS: An SGI size of 12-13 nm was determined by TEM images and its zeta potential was measured at -23.8 ± 5.8 mV. MCF-7 and HT-29 cells were exposed to a non-coherent light source at a wavelength of 730 nm and a range of 3...
July 14, 2018: Photodiagnosis and Photodynamic Therapy
Xiaoyang Hou, Yingkai Tao, Yanyu Pang, Xinxin Li, Guan Jiang, Yanqun Liu
Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various antitumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes...
July 7, 2018: International Journal of Cancer. Journal International du Cancer
Cunji Gao, Pei Dong, Zhaoxing Lin, Xiaolu Guo, Bang-Ping Jiang, Shichen Ji, Hong Liang, Xing-Can Shen
Indocyanine green (ICG) is an effective light absorber for laser-mediated photodynamic therapy. However, applications of ICG are limited due to its rapid degradation and poor photostability in water. Herein, we report the development of a multifunctional nanoplatform by coating ICG on the surface of single-walled carbon nanohorns (SWNHs) through π-π stacking, obtaining SWNH-ICGs with high solubility and stability under physiological conditions. The SWNH-ICGs could be used as a single nanoplatform to simultaneously produce satisfactory hyperthermia and reactive oxygen species under near-infrared (NIR) laser irradiation...
September 3, 2018: Chemistry: a European Journal
Siyu Wang, Fang Guo, Yanhui Ji, Meng Yu, Jinping Wang, Nan Li
Photodynamic therapy (PDT) is commonly restricted by inefficient tumor selectivity during clinical study. Hence, a mitochondria-targeting multifunctional nanocarrier "theranosome (TNS)" was developed for near-infrared fluorescent (NIRF) imaging and photoacoustic (PA) imaging. What's more, the TNS can also enhance PDT efficacy. In this work, chlorin e6 (Ce6) undertakes reactive oxygen generation and fluorescence emission. Ce6 was quenched when being encapsulated into TNS together with IR780 iodide...
August 6, 2018: Molecular Pharmaceutics
Vivek Raju, NipunBabu Varukattu, Rejeeth Chandrababu, Sharma Alok, Ponraj Thondhi, Vasanthakumar Alagarsamy, Kannan Soundarapandian
Herein, we posit a biocompatible and pH-switchable integrated nanodelivery of CBP/ICG to the in vitro and in vivo experiments demonstrate that nanoparticles (NPs) have insignificant toxicity and good biocompatibility, and possess excellent tumor targeting efficiency as evidenced by highly efficient tumor ablation under near infrared (NIR) illumination. In addition, we have conjugated folic acid as a targeting ligand for folate receptor-targeted delivery. Particularly, targeted delivery of dual CBP/ICG loaded NPs provide targeted detection and transporting potential to specific receptor-expressing tumors, and then CBP interfering with DNA damage and ICG generates singlet oxygen as well as photothermal heat when irradiated with NIR for simultaneous trimodal PDT/PTT/Chemotherapy...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
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