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Jing Bai, Xiaodan Jia, Yudi Ruan, Chao Wang, Xiue Jiang
Phototherapy, including photothermal therapy (PTT)/photodynamic therapy (PDT), is usually considered as a promising strategy for cancer treatment due to its noninvasive and selective therapeutic effect by laser irradiation. A light-activatable nanoplatform based on bovine serum albumin (BSA)-coated Bi2 Te3 nanosheets conjugated with methylene blue (MB) was successfully designed and constructed for bimodal PTT/PDT combination therapy. The resultant nanoconstruct (BSA-Bi2 Te3 /MB) exhibited high stability in various physiological solutions and excellent biocompatibility...
August 8, 2018: Inorganic Chemistry
Ying Wang, Feng Zhang, Qian Wang, Piaoping Yang, Huiming Lin, Fengyu Qu
The construction of nanoplatforms that integrate multiple therapies has attracted much attention in the field of cancer treatment. Herein, selenide molybdenum (MoSe2) nanoflowers were synthesized as nanocarriers capable of delivering NIR-mediated synergetic photothermal therapy (PTT), photodynamic therapy (PDT), and drug release. All of the MoSe2 nanoflowers (150-180 nm) are made up of many thin nanosheets of about 3-4 layers of MoSe2. With the novel hierarchical nanostructure and small band gap (1.24 eV), the as-synthesized MoSe2 nanoflowers possess strong near-infrared (NIR) absorption and high photothermal conversion efficiency (61...
August 2, 2018: Nanoscale
Farzaneh Ghorbani, Armin Imanparast, Fatemeh Hataminia, Ameneh Sazgarnia
BACKGROUND: In this study, iron oxide nanoparticles (SPIONs) were synthesized and coated by GA (SG) and then SG was encapsulated by ICG (SGI). After identifying specifications and cytotoxicity of the agents, the potential of SGI for photodynamic therapy (PDT) and photothermal therapy (PTT) was studied. METHODS: An SGI size of 12-13 nm was determined by TEM images and its zeta potential was measured at -23.8 ± 5.8 mV. MCF-7 and HT-29 cells were exposed to a non-coherent light source at a wavelength of 730 nm and a range of 3...
July 14, 2018: Photodiagnosis and Photodynamic Therapy
Xiaoyang Hou, Yingkai Tao, Yanyu Pang, Xinxin Li, Yanqun Liu, Guan Jiang
Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion, and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various anti-tumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines, and the transformation of memory T lymphocytes...
July 7, 2018: International Journal of Cancer. Journal International du Cancer
Cunji Gao, Pei Dong, Zhaoxing Lin, Xiaolu Guo, Bang-Ping Jiang, Shichen Ji, Hong Liang, Xing-Can Shen
Indocyanine green (ICG) is an effective light absorber for laser-mediated photodynamic therapy. However, applications of ICG were limited due to its fast degradation and poor photostability in water. Herein, we developed a multifunctional nanoplatform by coating ICG on the surface of single-walled carbon nanohorns (SWNHs) via π-π stacking, obtaining SWNH-ICGs with high solubility and stability in physiological conditions. The SWNH-ICGs could be used as a single nanoplatform to simultaneously produce satisfactory hyperthermia and reactive oxygen species under near-infrared (NIR) laser irradiation...
July 5, 2018: Chemistry: a European Journal
Siyu Wang, Fang Guo, Yanhui Ji, Meng Yu, Jinping Wang, Nan Li
Photodynamic therapy (PDT) is commonly restricted by inefficient tumor selectivity during clinical study. Hence, a mitochondria-targeting multifunctional nanocarrier "theranosome (TNS)" was developed for near-infrared fluorescent (NIRF) imaging and photoacoustic (PA) imaging. What's more, the TNS can also enhance PDT efficacy. In this work, chlorin e6 (Ce6) undertakes reactive oxygen generation and fluorescence emission. Ce6 was quenched when being encapsulated into TNS together with IR780 iodide...
July 18, 2018: Molecular Pharmaceutics
Vivek Raju, NipunBabu Varukattu, Rejeeth Chandrababu, Sharma Alok, Ponraj Thondhi, Vasanthakumar Alagarsamy, Kannan Soundarapandian
Herein, we posit a biocompatible and pH-switchable integrated nanodelivery of CBP/ICG to the in vitro and in vivo experiments demonstrate that nanoparticles (NPs) have insignificant toxicity and good biocompatibility, and possess excellent tumor targeting efficiency as evidenced by highly efficient tumor ablation under near infrared (NIR) illumination. In addition, we have conjugated folic acid as a targeting ligand for folate receptor-targeted delivery. Particularly, targeted delivery of dual CBP/ICG loaded NPs provide targeted detection and transporting potential to specific receptor-expressing tumors, and then CBP interfering with DNA damage and ICG generates singlet oxygen as well as photothermal heat when irradiated with NIR for simultaneous trimodal PDT/PTT/Chemotherapy...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
M Hoegh, K K Petersen, T Graven-Nielsen
BACKGROUND: Conditioned pain modulation (CPM) may be impaired in chronic pain patients compared with healthy subjects. The CPM-effect is the difference between pain sensitivity assessments (test-stimuli) with and without a painful conditioning stimulus. CPM has been extensively explored but effects of repeated CPM-effects and differences between repeated CPM assessments and comparable control conditions are less studied. METHODS: In 20 healthy men, four 5-min bouts with a test-stimulus in the beginning and midway were applied by cuff-algometry to the dominant leg...
June 29, 2018: European Journal of Pain: EJP
Thomas Kurien, Lars Arendt-Nielsen, Kristian K Petersen, Thomas Graven-Nielsen, Brigitte E Scammell
Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain symptoms and pain sensitisation. OA patients were pain phenotyped into two groups based on the PainDETECT questionnaire: High PainDETECT group (scores ≥19) indicating neuropathic pain-like symptoms, Low PainDETECT group (scores <19) indicating nociceptive or mixed pain...
June 16, 2018: Journal of Pain: Official Journal of the American Pain Society
Yu Han, Zhongping Chen, Hong Zhao, Zengshi Zha, Wendong Ke, Yuheng Wang, Zhishen Ge
Tumor hypoxia strikingly restricts photodynamic therapy (PDT) efficacy and limits its clinical applications in cancer therapy. The ideal strategy to address this issue is to develop oxygen-independent PDT systems. Herein, the rationally designed tumor pH-responsive polymeric micelles are devised to realize oxygen-independent combined PDT and photothermal therapy (PTT) under near-infrared light (NIR) irradiation. The triblock copolymer, poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-(piperidin-1-yl)ethyl methacrylate) (PEG-b-PCL-b- PPEMA), was prepared to co-encapsulate cypate and singlet oxygen donor (diphenylanthracene endoperoxide, DPAE) via self-assembly to obtain the micellar delivery system (C/O@N-Micelle)...
August 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jinyuan Ma, Dengyue Chen, Yang Li, Yilin Chen, Qiuhong Liu, Xinyi Zhou, Kun Qian, Zongxi Li, Hang Ruan, Zhenqing Hou, Xuan Zhu
For the purpose of precision theranostic of tumor, multifunctional drug delivery systems are always receiving great attentions. Here, we developed a zinc phthalocyanine-soybean phospholipid (ZnPc-SPC) complex based drug delivery system with doxorubicin (Dox) as loading cargo to achieve additional chemotherapy while the carrier itself could serve as multifunctional and switchable theranostic agent. In the early phase, the ZnPc-SPC complex assembled to nanostructure displaying photothermal therapy (PTT) and photoacoustic (PA) properties while in the late phase, the prepared NPs dis-assembled into ZnPc-SPC complex again performing photodynamic therapy (PDT) and low-background fluorescence (FL) image...
August 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Lei Chen, Chuan Chen, Wei Chen, Ke Li, Xiaozhen Chen, Xudong Tang, Ganfeng Xie, Xi Luo, Xiaojiao Wang, Houjie Liang, Songtao Yu
Human telomerase reverse transcriptase (hTERT) has been found to be closely related to tumor transformation, growth, and metastasis. Thus, the delivery of hTERT small interfering RNA (siRNA) is an important approach for cancer gene therapy. However, the single anticancer effect of gene silencing is often limited by poor specificity or low efficiency in siRNA delivery and release. In this work, we present small and thin black phosphorus (BP) nanosheets as a biodegradable delivery system for hTERT siRNA. The BP nanosheets prepared with poly(ethylene glycol) (PEG) and polyethylenimine (PEI) modification (PPBP), exhibited high siRNA loading capacity and robust cell uptake...
June 27, 2018: ACS Applied Materials & Interfaces
Barbara Poinard, Samuel Zhan Yuan Neo, Eugenia Li Ling Yeo, Howard Peng Sin Heng, Koon Gee Neoh, James Chen Yong Kah
Our study shows a facile two-step method which does not require the use of core templates to load a hydrophobic photosensitizer drug chlorin e6 (Ce6) within polydopamine (PDA) nanoparticles (NPs) while maintaining the intrinsic surface properties of PDA NPs. This structure is significantly different from hollow nanocapsules which are less stiff as they do not possess a core. To our knowledge, there exist no similar studies in the literature on drug loading within the polymer matrix of PDA NPs. We characterized the drug loading and release behavior of the photosensitizer Ce6 and demonstrated the therapeutic efficacy of the combined photodynamic (PDT) and photothermal therapy (PTT) from Ce6 and PDA, respectively, under a single wavelength of 665 nm irradiation on bladder cancer cells...
June 27, 2018: ACS Applied Materials & Interfaces
M E McPhee, K K Petersen, M S Hoegh, T Graven-Nielsen
Aims Stimulus intensity used for assessing temporal summation of pain (TSP) is commonly set at the participants' pain tolerance. Yet pain ratings during TSP rarely reach that initial pain tolerance pain rating. This study aimed to explore the differences between baseline pain tolerance assessed by cuff algometry and subsequent pain ratings of the same stimulus intensity, and the reliability of these ratings over 2 sessions. Methods In two sessions, separated by one week, 24 healthy, pain-free males had their pressure pain detection (PDT) and tolerance threshold (PTT) recorded using a staircase inflation paradigm (5 kPa increments, 1sec-ON:4sec-OFF) with a cuff algometry system...
December 29, 2017: Scandinavian Journal of Pain
M Hoegh, K K Petersen, T Graven-Nielsen
Aims Conditioned pain modulation (CPM) is used to assess descending pain modulation through a test stimulation (TS) and a conditioning stimulation (CS). Due to potential carry-over effects, sequential CPM paradigms might alter the intensity of the CS, which potentially can alter the CPM-effect. This study aimed to investigate the difference between a fixed and adaptive CS intensity on CPM-effect. Methods On the dominant leg of 20 healthy subjects the cuff pressure detection threshold (PDT) was recorded as TS and the pain tolerance threshold (PTT) was assessed on the non-dominant leg for estimating the CS...
December 29, 2017: Scandinavian Journal of Pain
Ming Zhang, Wentao Wang, Yingjun Cui, Ninglin Zhou, Jian Shen
Background: Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, high-efficiency, and safe photosensitizers/photothermal agents remains a significant challenge. Methods: A novel nanocomposite has been developed via the assembly of iron oxide carbon dot (Fe3 O4 -CDs) nanoparticles and black phosphorus quantum dots (genipin [GP]-polyglutamic acid [PGA]-Fe3 O4 -CDs@BPQDs), and this nanocomposite shows a broad light-absorption band and a photodegradable character...
2018: International Journal of Nanomedicine
Fanli Xu, Mengxue Liu, Xin Li, Zhijuan Xiong, Xueyan Cao, Xiangyang Shi, Rui Guo
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) in cancer treatment has attracted much attention in recent years. However, developing highly efficient and targeted therapeutic nanoagents for amplifying PTT and PDT treatments remains challenging. In this work, we developed a novel photothermal and photodynamic therapeutic nanoplatform for treatment of cancer cells overexpressing integrin αv β₃ through the coating of polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) and then further conjugating polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) as targeted agents on the surface...
May 19, 2018: Nanomaterials
Thorvaldur Skuli Palsson, Shellie A Boudreau, Hans Jørgen Krebs, Thomas Graven-Nielsen
Facilitated pain mechanisms have been demonstrated in musculoskeletal pain, but it is unclear whether a recent painful injury leaves the pain system sensitized. Pain characteristics were assessed in individuals who recently recovered from ankle pain (recovered pain group; n = 25) and sex-matched control subjects (n = 25) in response to tonic pressure pain and saline-induced pain applied at the shin muscle. Pain intensity and pain referral patterns were recorded bilaterally after the painful muscle stimulus...
May 17, 2018: Journal of Pain: Official Journal of the American Pain Society
Qingyan Jia, Xiuli Zheng, Jiechao Ge, Weimin Liu, Haohui Ren, Shiqing Chen, Yongmei Wen, Hongyan Zhang, Jiasheng Wu, Pengfei Wang
As phototheranostic agents, carbon dots (CDs), have recently drawn considerable attention due to their excellent physicochemical properties. However, the complex synthetic route and high-cost of CDs greatly limit their practical application. To address this issue, given their nearly infinite supply from nature, Hypocrella bambusae is used as the precursor for the preparation of CDs in this study. The obtained Hypocrella bambusae CDs (HBCDs) possess good water solubility, broad absorption (350-800 nm), red-light emission (maximum peak at 610 nm), and low biotoxicity...
September 15, 2018: Journal of Colloid and Interface Science
Yu Cao, Xiangdan Meng, Dongdong Wang, Kai Zhang, Wenhao Dai, Haifeng Dong, Xueji Zhang
Lately, photothermal therapy (PTT) and photodynamic therapy (PDT) dual-modal therapy has attracted much attention in cancer therapy as a synergistic therapeutic model. However, the integration of PDT and PTT in a single nanoagent for cancer therapy is still a challenging task. Herein, an intelligent MnO2 /Cu2- x S-siRNA nanoagent simultaneously overcoming inherent limitations of PDT and PTT with remarkable PTT&PDT therapeutic efficiency enabling a multimode accurate tumor imaging diagnostic is designed...
May 30, 2018: ACS Applied Materials & Interfaces
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