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Pengfei Wu, Shan He, Hongliang Liu
We report on the fabrication of annular cladding waveguides in Nd:YAG laser crystal by using femtosecond laser inscription. The circular cross sections of the optical waveguides were in dual-cladding and tri-cladding shapes with different diameters. Under the optical pump at 808 nm, the generated continuous-wave lasers at 1064 nm have been realized in the annular cladding waveguides. For dual-cladding and tri-cladding waveguides, the slope efficiencies of the waveguide lasers were calculated to be 21.3% and 20%, and the maximum output powers measured were 82 mW and 84 mW, respectively...
July 1, 2018: Applied Optics
So-Young Chang, Yong-Ho Park, Nathaniel T Carpena, Tiffany T Pham, Phil-Sang Chung, Jae Yun Jung, Min Young Lee
Gene therapy is the delivery of a therapeutic gene into target cells to treat disorders by replacing disease-causing mutated genes with healthy ones. Gene therapy of the inner ear has been recently described, with applications for sensorineural hearing loss. However, gene delivery to the location of the inner ear, and thus efficacy of therapy, is challenging. Photobiomodulation (PBM) with a low-level laser has been suggested to have a therapeutic effect and has the potential to augment gene therapy. To investigate whether PBM improves the rate of adenovirus (Ad)-mediated viral delivery, we compared low-level laser therapy (LLLT) and non-LLLT HEI-OC1 cells treated with an Ad viral vector carrying green fluorescent protein (GFP)...
August 13, 2018: Lasers in Medical Science
Qing-Lan Li, Yao Sun, Li Ren, Xin Wang, Chen Wang, Lin Li, Ying-Wei Yang, Xianghui Yu, Jihong Yu
A smart supramolecular nanosystem integrating targeting, chemotherapy and photothermal therapy, was constructed based on carboxylatopillar[5]arene (CP[5]A)-functionalized CuS nanoparticles (CuS@CP NPs). CuS@CP NPs with good monodispersibility and strong near-infrared absorption were synthesized in aqueous solution through a facile one-pot supramolecular capping method, followed by surface installation of a liver cancer-targeted galactose derivative through host-guest binding interaction. The resulting smart supramolecular nanosystem, namely CuS@CPG, exhibited excellent photothermal ablation capability to HepG2 cells upon irradiation with laser at 808 nm...
August 9, 2018: ACS Applied Materials & Interfaces
Yuanyuan Qiu, Yuqing Zhang, Mingwang Li, Gaoxian Chen, Chenchen Fan, Kai Cui, Jian-Bo Wan, Anpan Han, Jian Ye, Zeyu Xiao
The inability to intraoperatively diagnose and eliminate microscopic residual tumors represents a significant challenge in cancer surgery. These residual microtumors cause lethal recurrence and metastasis. Herein, we show a crucial example of Raman imaging with gap-enhanced Raman tags (GERTs) to serve as a robust platform for intraoperative detection and eradication of residual microscopic foci, which exist in surgical margins, tumor invasion, and multifocal tumor spread. The GERTs feature gap-enhanced gold core-shell nanostructures, with Raman reporters embedding inside the interior gap junction...
August 6, 2018: ACS Nano
Vahid Hosseini, Mehri Mirrahimi, Ali Shakeri-Zadeh, Fereshteh Koosha, Behafarid Ghalandari, Shayan Maleki, Ali Komeili, S Kamran Kamrava
In this study, gold coated iron oxide nanoparticle (Au@Fe2 O3 NP) was synthesized in a core-shell structure. Photothermal and radiosensitization effects of Au@Fe2 O3 NPs were investigated on KB human mouth epidermal carcinoma cell line. Cell death and apoptosis were measured to study the effects of nanoparticles in combination with both radiotherapy (RT) and photothermal therapy (PTT). The KB cells were treated with Au@Fe2 O3 NPs (20 μg/ml; 4 h) and then received different treatment regimens of PTT and/or RT using laser (808 nm, 6 W/cm2 , 10 min) and/or 6 MV X-ray (single dose of 2 Gy)...
August 2, 2018: Photodiagnosis and Photodynamic Therapy
Sireesh Babu Maddinedi, Jegatheeswaran Sonamuthu, Serap SuzuK Yildiz, Guobin Han, Yurong Cai, Junkuo Gao, Qingqing Ni, Juming Yao
Nowadays, photothermal agents have attained considerable attention in nanomedicine for the treatment of cancer after chemotherapy, surgery, biological therapy and radiotherapy. In this work, we showed a sericin-based, simple approach for synthesis of sericin functionalized reduced graphene oxide (SRGO) with low cytotoxicity and photo thermal efficiency. During the synthesis, the GO is deoxygenated in situ and functionalized by sericin, a low-cost, silk protein and concurrently forms SRGO. The subsequent SRGO disperse well in water with higher biocompatibility because of the decoration of sericin on graphene sheets...
September 2018: Journal of Photochemistry and Photobiology. B, Biology
Brian Bicknell, Ann Liebert, Daniel Johnstone, Hosen Kiat
The human microbiome is intimately associated with human health, with a role in obesity, metabolic diseases such as type 2 diabetes, and divergent diseases such as cardiovascular and neurodegenerative diseases. The microbiome can be changed by diet, probiotics, and faecal transplants, which has flow-on effects to health outcomes. Photobiomodulation has a therapeutic effect on inflammation and neurological disorders (amongst others) and has been reported to influence metabolic disorders and obesity. The aim of this study was to examine the possibility that PBM could influence the microbiome of mice...
August 3, 2018: Lasers in Medical Science
Chao Xie, Longhui Zeng, Zhixiang Zhang, Yuen-Hong Tsang, Linbao Luo, Jung-Ho Lee
Two-dimensional group-10 transition metal dichalcogenides have recently attracted increasing research interest because of their unique electronic and optoelectronic properties. Herein, we present vertical hybrid heterojunctions of multilayered PtSe2 and Si, which take advantage of large-scale homogeneous PtSe2 films grown directly on Si substrates. These heterojunctions show obvious rectifying behavior and a pronounced photovoltaic effect, enabling them to function as self-driven photodetectors operating at zero bias...
August 16, 2018: Nanoscale
Xiuhua Wang, Lei Tan, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin W K Yeung, Paul K Chu, Shuilin Wu
Near infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapid in situ disinfection of bacterially infected artificial implants due to its penetration ability into tissues. However, the lower oxygen content in vivo may restrict the yields of reactive oxygen species (ROS), thus reducing the antibacterial efficacy of PADT significantly. Herein, liposome encapsulated photosensitizers (PS), IR780 and perfluorohexane (PFH), have been constructed on the surface of Ti implants via a covalent linkage to overcome this issue...
August 1, 2018: Biomaterials Science
Chenyang Xing, Shiyou Chen, Xin Liang, Quan Liu, Mengmeng Qu, Qingshuang Zou, Jihao Li, Hui Tan, Liping Liu, Dianyuan Fan, Han Zhang
Two-dimensional (2D) MXenes have recently been shown to be promising for applications in anticancer photothermal therapy (PTT), owing to their outstanding photothermal performance. However, as with the other inorganic 2D nanomaterials, the MXene-based nanoplatforms lack the appropriate biocompatibility and stability in physiological conditions, targeting capability, and controlled release of drug, for cancer therapy. Fabricating a smart MXene-based nanoplatform for the treatment of cancer therefore remains a challenge...
August 13, 2018: ACS Applied Materials & Interfaces
Andy Hernández Montoto, Roberto Montes, Akbar Samadi, Mónica Gorbe, José Manuel Terrés, Roberto Cao-Milán, Elena Aznar, Javier Ibañez, Rafael Masot, María Dolores Marcos, Mar Orzáez, Félix Sancenón, Lene B Oddershede, Ramón Martínez-Máñez
Herein, a novel drug photorelease system based on gold nanostars (AuNSts), coated with a mesoporous silica shell and capped with paraffin as thermosensitive molecular gate, is reported. Direct measurements of the surface temperature of a single gold nanostar irradiated using a tightly focused laser beam are performed via a heat-sensitive biological matrix. The surface temperature of a AuNSt increases by hundreds of degrees (°C) even at low laser powers. AuNSts coated with a mesoporous silica shell using a surfactant-templated synthesis are used as chemotherapeutic nanocarriers...
August 8, 2018: ACS Applied Materials & Interfaces
Joshua M Burns, Raviraj Vankayala, Jenny T Mac, Bahman Anvari
Nanoparticles activated by near-infrared (NIR) excitation provide a capability for optical imaging and photodestruction of tumors. We have engineered optical nanoconstructs derived from erythrocytes, which are doped with the FDA-approved NIR dye, indocyanine green (ICG). We refer to these constructs as NIR erythrocyte-mimicking transducers (NETs). Herein, we investigate the phototheranostic capabilities of NETs for fluorescence imaging and photodestruction of SKBR3 breast cancer cells and subcutaneous xenograft tumors in mice...
August 9, 2018: ACS Applied Materials & Interfaces
Lorelei Donovan Tucker, Yujiao Lu, Yan Dong, Luodan Yang, Yong Li, Ningjun Zhao, Quanguang Zhang
Photobiomodulation (PBM) has been demonstrated as a neuroprotective strategy, but its effect on perinatal hypoxic-ischemic encephalopathy is still unknown. The current study was designed to shed light on the potential beneficial effect of PBM on neonatal brain injury induced by hypoxia ischemia (HI) in a rat model. Postnatal rats were subjected to hypoxic-ischemic insult, followed by a 7-day PBM treatment via a continuous wave diode laser with a wavelength of 808 nm. We demonstrated that PBM treatment significantly reduced HI-induced brain lesion in both the cortex and hippocampal CA1 subregions...
July 22, 2018: Journal of Molecular Neuroscience: MN
Xiaomo Xu, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Shengli Zhu, Zhaoyang Li, Xubo Yuan, Yufeng Zheng, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Since skin wounds are subject to bacterial infection and tissue regeneration may be impeded, there is demand for biomaterials that possess rapid bactericidal and tissue repair capability. Herein we report in situ promotion of wound healing by a photothermal therapy (PTT) assisted nanocatalytic antibacterial system utilizing a polydopamine (PDA) coating on hydroxyapatite (HAp) incorporated with gold nanoparticles (Au-HAp). The PDA@Au-HAp NPs produce hydroxyl radicals (OH) via catalysis of a small concentration of H2 O2 to render bacteria more vulnerable to the temperature change...
July 17, 2018: Acta Biomaterialia
Min Ah Kim, Soon Do Yoon, Eun-Min Kim, Hwan-Jeong Jeong, Chang-Moon Lee
Photothermal therapy requires a biocompatible material to absorb near-infrared (NIR) light and generate sufficient heat. Herein, we suggest natural melanin-loaded nanovesicles (melasicles) as photothermal therapeutic agents (PTA) for NIR mediated cancer therapy in vivo. The mean size of these melasicles was 140 ± 15 nm. They showed excellent colloidal stability. After irradiation from 808 nm NIR laser at 1.5 W cm-2 , the melasicles showed good photothermal conversion efficiencies both in vitro and in vivo...
October 12, 2018: Nanotechnology
Nooshafarin Kazemikhoo, Reza Vaghardoost, Mostafa Dahmardehei, Soheila Mokmeli, Mahnoush Momeni, Mohammad Ali Nilforoushzadeh, Fereshteh Ansari, Mohammad Reza Razagi, Zahra Razagi, Mohammad Amir Amirkhani, Mohammad Reza Masjedi
Introduction: Skin graft is the standard therapeutic technique in patients with deep ulcers, but like every surgical procedure, it may present some complications. Although several modern dressings are available to enhance comfort of donor site, the use of techniques that accelerate wound healing may enhance patient's satisfaction. Low level laser therapy (LLLT) has been used in several medical fields, especially for wound healing, but it may take several months for large ulcers treated with laser to heal completely...
2018: Journal of Lasers in Medical Sciences
Elisabetta Merigo, Luigi Cella, Aldo Oppici, Maria Cristina Arbasi, Fabio Clini, Matteo Fontana, Carlo Fornaini
Introduction: The proper therapeutic plan for medication-related osteonecrosis of the Jaw (MRONJ) is still lacking long-term data up to today. They were several high-technological appliances proposed for the different intervention steps, in addition to tissue repair promoters. The reason for proposing an integrated technique is justified, beyond better compliance of the patients associated to the pain and inflammation reduction and bleeding control, there is also achieving better hard and soft tissues healing...
2018: Journal of Lasers in Medical Sciences
Alla B Bucharskaya, Galina N Maslyakova, Marina L Chekhonatskaya, Georgy S Terentyuk, Nikita A Navolokin, Boris N Khlebtsov, Nikolai G Khlebtsov, Alexey N Bashkatov, Elina A Genina, Valery V Tuchin
BACKGROUND: The analysis of recent studies on plasmonic photothermal therapy (PPT) after intravenous administration of gold nanorods (GNRs) has demonstrated that the effectiveness of nanoparticle-assisted laser hyperthermia depends on a correct dosage strategy of nanoparticle administration. Accumulation of GNRs in tumor tissue dramatically increases the local heating of the tumor without damage to healthy tissues. However, the optimal doses of GNR intravenous injections (IVIs) for effective accumulation in tumors, and optimal protocols of PPT are not designed yet...
July 19, 2018: Lasers in Surgery and Medicine
Yung-Chieh Chan, Ming-Hsien Chan, Chieh-Wei Chen, Ru-Shi Liu, Michael Hsiao, Din Ping Tsai
The matrix metalloproteinases (MMPs) are well-known mediators that are activated in tumor progression. MMP2 is a kind of gelatinase in extracellular matrix remodeling and cancer metastasis processes. MMP2 secretion increased in many types of cancer diseases, and its abnormal expression is associated with a poor prognosis. We fabricated a nanocomposite that sensed MMP2 expression by a red and blue light change. This nanocomposite consisted of an upconversion nanoparticle (UCNP), MMP2-sensitive peptide, and CuInS2 /ZnS quantum dot (CIS/ZnS QD)...
February 28, 2018: ACS Omega
Rui Gao, Xuan Mei, Dongpeng Yan, Ruizheng Liang, Min Wei
Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibility. Here, we develop near-infrared laser activated supramolecular photosensitizers (isophthalic acid/layered double hydroxide nanohybrids) for efficient two-photon photodynamic therapy. The singlet oxygen quantum yield of nanohybrid is up to 0...
July 18, 2018: Nature Communications
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