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https://www.readbyqxmd.com/read/30509355/investigating-the-photo-thermo-radiosensitization-effects-of-folate-conjugated-gold-nanorods-on-kb-nasopharyngeal-carcinoma-cells
#1
Mohammad Mehdi Movahedi, Alireza Mehdizadeh, Fereshteh Koosha, Neda Eslahi, Vahid Pirhajati Mahabadi, Habib Ghaznavi, Ali Shakeri-Zadeh
In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods. Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm2 ) or RT (6 MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. The effects of different treatments were studies using MTT assay, inductively coupled plasma-mass spectrometry (ICP-MS) and transmission electron microscopy (TEM)...
December 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/30501190/polymethine-thiopyrylium-fluorophores-with-absorption-beyond-1000-nm-for-biological-imaging-in-the-second-near-infrared-sub-window
#2
Bingbing Ding, Yuling Xiao, Hui Zhou, Xiao Zhang, Chunrong Qu, Fuchun Xu, Zixin Deng, Zhen Cheng, Xuechuan Hong
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes with both absorption and emission in NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in NIR-IIa (1300-1400 nm) sub-window under 1064 nm excitation with that in NIR-II window under 808 nm excitation...
December 2, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30501026/up-conversion-luminescence-properties-of-lanthanide-gold-hybrid-nanoparticles-as-analyzed-with-discrete-dipole-approximation
#3
Ruichan Lv, Miao Feng, Wolfgang J Parak
Up-conversion nanoparticles (UCNP) under near-infrared (NIR) light irradiation have been well investigated in the field of bio-imaging. However, the low up-conversion luminescence (UCL) intensity limits applications. Plasmonic modulation has been proposed as an effective tool to adjust the luminescence intensity and lifetime. In this study discrete dipole approximation (DDA) was explored concerning guiding the design of UCNP@mSiO₂-Au structures with enhanced UCL intensity. The extinction effects of gold shells could be changed by adjusting the distance between the UCNPs and the Au NPs by synthesized tunable mesoporous silica (mSiO₂) spacers...
November 29, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30499975/broadband-main-opcpa-amplifier-at-808-nm-wavelength-in-high-deuterated-dkdp-crystals
#4
Xiao Liang, Xinglong Xie, Cheng Zhang, Jun Kang, Qingwei Yang, Ping Zhu, Ailin Guo, Haidong Zhu, Shunhua Yang, Ziruo Cui, Meizhi Sun, Jianqiang Zhu
The optical aperture of ultrashort extreme intensity laser facilities, which reach 10 PW, will be beyond several hundred millimeters. DKDP is by now the only nonlinear crystal that can be grown to such diameter and used in the main optical parametric chirped-pulse amplification (OPCPA) amplifier of such a laser system. Here, at the signal wavelength of 808 nm for the first time, we experimentally present a broadband OPCPA system that consists of a pre-amplifier in BBO crystals and a main OPCPA amplifier in two 95% deuterated DKDP crystals...
December 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/30499655/near-infrared-irradiation-affects-lipid-metabolism-in-neuronal-cells-inducing-lipid-droplets-formation
#5
Svitlana M Levchenko, Andrey N Kuzmin, Tymish Y Ohulchanskyy, Artem Pliss, Junle Qu, Paras N Prasad
It is known that lipids play an outstanding role in cellular regulation and their dysfunction has been linked to many diseases. Thus, modulation of lipid metabolism may provide new pathways for disease treatment or prevention. In this work, near infrared (NIR) light was applied to modulate lipid metabolism, and increase intracellular lipid content in rat cortical neurons (RCN). Using label-free CARS microscopy, we have monitored the intracellular lipid content in RCN at a single cell level. A major increase in average level of lipid per cell after treatment with laser diode at 808 nm was found, nonlinearly dependent on the irradiation dose...
November 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30483386/the-application-of-titanium-dioxide-tio-2-nanoparticles-in-the-photo-thermal-therapy-of-melanoma-cancer-model
#6
Mohammad Ali Behnam, Farzin Emami, Zahra Sobhani, Amir Reza Dehghanian
Objectives: Photo-thermal therapy (PTT) is a therapeutic method in which photon energy is converted into heat to induce hyperthermia in malignant tumor cells. In this method, energy conversion is performed by nanoparticles (NPs) to enhance induced heat efficacy. The low-cytotoxicity and high optical absorbance of NPs used in this technique are very important. In the present study, titanium dioxide (TiO2 ) NPs were used as agents for PTT. For increasing water dispersibility and biocompatibility, polyethylene glycol (PEG)-TiO2 NPs (PEGylated TiO2 NPs) were synthesized and the effect of these NPs on reducing melanoma tumor size after PTT was experimentally assessed...
November 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30480436/enhanced-red-emission-in-er-3-sensitized-naluf-4-upconversion-crystals-via-energy-trapping
#7
Hao Lin, Dekang Xu, Yongjin Li, Lu Yao, Liqin Xu, Ying Ma, Shenghong Yang, Yueli Zhang
Luminescence efficiency of trivalent lanthanide-doped upconversion (UC) materials is significantly limited by luminescence concentration quenching. In this work, red UC emission is dramatically enhanced in Er3+ -sensitized NaLuF4 UC crystals through energy trapping under multiple excitation wavelengths. Cross-relaxation quenching and the energy migration to internal lattice defects are simultaneously suppressed by confining the excitation energy in the Er3+ activator after introducing the Tm3+ or Ho3+ energy trapping center...
November 27, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/30472618/stable-mesoporous-silica-nanoparticles-incorporated-with-mos2-and-aie-for-targeted-fluorescence-imaging-and-photothermal-therapy-of-cancer-cells
#8
Jie Wang, Maosheng Xu, Ke Wang, Zuanguang Chen
Theranostics for imaging-guided cancer treatment have obtained great attention in recent years for their outstanding capability of both tumor diagnosis and treatment. Molybdenum disulfide (MoS2 ) nanosheets revealed excellent photothermal conversion efficiency, which could be used as photothermal agents. However, MoS2 nanosheets would often quench or decrease the emission of fluorescence dyes when they were incorporated with these dyes to construct fluorescence-imaging-guided nanotheranostic systems. In this work, MoS2 nanosheets were embedded into mesoporous silica nanoparticles (MSNs), and Aggregation Induced Emission (AIE) fluorogen PhENH2 was chemically modified on the surface of MSNs, which could demonstrate more stable fluorescence emission compared with other MSNs with physically absorbed luminescent molecules...
November 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30465053/folate-receptor-targeted-theranostic-irs-x-nanoparticles-for-multimodal-imaging-guided-combined-chemo-photothermal-therapy
#9
Dong-Yang Zhang, Yue Zheng, Hang Zhang, Gang-Gang Yang, Cai-Ping Tan, Liang He, Liang-Nian Ji, Zong-Wan Mao
Nano-drug delivery systems with multi-modality imaging capacities are worth pursuing because they integrate diagnostic and therapeutic functions. Herein, we report the design, synthesis and evaluation of modified iridium sulfide (IrSx) nanoparticles (NPs) for cancer therapy in vitro and in vivo. This nanosystem was prepared by modifying IrSx with polyethylene glycol (PEG) conjugated to the targeting ligand folate (FA) for multimodal imaging-guided combined chemo-photothermal therapy. Upon PEG modification, the small IrSx NPs (about 4 nm) self-assembled into much larger (about 120 nm) IrSx-PEG-FA NPs, which exhibited high photostability, ideal photothermal effect, high drug loading and pH-/photothermal-responsive drug release properties...
November 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/30464463/nitroxide-radicals-modified-gold-nanorods-for-in-vivo-ct-mri-guided-photothermal-cancer-therapy
#10
Luyao Xia, Chao Zhang, Min Li, Kaiyu Wang, Yushan Wang, Peipei Xu, Yong Hu
Purpose: This article presents a report of the synthesis, characterization, and biomedical application of nitroxide-radicals-modified gold nanorods (Au-TEMPO NRs) for imaging-guided photothermal cancer therapy. Patients and methods: Au nanorods were synthesized through seed-mediated growth method, 4-Amino-TEMPO was added and the reaction proceeded under magnetic stirring. Results: With a mean length of 39.2 nm and an average aspect ratio of approximately 3...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30460521/does-low-level-laser-therapy-on-degenerated-ovine-testes-improve-post-thawed-sperm-characteristics
#11
Tamie Guibu de Almeida, Maíra Bianchi Rodrigues Alves, Leonardo Batissaco, Mariana Andrade Torres, André Furugen Cesar de Andrade, Rodolfo Daniel Mingoti, Rubens Paes de Arruda, Eneiva Carla Carvalho Celeghini
Low-level laser therapy (LLLT) can modulate redox state of the cell which could be useful to treat testicular degeneration and also prevent injuries by sperm cryopreservation. The aim of this study was to evaluate the effects of LLLT treatment on semen cryopreservation from rams submitted or not to testicular degeneration by testicular insulation. Eleven White Dorper rams were divided into four groups: animals that were not insulated (Control) and not treated (No Laser) (n = 2); animals that were not insulated and treated with LLLT (n = 3); animals that were insulated and not treated with LLLT (n = 3), and animals that were insulated and treated with LLLT (n = 3)...
November 21, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30450048/development-of-rifampicin-indocyanine-green-loaded-perfluorocarbon-nanodroplets-for-photo-chemo-probiotic-antimicrobial-therapy
#12
Kuang-Hung Hsiao, Chun-Ming Huang, Yu-Hsiang Lee
Acne vulgaris, generally resulted from overgrowth of Propionibacterium acnes ( P. acnes ), is one of the most difficult-to-treat facial dermatoses and more than 90% of adolescents experienced the disease worldwide. Because the innate non-lymphoid immune system cannot effectively eliminate excessive P. acnes from the skin surface, so far the therapy of acne vulgaris is still mainly dependent on antibiotic treatment. However, long-term or overdose of antibiotics may initiate microbial drug resistance and/or generate unexpected side effects that seriously hamper the use of antibiotics in the clinic...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30427028/one-scan-fluorescence-emission-difference-nanoscopy-developed-with-excitation-orthogonalized-upconversion-nanoparticles
#13
Bingru Huang, Qiusheng Wu, Xingyun Peng, Liqin Yao, Dengfeng Peng, Qiuqiang Zhan
We experimentally realized one-scan fluorescence emission difference nanoscopy (FED) by simultaneously imaging two different color emissions of NaYF4 :Er3+ @NaYF4 @NaYF4 :Yb3+ /Tm3+ upconversion nanoparticles. Under the irradiation of two synchronized laser beams, a solid 940 nm beam and a hollow 808 nm beam, green emission of Er3+ and blue emission of Tm3+ can be orthogonally generated and collected. After simple subtraction, a resulting super-resolution image featuring 54 nm resolution was obtained. This strategy of excitation orthogonality would greatly improve the imaging speed and the applicability of FED nanoscopy...
December 7, 2018: Nanoscale
https://www.readbyqxmd.com/read/30426987/use-of-an-nir-light-responsive-co-nanodonor-to-improve-the-epr-effect-in-photothermal-cancer-treatment
#14
Chongchong Wang, Yanqing Li, Xianqing Shi, Jiahong Zhou, Lin Zhou, Shaohua Wei
The carbon monoxide (CO)-carrying palladium nanosheet (PdNS-CO) was exploited as a photothermally triggered donor of CO. Irradiating material containing PdNS-CO with 808 nm-wavelength light caused a rapid heating of the material, triggering a release of CO. The enhanced permeability and retention (EPR) effect was found to be improved by such released CO and resulted in an increase in the accumulation of PdNS-CO at tumors and hence promoted its use in photothermal therapy (PTT) using a low laser power density...
November 27, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30418947/a-novel-near-infrared-triggered-dual-targeted-nanoplatform-for-mitochondrial-combined-photothermal-chemotherapy-of-cancer-in-vitro
#15
Hongshuai Wu, Chaoqun You, Jia Jiao, Fanghui Chen, Baiwang Sun, Xiaoli Zhu
A combination of photothermal-chemotherapy has received widespread attention in drug delivery systems for cancer treatment. However, the combination therapy operated in subcellular organelles, such as mitochondria, has been rarely reported. Herein, we designed a novel near-infrared (NIR) triggered dual-targeted nanoplatform (FA/TPP-DINPs) based on mitochondrial combined photothermal-chemotherapy by co-loading FDA-approved NIR dye indocyanine green (ICG) and anticancer drug doxorubicin (DOX). The resulting nanoparticles showed a monodispersed sphere and excellent colloidal stability...
January 18, 2019: Nanotechnology
https://www.readbyqxmd.com/read/30410328/photothermal-exposure-of-polydopamine-coated-branched-au-ag-nanoparticles-induces-cell-cycle-arrest-apoptosis-and-autophagy-in-human-bladder-cancer-cells
#16
Xiaoming Zhao, Tianyang Qi, Chenfei Kong, Miao Hao, Yuqian Wang, Jing Li, Baocai Liu, Yiyao Gao, Jinlan Jiang
Purpose: Polydopamine-coated branched Au-Ag nanoparticles (Au-Ag@PDA NPs) exhibit good structural stability, biocompatibility, and photothermal performance, along with potential anticancer efficacy. Here, we investigated the cytotoxicity of Au-Ag@PDA NPs against human bladder cancer cells (T24 cells) in vitro and in vivo, as well as the underlying molecular mechanisms of photothermal therapy-induced T24 cell death. Materials and methods: T24 cells were treated with different doses of Au-Ag@PDA NPs followed by 808 nm laser irradiation, and the effects on cell proliferation, cell cycle, apoptosis, and autophagy were analyzed...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30410326/short-duration-cancer-treatment-inspired-by-a-fast-bio-resorbable-smart-nano-fiber-device-containing-nir-lethal-polydopamine-nanospheres-for-effective-chemo-photothermal-cancer-therapy
#17
Francis O Obiweluozor, Gladys A Emechebe, Arjun Prasad Tiwari, Ju Yeon Kim, Chan Hee Park, Cheol Sang Kim
Background: The objective of this study was to evaluate the efficacy of a combination of Photothermal therapy (PTT) and chemotherapy in a single nano-fiber platform containing lethal polydopamine nanopheres (PD NPs) for annihilation of CT 26 cancer cells. Method: Polydioxanone (PDO) nanofiber containing PD and bortezomib (BTZ) was fabricated via electrospinning method. The content of BTZ and PD after optimization was 7% and 2.5% respectively with respect to PDO weight...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30408413/combination-responsive-moo-3-x-hybridized-hyaluronic-acid-hollow-nanospheres-for-cancer-phototheranostics
#18
Yuan-Yuan Wang, Wen-Long Wang, Xing-Can Shen, Bo Zhou, Ting Chen, Zhengxi Guo, Chang-Chun Wen, Bang-Ping Jiang, Hong Liang
It is of extreme importance to reduce side effects resulted from the nonspecific uptake of phototherapeutic agents by normal tissues. Currently, single responsive strategy still cannot entirely satisfy the requirements of practical applications. In this study, we developed one kind of combination-responsive phototherapeutic nanoplatforms, where oxygen deficient molybdenum oxide (MoO3-x ) hybridized hyaluronic acid (HA) hollow nanospheres, namely MoO3-x @HA HNSs, were constructed via a facile one-step method...
November 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30404202/a-broadband-phototransistor-based-on-three-dimensional-reduced-graphene-oxide-foam
#19
Yifan Li, Yating Zhang, Yu Yu, Zhiliang Chen, Lufan Jin, Mingxuan Cao, Haitao Dai, Jianquan Yao
Three-dimensional (3D) cross-linked polymer-like reduced graphene oxide foams (rGOFs) with a seamlessly continuous graphene network, exhibit high photoresponsive and conductivity and have received much attention regarding solar cells and supercapacitors. However, little attention has been paid to photodetection applications of 3D rGOFs. Here we report a novel broadband phototransistor based on metal-3D GFs-metal, which exhibits a high light absorption and a wide spectra response ranging at least from 400 to 1600 nm wavelength with a maximum photoresponsivity of 10 mA/W at 400 nm...
November 6, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30403239/interfacially-synthesized-fe-soc-mof-nanoparticles-combined-with-icg-for-photothermal-photodynamic-therapy
#20
Xuechao Cai, Bei Liu, Maolin Pang, Jun Lin
Recently, fabrication of nanoscale MOFs (NMOFs) has attracted great attention for biomedical applications. NMOFs not only maintain the structural diversity and physicochemical properties of bulk MOFs, but also possess suitable dimensions, making them potential nanocarriers for imaging agents and drug molecules. In this work, highly monodispersed Fe-soc-MOF nanoparticles (about 100 nm) were fabricated through the liquid-solid-solution (LSS) method. Indocyanine green (ICG) was conjugated to the surface-modified Fe-soc-MOF to construct a multifunctional theranostic platform...
November 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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