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https://www.readbyqxmd.com/read/30316298/polymer-coated-gold-ferric-oxide-superparamagnetic-nanoparticles-for-theranostic-applications
#1
Muhammad Raisul Abedin, Siddesh Umapathi, Harika Mahendrakar, Tunyaboon Laemthong, Holly Coleman, Denise Muchangi, Santimukul Santra, Manashi Nath, Sutapa Barua
BACKGROUND: Engineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-L-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and the internalization of the NPs toward living mammalian cells is profoundly affected...
October 13, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/30311065/artesunate-loaded-and-near-infrared-dye-conjugated-albumin-nanoparticles-as-high-efficiency-tumor-targeted-photo-chemo-theranostic-agent
#2
Hainan Yang, Zaijia Liu, Xufeng Li, Zhenfeng Zhang, Deji Chen, Hui Lian
Herein, a tumor-targeted multifunctional theranostic agent was synthetized using a facile method, combining four clinically approved materials: artesunate (Arte), human serum albumin (HSA), folic acid (FA), and indocyanine green (ICG). The obtained nanocomposites (FA-IHA NPs) showed an excellent photo- and physiological stability. The ICG in the FA-IHA NPs was used not only for near infrared (NIR) fluorescence imaging, but also for photothermal and photodynamic (PTT-PDT) therapy under a single NIR irradiation...
October 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/30307703/functionalized-mos-2-nanovehicle-with-near-infrared-laser-mediated-nitric-oxide-release-and-photothermal-activities-for-advanced-bacteria-infected-wound-therapy
#3
Qin Gao, Xiao Zhang, Wenyan Yin, Dongqing Ma, Changjian Xie, Lirong Zheng, Xinghua Dong, Linqiang Mei, Jie Yu, Chaozhan Wang, Zhanjun Gu, Yuliang Zhao
The rising dangers of bacterial infections have created an urgent need for the development of a new generation of antibacterial nanoagents and therapeutics. A new near-infrared 808 nm laser-mediated nitric oxide (NO)-releasing nanovehicle (MoS2 -BNN6) is reported through the simple assembly of α-cyclodextrin-modified MoS2 nanosheets with a heat-sensitive NO donor N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine (BNN6) for the rapid and effective treatment of three typical Gram-negative and Gram-positive bacteria (ampicillin-resistant Escherichia coli, heat-resistant Escherichia faecalis, and pathogen Staphylococcus aureus)...
October 11, 2018: Small
https://www.readbyqxmd.com/read/30305223/perfluorocarbon-nanocapsules-improve-hypoxic-microenvironment-for-the-tumor-ultrasound-diagnosis-and-photodynamic-therapy
#4
Niannian Li, Fei Xu, Jiejun Cheng, Ying Zhang, Gang Huang, Jun Zhu, Xi Shen, Dannong He
Amelioration of hypoxia is an important factor increasing the effects of anti-tumor therapies. In the present experiments, nanocapsules of poly(lactide-co-glycolide)-poly(ethylene glycol)/perfluorooctyl bromide (PFOB)/photosensitizers (IR780) have been developed to increase oxygen concentration inside the tumor and improve the outcome of photodynamic therapy (PDT). PFOB has high oxygen solubility, and IR780 is a photosensitizer particularly suited for a highly effective photodynamic therapy under the 808-nm laser irradiation...
December 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30305209/self-assembled-hydroxyapatite-graphene-scaffold-for-photothermal-cancer-therapy-and-bone-regeneration
#5
Dejian Li, Wei Nie, Liang Chen, David McCoul, Dinghua Liu, Xu Zhang, Ying Ji, Baoqing Yu, Chuanglong He
Repairing large tumor-related bone defects remains a difficult clinical problem because of the significant risk of locoregional relapse after surgical curettage. In this study, a composite scaffold of nano-hydroxyapatite (nHA) and reduced graphene oxide (rGO) sheets was fabricated by self-assembly, and a 20 wt% nHA-rGO sheet solution formed the most stable hydrogel. In vitro , nHA-rGO scaffolds killed all but 8% of osteosarcoma cells (MG-63) under 808 nm near-infrared laser irradiation for 20 min. SEM images and live/dead staining of MG-63 cells in nHA-rGO also confirmed the therapeutic efficacy of the scaffolds...
December 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30298300/low-power-laser-alters-mrna-levels-from-dna-repair-genes-in-acute-lung-injury-induced-by-sepsis-in-wistar-rats
#6
Luiz Philippe da Silva Sergio, Andrezza Maria Côrtes Thomé, Larissa Alexsandra da Silva Neto Trajano, Solange Campos Vicentini, Adilson Fonseca Teixeira, Andre Luiz Mencalha, Flavia de Paoli, Adenilson de Souza da Fonseca
Acute lung injury (ALI) is defined as respiratory failure syndrome, in which the pathogenesis could occur from sepsis making it a life-threatening disease by uncontrolled hyperinflammatory responses. A possible treatment for ALI is the use of low-power infrared lasers (LPIL), whose therapeutical effects depend on wavelength, power, fluence, and emission mode. The evaluation mRNA levels of repair gene related to oxidative damage after exposure to LPIL could provide important information about the modulation of genes as treatment for ALI...
October 8, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30294538/a-clinico-microbiologic-study-comparing-the-efficacy-of-locally-delivered-chlorhexidine-chip-and-diode-laser-as-an-adjunct-to-non-surgical-periodontal-therapy
#7
Vrishti Bansal, Rajan Gupta, Parveen Dahiya, Mukesh Kumar, Japnit Kaur Samlok
Background: Considering the microbial etiology of the periodontal disease, the periodontal therapy aims to control or abolish the pathogenic microbes. The gold standard scaling and root planing procedure has been used since time immemorial but the drawbacks associated with it have led to the development of various adjunctive means. The current study was therefore, performed to comparatively assess the efficacy of local delivery of chlorhexidine and 808-nm diode LASER as an appurtenance to scaling and root planing in patients with chronic periodontitis...
January 2019: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/30288516/a-biodegradable-fluorescent-nanohybrid-for-photo-driven-tumor-diagnosis-and-tumor-growth-inhibition
#8
Rajendra Prasad, Deepak S Chauhan, Amit S Yadav, Janhavi Devrukhkar, Barkha Singh, Mahadeo Gorain, Mayur Temgire, Jayesh Bellare, Gopal C Kundu, Rohit Srivastava
Specific targeting and phototriggered therapy in mouse model have recently emerged as the starting point of cancer theragnosis. Herein, we report a bioresponsive and degradable nanohybrid, a liposomal nanohybrid decorated with red emissive carbon dots, for localized tumor imaging and light-mediated tumor growth inhibition. Unsaturated carbon dots (C-dots) anchored to liposomes convert near-infrared (NIR) light into heat and also produce reactive oxygen species (ROS), demonstrating the capability of phototriggered cancer cell death and tumor regression...
October 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/30286310/carrier-free-core-shell-nanodrugs-for-synergistic-two-photon-photodynamic-therapy-of-cervical-cancer
#9
Jingwen Wang, Min Zheng, Zhigang Xie
Carrier-free nanodrugs named BCNPs were prepared by the coassembly of 2,5-bis(4-(diethylamino)benzylidene)cyclopentanone (BDBC) and curcumin (CCM) in the absence of surfactants. The as-synthesized BCNPs possess high dispersity and stability in aqueous media, along with favorable photostability and good biocompatibility. Comparing with their counterparts BDBC and CCM, BCNPs exhibit higher singlet oxygen yield and better two-photon photodynamic therapy (PDT) efficacy. Moreover, BCNPs display dramatically enhanced ability for inhibiting the growth of HeLa cells, which benefits from the synergistic treatment of BDBC and CCM under the irradiation of 450/808 nm...
September 27, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30281860/solution-processable-two-dimensional-in2se3-nanosheets-as-efficient-photothermal-agents-for-elimination-of-bacteria
#10
Chunli Zhu, Haijing Shen, Haoyang Liu, Xiaobo Lv, Zhihao Li, Quan Yuan
Two-dimensional (2D) layered nanoflakes have emerged as a pretty appealing class of materials for optoelectronics applications due to their dimensionality and unique electronic properties. However, the lack of effective and easy-to-manipulate methods for large-scale production of these materials limits their potential for applications. Also, few efforts have been made to explore their applications in biological fields. Here, we report the preparation of large-scale 2D In2Se3 nanosheets by a solvent exfoliation technique...
October 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30276886/graphene-organic-semiconductor-heterojunction-phototransistors-with-broadband-and-bi-directional-photoresponse
#11
Jiayue Han, Jun Wang, Ming Yang, Xiao Kong, Xiaoqing Chen, Zehua Huang, Hui Guo, Jun Gou, Silu Tao, Zhijun Liu, Zhiming Wu, Yadong Jiang, Xinran Wang
A graphene-semiconductor heterojunction is very attractive for realizing highly sensitive phototransistors due to the strong absorption of the semiconductor layer and the fast charge transport in the graphene. However, the photoresponse is usually limited to a narrow spectral range determined by the bandgap of the semiconductor. Here, an organic heterojunction (C60 /pentacene) is incorporated on graphene to realize a broadband (405-1550 nm) phototransistor with a high gain of 5.2 × 105 and a response time down to 275 µs...
October 1, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30274517/an-nir-guided-aggregative-and-self-immolative-nanosystem-for-efficient-cancer-targeting-and-combination-anticancer-therapy
#12
Qiang Zheng, Yun He, Qing Tang, Yanfang Wang, Ning Zhang, Jin Liu, Qiang Liu, Sheng Zhao, Ping Hu
Nanosized drug delivery systems have offered promising approaches for cancer therapy. However, few was effective to selectively target cancer cells and release drug at desired tumor sites. Here, we report a "smart" polymeric nanoplatform which could actively accumulate at tumor sites and dissociate to release encapsulated cargos upon near infrared laser (NIR) irradiation. This nanoplatform composed of a novel amphiphilic block copolymer poly(propylene sulphide)-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (PPS-P(NIPAM-co-DMAA)) formed spherical structures in aqueous solution and responded to both oxidants and elevated temperature...
October 1, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30273481/superhydrophobic-sic-cnts-coatings-with-photothermal-deicing-and-passive-anti-icing-properties
#13
Guo Jiang, Liang Chen, Shuidong Zhang, Han-Xiong Huang
For faster and greener anti-icing/deicing, new generation anti-icing materials are expected to possess both passive anti-icing properties and active de-icing properties. The photothermal effect of CNTs is used in the field of photothermal cancer therapy, while the application in anti-icing/deicing is seldom investigated. Superhydrophobic SiC/CNTs coatings with photothermal deicing and passive anti-icing properties were first prepared by a simple spray-coating method. The results of 3D profile and microstructure observed via scanning electron microscopy demonstrates that the micro-nanostructure combined with peak-like SiC microstructure and villiform CNTs nanostructure makes the coatings surface superhydrophobic, exhibiting a water contact angle of up to 161° and a roll angle as low as 2°...
October 1, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30270415/biophysical-skin-measurements-to-evaluate-the-effectiveness-of-photobiomodulation-therapy-in-the-prevention-of-acute-radiation-dermatitis-in-breast-cancer-patients
#14
Jolien Robijns, Sandrine Censabella, Stefan Claes, Luc Pannekoeke, Lore Bussé, Dora Colson, Iris Kaminski, Joy Lodewijckx, Paul Bulens, Annelies Maes, Leen Noé, Marc Brosens, An Timmermans, Ivo Lambrichts, Veerle Somers, Jeroen Mebis
PURPOSE: The purpose of this study was to evaluate objectively the effectiveness of photobiomodulation therapy (PBMT) for the prevention of acute radiation dermatitis (ARD) by using biophysical skin measurements. METHODS: A randomized, placebo-controlled trial with 120 breast cancer patients who underwent an identical radiotherapy (RT) regimen post-lumpectomy was performed (TRANSDERMIS trial). Patients were randomized to receive PBM (808 nm CW/905 nm pulsed, 168 mW/cm2 , spot size 19...
October 1, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30268950/effect-of-laser-irradiation-on-aphthae-pain-management-a-four-different-wavelengths-comparison
#15
Jean-Paul Rocca, Meng Zhao, Carlo Fornaini, Lixin Tan, Zengyi Zhao, Elisabetta Merigo
Recurrent Aphthous Stomatitis (RAS) is an oral condition characterized by painful ulcerations of the mucosa, healing spontaneously in 10-14 days but sometimes, due to their number, size and frequency of recurrence, lesions may be the cause of a severe disconfort with an impact on the quality of life of the patients due to the increased difficulty to eat, swallow and speak. For RAS, different protocols and treatments have been proposed as standard topical treatment to provide symptomatic relief, immunomodulating drugs as thalidomide, colchicine and steroids have been also proposed with the outcome to relief the pain, accelerating the healing process and increase the duration of ulcer-free period but without definitive results and without side effects...
September 20, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30264563/flexible-low-voltage-and-n-type-infrared-organic-phototransistors-with-enhanced-photosensitivity-via-interface-trapping-effect
#16
Guiheng Wang, Kaiqiang Huang, Zhen Liu, Yuchang Du, Xiaohong Wang, Hongbo Lu, Guobing Zhang, Longzhen Qiu
Flexible and low-voltage near-infrared organic phototransistors (NIR OPTs) were prepared with a low-bandgap donor-acceptor (D-A) conjugated polymer as the semiconductor layer, and n-octadecyl phosphonic acid modified anodic alumina (AlOx/ODPA) as the insulating layer. The phototransistors exhibit the typical n-type transistor characteristics at a voltage below 5 V. The photosensitivity of phototransistors can be enhanced by the formation of different trap states through the regulation of the packing densities of the ODPA self-assembled monolayers...
September 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30256766/enhancement-of-1-5-%C3%A2%C2%B5m-fluorescence-signal-from-er3-due-to-yb3-in-yttrium-silicate-powders-pumped-at-975-and-808-nm
#17
Nikifor Rakov, Glauco S Maciel
The effect of the presence of ytterbium (Yb3+) on the near-infrared (NIR) emission profile of erbium (Er3+), more specifically the 4I13/2 → 4I15/2 radiative transition around 1.5 µm, in yttrium silicate crystalline ceramic powders prepared by combustion synthesis was investigated under different NIR laser excitation wavelengths (λ = 808 and 975 nm). Enhancement of fluorescence around 1.5 µm due to the presence of Yb3+ was observed, which has potential use in medicine (NIR-III biological window) and optical communications (C-band transmission window)...
September 26, 2018: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/30255863/thermosensitive-drug-loading-system-based-on-copper-sulfide-nanoparticles-for-combined-photothermal-therapy-and-chemotherapy-in-vivo
#18
Zhenwei Yuan, Sisi Qu, Yuanyuan He, Yue Xu, Li Liang, Xiaojing Zhou, Lijuan Gui, Yuqing Gu, Haiyan Chen
A phase-change material (PCM) is an efficient energy storage material, but its poor thermal conductivity has limited its application in nanomedicine research. In this study, we used the photothermal material copper sulfide (CuS) to tackle this challenge. The designed CuS-DOX-MBA@PCM nanoparticles (NPs) were prepared by a nanoprecipitation method, and were composed of CuS, the anticancer drug (DOX), and near-infrared (NIR) dyes (MBA) encapsulated with stearic acid and lauric acid, which are characterized by a low eutectic point close to human physiological temperature...
September 26, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30248614/sacrificial-template-based-synthetic-approach-of-polypyrrole-hollow-fibers-for-photothermal-therapy
#19
Deval Prasad Bhattarai, Arjun Prasad Tiwari, Bikendra Maharjan, Batgerel Tumurbaatar, Chan Hee Park, Cheol Sang Kim
In the present work, polypyrrole hollow fibers (PPy-HFs) were fabricated by sacrificial removal of soft templates of electrospun polycaprolactone (PCL) fibers with polypyrrole (PPy) coating through chemical polymerization of pyrrole monomer. Different physicochemical properties of as-fabricated PPy-HFs were then studied by Field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Fourier transform infra-red (FT-IR) spectroscopy, Differential scanning calorimetry/Thermogravimetric analysis (DSC/TGA), and X-ray photoelectron spectroscopy (XPS)...
September 17, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30244400/biochemical-changes-in-injured-sciatic-nerve-of-rats-after-low-level-laser-therapy-660-nm-and-808-nm-evaluated-by-raman-spectroscopy
#20
Melissa de Almeida Melo Maciel Mangueira, Nilton Maciel Mangueira, Ozimo Pereira Gama Filho, Márcio Moysés de Oliveira, Renato Albuquerque Heluy, Landulfo Silveira, Egas Caparelli Moniz de Aragão Dáquer
The aim of this study was to identify biochemical changes in sciatic nerve (SN) after crush injury and low-level laser therapy (LLLT) with 660 nm and 808 nm by Raman spectroscopy (RS) analysis. A number of 32 Wistar rats were used, divided into four groups (control 1, control 2, LASER 660 nm, and LASER 808 nm). All animals underwent surgical procedure of the SN and groups control 2, LASER 660 nm, and LASER 808 nm were submitted to SN crush damage (axonotmesis). The LLLT in the groups LASER 660 nm and LASER 808 nm was applied daily for 21 consecutive days (100 mW, 30 s, 133 J/cm2 fluence)...
September 22, 2018: Lasers in Medical Science
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