Vasily Belov, Nicolas J Guehl, Sridhar Duvvuri, Philip Iredale, Sung-Hyun Moon, Maeva Dhaynaut, Srinivas Chakilam, Alexander C MacDonagh, Peter A Rice, Daniel L Yokell, John J Renger, Georges El Fakhri, Marc D Normandin
Stimulation of the M4 muscarinic acetylcholine receptor reduces striatal hyperdopaminergia, suggesting its potential as a therapeutic target for schizophrenia. Emraclidine (CVL-231) is a novel, highly selective, positive allosteric modulator (PAM) of M4 muscarinic acetylcholine receptors i.e. acts as a modulator that increases the response of these receptors. First, we aimed to further characterize the positron emission tomography (PET) imaging and quantification performance of a recently developed M4 PAM radiotracer, [11 C]MK-6884, in non-human primates (NHPs)...
March 13, 2024: Journal of Cerebral Blood Flow and Metabolism