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Blueberry supplement

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https://www.readbyqxmd.com/read/30057677/blackberry-and-blueberry-anthocyanin-supplementation-counteract-high-fat-diet-induced-obesity-by-alleviating-oxidative-stress-and-inflammation-and-accelerating-energy-expenditure
#1
Tao Wu, Yufang Gao, Xueqi Guo, Min Zhang, Lingxiao Gong
Many studies indicate that an anthocyanin-rich diet has beneficial effects preventing metabolic disease. In the present study, the molecular mechanism underlying the antiobesity effect of consuming blackberry anthocyanins (BLA) and blueberry anthocyanins (BBA) was investigated in high-fat-diet- (HFD-) fed C57BL/6 mice. Sixty mice were administered a low-fat diet (LFD), a HFD, or a HFD plus orlistat, and BLA or BBA in their daily food for 12 weeks. As a result, the consumption of BLA and BBA inhibited body weight gain by 40...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30054757/heterologous-production-of-resveratrol-in-bacterial-hosts-current-status-and-perspectives
#2
REVIEW
A Braga, P Ferreira, J Oliveira, I Rocha, N Faria
The polyphenol resveratrol (3,5,4'-trihydroxystilbene) is a well-known plant secondary metabolite, commonly used as a medical ingredient and a nutritional supplement. Due to its health-promoting properties, the demand for resveratrol is expected to continue growing. This stilbene can be found in different plants, including grapes, berries (blackberries, blueberries and raspberries), peanuts and their derived food products, such as wine and juice. The commercially available resveratrol is usually extracted from plants, however this procedure has several drawbacks such as low concentration of the product of interest, seasonal variation, risk of plant diseases and product stability...
July 27, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/30032176/polyphenols-from-grape-and-blueberry-improve-episodic-memory-in-healthy-elderly-with-lower-level-of-memory-performance-a-bicentric-double-blind-randomized-placebo-controlled-clinical-study
#3
Julien Bensalem, Stéphanie Dudonné, Nicole Etchamendy, Hermine Pellay, Camille Amadieu, David Gaudout, Séverine Dubreuil, Marie-Eve Paradis, Sonia Pomerleau, Lucile Capuron, Carol Hudon, Sophie Layé, Yves Desjardins, Véronique Pallet
Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. The present study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary outcome was the CANTAB Paired Associate Learning (PAL), a visuospatial learning and episodic memory test...
July 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29845904/dietary-supplementation-with-blueberry-partially-restores-t-cell-mediated-function-in-high-fat-diet-induced-obese-mice
#4
Erin D Lewis, Zhihong Ren, Jason DeFuria, Martin S Obin, Simin N Meydani, Dayong Wu
Blueberry, rich in antioxidant and anti-inflammatory phytochemicals, has been demonstrated to lower inflammatory status in adipose induced by high-fat diet (HFD) and obesity. The effect of blueberry on systemic immune functions has not been examined. C57BL/6 mice were randomised to one of three diets - low-fat diet (LFD), HFD and HFD plus 4 % (w/w) blueberry (HFD+B) - for 8 or 12 weeks. Ex vivo T-cell mitogens (concanavalin A (Con A); phytohaemagglutinin), T-cell antibody (anti-CD3; anti-CD3/CD28)-stimulated T-cell proliferation and cytokine production were assessed...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29781405/changes-of-hippocampus-proteomic-profiles-after-blueberry-extracts-supplementation-in-app-ps1-transgenic-mice
#5
Hai-Qiang Li, Long Tan, Hong-Peng Yang, Wei Pang, Tong Xu, Yu-Gang Jiang
OBJECTIVE: To examine protein changes in the hippocampus of APP/PS1 transgenic mice after blueberry extracts (BB) intervention. METHODS: Eight APP/PS1 transgenic mice were randomly assigned to Alzheimer's disease (AD)+BB group (n=4) and AD+control group (n=4). After a 16-week treatment, 2-DE and MALDI-TOF-MS were used to compare the proteomic profiles of the hippocampus in the two groups and Western blot was used to confirm the important differentially expressed proteins...
May 21, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29717416/lowbush-cranberry-acts-through-daf-16-foxo-signaling-to-promote-increased-lifespan-and-axon-branching-in-aging-posterior-touch-receptor-neurons
#6
Courtney Scerbak, Elena Vayndorf, Alicia Hernandez, Colin McGill, Barbara Taylor
Medicinal berries are appreciated for their health benefits, in traditional ecological knowledge and nutrition science. Determining the cellular mechanisms underlying the effects of berry supplementation may contribute to our understanding of aging. Here, we report that lowbush cranberry (Vaccinium vitis-idaea) treatment causes marked nuclear localization of the central aging-related transcription factor DAF-16/FOXO in aged Caenorhabditis elegans. Further, functional DAF-16 is required for the lifespan extension, improved mechanosensation, and posterior touch receptor neuron morphological changes induced by lowbush cranberry treatments...
April 2018: GeroScience
https://www.readbyqxmd.com/read/29544868/blueberry-metabolites-restore-cell-surface-glycosaminoglycans-and-attenuate-endothelial-inflammation-in-diabetic-human-aortic-endothelial-cells
#7
Brett Ronald Cutler, Samira Gholami, Jie Shi Chua, Balagurunathan Kuberan, Pon Velayutham Anandh Babu
BACKGROUND: Glycosaminoglycan (GAG), a major component of the endothelial glycocalyx, is severely perturbed in diabetic vasculature leading to endothelial inflammation and vascular disease in diabetes. We tested the hypothesis that blueberry metabolites (BBM) ameliorate endothelial inflammation in diabetic endothelial cells (ECs) by restoring cell surface GAGs. METHODS: ECs isolated from healthy individuals [human aortic ECs (HAECs)] and diabetic patients (diabetic HAECs) were treated with ±BBM (benzoic acid-4-sulfate, hippuric acid, hydroxyhippuric acid, isovanillic acid-3-sulfate, and vanillic acid-4-sulfate at concentrations known to circulate in human plasma following blueberry consumption) for 3 days, and indices for endothelial inflammation were measured...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29536552/effects-of-a-foliar-spray-of-selenite-or-selenate-at-different-growth-stages-on-selenium-distribution-and-quality-of-blueberries
#8
Mingfeng Li, Zhuqing Zhao, Jiajie Zhou, Daowen Zhou, Boning Chen, Liqiang Huang, Zhihua Zhang, Xinwei Liu
BACKGROUND: Foliar spraying of selenium (Se) has increasingly been applied to improve Se concentrations in grain crops, although little information is available about the properties of Se-enriched fruits. In the present study, selenium distribution in blueberry and Se effect on blueberry quality were investigated by foliar spraying selenite or selenate (200 g ha-1 ) on two blueberry cultivars (Bluecrop and Northland) during the young fruit or coloring stage. RESULTS: Selenium concentration in blueberry was mainly affected by cultivar and spray stage relative to the Se source...
March 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29490092/blueberry-supplementation-influences-the-gut-microbiota-inflammation-and-insulin-resistance-in-high-fat-diet-fed-rats
#9
Sunhye Lee, Katherine I Keirsey, Rebecca Kirkland, Zachary I Grunewald, Joan G Fischer, Claire B de La Serre
Background: Gut microbiota dysbiosis has been linked to obesity-associated chronic inflammation. Microbiota manipulation may therefore affect obesity-related comorbidities. Blueberries are rich in anthocyanins, which have anti-inflammatory properties and may alter the gut microbiota. Objective: We hypothesized that blueberry supplementation would alter the gut microbiota, reduce systemic inflammation, and improve insulin resistance in high-fat (HF)-diet-fed rats...
February 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29486772/probiotic-fruit-beverages-with-different-polyphenol-profiles-attenuated-early-insulin-response
#10
Jie Xu, Tommy Jönsson, Merichel Plaza, Åsa Håkansson, Martin Antonsson, Irini Lazou Ahrén, Charlotta Turner, Peter Spégel, Yvonne Granfeldt
BACKGROUND: Consumption of polyphenol-rich fruits and vegetables may improve postprandial glucose and insulin levels and hence promote well-being. Previously it has been observed that consumption of bilberry decreases the postprandial insulin demand. The intention with the present study was to compare the impact of different supplements with various polyphenol profiles, on the postprandial glucose and insulin responses in healthy young adults. METHODS: In a randomized, controlled, crossover study the postprandial glycemic and insulin responses were observed in eleven healthy adults after intake of five different beverages containing bilberry (European blueberry), blackcurrant, beetroot, mango and rose hip, respectively; all drinks were enriched with the same composition of fermented oatmeal and probiotics...
February 27, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29458842/cognitive-response-to-fish-oil-blueberry-and-combined-supplementation-in-older-adults-with-subjective-cognitive-impairment
#11
Robert K McNamara, Wilhelmina Kalt, Marcelle D Shidler, Jane McDonald, Suzanne S Summer, Amanda L Stein, Amanda N Stover, Robert Krikorian
Given evidence that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and anthocyanin-rich blueberries provide neurocognitive benefit, we investigated long-term supplementation in older adults with cognitive complaints. In a 24-week randomized, double-blind, placebo-controlled trial, elderly men and women received daily fish oil (FO) or blueberry (BB) or both. Diet records confirmed that participants reduced background consumption of EPA, DHA, and anthocyanins as prescribed. Erythrocyte EPA + DHA composition increased in the FO groups (p = 0...
April 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29435127/%C3%AE-tocopherol-succinate-enhances-pterostilbene-anti-tumor-activity-in-human-breast-cancer-cells-in-vivo-and-in-vitro
#12
Ka-Wai Tam, Chi-Tang Ho, Shih-Hsin Tu, Wen-Jui Lee, Ching-Shui Huang, Ching-Shyang Chen, Chih-Hsiung Wu, Chia-Hwa Lee, Yuan-Soon Ho
Vitamin E (Vit. E) is considered an essential dietary nutrient for humans and animals. An enormous body of evidence indicates the biological and protective effects of Vit. E consumption. Tocopherol-associated protein (TAP) is a major tocopherol-binding protein affecting Vit. E stimulation and downstream signaling transduction. However, how Vit. E utilizes TAP as an anti-cancer mechanism remains unclear. Microarray analysis of signature gene profiles in breast cancer cells treated with α-tocopheryl succinate (α-TOS, a Vit...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29345498/effects-of-blueberry-and-cranberry-consumption-on-type-2-diabetes-glycemic-control-a-systematic-review
#13
Daniela Mayumi Usuda Prado Rocha, Ana Paula Silva Caldas, Bárbara Pereira da Silva, Helen Hermana Miranda Hermsdorff, Rita de Cássia Gonçalves Alfenas
The metabolic effects of cranberry and blueberry consumption on glycemic control have been evaluated in vitro and in animal models as well as in human studies, although findings have not been systematically reviewed yet. Therefore, a systematic review was carried out of relevant randomized clinical trials (RCTs) in order to assess the effect of berries (blueberry and cranberry) consumption on type 2 diabetes (T2DM) glycemic control. Some evidences were also discussed on the anti-diabetic mechanisms exerted by berries polyphenols...
January 18, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29184669/repeat-dose-nrpt-nicotinamide-riboside-and-pterostilbene-increases-nad-levels-in-humans-safely-and-sustainably-a-randomized-double-blind-placebo-controlled-study
#14
Ryan W Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD+) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X)...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29152239/effects-of-dietary-supplementation-with-a-mixed-blueberry-and-grape-extract-on-working-memory-in-aged-beagle-dogs
#15
V Fragua, A Lepoudère, V Leray, C Baron, J A Araujo, P Nguyen, N W Milgram
Cellular oxidative damage is thought to be one of the key mechanisms underlying age-related cognitive impairment in dogs. Several nutritional interventions to limit cognitive decline are reported in the literature. To our knowledge, the association of grape and blueberry extracts has never been tested in aged dogs. Our objective was to evaluate the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on oxidative status and cognitive performances in aged dogs. A total of thirty-five beagle dogs (aged 8·0-14·5 years) were fed a basal diet with PEGB at either 0 parts per million (ppm) ( n 11; control), 240 ppm ( n 12; PEGB1) or 480 ppm ( n 12; PEGB2) for 75 d...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29134464/phytochemical-properties-and-antioxidant-activities-of-extracts-from-wild-blueberries-and-lingonberries
#16
Paulina Dróżdż, Vaida Šėžienė, Krystyna Pyrzynska
Among Vaccinium species, blueberries (Vaccinium myrtillus L.) and lingonberries (Vaccinium vitis-idaea) are popular in the human diet. In this study, total phenolic, total flavonoid and total monomeric anthocyanin contents in the ethanol-water extracts of blueberry and lingonberry fruits grown wild in the forests in the central region of Poland were assayed. Antioxidant activities of the extracts from each plant were also evaluated for scavenging ability on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and reducing power by cupric reducing antioxidant capacity (CUPRAC) method...
December 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29123512/alternative-growth-promoters-modulate-broiler-gut-microbiome-and-enhance-body-weight-gain
#17
Serajus Salaheen, Seon-Woo Kim, Bradd J Haley, Jo Ann S Van Kessel, Debabrata Biswas
Antibiotic growth promoters (AGPs) are frequently used to enhance weight-gain in poultry production. However, there has been increasing concern over the impact of AGP on the emergence of antibiotic resistance in zoonotic bacterial pathogens in the microbial community of the poultry gut. In this study, we adopted mass-spectrophotometric, phylogenetic, and shotgun-metagenomic approaches to evaluate bioactive phenolic extracts (BPE) from blueberry ( Vaccinium corymbosum ) and blackberry ( Rubus fruticosus ) pomaces as AGP alternatives in broilers...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29026903/the-effect-of-cognitive-demand-on-performance-of-an-executive-function-task-following-wild-blueberry-supplementation-in-7-to-10-years-old-children
#18
RANDOMIZED CONTROLLED TRIAL
A R Whyte, G Schafer, C M Williams
The cognitive benefits of acute flavonoid interventions have been well documented, however, research to date has found that, depending on developmental stage, these benefits manifest themselves in different cognitive domains. It is argued that the lack of global cognitive effects following flavonoid intervention may be a result of insufficient task sensitivity for those domains where no benefits are found. In children, executive function is a cognitive domain which has shown little apparent benefit following flavonoid intervention...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29022978/freeze-dried-strawberry-and-blueberry-attenuates-diet-induced-obesity-and-insulin-resistance-in-rats-by-inhibiting-adipogenesis-and-lipogenesis
#19
Paula Aranaz, Ana Romo-Hualde, María Zabala, David Navarro-Herrera, Marina Ruiz de Galarreta, Ana Gloria Gil, J Alfredo Martinez, Fermín I Milagro, Carlos J González-Navarro
Obesity and type 2-diabetes are becoming a worldwide health problem, reiterating the importance of alternative therapies to tackle their progression. Here, we hypothesized that supplementation of diet with 6% w/w of a freeze-dried strawberry-blueberry (5 : 1) powder (FDSB) could exert beneficial metabolic effects on Wistar rats. FDSB-supplemented animals experienced significantly reduced body weight gain, food efficiency and visceral adiposity accumulation in two independent experiments. FDSB supplementation also contributed to lower area under the curve after an intraperitoneal GTT and reduced serum insulin levels and an insulin resistance index (IR-HOMA) in HFS diet-fed animals, together with reduced plasma MCP-1 inflammation marker concentrations...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29019365/blueberry-supplementation-attenuates-oxidative-stress-within-monocytes-and-modulates-immune-cell-levels-in-adults-with-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Anand R Nair, Nithya Mariappan, April J Stull, Joseph Francis
BACKGROUND: Blueberries (BB) have been shown to improve insulin sensitivity and endothelial function in obese and pre-diabetic humans, and decrease oxidative stress and inflammation, and ameliorate cardio-renal damage in rodents. This indicates that blueberries have a systemic effect and are not limited to a particular organ system. In order for blueberries to exert beneficial effects on the whole body, the mechanism would logically have to operate through modulation of cellular humoral factors...
November 15, 2017: Food & Function
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