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PNES AND Seizures

Shitanshu Kusmakar, Chandan Karmakar, Bernard Yan, Ramanathan Muthuganapathy, Patrick Kwan, Terence J O'Brien, Marimuthu Swami Palaniswami
OBJECTIVE: To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNES. METHODS: In this study, motor data were recorded using wrist-worn ACM-based devices. A total of 83 clinical events were recorded: 39 generalized tonic-clonic seizures (GTCS) from 12 patients with epilepsy, and 44 convulsive PNES from 7 patients (one patient had both GTCS and PNES)...
December 9, 2018: Epilepsia
Ali A Asadi-Pooya, Zahra Bahrami
PURPOSE: The aim of this study was to investigate the frequency of antiepileptic drug (AED) use in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical risk factors that may be associated with such a practice. METHODS: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were studied. Patients with concomitant epilepsy or abnormal Electroencephalogram (EEG) were not included...
December 7, 2018: Epilepsy & Behavior: E&B
Ali A Asadi-Pooya, Raidah AlBaradie, Tyson Sawchuk, Zahra Bahrami, Abeer Al Amer, Jeffrey Buchhalter
PURPOSE: We compared various clinical characteristics of psychogenic nonepileptic seizures (PNES) between young patients from Iran, Saudi Arabia, and Canada, three nations with significantly different socioeconomic and demographic characteristics. This international cross-cultural comparative study may advance our knowledge and understanding of PNES in children and adolescents across the cultures and borders. METHODS: In this retrospective study, we investigated all patients 16 years of age or younger, with PNES admitted to the epilepsy monitoring units at one center in Iran, one center in Saudi Arabia, and one center in Canada...
December 2, 2018: Epilepsy & Behavior: E&B
Shitanshu Kusmakar, Chandan K Karmakar, Bernard Yan, Terence J OrBrien, Marimuthu Palaniswami, Ramanathan Muthuganapathy
A high number of patients with epileptic seizures (ES) are misdiagnosed due to prevalence of mimic conditions. The clinical characteristics of mimics are often similar to ES. The events mostly misdiagnosed are of psychogenic origin and are termed as psychogenic non-epileptic seizures (PNES). The gold standard for diagnosis of PNES is video-electroencephalography monitoring (VEM), which is a resource demanding process. Hence, need for a more object method of PNES diagnosis is created. Accelerometer sensors have been used previously for the diagnosis of ES...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Rana Raoof, Sebastian Bauer, Hany El Naggar, Niamh M C Connolly, Gary P Brennan, Elizabeth Brindley, Thomas Hill, Hazel McArdle, Elaine Spain, Robert J Forster, Jochen H M Prehn, Hajo Hamer, Norman Delanty, Felix Rosenow, Catherine Mooney, David C Henshall
BACKGROUND: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression, mechanistic links to brain excitability, and stable detection in biofluids. Altered levels of circulating microRNAs have been reported in human epilepsy, but most studies collected samples from one clinical site, used a single profiling platform or conducted minimal validation...
November 2, 2018: EBioMedicine
Mansur A Kutlubaev, Ying Xu, Maree L Hackett, Jon Stone
Comorbid epilepsy and psychogenic nonepileptic seizures (PNES) represent a serious challenge for the clinicians. However, the frequency, associations, and outcomes of dual diagnosis of epilepsy and PNES are unclear. The aim of the review was to determine the frequency, correlates, and outcomes of a dual diagnosis. A systematic review of all published observational studies (from inception to Dec. 2016) was conducted to determine the frequency, correlates, and outcomes of dual diagnosis. We included studies of individuals of any age reporting a dual diagnosis of epilepsy and PNES...
December 2018: Epilepsy & Behavior: E&B
F Brigo, S Lattanzi
No abstract text is available yet for this article.
October 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Bhargavi Ramanujam, Deepa Dash, Manjari Tripathi
PURPOSE: To assess the contribution home-videos made on mobile phones can make to the diagnosis of Psychogenic Nonepileptic Seizures (PNES). METHODS: Consecutive patients 10-50 years old, with episodes of altered behavior or abnormal movements, unresponsiveness, or falls, were recruited after they had obtained 'good' or 'fair' quality (quality of video scale (QOV)) home-videos of their episodes on personal mobile phones; these subjects underwent video-electroencephalography (VEEG)...
October 3, 2018: Seizure: the Journal of the British Epilepsy Association
Iliana Kotwas, Jean-Arthur Micoulaud-Franchi, Stéphanie Khalfa, Aileen McGonigal, Mireille Bastien-Toniazzo, Fabrice Bartolomei
BACKGROUND: Temporal lobe epilepsy (TLE) and psychogenic non-epileptic seizures (PNES) are conditions frequently associated with dysfunction in emotional regulation leading to increased risk of affective disorders. This study investigates emotional processing with an objective measure of emotional reactivity in patients with TLE and patients with PNES. METHODS: 34 patients with TLE and 14 patients with PNES were evaluated on skin conductance responses (SCR) to emotions induced by short films and compared to 34 healthy controls...
February 1, 2019: Journal of Affective Disorders
Sara Gasparini, Ettore Beghi, Edoardo Ferlazzo, Massimiliano Beghi, Vincenzo Belcastro, Klaus P Biermann, Gabriella Bottini, Giuseppe Capovilla, Rosa A Cervellione, Vittoria Cianci, Giangennaro Coppola, Cesare M Cornaggia, Pasquale De Fazio, Salvatore De Masi, Giovambattista De Sarro, Maurizio Elia, Giuseppe Erba, Lucia Fusco, Antonio Gambardella, Valentina Gentile, Anna T Giallonardo, Renzo Guerrini, Francesca Ingravallo, Alfonso Iudice, Angelo Labate, Ersilia Lucenteforte, Adriana Magaudda, Laura Mumoli, Costanza Papagno, Giovanni B Pesce, Eugenio Pucci, Pietrantonio Ricci, Antonino Romeo, Rui Quintas, Chiara Sueri, Giovanna Vitaliti, Riccardo Zoia, Umberto Aguglia
BACKGROUND: The International League Against Epilepsy (ILAE) proposed a diagnostic scheme for psychogenic nonepileptic seizures (PNES). The debate on ethical aspects of the diagnostic procedures is ongoing, the treatment is not standardized, and management might differ according to the age groups. OBJECTIVE: To reach an expert and stakeholder consensus on PNES management. METHODS: A board comprising adult and child neurologists, neuropsychologists, psychiatrists, pharmacologists, experts in forensic medicine and bioethics as well as patients' representatives was formed...
October 9, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Gregg H Rawlings, Ian Brown, Markus Reuber
PURPOSE: This study is based on a narrative analysis of individuals' written accounts of living with epilepsy (n = 29) or psychogenic non-epileptic seizures (n = 20, PNES). Narrative analysis looks at both the content and structure of the personal account. We used a form of narrative analysis that allowed us to identify common story lines, otherwise known as narrative typologies, potentially characteristic of these patient groups. Different narrative typologies were described and compared between writers with the two conditions...
September 28, 2018: Seizure: the Journal of the British Epilepsy Association
David K Chen, Hina Dave, Kareem Gadelmola, Myrtle Jeroudi, Melissa Fadipe
We aim to demonstrate, in a sufficiently powered and standardized study, that the success rate of inducing psychogenic nonepileptic seizures (PNES) without placebo (saline infusion) is noninferior to induction with placebo. The clinical data of 170 consecutive patients with suspected PNES who underwent induction with placebo from January 21, 2009 to March 31, 2013 were pair-matched with 170 consecutive patients with suspected PNES who underwent the same induction technique but without addition of placebo from April 1, 2013 to February 7, 2018 at the same center...
November 2018: Epilepsia
Roberta Vasta, Antonio Cerasa, Alessia Sarica, Emanuele Bartolini, Iolanda Martino, Francesco Mari, Tiziana Metitieri, Aldo Quattrone, Antonio Gambardella, Renzo Guerrini, Angelo Labate
Psychogenic nonepileptic seizures (PNES) are episodes of paroxysmal impairment associated with a range of motor, sensory, and mental manifestations, which perfectly mimic epileptic seizures. Several patterns of neural abnormalities have been described without identifying a definite neurobiological substrate. In this multicenter cross-sectional study, we applied a multivariate classification algorithm on morphological brain imaging metrics to extract reliable biomarkers useful to distinguish patients from controls at an individual level...
September 28, 2018: Epilepsy & Behavior: E&B
Shahram Izadyar, Vishal Shah, Brandon James
BACKGROUND: The available information on postictal semiology and behavior in patients with psychogenic nonepileptic seizure (PNES) is limited. In this study, we explore the differences in postictal semiology and behavior between patients with epileptic seizure (ES) and PNES and focus on clinical features that may be helpful in differentiating these two conditions. METHODS: In this retrospective study, video-electroencephalograph (video-EEG) of 144 seizures from 64 patients with PNES and 66 seizures from 42 patients with ES were reviewed...
November 2018: Epilepsy & Behavior: E&B
Cayla J Duncan, Nicole A Roberts, Kristin A Kirlin, David Parkhurst, Mary H Burleson, Joseph F Drazkowski, Joseph I Sirven, Katherine H Noe, Amy Z Crepeau, Matthew T Hoerth, Dona E C Locke
Psychological assessment measures are frequently used to evaluate patients in epilepsy monitoring units. One goal of that assessment is to contribute information that may help with differential diagnosis between epilepsy and psychogenic nonepileptic seizures (PNES). The Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) is one such measure. Del Bene et al. (2017) recently published an analysis that was the first to compare MMPI-2-RF scale elevations between diagnostic groups stratified by sex...
November 2018: Epilepsy & Behavior: E&B
Jerzy P Szaflarski, W Curt LaFrance
No abstract text is available yet for this article.
July 2018: Epilepsy Currents
Marjan Asadollahi, Leila Simani
OBJECTIVE: To assess the value of postictal serum Ubiquitin C-terminal hydrolase (UCHL-1), a neuronal biomarker, and S100-B, a glial biomarker, levels, in differentiate epileptic seizures (ES) form psychogenic attacks. METHODS: In this analytical cross-sectional study, serum UCHL-1 and S100-B levels were measured within six hours of occurring seizure, in 43 patients with ES, 20 patients with psychogenic non-epileptic seizures (PNES) and 19 healthy individuals by electrochemiluminescence immunoassay...
September 22, 2018: Brain Research
Kirsten Labudda, Michael Frauenheim, Dominik Illies, Inga Miller, Mario Schrecke, Nadine Vietmeier, Christian Brandt, Christian G Bien
Several studies found high prevalence rates of psychiatric disorders in patients with pure psychogenic nonepileptic seizures (PNES). Traumatic experiences were also reported to be elevated in patients with PNES and were discussed as a crucial risk factor for the development of PNES. Much less is known about psychiatric comorbidities and specifically, about trauma history in patients with PNES and coexisting epilepsy. Here, we aimed at directly comparing psychiatric disorders and traumatic life experiences in patients with pure PNES and in patients with PNES and coexisting epilepsy...
November 2018: Epilepsy & Behavior: E&B
Alexandra Carter, Alyssa Denton, Lady D Ladino, Islam Hassan, Tyson Sawchuk, Thomas Snyder, Mirna Vrbancic, Markus Reuber, Richard Huntsman, Jose F Tellez-Zenteno
PURPOSE: Psychogenic nonepileptic seizures (PNES) are one of the most common differential diagnoses of epilepsy. Our objective is to describe current medical care in Canada and identify patterns of practice and service gaps. METHODS: In 2015, a 36-question survey was sent via email to the 131 members of the Canadian League Against Epilepsy. The questions were designed after literature review and discussion with the ILAE PNES Task Force. Questions were separated into 5 sections: 1) the role of the respondent and their exposure to PNES, 2) diagnostic methods, 3) management of PNES, 4) etiological factors, and 5) problems accessing health care...
October 2018: Seizure: the Journal of the British Epilepsy Association
Hiroto Iwasa, Reiko Hosaka, Sunao Kaneko
Psychiatric comorbidities, including mood, anxiety, psychotic disorders, and autism spectrum disorder are common in patients with epilepsy (PWE), often occurring at rates 2-3-fold or higher than in the general population without epilepsy. Furthermore, an attention should be paid to psychiatric symptoms together with those caused by antiepileptic drug therapy, epilepsy surgery, and vagus nerve stimulation because these therapies sometimes induce psychiatric comorbidities. It is important to differentiate psychogenic non epileptic seizures (PNES) from epilepsy, and to provide patients with psychiatric treatment...
September 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
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