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Nadav Schwartz, Julia Siegal, Aaron Rourke, Chandra M Sehgal
OBJECTIVES: Vascular resistance is known to be one of the determinants of pulsatile flow. This study aimed to investigate whether quantitative 2-dimensional Doppler ultrasound can capture and evaluate the pulsatility within the placental bed vasculature. METHODS: The placental bed vasculature was imaged by directional power Doppler ultrasound. Ten-second cine clips were recorded by using standardized machine settings. A region of interest with a prominent Doppler signal in the uteroplacental interface was analyzed for the percentage of vascularity to generate a time-vascularity waveform...
August 19, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Nir Haya, Benjamin Feiner, Kaven Baessler, Corina Christmann-Schmid, Christopher Maher
BACKGROUND: Pelvic organ prolapse (POP) affects as many as 50% of parous women, with 14% to 19% of women undergoing a surgical correction. Although surgery for the treatment of POP is common, limited supportive data can be found in the literature regarding the preoperative and postoperative interventions related to these procedures. The main goal of perioperative interventions is to reduce the rate of adverse events while improving women's outcomes following surgical intervention for prolapse...
August 19, 2018: Cochrane Database of Systematic Reviews
Kaven Baessler, Corina Christmann-Schmid, Christopher Maher, Nir Haya, Tineke J Crawford, Julie Brown
BACKGROUND: Pelvic organ prolapse (POP) is common in women and is frequently associated with stress urinary incontinence (SUI). In many cases however, SUI is present only with the prolapse reduced (occult SUI) or may develop after surgical treatment for prolapse (de novo SUI). OBJECTIVES: To determine the impact on postoperative bladder function of surgery for symptomatic pelvic organ prolapse with or without concomitant or delayed two-stage continence procedures to treat or prevent stress urinary incontinence...
August 19, 2018: Cochrane Database of Systematic Reviews
Michel Koole, June van Aalst, Martijn Devrome, Nathalie Mertens, Kim Serdons, Brigitte Lacroix, Joel Mercier, David Sciberras, Paul Maguire, Koen Van Laere
PURPOSE: A [11 C]UCB-J blocking study was performed in healthy volunteers to validate simplified, non-invasive measures for quantifying presynaptic SV2A expression using subcortical white matter as reference tissue. METHODS: Ninety minutes dynamic [11 C]UCB-J PET scanning with arterial blood sampling was performed in 10 healthy volunteers (8 M/2F; age 27.6 ± 10.0 yrs), before and after administration of a novel chemical entity with selective affinity for SV2A...
August 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Nathaniel W Taggart, Brent M Gordon, Gareth J Morgan, Bryan H Goldstein
The complex nature of congenital heart disease (CHD) has hindered the establishment of management standards for peri-catheterization anticoagulation. We sought to describe anticoagulation practice variability among providers performing cardiac catheterization in children and adults with CHD. A web-based survey ( ) was distributed to pediatric and congenital interventional cardiologists. Respondents were queried on their training, practice setting, years in practice, and case volume...
August 18, 2018: Pediatric Cardiology
Marina Carbone, Vincenzo Ferrari, Michele Marconi, Roberta Piazza, Andrea Del Corso, Daniele Adami, Quintilia Lucchesi, Valeria Pagni, Raffaella Berchiolli
In non-urban scenarios: rural areas or small cities, there is often a limited access to specialistic healthcare due to the inherent challenges associated with recruitment, retention, and access to healthcare professionals. Telemedicine is an economical and effective way to address this problem. In this research, we developed a framework for real-time communication during ultrasound examination that combines interaction via standard video conference protocols and basic AR functionalities (commercial) and a custom-developed application...
August 18, 2018: Updates in Surgery
Dorien Geertsema, Joris E Meinardi, Dagmar R J Kempink, Marta Fiocco, Michiel A J van de Sande
PURPOSE: To assess whether delayed radiological hip screening at five months (versus ultrasound at 3 months) results in a higher incidence of persistent developmental dysplasia of the hip (DDH) at 18 months. METHODS: We analyzed 3536 screened neonates (2009-2013) at age two to three weeks. In the case of risk factors for DDH, 460 infants were assigned to a pelvic radiograph at five months between 2009 and 2010 and 651 infants were assigned to an ultrasound at three months (2011-2013)...
August 18, 2018: International Orthopaedics
Daniela Calvetti, Annalisa Pascarella, Francesca Pitolli, Erkki Somersalo, Barbara Vantaggi
A recently proposed iterated alternating sequential (IAS) MEG inverse solver algorithm, based on the coupling of a hierarchical Bayesian model with computationally efficient Krylov subspace linear solver, has been shown to perform well for both superficial and deep brain sources. However, a systematic study of its ability to correctly identify active brain regions is still missing. We propose novel statistical protocols to quantify the performance of MEG inverse solvers, focusing in particular on how their accuracy and precision at identifying active brain regions...
August 18, 2018: Brain Topography
Dmitry Loktionov, Claire M McCarthy, Mark C Skehan
BACKGROUND: The rate of induction of labour varies across Health Service Executive hospital regions in Ireland averaging at 23.3 per 100 deliveries in 2005-2009. The increasing rate of elective induction of labour in Ireland calls for more studies looking into associated maternal and/or neonatal outcomes. STUDY AIM: The aim of this study is to show that an elective induction policy with management by a sole consultant obstetrician can decrease caesarean section rates as well as positively impact maternal and neonatal complications...
August 18, 2018: Irish Journal of Medical Science
Anja Wehrle, Sarah Kneis, Hans-Hermann Dickhuth, Albert Gollhofer, Hartmut Bertz
PURPOSE: Acute leukemia (AL) and its initial treatment can impair physical functioning and capacity significantly. Exercise as a countermeasure has been investigated in few studies confirming its feasibility and safety during intensive induction chemotherapy, but the relative effects of diverse exercise programs have not been analyzed. Therefore, we aimed to investigate independent effects of endurance and resistance training on physical capacity and quality of life (QOL). METHODS: Twenty-nine adult AL patients were randomly allocated to an endurance (EG), resistance (RG), or control (CG) group...
August 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Noelia S La Colla, Sandra E Botté, Vanesa L Negrin, Analía V Serra, Jorge E Marcovecchio
Coastal areas are urbanized and industrialized environments, affected by dredging operations, discharges of untreated municipal wastewaters, and farming. Developing countries are in continuous growth and will deal, in a close future, with the highest rate of coastal transformation, posing serious risks for the ecological and environmental value of ecosystem assets. This research aims to study the dissolved and particulate Cr, Ni, Pb and Zn values within an argentinean estuarine environment which is currently under human-induced pressures...
August 18, 2018: Environmental Monitoring and Assessment
Mathew Gitau Gicheha, Indusa Clinton Akidiva, Ronald Yosei Cheruiyot
We hypothesised that use of reproductive technologies (RTs) would result in increases in economic and genetic gains of a dairy cattle breeding programme. A deterministic approach was used to compare RTs that can be utilised to increase dairy cattle productivity and profitability in Kenya. These were artificial insemination (AI), embryo transfer (ET) using old (ETOB ) and young (ETYB ) bulls and in vitro fertilisation (IVF). Natural mating (NAm ) was assumed to be the standard reproduction practice in Kenya against which the genetic and economic efficiencies of the RTs were compared...
August 18, 2018: Tropical Animal Health and Production
Jacob H Rand, Douglas J Taatjes
The antiphospholipid syndrome (APS) is an autoimmune thrombophilic disorder that was described as a diagnostic entity over 30 years ago. And yet the pathogenic mechanisms that are responsible for its clinical manifestations remain to be definitively established. The syndrome is defined by (1) the concurrence of vascular thrombosis and/or pregnancy complications together with (2) positivity for immunoassays and coagulation tests that were derived from clinical observations of two anomalous laboratory test results-specifically, false positivity for syphilis infection in uninfected individuals and the finding of inhibitors of blood coagulation in patients who lacked any bleeding tendencies...
August 18, 2018: Histochemistry and Cell Biology
Mollie McDermott, Cemal B Sozener
PURPOSE OF REVIEW: We discuss the evidence and guidelines for acute blood pressure (BP) management for patients presenting with acute ischemic stroke or spontaneous cerebral hemorrhage. RECENT FINDINGS: Observational data suggest that the extremes of BP should be avoided in patients presenting with acute ischemic stroke. There is no convincing evidence that active BP reduction results in improved outcomes for ischemic stroke patients. Current guidelines recommend that BP be maintained ≤ 185/110 mmHg in patients who are candidates for intravenous tissue plasminogen activator (IV tPA) or mechanical thrombectomy and that BP be maintained ≤ 180/105 mmHg for at least 24 h in patients who have received IV tPA or have undergone mechanical thrombectomy...
August 18, 2018: Current Treatment Options in Neurology
Jannette Y Berkley-Patton, Carole Bowe Thompson, Erin Moore, Starlyn Hawes, Marcie Berman, Jenifer Allsworth, Eric Williams, Cassandra Wainright, Andrea Bradley-Ewing, Alexandria G Bauer, Delwyn Catley, Kathy Goggin
The updated National HIV/AIDS Strategy recommends widespread HIV education and testing and calls the faith community to assist in these efforts. Yet, limited information exist on church-based HIV testing interventions. This study examined feasibility and assessed HIV testing outcomes of Taking It to the Pews (TIPS), a multilevel HIV education and testing intervention. Four African American churches were matched and randomized to TIPS or a standard-information control arm. Intervention churches delivered the religiously-tailored TIPS Tool Kit, which included educational materials to individuals and ministry groups; pastoral activities (e...
August 18, 2018: AIDS and Behavior
Leah D Doane, Reagan S Breitenstein, Charles Beekman, Sierra Clifford, Trevor J Smith, Kathryn Lemery-Chalfant
Despite identified concurrent socioeconomic disparities in children's sleep, little research has examined pathways explaining such associations. This study examined the quality of the home environment as a direct predictor of sleep and potential mediator of associations between early life socioeconomic status and objective and subjective indicators of sleep in middle childhood. A socioeconomically and ethnically diverse sample of 381 twin children (50% female; 46.6% lower middle class or living at or below the poverty line; 26% Hispanic/Latino) were assessed at 12 months for SES and eight years using gold-standard home environment interviews and actigraphy-measured sleep...
August 18, 2018: Journal of Youth and Adolescence
Arash Haghikia, Johannes Schwab, Jens Vogel-Claussen, Dominik Berliner, Tobias Pfeffer, Tobias König, Carolin Zwadlo, Valeska Abou Moulig, Annegret Franke, Marziel Schwarzkopf, Philipp Ehlermann, Roman Pfister, Guido Michels, Ralf Westenfeld, Verena Stangl, Uwe Kühl, Edith Podewski, Ingrid Kindermann, Michael Böhm, Karen Sliwa, Denise Hilfiker-Kleiner, Johann Bauersachs
BACKGROUND: Right ventricular (RV) dysfunction predicts adverse outcome in peripartum cardiomyopathy (PPCM). We recently demonstrated beneficial effects associated with the prolactin release inhibitor bromocriptine at different doses when added to standard heart failure therapy in PPCM. Here, we evaluated for the first time the therapeutic potential of bromocriptine particularly in PPCM patients with RV involvement. METHODS: In this study, 40 patients with PPCM were included, of whom 24 patients had reduced RV ejection fraction (RVEF < 45%)...
August 18, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
M D Aidayanti, H Salina, B S Gendeh, D Z Farah, M Z Faezah
Endoscopic sinus surgery (ESS) is a standard treatment for rhinosinusitis, which failed optimum medical therapy. Iatrogenic cerebrospinal fluid (CSF) rhinorrhoea can occur during ESS warrants early repair of the leakage. The common sites for CSF leakage are cribriform plate, fovea ethmoidalis, and anterior ethmoid sinuses. We present five cases of iatrogenic CSF rhinorrhoea due to ESS and its management.
August 2018: Medical Journal of Malaysia
Nicole Salame, Lourdes M Perez-Chada, Sanminder Singh, Kristina Callis Duffin, Amit Garg, Alice B Gottlieb, John Latella, Joseph F Merola, April W Armstrong
Treatment satisfaction is paramount to the field of dermatology. Treatment dissatisfaction directly impacts patient outcomes and health care delivery. A critical need exists for standardized, validated treatment satisfaction measures in dermatology. Comprehensive evaluation of the performance of treatment satisfaction instruments used in psoriasis is lacking. We sought to critically appraise the literature on measurement properties of treatment satisfaction instruments used in psoriasis. We performed a systematic review to identify treatment satisfaction instruments used in psoriasis and corresponding studies on their measurement properties...
August 17, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Michelle Helena Van Velthoven, James Smith, Glenn Wells, David Brindley
INTRODUCTION: There is currently a lack of clear and accepted standards for the development (planning, requirement analysis and research, design and application testing) of apps for medical and healthcare use which poses different risks to developers, providers, patients and the public. The aim of this work is to provide an overview of the current standards, frameworks, best practices and guidelines for the development of digital health apps. This review is a critical 'stepping stone' for further work on producing appropriate standards that can help mitigate risks (eg, clinical, privacy and economic risks)...
August 17, 2018: BMJ Open
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