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Péter Rajna, János Tajti
Two leading managers of the scientific journal currently publishing its 71st volume give an overview on the history and content- and form-related development of the journal. Recognizing the constantly decreasing role of paper-based literature products, the value system and the priorities of the journal were established more than 20 years ago: 1) preservation of high standards by achieving and maintaining international registration and annual qualification (i.e. impact factor); 2) enabling publication in Hungarian language for scientists living in Hungary and abroad; 3) displaying an ever broader spectrum of clinical neurosciences in the publications; 4) presentation of cutting-edge findings (related to the etiology, diagnostics, therapy, and care) of the most frequent and most relevant diseases in order to assure and enhance the quality of national clinical practice; 5) providing the possibility for the highest possible standard of scientific publication for Hungarian clinical neuroscientist; and finally 6) maintaining a readily available interaction surface and debate forum for the involved professionals in clinical questions of public interest...
September 30, 2018: Ideggyógyászati Szemle
Viktor Szabó, András Büki, Tamás Dóczi, Attila Schwarcz
In spine surgery, minimally invasive approaches (MIS) are getting accepted and more popular worldwide during the last decades. It is due to the reduced intraoperative blood loss, decreased infection rate, less postoperative pain and earlier discharge from hospital compared to traditional approaches. The present paper puts forward a minimally invasive extrapleural approach to the thoracic spine that is not applied in Hungary. This new approach, in contrast to the standard costotransversectomy, provides direct visual control over the ventral surface of the dural sac...
September 30, 2018: Ideggyógyászati Szemle
B Szabo, J Schmitt, A Gothot
Patient Blood Management (PBM) is a comprehensive hospital approach to the anemic patient or at risk of becoming anemic, aimed at protecting and optimizing the patient's blood capital and resistance. The main aim of BPM is to combat the risk factors of anaemia, hemorrhage and blood transfusion. PBM involves transdisciplinary collaboration ranging from pre-hospital prevention to post-hospital follow-up. This combination of techniques and preventive actions considerably improves the medicosurgical prognosis and contributes to the drastic reduction in the use of blood transfusion...
October 2018: Revue Médicale de Liège
Lina Marcela Barrera, León Darío Ortiz, Hugo Grisales, Mauricio Rojas, Mauricio Camargo
Introduction: The quantification of chromosomal instability is an important parameter to assess genotoxicity and radiosensitivity. Most conventional techniques require cell cultures or laborious microscopic analyses of chromosomes or nuclei. However, a flow cytometry that selects the reticulocytes has been developed as an alternative for in vivo studies, which expedites the analytical procedures and increases up to 20 times the number of target cells to be analyzed. Objectives: To standardize the flow cytometry parameters for selecting and quantifying the micronucleated reticulocytesCD71+ (MN-RET) from freshly drawn peripheral blood and to quantify the frequency of this abnormal cell subpopulation as a measure of cytogenetic instability in populations of healthy volunteers (n =25), and patients (n=25), recently diagnosed with high-grade gliomas before the onset of treatment...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
Tao Wu, Jiří Kessler, Jakub Kaminský, Petr Bouř
Identification of saccharides is difficult due to their similar chemical structure. However, they interact very selectively with lanthanide probes. To explore the potential for saccharide identification, we compare circularly polarized luminescence induced by a variety of oligo- and polysaccharides in three europium compounds. Measurement on a standard Raman optical activity spectrometer made it possible to use high excitation powers and provided very distinct spectral patterns, which were sensitive both to the local structure and differences in molecular size...
October 18, 2018: Chemistry, An Asian Journal
Maighan A Seagrove-Guffey, Haris Hatic, Haoran Peng, Kimberly C Bates, A Ola Odugbesan
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was created to establish a standard terminology regarding thyroid nodules that can be shared between endocrinologists, pathologists, radiologists, and surgeons. Since its inception and use in 2009, multiple large hospitals and academic institutions have performed retrospective studies to compare their classification rates, specifically those of atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), with the recommended rates created by the National Cancer Institute...
October 18, 2018: Cancer Cytopathology
Sharla M Wells-Di Gregorio, Donald R Marks, Joseph DeCola, Juan Peng, Danielle Probst, Alexandra Zaleta, Don Benson, David Cohn, Maryam Lustberg, William Carson, Uly Magalang
OBJECTIVE: This study evaluated a three-session acceptance-based cognitive-behavioral intervention (CBT-ACT) targeting a common symptom cluster in advanced cancer - worry-insomnia-depression-fatigue. METHODS: Twenty-eight patients with advanced cancers were randomly assigned to the CBT-ACT intervention or waitlist. At pre-intervention, participants completed a psycho-diagnostic interview, standardized questionnaires, and a sleep diary. Intervention and waitlist groups were re-assessed after six weeks, at which point the waitlist group completed the intervention...
October 18, 2018: Psycho-oncology
Georgios A Maragkos, Georgios Geropoulos, Konstantinos Kechagias, Ioannis A Ziogas, Konstantinos S Mylonas
BACKGROUND: Pediatric epilepsy surgery is a treatment modality appropriate for select patients with debilitating medication-resistant seizures. Previous publications have studied seizure freedom as the main outcome of epilepsy surgery. However, there has been no systematic assessment of the postoperative life quality for these children. OBJECTIVE: To estimate the quality of life (QOL) long-term outcomes after surgery for intractable epilepsy in pediatric patients...
October 17, 2018: Neurosurgery
Marielena Gutt-Will, Michael Murek, Christa Schwarz, Ekkehard Hewer, Sonja Vulcu, Jürgen Beck, Andreas Raabe, Philippe Schucht
BACKGROUND: In contrast to isocitrate dehydrogenase (IDH) mutation analysis, which is homogenous within a given tumor, diagnostic errors in histological analysis following the 2016 World Health Organization (WHO) classification could be due to small samples because of histological heterogeneity. OBJECTIVE: To assess whether the sample size sent to histopathology influences the tumor grading in IDH wild-type gliomas. METHODS: Histologically diagnosed WHO grade, sample volume, and preoperative tumor volume data of 111 patients aged who received resection of IDHwt gliomas between January 2007 and December 2015 at our hospital were evaluated...
October 17, 2018: Neurosurgery
Lisa J Meltzer, Michelle Short, Genery D Booster, Michael Gradisar, Christine A Marco, Amy R Wolfson, Mary A Carskadon
Study Objectives: Provide actigraphic reference values for motor activity during sleep for children and adolescents ages 8-17 years. Methods: Participants were 671 healthy community-dwelling children and adolescents (52% female, mean age 13.5+2.4 years) from the United States (64%) and Australia (36%). All participants wore an Ambulatory-Monitoring Inc. (AMI, Ardsley, NY) actigraph on their non-dominant wrist for ≥5 nights and completed daily sleep diaries. Actigraphy data were scored with standard methods and a validated algorithm...
October 17, 2018: Sleep
Joseph R Linzey, Elyne N Kahn, Maksim A Shlykov, Kyle T Johnson, Katie Sullivan, Aditya S Pandey
BACKGROUND: In an era of growing healthcare costs, there is increased pressure on medical care providers to discharge patients once they are medically fit. However, it is not uncommon for patients to stay beyond medical readiness (BMR). OBJECTIVE: To analyze the frequency with which patients remain in the hospital BMR. METHODS: A prospective cohort analysis utilizing a database maintained between 2014 and 2015 included 718 adults admitted to the neurosurgical service...
October 17, 2018: Neurosurgery
B P Hobbs, M J Kane, D S Hong, R Landin
Within the evidentiary hierarchy of experimental inquiry, randomized trials are the gold standard. Oncology patients enter clinical studies with diverse lifestyles, treatment pathways, host tissue environments, and competing co-morbidities. Randomization attempts to balance prognostic characteristics among study arms, thereby enabling statistical inference of "average benefit" and attribution to the studied therapies. In contrast, interpretations of uncontrolled trials require additional scrutiny to attempt to place the findings in the context of external evidence...
October 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Yu I Osmanov, Zh A Gaibov, E A Kogan, S G Radenska-Lopovok, Kh Z Tursunov
Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. OBJECTIVE: To comparatively analyze the morphological and immunophenotypic parameters of urothelial carcinomas of the renal pelvis and bladder...
2018: Arkhiv Patologii
Daniel Stuart, Robin Christian, Hartmut Uschmann, Michelle Palokas
OBJECTIVE: The objective of this review was to determine the effectiveness of intrathecal nicardipine compared to usual care on cerebral vasospasm and its impact on the following outcome measures: mean flow velocities, angiographic and/or clinical vasospasm, and infection rates. INTRODUCTION: The results of non-traumatic (aneurysmal) subarachnoid hemorrhage can have devastating effects on patients in terms of functional outcomes. Although other medications have been and continue to be used, Nimodipine is the only Food and Drug Administration-approved medication for treating and improving outcomes following non-traumatic subarachnoid hemorrhage, which may be caused by aneurysmal rupture or arteriovenous malformation...
October 2018: JBI Database of Systematic Reviews and Implementation Reports
Li Hui Tay, Andrew Kok Wah Ong, Dora Siew Ping Lang
INTRODUCTION: Counseling is a brief psycho-educational intervention that is useful in facilitating personal growth and adaptive resolution of life stresses. With increased recognition on the psycho-emotional needs of patients with cancer, it is prudent to consider the possibility of expanding the role of nurses in the provision of counseling. OBJECTIVE: This qualitative systematic review aimed to establish the best available evidence on the experiences of adult cancer patients receiving counseling provided by nurses...
October 2018: JBI Database of Systematic Reviews and Implementation Reports
Fu-Ju Tsai, Cheng-Yu Chen, Gwo-Liang Yeh, Yih-Jin Hu, Chie-Chien Tseng, Si-Chi Chen
Nursing educators have a core responsibility to develop nursing students' health promotion. The purpose of this study was to explore nursing students regarding their relationships among meaning in life, well-being, and positive beliefs. A cross-sectional survey design was adopted in this study. Purposive sampling was used. A total of 219 nursing students participated in the study. Quantitative analysis was utilized for the data analyses. The study found that nursing students had the following mean scores on the meaning in life, 4...
October 2018: Medicine (Baltimore)
Minghui Shen, Ya Gao, Xueni Ma, Bo Wang, Jiarui Wu, Jiancheng Wang, Jipin Li, Jinhui Tian, Junhai Jia
BACKGROUND: Endometriosis is a major cause of disability and compromised the quality of life in women and teenage girls. The gold standard for diagnosis of endometriosis is laparoscopy with histology of excised endometriosis lesions. However, women can suffer for 8 to 12 years before obtaining a correct diagnosis. Several biomarkers showed good diagnostic value for endometriosis, but no studies directly or indirectly compare the diagnostic value of different biomarkers. We perform this network meta-analysis (NMA) to assess the diagnostic accuracy of hormonal biomarkers, and to find a most effective hormonal biomarker for the diagnosis of endometriosis...
October 2018: Medicine (Baltimore)
Junhui Xie, Shuhong Hu
Low-density lipoprotein (LDL) cholesterol (LDL-C) always underestimates the true cholesterol burden in diabetic patients. We aimed to explore the impact of the inclusion of apolipoprotein B (apoB) or non-high-density lipoprotein (HDL) cholesterol (non-HDL-C), which are alternative markers of LDL-related risk, results in a better classification of glycated hemoglobin (HbA1c)-defined diabetic patients into different dyslipidemic phenotypes.We used data from the nationwide China Health and Nutrition Survey 2009 in which standardized HbA1c was measured...
October 2018: Medicine (Baltimore)
Ricardo Becerro de Bengoa Vallejo, David Sevillano Fernandez, Luis Alou Cervera, Laura Martín Aragón, Marta Elena Losa Iglesias, Luis Rodolfo Collado Yurrita, Daniel Lopez Lopez
BACKGROUND: Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy "in vivo. METHODS: We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1)...
October 2018: Medicine (Baltimore)
Kevser Oksuzoglu, Tunc Ones, Salih Ozguven, Sabahat Inanir, Halil Turgut Turoglu, Emine Bozkurtlar, Cigdem Ataizi Celikel, Tanju Yusuf Erdil
Delayed 18F-2-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography (PET) imaging has been associated with improved diagnostic yield in several malignancies; however, data on the use of delayed imaging in patients with hepatocellular carcinoma (HCC) is scarce. This study aimed to examine tumoral and background standardized uptake value (SUV) alterations in dual-phase F-FDG PET/computed tomography (CT) imaging.Fifty-two HCC cases underwent dual-time-point F-FDG PET/CT examination where early and delayed images were obtained...
October 2018: Medicine (Baltimore)
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