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Isaac D Buck
For the better part of a decade, Americans have had a front-row seat to a fervent and turbulent debate over the future of their health care system. The passage of the Patient Protection and Affordable Care Act of 2010 (ACA), the most comprehensive health reform effort since the mid-1960s, ushered in a new era in health law and policy, granting millions of Americans access to health care. After multiple legal challenges and congressional efforts that ultimately failed to slay the law, the ACA had become entrenched by the end of the Obama administration, even though pieces of the law had failed to work exactly as planned...
2019: Seton Hall Law Review
Jung-Whan Chon, Young-Ji Kim, Dong-Hyeon Kim, Kwang-Young Song, Hyunsook Kim, Kun-Ho Seo
The presence of unwanted competing flora has been the most common confounding factor in the enumeration of Bacillus cereus (B. cereus) using selective media such as mannitol-yolk-polymyxin B agar (MYPA). The objective of this study was to improve MYPA selectivity for B. cereus by supplementation with a second-generation cephalosporin, cefuroxime. The performance of cefuroxime-supplemented MYPA (cefu-MYPA) was evaluated by comparison with original MYPA in 60 food products with established microbiological standards for B...
December 17, 2018: Journal of Food Science
Mustafa Doğan, Elif Ertan
BACKGROUND: To compare the repeatability and agreements of central corneal thickness measurements of healthy individuals obtained by Scheimpflug-Placido topographer (Sirius), anterior segment spectral domain optical coherence tomography (Spectralis) (AS-OCT), optical biometry (AL-Scan) and ultrasonic pachymetry. METHODS: Sixty-four eyes of 32 subjects with no ocular or systemic diseases were included in this study. Central corneal thickness measurements performed with Sirius, AS-OCT, optical biometry AL-Scan and ultrasonic pachymetry were compared...
December 17, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Rufielyn S Gravador, Sabine M Harrison, Frank J Monahan, Vasiliki Gkarane, Linda J Farmer, Nigel P Brunton
A rapid microwave-assisted extraction and derivatization of three branched chain fatty acids (BCFA): 4-methyloctanoic acid (MOA), 4-ethyloctanoic acid (EOA) and 4-methylnonanoic acid (MNA) from subcutaneous adipose tissue (SAT) of lamb was developed and validated. Linearity was excellent (R2 > 0.99), and the limits of detection and quantification (μg/mL) were between 0.03 to 0.05 and 0.04 to 0.06, respectively. The relative response factors were 0.9416, 1.2840, and 1.0370 determined with high precision (RSD: 5...
December 17, 2018: Journal of Food Science
Joon Seok Lee, Jeung Ryeol Eom, Jeong Woo Lee, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Jung Dug Yang
Nipple-areolar complex reconstruction represents the final step in breast reconstruction. However, there is no gold standard nipple reconstruction technique that addresses the issue of blood circulation in the flap, which is the most basic complication. Nipple reconstruction was performed in 21 patients. A delayed procedure was performed when a poor outcome was expected due to marginal pinpoint bleeding in the distal tip after flap elevation during nipple reconstruction. The delayed nipple reconstruction can be viewed as a safe and reliable method for improving nipple blood circulation, reducing complications, and enabling long-term nipple projection maintenance in high-risk patients...
December 17, 2018: Breast Journal
Shan Wu, Jian Jun Zhou, Jing Guo, Zhan Hua, Jian Chen Li, Zai Wang
Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. The aim of this study was to compare the antitumor efficacy of apatinib with that of the standard PNET drug sunitinib in our subcutaneous and liver metastasis models of insulinoma and non-functional PNET...
December 1, 2018: Endocrine Connections
M Roxanne Sopp, Alexandra H Brueckner, Sarah K Schäfer, Johanna Lass-Hennemann, Tanja Michael
BACKGROUND: Extensive empirical evidence indicates that sleep plays an active role in memory consolidation. Moreover, sleep has been found to preferentially enhance emotional memories and may modulate affective reactions to previously encountered stimuli. Notably, recent findings suggest that disruptions of sleep-related memory processing could be involved in posttraumatic symptom development such that sleep disturbances may accelerate symptoms of intrusive re-experiencing. METHODS: Based on this emerging evidence, we investigated whether an analogue traumatic event would result in immediate impairments of sleep quality in a group of healthy, robust sleepers...
November 19, 2018: Sleep Medicine
Dongsheng Zhang, Weixiang Li, Zhanfang Ma, Hongliang Han
Enzyme-linked immunosorbent assay (ELISA), a gold-standard method for protein detection, has been widely utilized in disease diagnosis. Nevertheless, the method is constrained by its dependence on a colorimetric readout that, due to its relatively low sensitivity, prevents its use in tumor marker detection. Here we demonstrate an ELISA that incorporates an electro-readout mode in place of a colorimetric readout to achieve ultrasensitive and convenient tumor marker detection. Briefly, because hemin molecules supported by carbon sphere (CS) can catalyze dye degradation upon H2 O2 addition, CS incorporating hemin was employed as a label...
December 7, 2018: Biosensors & Bioelectronics
Saurav Islam, Shruti Shukla, Vivek K Bajpai, Young-Kyu Han, Yun Suk Huh, Ashok Kumar, Arindam Ghosh, Sonu Gandhi
Human immunodeficiency virus (HIV), which isa worldwide public health issue, is commonly associated with cardiovascular disorders (CVDs) and rheumatoid arthritis (RA). A smart nanosensor was developed for the detection of HIV and its related diseases (CVDs and RA) using graphene-based field-effect transistors (FETs). In this study, amine-functionalized graphene (afG) was conjugated with antibodies [anti-p24 for HIV, anti-cardiac troponin 1 (anti-cTn1) for CVDs, and anti-cyclic citrullinated peptide (anti-CCP) for RA] to detect various biomarkers...
December 7, 2018: Biosensors & Bioelectronics
Baile Xu, Furao Shen, Jinxi Zhao
Data stream clustering is a branch of clustering where patterns are processed as an ordered sequence. In this paper, we propose an unsupervised learning neural network named Density Based Self Organizing Incremental Neural Network(DenSOINN) for data stream clustering tasks. DenSOINN is a self organizing competitive network that grows incrementally to learn suitable nodes to fit the distribution of learning data, combining online unsupervised learning and topology learning by means of competitive Hebbian learning rule...
November 27, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Cong-En Zhang, Li-Juan Liang, Xiao-Hong Yu, Hao Wu, Peng-Fei Tu, Zhi-Jie Ma, Kui-Jun Zhao
To identify more chemical markers for improving the quality standard and evaluate producing areas differentiation of Astragali Radix (AR), a simple, low-cost and reliable chromatography method based on a high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detector and charged aerosol detector (CAD) for separation of 13 major chemical components, including 8 flavonoids and 5 astragalosides in AR extract, was developed. The contents of 13 compounds in total of 27 herb samples, collected from different cultivating regions, were determined and compared...
December 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
Tobias Fischer, Ulrike Och, Thorsten Marquardt
OBJECTIVES: Multiple acyl-CoA dehydrogenase deficiency (MADD) is the most severe disorder of mitochondrial fatty acid β-oxidation. Treatment of this disorder is difficult because the functional loss of the electron transfer flavoprotein makes energy supply from fatty acids impossible. Acetyl-CoA, provided by exogenous ketone bodies such as NaßHB, is the only treatment option in severe cases. Short-term therapy attempts have shown positive results. To our knowledge, no reports exist concerning long-term application of ketone body salts in patients with severe MADD...
October 22, 2018: Nutrition
Can Cheng, Wenbao Jia, Daqian Hei, Jiatong Li, Pingkun Cai, Dong Zhao, Zhiyong Wei
In this work, a method was proposed for efficiency calibration of HPGe detector employed in a prompt gamma-ray neutron activation analysis (PGNAA) system for large aqueous sample analysis. Experimental measurements of a reference surface gamma-ray source were combined with efficiency transfer method to obtain efficiency of a volumetric source. Then efficiency curve over the energy range 0.5-8.5 MeV were determined with prompt gamma-rays of chlorine. To evaluate the performance of the calibration curve, an internal standard method was used to determine the aqueous sample containing manganese based on the calibration curve...
December 7, 2018: Applied Radiation and Isotopes
Natalie Busby, Ajay D Halai, Geoff J M Parker, David J Coope, Matthew A Lambon Ralph
In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal lobectomy). This procedure is the gold standard to alleviate seizures but is associated with chronic cognitive deficits. In recent years there have been multiple attempts to find the optimum balance between minimising the size of resection in order to preserve cognitive function, while still ensuring seizure freedom...
November 17, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Thomas B Casale, Tmirah Haselkorn, Christina E Ciaccio, Panida Sriaroon, Bradley E Chipps
Currently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic purposes, but extrapolation of the specific terminology used in food allergy diagnosis to interpretation of efficacy in clinical trials is incongruent and difficult to apply...
December 14, 2018: Journal of Allergy and Clinical Immunology in Practice
Carmen Vidal, Pablo Rodríguez Del Río, Francisco Gude, Thomas Casale, Linda Cox, Jocelyne Just, Oliver Pfaar, Pascal Demoly, Moises A Calderón
BACKGROUND: Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking. OBJECTIVE: The present post hoc analysis was aimed to investigate the practicality of the most relevant international classifications proposed by the European Academy of Allergology and Clinical Immunology (EAACI), the American Academy of Asthma, Allergology and Clinical Immunology /American College of Allergy, Asthma and Immunology (AAAACI/ACAAI), and the World Allergy Organization (WAO) using data provided by the longitudinal European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI) based on daily clinical practice in 3 countries in Europe...
December 14, 2018: Journal of Allergy and Clinical Immunology in Practice
Igor Popovic, Ricardo J Soares Magalhaes, Erjia Ge, Guy B Marks, Guang-Hui Dong, Xiaolin Wei, Luke D Knibbs
Ambient air pollution is the leading environmental risk factor for disease globally. Air pollutants can increase the risk of some respiratory infections, but their effects on tuberculosis (TB) are unclear. In this systematic literature review, we aimed to assess epidemiological studies on the association between outdoor air pollutants and TB incidence, hospital admissions and death (collectively referred to here as 'TB outcomes'). We sought to consolidate available evidence on this topic and propose recommendations for future studies...
December 7, 2018: Environmental Research
Jasper A J Smits, Michael J Zvolensky, David Rosenfield, Richard A Brown, Slaton Z Freeman, Christina D Dutcher, Haley E Conroy, Noura Alavi
Extant evidence suggests that exercise can reduce anxiety related vulnerability factors, such as anxiety sensitivity (AS), or fear of bodily sensations related to anxiety, that negatively impact smoking cessation outcomes. Building upon emerging evidence supporting the efficacy of exercise as an aid for smoking cessation in adults with high AS, we are conducting a trial to examine the efficacy and feasibility of this clinical application when implemented in a community setting. Partnering with the YMCA, this study aims to enroll 150 adults in a standard smoking cessation protocol (i...
December 14, 2018: Contemporary Clinical Trials
Talia James, Sam Salman, Brittany Stevenson, Christine Bundell, Gavin Kelly, David Nolan, Mina John
Bullous pemphigoid (BP) is a blistering dermopathy and a prototypic antibody-mediated autoimmune disease. Detection of IgG autoantibodies against hemidesmosomal proteins BP180 and/or BP230 are diagnostic and levels can correlate with disease activity. Therapies include corticosteroids and oral immunosuppressants, while intravenous immunoglobulin and rituximab are reserved for treatment resistant cases. Here we describe a patient with severe BP which was refractory to standard first line therapy, intravenous immunoglobulin and rituximab induced depletion of peripheral B cells...
December 14, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Bayram Çevik, Hatice Kıvrak, Mehtap Şahin-Çevik
A graft inoculation method coupled with RT-qPCR was developed for monitoring ToCV infection in tomato plants. Ten seed-grown tomato seedlings were graft inoculated with phloem tissue-containing stem segments from a ToCV-infected tomato plants. Another group of tomato seedling were grafted with similar stem segments from a healthy tomato plant as mock inoculated control. The CP gene of ToCV was cloned under the control of T7 promoter and in vitro synthesized RNA was used as a standard for quantification. Total RNA was isolated from leaf samples of ToCV-inoculated and mock-inoculated control plants before the inoculation and 1-60 days post inoculation (dpi)...
December 14, 2018: Journal of Virological Methods
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