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Breast cancer, treatment

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https://www.readbyqxmd.com/read/30557378/tumor-suppressor-rarres1-a-novel-regulator-of-fatty-acid-metabolism-in-epithelial-cells
#1
Sara Maimouni, Naiem Issa, Selina Cheng, Chokri Ouaari, Amrita Cheema, Deepak Kumar, Stephen Byers
Retinoic acid receptor responder 1 (RARRES1) is silenced in many cancers and is differentially expressed in metabolism associated diseases, such as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS, we discovered that RARRES1 depletion in epithelial cells caused a global increase in lipid synthesis. RARRES1-depleted cells rewire glucose metabolism by switching from aerobic glycolysis to glucose-dependent de novo lipogenesis (DNL)...
2018: PloS One
https://www.readbyqxmd.com/read/30557203/correlation-between-pathologic-complete-response-in-the-breast-and-absence-of-axillary-lymph-node-metastases-after-neoadjuvant-systemic-therapy
#2
Sanaz Samiei, Thiemo J A van Nijnatten, Linda de Munck, Kristien B M I Keymeulen, Janine M Simons, Loes F S Kooreman, Sabine Siesling, Marc B I Lobbes, Marjolein L Smidt
OBJECTIVE: The aim was to investigate whether pathologic complete response (pCR) in the breast is correlated with absence of axillary lymph node metastases at final pathology (ypN0) in patients treated with neoadjuvant systemic therapy (NST) for different breast cancer subtypes. BACKGROUND: Pathologic complete response rates have improved on account of more effective systemic treatment regimens. Promising results in feasibility trials with percutaneous image-guided tissue sampling for the identification of breast pCR after NST raise the question whether breast surgery is a redundant procedure...
December 13, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30556740/adjuvant-endocrine-therapy-side-effects-among-postmenopausal-breast-cancer-patients-in-malaysia
#3
S B Choo, A Saifulbahri, S N Zullkifli, M L Fadzil, A Md Redzuan, N Abdullah, R S Ahmad Bustamam, H Z Ahmad, N Mohamed Shah
OBJECTIVE: This study was conducted to determine the prevalence and severity of menopausal symptoms and their associated risk factors among postmenopausal breast cancer patients receiving adjuvant endocrine therapy. METHODS: Postmenopausal breast cancer patients on endocrine therapy were recruited at three hospitals in Malaysia. Presence and severity of menopausal symptoms were determined using the Menopause Rating Scale. Sociodemographic and clinical data were collected from medical records...
December 17, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30556532/perceived-work-ability-at-return-to-work-in-women-treated-for-breast-cancer-a-questionnaire-based-study
#4
Muriel Assunta Musti, Natalina Collina, Elisa Stivanello, Roberta Bonfiglioli, Stefano Giordani, Carla Morelli, Paolo Pandolfi
BACKGROUND: Breast cancer survivors often perceive reduced work ability upon returning to work. OBJECTIVES: To identify predictors of perceived reduced work ability following return to work among women treated for breast cancer and to describe workplace interventions and support after returning to work. METHODS: A questionnaire was sent to 18-65 years-old women (no. 1578) treated for breast cancer and residing in the catchment area of the Bologna Local Health Authority between 2010 and 2012...
December 20, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/30556371/impact-of-radiotherapy-on-cardiovascular-health-of-women-with-breast-cancer
#5
Ross Lawrenson, Chunhuan Lao, Ahmed Ali, Ian Campbell
INTRODUCTION: This study aims to examine the impact of radiotherapy on the cardiovascular health of women diagnosed with breast cancer in the Waikato region in New Zealand. METHODS: Women diagnosed with stage 0-III breast cancer and recorded in the Waikato Breast Cancer Registry were divided into two groups: a radiotherapy group and a no-radiotherapy group. Baseline characteristics and treatments were compared in the two groups. Kaplan-Meier survival analysis was performed to compare cardiovascular morbidity and mortality...
December 17, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/30556331/quality-assessment-of-ki67-staining-using-cell-line-proliferation-index-and-stain-intensity-features
#6
Mathias Buus Lanng, Cecilie Brochdorff Møller, Anne-Sofie Hendrup Andersen, Ásgerður Arna Pálsdóttir, Rasmus Røge, Lasse Riis Østergaard, Alex Skovsbo Jørgensen
Breast cancer is the most frequent cancer among women worldwide. Ki67 can be used as an immunohistochemical pseudo marker for cell proliferation to determine how aggressive the cancer is and thereby the treatment of the patient. No standard Ki67 staining protocol exists, resulting in inter-laboratory stain variability. Therefore, it is important to determine the quality control of a staining protocol to ensure correct diagnosis and treatment of patients. Currently, quality control is performed by the organization NordiQC that use an expert panel-based qualitative assessment system...
December 17, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/30555944/pituitary-metastasis-of-breast-cancer-mimicking-igg4-related-hypophysitis
#7
Kanako Nose, Toshiyasu Ogata, Jun Tsugawa, Tooru Inoue, Kazuki Nabeshima, Yoshio Tsuboi
IgG4-related hypophysitis, which is the pituitary gland inflammation caused by IgG4 positive lymphocytes, can affect cavernous sinus and orbital apex leading to developing cranial nerve related symptoms such as orbital apex syndrome (OAS). Here we report a case of hypopituitarism associated with OAS caused by pituitary metastasis of the breast cancer with elevated serum IgG4 level, who initially resembled to IgG4-related hypophysitis. Although this case had some features in common with igG4-related hypophysitis...
March 2019: ENeurologicalSci
https://www.readbyqxmd.com/read/30555923/lymphedema-following-breast-cancer-the-importance-of-surgical-methods-and-obesity
#8
Rebecca J Tsai, Leslie K Dennis, Charles F Lynch, Linda G Snetselaar, Gideon K D Zamba, Carol Scott-Conner
Background: Breast cancer-related arm lymphedema is a serious complication that can adversely affect quality of life. Identifying risk factors that contribute to the development of lymphedema is vital for identifying avenues for prevention. The aim of this study was to examine the association between the development of arm lymphedema and both treatment and personal (e.g., obesity) risk factors. Methods: Women diagnosed with breast cancer in Iowa during 2004 and followed through 2010, who met eligibility criteria, were asked to complete a short computer assisted telephone interview about chronic conditions, arm activities, demographics, and lymphedema status...
June 2018: Frontiers in Women's Health
https://www.readbyqxmd.com/read/30555636/synthetic-lethal-combinations-of-low-toxicity-drugs-for-breast-cancer-identified-in-silico-by-genetic-screens-in-yeast
#9
Maximilian Marhold, Erwin Tomasich, Michael Schwarz, Simon Udovica, Andreas Heinzel, Paul Mayer, Peter Horak, Paul Perco, Michael Krainer
In recent years, the concept of synthetic lethality, describing a cellular state where loss of two genes leads to a non-viable phenotype while loss of one gene can be compensated, has emerged as a novel strategy for cancer therapy. Various compounds targeting synthetic lethal pathways are either under clinical investigation or are already routinely used in multiple cancer entities such as breast cancer. Most of them target the well-described synthetic lethal interplay between PARP1 and BRCA1/2. In our study, we investigated, using an in silico methodological approach, clinically utilized drug combinations for breast cancer treatment, by correlating their known molecular targets with known homologous interaction partners that cause synthetic lethality in yeast...
November 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/30555632/antitumor-properties-of-salvianolic-acid-b-against-triple-negative-and-hormone-receptor-positive-breast-cancer-cells-via-ceramide-mediated-apoptosis
#10
Wei Sha, Yanfei Zhou, Zhi-Qiang Ling, Guiqin Xie, Xiaowu Pang, Paul Wang, Xinbin Gu
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. It is urgent to develop new therapeutics against this disease. Salvinolic acid B (Sal-B) is a leading bioactive component of Salvia miltiorrhiza Bunge, a well-known Chinese medicine for treating various diseases without appreciable adverse effects. To understand the antitumor properties of Sal-B against TNBC, we analyzed its effects on the cell viability, cell cycle and apoptosis of triple-negative MDA-MB-231 cells with the hormone receptor-positive MCF-7 cells as the control...
November 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/30555244/vandetanib-zd6474-induces-antiangiogenesis-through-mtor-hif-1-alpha-vegf-signaling-axis-in-breast-cancer-cells
#11
Ling Li, Jingkui Yu, Shuhong Jiao, Wei Wang, Fen Zhang, Shiqing Sun
Objective: Vandetanib, also known as ZD6474, has recently been proved to be a clinical drug for cancer by targeting vascular endothelial growth factor receptor 2 (VEGFR2), EGFR, and RET tyrosine kinases. We hypothesized that vandetanib will be a drug candidate for breast cancer treatment by targeting angiogenesis. Materials and methods: Vandetanib was used to treat different breast cancer cell lines, and its effect on growth, apoptosis, and cell cycle was studied by MTT assay and flow cytometry...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30555232/activation-of-polymeric-nanoparticle-intracellular-targeting-overcomes-chemodrug-resistance-in-human-primary-patient-breast-cancer-cells
#12
Amoura M Abou-El-Naga, Ghada Mutawa, Ibrahim M El-Sherbiny, Shaker A Mousa
Background: Successfully overcoming obstacles due to anticancer drugs' toxicity and achieving effective treatment using unique nanotechnology is challenging. The complex nature of breast tumors is mainly due to chemoresistance. Successful docetaxel (DTX) delivery by nanoparticles (NPs) through inhibition of multidrug resistance (MDR) can be a bridge to enhance intracellular dose and achieve higher cytotoxicity for cancer cells. Purpose: This study tested primary patient breast cancer cells in vitro with traditional free DTX in comparison with polymeric nanocarriers based on poly lactic co-glycolic acid (PLGA) NPs...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30555230/functional-chlorin-gold-nanorods-enable-to-treat-breast-cancer-by-photothermal-photodynamic-therapy
#13
Lei Liu, Hong-Jun Xie, Li-Min Mu, Rui Liu, Zhan-Bo Su, Yi-Nuo Cui, Ying Xie, Wan-Liang Lu
Background: The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect. Methods: Functional chlorin gold nanorods (Ce6-AuNR@SiO2 -d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). The nanostructure was developed by synthesizing Au nanorods as the photothermal conversion material, and by coating the pegylated mesoporous SiO2 as the shell for entrapping photosensitizer Ce6 and for linking the D-type cell penetrating peptide (d-CPP)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30555223/the-synergistic-effect-of-2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucoside-combined-with-adriamycin-on-mcf-7-breast-cancer-cells
#14
Jianfen Shen, Youzhi Zhang, Hui Shen, Hua Pan, Longsheng Xu, Linna Yuan, Zhiying Ding
Objective: Breast cancer has been reported to be a serious disease and a threat to women's health. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside (THSG) is a bioactive natural compound originating from Polygonum multiflorum Thunb., which has been shown to possess anti-inflammatory and antitumor properties. Adriamycin (ADM) is a chemotherapy agent used in tumor therapy that is limited by its side effects. However, little is known about the synergistic effect of THSG combined with ADM on breast cancer...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/30555156/the-oral-selective-oestrogen-receptor-degrader-serd-azd9496-is-comparable-to-fulvestrant-in-antagonising-er-and-circumventing-endocrine-resistance
#15
Agostina Nardone, Hazel Weir, Oona Delpuech, Henry Brown, Carmine De Angelis, Maria Letizia Cataldo, Xiaoyong Fu, Martin J Shea, Tamika Mitchell, Jamunarani Veeraraghavan, Chandandeep Nagi, Mark Pilling, Mothaffar F Rimawi, Meghana Trivedi, Susan G Hilsenbeck, Gary C Chamness, Rinath Jeselsohn, C Kent Osborne, Rachel Schiff
BACKGROUND: The oestrogen receptor (ER) is an important therapeutic target in ER-positive (ER+) breast cancer. The selective ER degrader (SERD), fulvestrant, is effective in patients with metastatic breast cancer, but its intramuscular route of administration and low bioavailability are major clinical limitations. METHODS: Here, we studied the pharmacology of a new oral SERD, AZD9496, in a panel of in vitro and in vivo endocrine-sensitive and -resistant breast cancer models...
December 17, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30555068/single-nucleotide-polymorphisms-and-mrna-expression-of-cyp1b1-influence-treatment-response-in-triple-negative-breast-cancer-patients-undergoing-chemotherapy
#16
Ahmad Aizat Abdul Aziz, Md Salzihan Md Salleh, Ibtisam Mohamad, Venkata Murali Krishna Bhavaraju, Maya Mazuwin Yahya, Andee Dzulkarnaen Zakaria, Siew Hua Gan, Ravindran Ankathil
Triple negative breast cancer (TNBC) is typically associated with poor and interindividual variability in treatment response. Cytochrome P450 family 1 subfamily B1 ( CYP1B1 ) is a metabolizing enzyme, involved in the biotransformation of xenobiotics and anticancer drugs. We hypothesized that, single-nucleotide polymorphisms (SNPs), CYP1B1 142 C>G, 4326 C>G and 4360 A>G, and CYP1B1 mRNA expression might be potential biomarkers for prediction of treatment response in TNBC patients. CYP1B1 SNPs genotyping (76 TNBC patients) was performed using allele-specific polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods and mRNA expression of CYP1B1 (41 formalin-fixed paraffin embeddedblocks) was quantified using quantitative reverse transcription PCR...
December 2018: Journal of Genetics
https://www.readbyqxmd.com/read/30554991/long-term-results-of-multicatheter-interstitial-high-dose-rate-brachytherapy-for-accelerated-partial-breast-irradiation
#17
Marc Gaudet, Mathieu Pharand-Charbonneau, Debbie Wright, Jonathan Nguyen, Jade Trudel-Sabourin, Mustapha Chelfi
PURPOSE: The purpose of this study was to report the long-term results of women treated in one center with accelerated partial-breast irradiation (APBI) with interstitial high-dose-rate (HDR) brachytherapy. MATERIALS AND METHODS: We analyzed data from women treated in one center with adjuvant interstitial HDR brachytherapy for early-stage breast cancer. Treatment regimen was homogeneous for all women with treatment dose 32Gy in 8 fractions twice daily given to the tumor bed with interstitial HDR brachytherapy...
December 13, 2018: Brachytherapy
https://www.readbyqxmd.com/read/30554535/protective-effect-of-gastrodin-on-peripheral-neuropathy-induced-by-anti-tumor-treatment-with-vincristine-in-rat-models
#18
Bingjie Qin, Ni Luo, Yuxing Li, Denghui Gong, Jun Zheng, Xiao Tan, Weihong Zheng
Cancer is a common disease threatening human health, chemotherapy is widely used in clinical treatment of cancer, but chemotherapy-induced peripheral neuropathy (CIPN) has a relevant impact on life quality of cancer patients. Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). However, its exact molecular mechanisms remain unclear. In this study, we established an animal model of CIPN using Walker-256 breast cancer cell and vincristine...
December 17, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/30554376/radiotherapy-for-oligometastatic-cancer-a-survey-among-radiation-oncologists-of-lombardy-airo-lombardy-italy
#19
Barbara Alicja Jereczek-Fossa, Barbara Bortolato, Marianna Alessandra Gerardi, Samantha Dicuonzo, Virginia Maria Arienti, Stefania Berlinghieri, Stefano Bracelli, Michela Buglione, Mariangela Caputo, Gianpiero Catalano, Luigi Franco Cazzaniga, Luigi De Cicco, Nadia Di Muzio, Francesco Romeo Filippone, Andrei Fodor, Davide Franceschini, Paolo Frata, Stefania Gottardo, Giovanni Battista Ivaldi, Antonio Laudati, Stefano Maria Magrini, Elisa Mantero, Ilaria Meaglia, Sara Morlino, Mauro Palazzi, Fabio Piccoli, Paola Romanelli, Marta Scorsetti, Flavia Serafini, Luciano Scandolaro, Riccardo Valdagni, Roberto Orecchia, Paolo Antognoni
AIMS: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy. METHODS AND STUDY DESIGN: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. RESULTS: Thirteen centers answered the survey (38%). All centers responded to general items and 12 centers submitted patient/disease/treatment data...
December 15, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/30554174/preoperative-stereotactic-radiosurgery-before-planned-resection-of-brain-metastases-updated-analysis-of-efficacy-and-toxicity-of-a-novel-treatment-paradigm
#20
(no author information available yet)
OBJECTIVEPreoperative stereotactic radiosurgery (SRS) is a feasible alternative to postoperative SRS and may lower the risk of radiation necrosis (RN) and leptomeningeal disease (LMD) recurrence. The study goal was to report the efficacy and toxicity of preoperative SRS in an expanded patient cohort with longer follow-up period relative to prior reports.METHODSThe records for patients with brain metastases treated with preoperative SRS and planned resection were reviewed. Patients with classically radiosensitive tumors, planned adjuvant whole brain radiotherapy, or no cranial imaging at least 1 month after surgery were excluded...
December 14, 2018: Journal of Neurosurgery
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