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https://www.readbyqxmd.com/read/28098891/nhe1-is-upregulated-in-gastric-cancer-and-regulates-gastric-cancer-cell-proliferation-migration-and-invasion
#1
Rui Xie, Haibo Wang, Hai Jin, Guorong Wen, Biguang Tuo, Jingyu Xu
Na+/H+ exchanger isoform 1 (NHE1) is known to play a key role in regulating intracellular pH and osmotic homeostasis and is involved in the development and progression of several types of cancer. However, the function and specific mechanism of NHE1 in gastric cancer (GC) are not clearly understood. In the present study, we report that NHE1 is overexpressed in tissues and cell lines from GC patients, and knockdown or inhibition of NHE1 suppressed GC cell proliferation via regulation of G1/S and G2/M cell cycle phase transitions, concomitant with a marked decrease in positive cell cycle regulators, including cyclin D1 and cyclin B1...
January 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098881/overexpression-of-grp75-inhibits-inflammation-in-a-rat-model-of-intracerebral-hemorrhage
#2
Lian-Jie Lv, Jia Li, Hai-Bo Qiao, Ben-Jin Nie, Peng Lu, Feng Xue, Zhi-Ming Zhang
Glucose‑regulated protein 75 (GRP75) is a member of the heat shock protein 70 family and previous studies have demonstrated that GRP75 is involved in diseases of the central nervous system. However, the biological function of GRP75 in intracerebral hemorrhage (ICH) remains to be clarified. Thus, the aim of the present study was to evaluate the effects of GRP75 in a rat model of ICH. Western blotting was used to detect the protein expression of GRP75, active caspase‑3, Bax, Bcl‑2, p‑Akt and Akt in brain tissues following ICH...
January 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28098861/triptolide-inhibits-viability-and-induces-apoptosis-in-liver-cancer-cells-through-activation-of-the-tumor-suppressor-gene-p53
#3
Yan-Yan Sun, Lei Xiao, Dong Wang, Yan-Chao Ji, Yu-Peng Yang, Rong Ma, Xi-Hai Chen
The present study investigated the effect of triptolide on viability and apoptosis along with underlying mechanism in liver cancer cells. CCK-8 assay showed that triptolide treatment for 48 h significantly reduced the viability of HepG2 and QSG7701 cells at 50 µM concentration. Annexin V-FITC and propidium iodide staining showed that triptolide treatment of HepG2 cells at 50 µM concentrations induced apoptosis in 56.45% cells compared to only 2.36% cells in the control cultures. Western blot assay showed that treatment of HepG2 cells with 50 µM concentration of triptolide significantly induced phosphorylation of p53 in a 2 h-treatment...
January 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098360/morroniside-a-secoiridoid-glycoside-from-cornus-officinalis-attenuates-neuropathic-pain-by-activation-of-spinal-glucagon-like-peptide-1-receptors
#4
Meng Xu, Hai-Yun Wu, Hao Liu, Nian Gong, Yi-Rui Wang, Yong-Xiang Wang
BACKGROUND AND PURPOSE: Iridoid glycosides with intact double bond scaffold of cyclopentapyran were reversible and orthosteric agonists of glucagon-like peptide-1 (GLP-1) receptors and possess antinociception and neuroprotection. Morroniside, derived from the medicinal herb Cornus officinalis, is an atypical secoiridoid replaced by a six-membered cyclic inner ether fragment. This study investigated whether morroniside was an orthosteric GLP-1 receptor agonist and had antihypersensitivity activities in neuropathy...
January 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28098270/copper-i-tf-biphamphos-catalyzed-asymmetric-nitroso-diels-alder-reaction
#5
Jun Li, Hai-Yan Tao, Chun-Jiang Wang
A highly efficient enantioselective nitroso Diels-Alder reaction of 6-methyl-2-nitroso pyridine with various 1,3-dienes was successfully developed using a Cu(i)/(S)-TF-BiphamPhos complex as the catalyst. For most of the cyclic dienes, synthetically important heterocyclic 3,6-dihydro-1,2-oxazines were obtained in high yields with excellent regio-, diastereo- and enantioselectivities. Acyclic 2-silyloxy-1,3-diene also worked well in the reaction.
January 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28097785/down-regulation-of-bnda1-whose-gene-locus-is-associated-with-the-seeds-weight-improves-the-seeds-weight-and-organ-size-in-brassica-napus
#6
Jie-Li Wang, Min-Qiang Tang, Sheng Chen, Xiang-Feng Zheng, Hui-Xian Mo, Sheng-Jun Li, Zheng Wang, Ke-Ming Zhu, Li-Na Ding, Sheng-Yi Liu, Yun-Hai Li, Xiao-Li Tan
Brassica napus L. is an important oil crop worldwide, and is the main raw material for biofuel. Seed weight and seed size are the main contributors to seed yield. DA1 (DA means big in Chinese) is an ubiquitin receptor and negatively regulates seed size. Down-regulation of AtDA1 in Arabidopsis leads to larger seeds and organs by increasing cell proliferation in integuments. In this study, BnDA1was down-regulated in B. napus by over expressed of AtDA1(R358K) , which is a functional deficiency of DA1 with an arginine-to-lysine mutation at the 358(th) amino acid...
January 17, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28097679/abnormal-levels-of-seven-amino-neurotransmitters-in-depression-rat-brain-and-determination-by-hplc-fld
#7
Ting Cui, Hong-Mei Qiu, Dan Huang, Qi-Xin Zhou, Xiao-Yan Fu, Hai-Yan Li, Xin-Hui Jiang
The determination of amino acids with the actions-like neurotransmitters or modulators have been increasingly important for diagnose in many neuropsychiatric diseases. A rapid and simple high performance liquid chromatography with fluorescence detection (HPLC-FLD) was developed for simultaneous determination of seven amino acids: aspartate (Asp), glutamate (Glu), serine (Ser), glutamine (Gln), glycine (Gly), taurine (Tau) and γ-aminobutyric acid (GABA). Homoserine (Hse) was used as an internal standard (IS)...
January 18, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28097270/prospective-study-analyzing-risk-factors-and-characteristics-of-healthcare-associated-infections-in-a-urology-ward
#8
José Medina-Polo, Raquel Sopeña-Sutil, Raúl Benítez-Sala, Alba Lara-Isla, Manuel Alonso-Isa, Javier Gil-Moradillo, Juan Justo-Quintas, Esther García-Rojo, Daniel Antonio González-Padilla, Juan Bautista Passas-Martínez, Ángel Tejido-Sánchez
PURPOSE: Healthcare-associated infections (HAIs) in urological patients have special features due to specific risk factors. Our objective was to evaluate the characteristics and risk factors for HAIs in patients hospitalized in a Urology ward. MATERIALS AND METHODS: We evaluated prospectively, from 2012 to 2015, the incidence, types and risk factor for HAIs, microbiological and resistance patterns. RESULTS: The incidence of HAIs was 6.3%. The most common types were urinary infections (70...
January 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28097093/vascular-endothelial-growth-factor-suppresses-tnfsf15-production-in-endothelial-cells-by-stimulating-mir-31-and-mir-20a-expression-via-activation-of-akt-and-erk-signals
#9
Hui-Ting Deng, Hai-Lin Liu, Bei-Bei Zhai, Kun Zhang, Guo-Ce Xu, Xue-Mei Peng, Qiang-Zhe Zhang, Lu-Yuan Li
Tumor necrosis factor superfamily-15 (TNFSF15; VEGI; TL1A) is a negative modulator of angiogenesis for blood vessel homeostasis and is produced by endothelial cells in a mature vasculature. It is known to be downregulated by vascular endothelial growth factor (VEGF), a major regulator of neovascularization but the mechanism of this interaction is unclear. Here we report that VEGF is able to stimulate the production of two microRNAs, miR-20a and miR-31, which directly target the 3'-UTR of TNFSF15. Additionally, we show that two VEGF-stimulated cell growth signals, Erk and Akt, are responsible for promoting the expression of miR-20a and miR-31...
January 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28096455/multicenter-prospective-study-on-device-associated-infection-rates-and-bacterial-resistance-in-intensive-care-units-of-venezuela-international-nosocomial-infection-control-consortium-inicc-findings
#10
Gabriel D Empaire, Maria E Guzman Siritt, Victor D Rosenthal, Fernando Pérez, Yvis Ruiz, Claudia Díaz, Gabriela Di Silvestre, Evelyn Salinas, Nelva Orozco
BACKGROUND: Device-associated healthcare-acquired infections (DA-HAI) pose a threat to patient safety in the intensive care unit (ICU). METHODS: A DA-HAI surveillance study was conducted by the International Nosocomial Infection Control Consortium (INICC) in two adult medical/surgical ICUs at two hospitals in Caracas, Venezuela, in different periods from March 2008 to April 2015, using the US Centers for Disease Control and Prevention's National Healthcare Safety Network (CDC/NHSN) definitions and criteria, and INICC methods...
January 2017: International Health
https://www.readbyqxmd.com/read/28096421/rfamide-related-peptide-3-rfrp-3-suppresses-sexual-maturation-in-a-eusocial-mammal
#11
Diana E Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, Ashlyn Swift-Gallant, Hai-Ying M Cheng, George E Bentley, Melissa M Holmes
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096384/holocene-enso-related-cyclic-storms-recorded-by-magnetic-minerals-in-speleothems-of-central-china
#12
Zongmin Zhu, Joshua M Feinberg, Shucheng Xie, Mark D Bourne, Chunju Huang, Chaoyong Hu, Hai Cheng
Extreme hydrologic events such as storms and floods have the potential to severely impact modern human society. However, the frequency of storms and their underlying mechanisms are limited by a paucity of suitable proxies, especially in inland areas. Here we present a record of speleothem magnetic minerals to reconstruct paleoprecipitation, including storms, in the eastern Asian monsoon area over the last 8.6 ky. The geophysical parameter IRMsoft-flux represents the flux of soil-derived magnetic minerals preserved in stalagmite HS4, which we correlate with rainfall amount and intensity...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095879/treatment-seeking-behaviour-and-barriers-to-service-access-for-sexually-transmitted-diseases-among-men-who-have-sex-with-men-in-china-a-multicentre-cross-sectional-survey
#13
Jun-Jie Xu, Yan-Qiu Yu, Qing-Hai Hu, Hong-Jing Yan, Zhe Wang, Lin Lu, Ming-Hua Zhuang, Xi Chen, Ji-Hua Fu, Wei-Ming Tang, Wen-Qing Geng, Yong-Jun Jiang, Hong Shang
BACKGROUND: Delayed or inappropriate treatment for sexually transmitted diseases (STDs) increases the risk of HIV acquisition and may cause other harmful outcomes. However, studies on STD treatment-seeking behaviour and correlated factors in men who have sex with men (MSM) are scarce. This information is crucial for the promotion of STD treatment-seeking behaviour and reduction of HIV transmission among Chinese MSM. METHODS: During 2012-2013, a multicentre cross-sectional study was conducted in 7 Chinese cities...
January 18, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28095261/serum-alkaline-phosphatase-a-risk-factor-for-non-alcoholic-fatty-liver-but-only-for-women-in-their-30s-and-40s-evidence-from-a-large-cohort-study
#14
Yu-Jie Zhou, Hai Zou, Ji-Na Zheng, Tian-Tian Zou, Alessandro Vitale, Luca Miele, Sven Van Poucke, Wen-Yue Liu, Shengrong Shen, Dong-Chu Zhang, Ke-Qing Shi, Ming-Hua Zheng
BACKGROUND: Several risk factors are able to predict non-alcoholic fatty liver (NAFL) development, but the predictive value of serum alkaline phosphatase (ALP) remains uncertain. Our aim is to investigate the association between serum ALP levels and NAFL. METHODS: 21,331 NAFL-free subjects were included. Sex-specific ALP quartiles (Q1 to Q4) were defined. With Q1 used as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated across each quartile...
January 17, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28094965/taxodikaloids-a-and-b-two-dimeric-abietane-type-diterpenoids-from-taxodium-ascendens-possessing-an-oxazoline-ring-linkage
#15
Xing-Hao Huang, Ling-Xue Tao, Chang-Qiang Ke, Chunping Tang, Hai-Yan Zhang, Yang Ye, Li-Gen Lin, Sheng Yao
Two dimeric diterpenoids, taxodikaloids A (1) and B (2), have been identified from the seeds of Taxodium ascendens. The diterpenoid structures were established on the basis of comprehensive spectroscopic analysis, and the absolute configuration of taxodikaloid A (1) was further confirmed by single-crystal X-ray diffraction. Both structures feature an unprecedented oxazoline ring linkage connecting two abietane diterpenoid monomers. A plausible biosynthetic pathway for compounds 1 and 2 is proposed. Both compounds show potential neuroprotective activity against Aβ25-35-induced damage in SH-SY5Y cells...
January 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28094809/genome-wide-identification-evolution-and-expression-analysis-of-ring-finger-protein-genes-in-brassica-rapa
#16
Intikhab Alam, Yan-Qing Yang, Yong Wang, Mei-Lan Zhu, Heng-Bo Wang, Boulos Chalhoub, Yun-Hai Lu
More and more RING finger genes were found to be implicated in various important biological processes. In the present study, a total of 731 RING domains in 715 predicted proteins were identified in Brassica rapa genome (AA, 2n = 20), which were further divided into eight types: RING-H2 (371), RING-HCa (215), RING-HCb (47), RING-v (44), RING-C2 (38), RING-D (10), RING-S/T (5) and RING-G (1). The 715 RING finger proteins were further classified into 51 groups according to the presence of additional domains...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094806/plant-toxin-%C3%AE-odap-activates-integrin-%C3%AE-1-and-focal-adhesion-a-critical-pathway-to-cause-neurolathyrism
#17
Rui-Yue Tan, Geng-Yan Xing, Guang-Ming Zhou, Feng-Min Li, Wen-Tao Hu, Fernand Lambein, Jun-Lan Xiong, Sheng-Xiang Zhang, Hai-Yan Kong, Hao Zhu, Zhi-Xiao Li, You-Cai Xiong
Neurolathyrism is a unique neurodegeneration disease caused by β-N-oxalyl-L-α, β- diaminopropionic (β-ODAP) present in grass pea seed (Lathyrus stativus L.) and its pathogenetic mechanism is unclear. This issue has become a critical restriction to take full advantage of drought-tolerant grass pea as an elite germplasm resource under climate change. We found that, in a human glioma cell line, β-ODAP treatment decreased mitochondrial membrane potential, leading to outside release and overfall of Ca(2+) from mitochondria to cellular matrix...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094766/matriptase-mediated-cleavage-of-epcam-destabilizes-claudins-and-dysregulates-intestinal-epithelial-homeostasis
#18
Chuan-Jin Wu, Xu Feng, Michael Lu, Sohshi Morimura, Mark C Udey
Congenital tufting enteropathy (CTE) is a severe autosomal recessive human diarrheal disorder with characteristic intestinal epithelial dysplasia. CTE can be caused by mutations in genes encoding EpCAM, a putative adhesion molecule, and HAI-2, a cell surface protease inhibitor. A similar phenotype occurs in mice whose intestinal epithelial cells (IECs) fail to express the tight junction-associated protein claudin-7. EpCAM stabilizes claudin-7 in IECs, and HAI-2 regulates the cell surface serine protease matriptase, a known modifier of intestinal epithelial physiology...
January 17, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28094459/investigation-of-binding-behavior-between-drug-molecule-5-fluoracil-and-m4l4-type-tetrahedral-cages-selectivity-capture-and-release
#19
Ji-Jun Jiang, Wei-Qin Xu, Yan-Zhong Fan, Hai-Ping Wang, Jun Teng, Yu-Hao Li, Cheng-Xia Chen, Dieter Fenske, Cheng-Yong Su
Two analogue M4L4 type tetrahedral cages (smaller MOC-19 and larger MOC-22) have been synthesized and investigated for their interactions with an anticancer drug 5-fluoracil (5-FU) by NMR, HRESI-MS and molecular simulation. The cage's size and window are of importance for the host-guest binding, of which the smaller MOC-19 with just right size of cavity window is found to have much strong H-bond interactions with 5-FU. The porous nanoparticle of MOC-19 exhibits outstanding behaviors to control release of 5-FU in simulated human body liquid PBS buffer...
January 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28094345/bacterial-plasmid-mediated-quinolone-resistance-genes-in-aquatic-environments-in-china
#20
Lei Yan, Dan Liu, Xin-Hua Wang, Yunkun Wang, Bo Zhang, Mingyu Wang, Hai Xu
Emerging antimicrobial resistance is a major threat to human's health in the 21(st) century. Understanding and combating this issue requires a full and unbiased assessment of the current status on the prevalence of antimicrobial resistance genes and their correlation with each other and bacterial groups. In aquatic environments that are known reservoirs for antimicrobial resistance genes, we were able to reach this goal on plasmid-mediated quinolone resistance (PMQR) genes that lead to resistance to quinolones and possibly also to the co-emergence of resistance to β-lactams...
January 17, 2017: Scientific Reports
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