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https://www.readbyqxmd.com/read/29232718/an-arabidopsis-nucleoporin-nup85-modulates-plant-responses-to-aba-and-salt-stress
#1
Yingfang Zhu, Bangshing Wang, Kai Tang, Chuan-Chih Hsu, Shaojun Xie, Hai Du, Yuting Yang, Weiguo Andy Tao, Jian-Kang Zhu
Several nucleoporins in the nuclear pore complex (NPC) have been reported to be involved in abiotic stress responses in plants. However, the molecular mechanism of how NPC regulates abiotic stress responses, especially the expression of stress responsive genes remains poorly understood. From a forward genetics screen using an abiotic stress-responsive luciferase reporter (RD29A-LUC) in the sickle-1 (sic-1) mutant background, we identified a suppressor caused by a mutation in NUCLEOPORIN 85 (NUP85), which exhibited reduced expression of RD29A-LUC in response to ABA and salt stress...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232579/structure-based-identification-of-a-nedd8-activating-enzyme-inhibitor-via-drug-repurposing
#2
Ke-Jia Wu, Hai-Jing Zhong, Guodong Li, Chenfu Liu, Hui-Min David Wang, Dik-Lung Ma, Chung-Hang Leung
NEDD8-activating enzyme (NAE) is an essential player of the NEDD8 conjugation pathway that regulates protein degradation. Meanwhile, drug repurposing is a cost-efficient strategy to identify new therapeutic uses for existing scaffolds. In this report, mitoxantrone (1) was repurposed as an inhibitor of NAE by virtual screening of an FDA-approved drug database. Compound 1 inhibited NAE activity in cell-free and cell-based systems with high selectivity and was competitive with ATP. Furthermore, compound 1 induced apoptosis of colorectal adenocarcinoma cancer cells through inhibiting the degradation of the neddylation substrate p53...
December 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232303/totally-endoscopic-cardiac-surgery-for-atrial-septal-defect-repair-on-beating-heart-without-robotic-assistance-in-25-patients
#3
Quang-Huy Dang, Ngoc-Thanh Le, Cong-Huu Nguyen, Dac-Dai Tran, Do-Hung Nguyen, Trung-Hieu Nguyen, Thi-Hai-Linh Ngo
OBJECTIVE: The aim of the study was to investigate the effectivity and safety of totally endoscopic cardiac surgery without robotic assistance for atrial septal defect (ASD) closure on beating hearts. METHODS: Twenty-five patients (adults/children: 15/10) underwent ASD closure using nonrobotically assisted totally endoscopic approach on beating heart. Three 5-mm trocars and one 12-mm trocar were used, only the superior vena cava is snared, filling the pleural and pericardial cavities with CO2, and the heart was beating during the surgery...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232021/investigation-of-diffusion-kurtosis-imaging-for-discriminating-tumors-from-inflammatory-lesions-after-treatment-for-bladder-cancer
#4
Fang Wang, Di Jin, Xiao-Lan Hua, Zi-Zhou Zhao, Lian-Ming Wu, Wei-Bo Chen, Guang-Yu Wu, Xiao-Xi Chen, Hai-Ge Chen
BACKGROUND: The bladder wall may thicken resulting from chronic inflammation after initial treatment (transurethral resection [TUR] or neoadjuvant chemotherapy), which may mimic the feature of recurrent or residual bladder tumors (RBT). Therefore, it is critical to discriminate RBT from benign lesions after initial treatment. PURPOSE: To investigate whether diffusion kurtosis imaging (DKI) could discriminate RBT from post-therapy bladder inflammatory lesions. STUDY TYPE: Retrospective...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29231711/embedding-capture-magneto-catalytic-activity-into-a-nano-catalyst-for-the-determination-of-lipid-kinase
#5
Tao Gao, Chaoli Mu, Hai Shi, Liu Shi, Xiaoxia Mao, Genxi Li
Using emerging nano-catalysts to investigate the activity of bio-catalysts (protein enzymes, catalytic RNAs, ect.) is increasingly receiving attention from material, analytical and biomedical scientists. Here, we have first fabricated a three-in-one nano-catalyst, the nitrilotriacetic acid (NTA)-modified magnetite nanoparticle (NTA-MNPs), to develop an integrated magneto-colorimetric (MagColor) assay for lipid kinase activity, so as to solve the inherent problems in lipid kinase assay. Based on three integrated functions of the NTA-MNPs (capture, magnetic separation and peroxidase activity), catalytic activity of lipid kinase is directly converted to colorimetric signals...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29231331/-bridge-role-of-jingming-bl-1-for-vdt-asthenopia-and-brainfag-based-on-human-instinct
#6
Wei Zhang, Huanan Li, Na Zhao, Xinghua Hai, Hua Dong, Jingui Wang
To explore the bridge role of Jingming (BL 1) for video display terminal (VDT) asthenopia and brainfag. Ancient literature and modern scientific research on the acupoint have been analyzed and summarized so as to explore pressing the acupoint the instinct feedback of brain after asthenopia. It is demonstrated that Jingming (BL 1) is a key channel between eyes, brain and the outside world, and it is one of major feedback points of brain after asthenopia. In this paper we try to establish a new research thinking and ascertain it, namely Jingming (BL 1) reflecting the relationship between asthenopia and brainfag...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231245/two-cases-of-human-cutaneous-anthrax-with-massive-tissue-damage-severe-edema-and-slight-injury-to-the-liver
#7
Hai-Ling Yuan, Yuan-Yuan Zheng, Wen Zhang, Hua Xie
No abstract text is available yet for this article.
December 12, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29231226/strong-magnetic-resonances-and-largely-enhanced-second-harmonic-generation-of-colloidal-mos2-and-res2-au-nanoantennas-with-assembled-2d-nanosheets
#8
Si-Jing Ding, Zhi-Jun Luo, Ya-Ming Xie, Gui-Ming Pan, Yun-Hang Qiu, Kai Chen, Li Zhou, Jianfang Wang, Hai-Qing Lin, Qu-Quan Wang
Colloidal disk-like and sphere-like MoS2 nanoantennas are synthesized. They consist of curly and interlaced 2D nanosheets. The resonance peak of the MoS2 nanoantennas can be tuned from 500 to 900 nm by adjusting the size and shape. The strong magnetic and electric resonances of the dielectric antennas are revealed by theoretical calculations with Mie theory. The second harmonic generation (SHG) of the exfoliated nanosheets and the synthesized nanodisks and nanospheres is investigated and compared by scanning the excitation laser wavelength...
December 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/29231215/involvement-of-fak-mediated-bmp-2-smad-pathway-in-mediating-osteoblast-adhesion-and-differentiation-on-nano-ha-chitosan-composite-coated-titanium-implant-under-diabetic-conditions
#9
Xiang-Yu Ma, Ya-Fei Feng, Tian-Sheng Wang, Wei Lei, Xiang Li, Da-Peng Zhou, Xin-Xin Wen, Hai-Long Yu, Liang-Bi Xiang, Lin Wang
Chitosan (CS)-based hydroxyapatite (HA) composites have emerged as a novel strategy for promoting bone regeneration. Here nanophase HA/CS composite coated porous titanium implants (nCT) were fabricated and their biological behavior under diabetic conditions was investigated. We proposed that the focal adhesion kinase (FAK)-mediated BMP-2/Smad pathway played a role in mediating the promotive effect of nCTs on osteoblast adhesion and differentiation under diabetes-induced high reactive oxygen species (ROS) condition...
December 12, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29231145/learning-from-multiple-classifier-systems-perspectives-for-improving-decision-making-of-qsar-models-in-medicinal-chemistry
#10
Hai V Pham-The, Nguyen-Hai Nam, Doan-Viet Nga, Dang Thanh Hai, Karel Dieguez-Santana, Yovani Marrero-Poncee, Juan A Castillo-Garit, Gerardo M Casanola-Martin, Huong Le-Thi-Thu
Quantitative Structure - Activity Relationship (QSAR) modeling has been widely used in medicinal chemistry and computational toxicology for many years. Today, as the amount of data on chemicals is increasing dramatically, QSAR methods have become pivotal for the purpose of handling the data, identifying a decision, and gathering useful information from data processing. The advances in this field have paved a way for numerous alternative approaches that require deep mathematics in order to enhance the learning capability of QSAR models...
December 11, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29231035/an-asymmetric-dehydrogenative-diels-alder-reaction-for-the-synthesis-of-chiral-tetrahydrocarbazole-derivatives
#11
Xiang Wu, Hai-Jie Zhu, Shi-Bao Zhao, Shu-Sen Chen, Yun-Fei Luo, You-Gui Li
An asymmetric dehydrogenative Diels-Alder reaction of 2-methyl-3-phenylmethylindoles and α,β-unsaturated aldehydes has been established. The successful in situ generation of the indole ortho-quinodimethane intermediate and the iminium activation of enals are the keys to success, providing various tetrahydrocarbazole derivatives with up to >99% ee.
December 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/29230621/electroacupuncture-stimulation-of-language-implicated-acupoint-tongli-ht-5-in-healthy-subjects-an-fmri-evaluation-study
#12
Lin-Ling Li, Xiao-Wu Liu, Fang Wu, Dong-Chang Tong, Li-Ping Ye, Hong-Xing Tao, Peng Liu, Yun-Hai Qiu, Wan-Zhang Yang
OBJECTIVE: To explore brain activations associated with electroacupuncture simulation at Tongli (HT 5) and its comparison with brain activations during picture-naming task. METHODS: Twenty healthy subjects were enrolled in this study. Half of them received electroacupuncture stimulation at HT 5 (ACUP group) and the other half of them received stimulation at a nonmeridian sham acupoint (SHAM group). All subjects performed picture-naming task. Each subject finished two runs of functional magnetic resonance imaging examinations in one session and picture-naming task was performed before electroacupuncture stimulation...
December 11, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29230583/mutation-screening-of-chinese-treacher-collins-syndrome-patients-identified-novel-tcof1-mutations
#13
Ying Chen, Luo Guo, Chen-Long Li, Jing Shan, Hai-Song Xu, Jie-Ying Li, Shan Sun, Shao-Juan Hao, Lei Jin, Gang Chai, Tian-Yu Zhang
Treacher Collins syndrome (TCS) (OMIM 154500) is a rare congenital craniofacial disorder with an autosomal dominant manner of inheritance in most cases. To date, three pathogenic genes (TCOF1, POLR1D and POLR1C) have been identified. In this study, we conducted mutational analysis on Chinese TCS patients to reveal a mutational spectrum of known causative genes and show phenotype-genotype data to provide more information for gene counselling and future studies on the pathogenesis of TCS. Twenty-two TCS patients were recruited from two tertiary referral centres, and Sanger sequencing for the coding exons and exon-intron boundaries of TCOF1, POLR1D and POLR1C was performed...
December 11, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29230541/theoretical-and-experimental-investigation-into-a-eutectic-system-of-3-4-dinitropyrazole-and-1-methyl-3-4-5-trinitropyrazole
#14
Shuang-Fei Zhu, Shu-Hai Zhang, Rui-Jun Gou, Fu-de Ren
Eutectic mixtures of 3,4-dinitropyrazole (DNP) and 1-methyl-3,4,5-trinitropyrazole (MTNP) were investigated by theoretical and experimental methods. The mass ratio of DNP and MTNP ranged from 0:100 to 100:0. Melting points of the mixtures were predicted through observing the inflection point of a specific volume vs. temperature in molecular dynamics (MD) simulation. The results are in good agreement with experimental results obtained from the differential scanning calorimeter (DSC) study. The binding energy of a 50/50 DNP/MTNP eutectic mixture is lower than those of other mixtures, in accordance with the common sense that the melting point of materials is linked to the strength of intermolecular interactions...
December 11, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29230037/author-correction-fam46c-is-critical-for-the-anti-proliferation-and-pro-apoptotic-effects-of-norcantharidin-in-hepatocellular-carcinoma-cells
#15
Qiao-Yan Zhang, Xiao-Qiang Yue, Yi-Ping Jiang, Ting Han, Hai-Liang Xin
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228678/high-expression-of-pdlim5-facilitates-cell-tumorigenesis-and-migration-by-maintaining-ampk-activation-in-prostate-cancer
#16
Xi Liu, Lu Chen, Hai Huang, Jian-Min Lv, Ming Chen, Fa-Jun Qu, Xiu-Wu Pan, Lin Li, Lei Yin, Xin-Gang Cui, Yi Gao, Dan-Feng Xu
PDZ and LIM domain 5 (PDLIM5) is a cytoskeleton-associated protein and has been shown to bind to a variety of proteins through its specific domain, thereby acting to regulate cell migration and tumor progression. Here, we found that PDLIM5 was abnormally upregulated in prostate cancer (PCa) tissues as compared with that in normal prostate tissue. ONCOMINE microarray data mining showed that PDLIM5 was closely correlated with the prognosis of PCa in terms of Gleason score, tumor metastasis and biochemical recurrence...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228637/sorafenib-improves-lipiodol-deposition-in-transarterial-chemoembolization-of-chinese-patients-with-hepatocellular-carcinoma-a-long-term-retrospective-study
#17
Lin Zheng, Chen-Yang Guo, Cheng-Shi Chen, Jin-Cheng Xiao, Hong-Tao Hu, Hong-Tao Cheng, Deng-Wei Zong, Li Jiang, Hai-Liang Li
Objective: Though synergy of sorafenib and transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) is well discussed in previous reports, association of lipiodol retention by sorafenib addition to TACE with the survival outcomes remain elusive. Therefore, we studied the impact of sorafenib addition to TACE on survival outcomes mediated by lipiodol retention. Materials and Methods: This is a long-term, retrospective, single-center study using medical records of patients diagnosed with HCC at the Department of Interventional Radiology of Zhengzhou University Affiliated Cancer Hospital (China) between April 2004 and March 2012...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228605/a-case-control-study-on-risk-factors-of-breast-cancer-in-han-chinese-women
#18
Li-Yuan Liu, Fei Wang, Shu-De Cui, Fu-Guo Tian, Zhi-Min Fan, Cui-Zhi Geng, Xu-Chen Cao, Zhen-Lin Yang, Xiang Wang, Hong Liang, Shu Wang, Hong-Chuan Jiang, Xue-Ning Duan, Hai-Bo Wang, Guo-Lou Li, Qi-Tang Wang, Jian-Guo Zhang, Feng Jin, Jin-Hai Tang, Liang Li, Shi-Guang Zhu, Wen-Shu Zuo, Li-Xiang Yu, Yu-Juan Xiang, Fei Zhou, Liang Li, Qiang Zhang, Qin-Ye Fu, Zhong-Bing Ma, De-Zong Gao, Yu-Yang Li, Lu Liu, Chun-Miao Ye, Yong-Jiu Wang, Wen-Zhong Zhou, Zhi-Gang Yu
This study aimed to investigate risk factors associated with breast cancer among Han Chinese women in northern and eastern China. A matched case-control study involving 1489 patients with breast cancer and 1489 controls was conducted across 21 hospitals in 11 provinces in China, from April 2012 to April 2013. We developed a structured questionnaire to record information from face-to-face interviews with participants. Student's t-tests, Pearson's chi-square tests, and univariate and multivariate conditional logistic regression analyses were used to identify variables with significant differences between the case and control groups...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228573/pnma5-is-essential-to-the-progression-of-meiosis-in-mouse-oocytes-through-a-chain-of-phosphorylation
#19
Xiao-Lan Zhang, Peng Liu, Zhi-Xia Yang, Jing-Jing Zhao, Lei-Lei Gao, Bo Yuan, Li-Ya Shi, Chun-Xiang Zhou, Hai-Feng Qiao, Ya-Hong Liu, Xiao-Yan Ying, Jun-Qiang Zhang, Xiu-Feng Ling, Dong Zhang
PNMA (paraneoplastic antigen MA) family includes Pnma1-6. Although other members have been found to be involved in paraneoplastic neurological disorders, death receptor-dependent apoptosis, and tumorigenesis, Pnma5 was thought to be a female fertility factor, as indicated by one genome-wide study. But until now there have not been any further functional studies about Pnma5 in female meiosis. Our preliminary study indicated that Pnma5 might play important roles in meiosis. To further address this, Pnma5 was knocked down in in-vitro maturated (IVM) mouse oocytes, which are common models for mammalian female meiosis, by specific siRNA, and results showed that the loss of Pnma5 significantly delayed the progression of meiosis I and increased chromosome segregation errors during anaphase I...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227939/influence-of-a-large-urban-park-on-the-local-urban-thermal-environment
#20
Hai Yan, Fan Wu, Li Dong
Green areas in the city can greatly improve the outdoor thermal environment, as well as mitigate the urban heat island effect by reducing summer air temperature. In a context of climate change, with the expected increase in temperature and intensity of heat waves, cooling by green areas is set to become increasingly important. In this study, field observations were carried out to investigate the thermal performance of a large urban vegetated park and its influence on thermal environment of the surrounding urban areas in Beijing, China...
December 8, 2017: Science of the Total Environment
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