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Chenyuan Pan, Ming Yang, Hai Xu, Bentuo Xu, Lihui Jiang, Minghong Wu
Fluoxetion (FLU) is an antidepressant pharmaceutical most commonly detected in the aquatic environment. The present study aims to elucidate the tissue accumulation and effects of FLU using two different fish models. First, the multiple effects and the FLU levels in fish, were examined in zebrafish (Danio rerio) embryos exposed to FLU concentrations (0, 0.1, 1, 10, 100, 1000 μg/L) from 4 h post-fertilization (hpf) until 120 hpf. Exposure to FLU accelerated heart rates, postponed hatching time, and increased swimming speed of fish...
April 16, 2018: Chemosphere
Xu Chang, Yan Wang, Hai-Peng Yu, Wei-Hao Zhang, Xue-Ling Yang, Zhi Guo
OBJECTIVE: Liver metastases occur in approximately 4%-14% of gastric cancer patients and are associated with high mortality. However, no standardized treatment approach is available for these patients. We aimed to assess the clinical outcomes of patients with gastric cancer liver metastases (GCLM) who underwent percutaneous cryoablation. METHODS: We retrospectively enrolled 19 patients with 27 metastatic hepatic tumors who underwent cryoablation for liver metastases after gastrectomy for primary gastric cancer...
April 18, 2018: Cryobiology
Hai Lin, Junfei Liu, Yingbo Dong, Kaiqiang Ren, Yu Zhang
The aim of the present study was to investigate three kinds of emergent macrophytes, i.e., Acorus calamus L., Phragmites communis Trin., and Alternanthera philoxeroides (Mart.) Griseb and their combination patterns on their removal efficiency of compound heavy metals (vanadium, chromium, and cadmium) from synthetic aqueous. The results showed that the optimal single-species for compound heavy metals removal was Acorus calamus L. and during experiment period, the average removal efficiency of V5+ , Cr6+ , and Cd2+ was 52...
April 20, 2018: Environmental Science and Pollution Research International
Steven J Verberne, Olivier P P Temmerman, Ben Hai Vuong, Pieter G Raijmakers
BACKGROUND: Fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel method of assessing suspected periprosthetic hip infection. However, a heterogeneity of sensitivity and specificity using different diagnostic criteria across clinical studies has been published. The objective of this study is to evaluate the various diagnostic criteria using FDG-PET in diagnosing periprosthetic hip infection. METHODS: FDG-PET scans of patients suffering from painful hip prostheses between 2008 and 2015 were retrospectively reviewed...
April 20, 2018: International Orthopaedics
Cheng-Long Xie, Qi-Shan Huang, Long Wu, Lei Xu, Hai-Cheng Dou, Xiang-Yang Wang, Zhong-Ke Lin
BACKGROUND: Transpedicular screws fixation has a biomechanical advantage of improving fusion rates. In the posterior thoracolumbar immobilization, a large number of screws cause perforation to pedicle or vertebra body. Techniques as radiograph and CT were used to minimize this complication. However, ultrasound in detecting the pedicle breach during the placement of the screw in unknown. Our goal is to evaluate the sensitivity of ultrasound for detecting the breaches. METHODS: A B-type transducer was used for scanning 216 Titanium pins inserted into the cadaveric pedicle...
April 17, 2018: World Neurosurgery
Yasser B Abulhasan, Najayeb Alabdulraheem, Ian Schiller, Susan P Rachel, Nandini Dendukuri, Mark R Angle, Charles Frenette
OBJECTIVE: Healthcare-associated infections (HAIs) after subarachnoid hemorrhage (SAH) are prevalent; however, data describing epidemiology of infection is limited. This study reports incidence rates, risk factors and the resulting SAH patient-related outcomes. METHODS: We studied the incidence of ICU-acquired HAIs over a 6-year period. We used Bayesian Model Averaging to identify risk factors associated with an increased risk of HAIs, particularly urinary tract infections (UTI), pneumonia and ventriculostomy-associated infections (VAI)...
April 17, 2018: World Neurosurgery
Cai-E Wang, Ke-Peng Lu, Zhao Chang, Meng-Li Guo, Hai-Ling Qiao
OBJECTIVE: Cyclosporine (CsA) is a substrate of cytochrome P450 (CYP) 3A4 with a narrow therapeutic index and large individual difference. CYP3A4*1B is reported to be associated with CsA pharmacokinetics parameters, but the relevance is still in dispute. Therefore, a meta-analysis was employed to evaluate the influence of CYP3A4*1B on CsA pharmacokinetics at different post-transplantation times in adult renal transplant recipients. METHODS: Studies on evaluating the CYP3A4*1B genotype and CsA pharmacokinetics were retrieved through a systematical search of relevant database including PubMed, Emabase, Web of science, the Cochrane Library, Clinical Trials...
April 17, 2018: Gene
Ye Ma, Lili Huang, Lu Zhang, Hai Yu, Bin Liu
BACKGROUND: Obesity as one of the risk factors for cardiovascular diseases increases mortality in general population. Several clinical studies investigated clinical outcomes in patients with different body mass index (BMI) after cardiac arrest (CA). Controversial data regarding BMI on clinical outcomes in those patients exist in those studies. Therefore, we conducted a meta-analysis to evaluate the effect of BMI on survival condition and neurological prognosis in those patients. METHODS: We searched Pubmed, Embase, Ovid/Medline and EBM reviews databases for relational studies investigating the association between BMI and clinical outcomes of patients after CA...
April 6, 2018: American Journal of Emergency Medicine
Nguyen Quoc Hai, Hyeongi Kim, In Sang Yoo, Ji Hyeon Kim, Jaehyun Hur
Nanocomposites of MoS2/graphite and MoSe2/graphite were formed from two-dimensional materials (MoS2 and MoSe2) and graphite using a one-step ball-milling method (high energy mechanical milling, HEMM). As anode materials for lithium-ion batteries (LIBs), these nanocomposites showed higher specific capacity and greater stability during long cyclic operation compared to their pure counterparts (MoS2 and MoSe2). X-ray diffraction and transmission electron microscopy revealed that graphite nanoflakes were effectively exfoliated and covered MoS2 or MoSe2 layers to form homogeneous nanostructures via HEMM...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Bo Li, Changshun Ruan, Yufei Ma, Zhifeng Huang, Zhenfei Huang, Gang Zhou, Jing Zhang, Hai Wang, Zhihong Wu, Guixing Qiu
INTRODUCTION: It is a common treatment strategy in the clinic to transplant a vascularized bone flap for a large bone defect. But it is difficult for peripheral blood vessels to grow into the central region of a large bone construct. In this study, we fabricated a vascularized bone flap from a 3D-printed biodegradable PLGA/β-TCP scaffold using the combination of an arteriovenous (AV) bundle and recombinant human bone morphogenetic protein-2 (rhBMP-2). MATERIALS AND METHODS: A degradable porous poly (lactide-co-glycolide) /-tri-calcium phosphate (PLGA/β-TCP) scaffold was prepared by adopting 3D plotting and a low-temperature deposition technique...
April 20, 2018: Tissue Engineering. Part A
Chun-Hui Zhai, Jian-Bang Xuan, Hai-Liu Fan, Teng-Fei Zhao, Jian-Lan Jiang
In order to make a further optimization of process design via increasing the stability of design space, we brought in the model of Support Vector Regression (SVR). In this work, the extraction of podophyllotoxin was researched as a case study based on QbD. We compared the fitting effect of SVR and the most used quadratic polynomial model (QPM) in QbD, and an analysis was made between the two design spaces obtained by SVR and QPM. As a result, the SVR stayed ahead of QPM in prediction accuracy, the stability of model and the generalization ability...
April 20, 2018: Drug Development and Industrial Pharmacy
Yu-Wen Zhao, Hai-Xia Wang, Song-Tao Bie, Qian Shao, Chun-Hua Wang, Dong-Heng Wang, Zheng Li
A new method for detection of Escherichia coli exist in licorice decoction was developed by using DNA-based electrochemical biosensor. The thiolated capture probe was immobilized on a gold electrode at first. Then the aptamer for Escherichia coli was combined with the capture probe by hybridization. Due to the stronger interaction between the aptamer and the E. coli, the aptamer can dissociate from the capture probe in the presence of E. coli in licorice decoction. The biotinylated detection probe was hybridized with the single-strand capture probe...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Chun-Yan Lv, Shao-Wa Lv, Guo-Yu Li, Hai-Xue Kuang
The combined administration of traditional Chinese medicine (TCM) aims at comprehensive adjustment of body based on the theory of TCM and the theory of Chinese medicine property. The natures and tastes of TCM are the core of the theory of TCM property. The combined administration of natures and tastes of TCM is one of the important theories of prescription compatibility. The objective of study on the combined administration of natures and tastes of prescriptions according to symptoms of disease is to clarify the compatibility mechanism of prescriptions...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Huan Du, Tong Xu, Hai-Jiao Li, Qi Li, Chen-Lei GangHuan, Gang Fan, Yi Zhang
Fecal Tibetan medicines have a long history of application in China, with a good clinical efficacy. In order to promote the development and modernization of these medicines, we consulted ancient and modern Tibetan medicine literatures to collect and summarize the names, original species, natures, flavor, functions and processing methods of fecal Tibetan medicines. A total of 35 fecal Tibetan medicines were collected, such as Jiufen, Heibingpian, Langfen, Mafen, Goufen, Gezifen. The most commonly used medicines were Jiufen and Heibingpian...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Hai-Xia Du, Hui-Fen Zhou, Yu He, Jie-Hong Yang, Yi-Yu Lu, Yi-Chen Fan, Hai-Tong Wan
This paper aimed to investigate the effect of Yinhua Pinggan granule and San-ao decoction on the immunologic mechanisms of influenza viral pneumonia mice in vivo , in order to study the activity of the combined administration of different formulas on influenza A/H1N1 virus. The model of pneumonia was established in mice through nasal dropping influenza virus, and then divided randomly into five groups: normal control group, influenza virus model group, oseltamivir control group, Yinhua Pinggan granule group, and San-ao decoction group...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Rong Zhao, Fei Shao, Hai-Bo Yin, Ting-Guo Kang
A rapid and accurate method was established by psbA-trnH sequence to distinguish Dioscorea nipponica from other species belonging to the same genus.In this study, we collected 144 samples of D. nipponica from 17 different producing areas in China, the psbA-trnH sequenced of 23 nucleotide sequences were downloaded from GenBank, the sequences from Dioscorea genus. DNAMAN 8.0 software was used to show splicing, MEGA 6.0 software was applied for sequence analysis and comparison. The results showed that the genetic relationship between D...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ping Xin, Hai-Xue Kuang, Xiao-Liang Li, Yu Wang, Ben-Mei Zhang, He Bu, Zhi-Bin Wang, Yong-Hai Meng, Yan-Hong Wang, Qiu-Hong Wang
There is no doubt that the traditional Chinese medicine(TCM) is effective, practical and scientific after it was used for thousands of years. However, the mechanisms of action of many TCM are still unclear because of their multi-component, multi-target and multi-level features, which hinder the modernization and internationalization of the TCM. Proteomics is to analyze the composition and activity of intracellular proteins which are changing dynamically from a holistic perspective. It is consistent with the holistic and dynamic views of the TCM and brings about the hope of clarifying the mechanism of action of the TCM...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Lei Cui, Zhi-Gang Li, Yi-Huan Chai, Jie Yu, Ju Gao, Xiao-Fan Zhu, Run-Ming Jin, Xiao-Dong Shi, Le-Ping Zhang, Yi-Jin Gao, Rui-Dong Zhang, Hu-Yong Zheng, Shao-Yan Hu, Ying-Hui Cui, Yi-Ping Zhu, Yao Zou, Margaret Hl Ng, Yan Xiao, Jun-Hui Li, Yong-Hong Zhang, Hai-Long He, Ying Xian, Tian-You Wang, Chi-Kong Li, Min-Yuan Wu
Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recruited from ten tertiary hospitals in eight cities. The patients were stratified according to clinical-biological characteristics and early treatment response. Standard risk (SR) and intermediate risk (IR) groups were treated with a modified BFM based protocol, and there was 25-50% dose reduction during intensification phases in the SR group...
April 20, 2018: American Journal of Hematology
Wen-Tao Yang, Gui-Lian Yang, Liang Zhao, Yu-Bei Jin, Yan-Long Jiang, Hai-Bin Huang, Chun-Wei Shi, Jian-Zhong Wang, Guan Wang, Yuan-Huan Kang, Chun-Feng Wang
Avian influenza virus (AIV) can infect poultry, mammals, and other hosts and causes enormous economic losses to the global poultry industry. In this study, to develop a novel and potent oral vaccine based on Lactobacillus plantarum (L. plantarum) for controlling the spread of AIV in the poultry industry, we constructed a recombinant L. plantarum strain displaying the 3M2e-HA2 protein of the influenza virus and determined the effect of N/pgsA'-3M2e-HA2 against AIV in chicks. We first confirmed that the 3M2e-HA2 fusion protein was expressed on the surface of L...
April 19, 2018: Applied Microbiology and Biotechnology
Fang-Zhou Jiao, Yao Wang, Hai-Yue Zhang, Wen-Bin Zhang, Lu-Wen Wang, Zuo-Jiong Gong
Neuroinflammation involves in the progression of many central nervous system diseases. Several studies have shown that histone deacetylase (HDAC) inhibitors modulated inflammatory responses in lipopolysaccharide (LPS) stimulated microglia. While, the mechanism is still unclear. The aim of present study was to investigate the effect of HDAC2 inhibitor CAY10683 on inflammatory responses and TLR4/NF-κB signaling pathways in LPS activated BV2 microglial cells and LPS induced mice neuroinflammation. The effect of CAY10683 on cell viability of BV2 microglial cells was detected by CCK-8 assay...
April 19, 2018: Neurochemical Research
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