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https://www.readbyqxmd.com/read/29928964/spinal-interleukin-10-produces-antinociception-in-neuropathy-through-microglial-%C3%AE-endorphin-expression-separated-from-antineuroinflammation
#1
Hai-Yun Wu, Xiao-Fang Mao, Xue-Qi Tang, Usman Ali, Evhy Apryani, Hao Liu, Xin-Yan Li, Yong-Xiang Wang
Interleukin 10 (IL-10) is antinociceptive in various animal models of pain without induction of tolerance, and its mechanism of action was generally believed to be mediated by inhibition of neuroinflammation. Here we reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, with ED50 values of 40.8 ng and 24 ng, and Emax values of 61.5% MPE and 100% MPE in male rats. Treatment with IL-10 specifically increased expression of the β-endorphin (but not prodynorphin) gene and protein in primary cultures of spinal microglia but not in astrocytes or neurons...
June 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29928884/lactic-acid-induces-lactate-transport-and-glycolysis-oxphos-interconversion-in-glioblastoma
#2
Ke Duan, Zhong-Jian Liu, Su-Qiong Hu, Hong-Yu Huo, Zhi-Ru Xu, Jian-Fei Ruan, Yang Sun, Li-Ping Dai, Chang-Bao Yan, Wei Xiong, Qing-Hua Cui, Hai-Jing Yu, Min Yu, Yang Qin
The Warburg effect is a dominant phenotype of most tumor cells. Recent reports have shown that the Warburg effect can be reprogrammed by the tumor microenvironment. Lactic acidosis and glucose deprivation are the common adverse microenvironments in solid tumor. The metabolic reprogramming induced by lactic acid and glucose deprivation remains to be elucidated in glioblastoma. Here, we show that, under glucose deprivation, lactic acid can preserve high ATP levels and resist cell death in U251 cells. At the same time, we find that MCT1 and MCT4 are significantly highly expressed...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928603/the-compression-of-l5-nerve-root-single-or-double-sites-radiographic-graded-signs-intra-operative-detect-technique-and-clinical-outcomes
#3
Ai-Min Wu, Kai Zhang, Xun-Lin Li, Xiao-Fei Cheng, Tang-Jun Zhou, Lin Du, Chen Chen, Hai-Jun Tian, Xiao-Jiang Sun, Chang-Qing Zhao, Yan Michael Li, Jie Zhao
Background: The L5 nerve root could be compressed at both L4-5 and L5-S1 regions. If L5 nerve root has confirmed compression at L4-5 level and questionable compression at L5-S1 foramina, performing both surgeries at L4-5 and L5-S1 levels may induce unnecessary extra surgery on L5-S1; however, ignoring foraminal stenosis of L5/S1 may require re-exploration. Methods: Two hundred seventeen patients with L5 nerve root compressed at L4-5 lateral access were performed with L4-5 decompression and interbody fusion...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928484/long-non-coding-rna-rab11b-as1-prevents-osteosarcoma-development-and-progression-via-its-natural-antisense-transcript-rab11b
#4
Zhixu Chen, Zezheng Liu, Yang Yang, Zhaoyin Zhu, Ridong Liang, Bin Huang, Di Wu, Lei Yang, Hai Lu, Dadi Jin, Qingchu Li
Long non-coding RNAs (lncRNAs) have been shown to exert essential roles in development and progression of tumors. Here we discovered a novel lncRNA, RAB11B antisense RNA (RAB11B-AS1), which is markedly down-regulated in human osteosarcoma (OS) and associated with OS metastasis and poor prognosis. We find that reduction of RAB11B-AS1 significantly facilitates proliferation, migration and invasiveness and prevents apoptosis of OS cells and results in lower sensitivity to cisplatin in these cells. In contrast, up-regulation of RAB11B-AS1 suppresses the aggressive behaviors of OS cells...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928347/hiwi-overexpression-does-not-affect-proliferation-migration-or-apoptosis-of-liver-cancer-cells-in-vitro-or-in-vivo
#5
Hao Li, Chen-Xi Shi, Hui Liu, Hai-Han Zhang, Huai-Ming Sang, Muhammad-Djaleel Soyfoo, Jiu-Liang Cao, Shun-Fu Xu, Jian-Xia Jiang
Piwi like RNA-mediated gene silencing 1 (Hiwi) is a human homolog of the Piwi gene family that has been reported to be upregulated in hepatocellular carcinoma (HCC). The present study aimed to investigate the role of Hiwi in the initiation and development of HCC in vitro and in vivo . Adenovirus-mediated Hiwi overexpression was established in primary murine hepatocytes and SMMC7721 HCC cells. Cell viability and proliferation were assessed using MTT and EdU assays, respectively. Cell migration was measured using a scratch migration assay...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928333/combined-treatment-with-acetazolamide-and-cisplatin-enhances-chemosensitivity-in-laryngeal-carcinoma-hep-2-cells
#6
Hong Gao, Hai Dong, Guijun Li, Hui Jin
The aim of the present study was to determine whether acetazolamide (Ace) treatment enhances the chemosensitivity of Hep-2 laryngeal cells to cisplatin (Cis). At the logarithmic growth phase, Hep-2 cells were treated with Ace, Cis or both, and cell viability was detected using an MTT assay. The degree of apoptosis was detected using flow cytometry. Expression levels of apoptosis-related proteins, including BCL2 apoptosis regulator (bcl-2), BCL2 associated X (bax) and caspase-3, and of proliferation-related proteins, including proliferating cell nuclear antigen (PCNA) and tumor protein p53 (P53), were detected using western blotting...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928331/mir-888-functions-as-an-oncogene-and-predicts-poor-prognosis-in-colorectal-cancer
#7
Su-Jun Gao, Lei Chen, Wei Lu, Li Zhang, Lu Wang, Hai-Hang Zhu
MicroRNAs (miRNAs) are important regulators of tumor formation, progression and metastasis. The present study characterized a novel miRNA (miR)-888, as a potent oncomiR in human colorectal cancer (CRC). The clinicopathological investigation on 126 cases of CRC patients demonstrated that the expression level of miR-888 was significantly upregulated in tumors compared with adjacent healthy tissue, and was associated with tumor stage and histological differentiation. A Kaplan-Meier analysis and log-rank test demonstrated that CRC patients with increased miR-888 expression exhibited a decreased overall survival (OS) and disease-free survival (DFS) compared with patients with low miR-888 expression...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928229/nrf2-is-a-key-regulator-on-puerarin-preventing-cardiac-fibrosis-and-upregulating-metabolic-enzymes-ugt1a1-in-rats
#8
Shao-Ai Cai, Ning Hou, Gan-Jian Zhao, Xia-Wen Liu, Ying-Yan He, Hai-Lin Liu, Yong-Quan Hua, Li-Rong Li, Yin Huang, Cai-Wen Ou, Cheng-Feng Luo, Min-Sheng Chen
Puerarin is an isoflavone isolated from Radix puerariae . Emerging evidence shown that puerarin possesses therapeutic benefits that aid in the prevention of cardiovascular diseases. In this study, we evaluated the effects of puerarin on oxidative stress and cardiac fibrosis induced by abdominal aortic banding (AB) and angiotensin II (AngII). We also investigated the mechanisms underlying this phenomenon. The results of histopathological analysis, as well as measurements of collagen expression and cardiac fibroblast proliferation indicated that puerarin administration significantly inhibited cardiac fibrosis induced by AB and AngII...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29928017/the-contribution-of-cause-effect-link-to-representing-the-core-of-scientific-paper-the-role-of-semantic-link-network
#9
Mengyun Cao, Xiaoping Sun, Hai Zhuge
The Semantic Link Network is a general semantic model for modeling the structure and the evolution of complex systems. Various semantic links play different roles in rendering the semantics of complex system. One of the basic semantic links represents cause-effect relation, which plays an important role in representation and understanding. This paper verifies the role of the Semantic Link Network in representing the core of text by investigating the contribution of cause-effect link to representing the core of scientific papers...
2018: PloS One
https://www.readbyqxmd.com/read/29927930/efficacy-and-safety-of-low-molecular-weight-heparin-after-knee-arthroscopy-a-meta-analysis
#10
Hai-Feng Huang, Jia-Liang Tian, Xian-Teng Yang, Li Sun, Ru-Yin Hu, Zhi-Hui Yan, Shan-Shan Li, Quan Xie, Xiao-Bin Tian
BACKGROUND: Venous thromboembolism (VTE) is considered a potentially serious complication of knee arthroscopy and leads to conditions such as deep venous thrombosis (DVT) and pulmonary embolism (PE). Low-molecular-weight heparin (LMWH) is widely employed in knee arthroscopy to reduce perioperative thromboembolic complications. However, the efficacy and safety of LMWH in knee arthroscopy remains unclear. METHODS: Seven randomized controlled clinical trials on LMWH in knee arthroscopy were identified and included in this meta-analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29927831/anatomical-characterization-and-three-dimensional-modeling-of-the-muscles-at-the-corner-of-the-mouth-an-iodine-staining-technique-based-on-microcomputed-tomography
#11
Min Sun, Guo C Chen, Yong Q Wang, Tao Song, Hai D Li, Di Wu, Ning B Yin
The anatomy of the modiolus and surrounding muscles is complicated and contributes to the morphology of the mouth corner. We used iodine staining and micro-computed tomography (CT) to observe the anatomy of the modiolus and surrounding muscles. Based on the micro-CT images and the 3D model construction, we found that the muscle fibers in the modiolus were oriented continuously in the running direction of the muscle itself and that there were no chaotic clumps in the region of muscle fiber convergence. The pars marginalis of the orbicularis oris muscle connects with the deep buccinators muscle, which may account for how the pars marginalis fibers act to press the upper lip against the maxillary teeth or invert it closer to the oral cavity...
June 14, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927648/toward-real-time-infoveillance-of-twitter-health-messages
#12
Jason B Colditz, Kar-Hai Chu, Sherry L Emery, Chandler R Larkin, A Everette James, Joel Welling, Brian A Primack
There is growing interest in conducting public health research using data from social media. In particular, Twitter "infoveillance" has demonstrated utility across health contexts. However, rigorous and reproducible methodologies for using Twitter data in public health are not yet well articulated, particularly those related to content analysis, which is a highly popular approach. In 2014, we gathered an interdisciplinary team of health science researchers, computer scientists, and methodologists to begin implementing an open-source framework for real-time infoveillance of Twitter health messages (RITHM)...
June 21, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29927087/trajectories-after-first-episode-psychosis-complement-to-ambiguous-outcomes-of-long-term-antipsychotic-treatment-by-exploring-a-few-hidden-cases
#13
Chen-Chung Liu, Yi-Ting Lin, Chih-Min Liu, Ming H Hsieh, Yi-Ling Chien, Tzung-Jeng Hwang, Hai-Gwo Hwu
AIM: Patient's long-term phenomenology after first-episode psychosis could be blurred due to early intervention. The contradictory messages regarding necessity of long-term antipsychotic treatment derived from different methodologies warrants careful reappraisal. METHODS: We approached a group of patients lost to follow-up in a previous study. Targeting these 44 missing patients, we sent 2 carefully worded letters to invite them for interviews to see if their life trajectories were different from those who stayed in a university-based hospital system...
June 21, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29926924/future-time-perspective-and-interpersonal-empathy-implications-for-preferring-autonomy-versus-dependency-oriented-helping
#14
Lily Chernyak-Hai, Samer Halabi
We examined whether potential help givers' future time perspective (FTP) accounts for the decision to give a person in need dependency-oriented help (i.e., providing the complete solution) or autonomy-oriented help (i.e., providing the means to solve a problem). In addition, building on past research on the effects of empathy in help giving decisions, the present research explored whether helpers' willingness to offer specific type of help is predicted by the interaction between FTP and interpersonal empathy...
June 21, 2018: British Journal of Social Psychology
https://www.readbyqxmd.com/read/29926834/small-worldness-of-brain-networks-after-brachial-plexus-injury-a-resting-state-functional-magnetic-resonance-imaging-study
#15
Wei-Wei Wang, Ye-Chen Lu, Wei-Jun Tang, Jun-Hai Zhang, Hua-Ping Sun, Xiao-Yuan Feng, Han-Qiu Liu
Research on brain function after brachial plexus injury focuses on local cortical functional reorganization, and few studies have focused on brain networks after brachial plexus injury. Changes in brain networks may help understanding of brain plasticity at the global level. We hypothesized that topology of the global cerebral resting-state functional network changes after unilateral brachial plexus injury. Thus, in this cross-sectional study, we recruited eight male patients with unilateral brachial plexus injury (right handedness, mean age of 27...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29926763/a-need-for-better-understanding-is-the-major-determinant-for-public-perceptions-of-human-gene-editing
#16
Tristan McCaughey, David Mark Budden, Paul G Sanfilippo, George E C Gooden, Li Fan, Eva Fenwick, Gwyneth Rees, Casimir MacGregor, Lei Si, Christine Chen, Helena Hai Liang, Alice Pebay, Timothy Baldwin, Alex W Hewitt
BACKGROUND: The CRISPR/Cas system could provide an efficient and reliable means of editing the human genome and has the potential to revolutionise modern medicine; however, rapid developments are raising complex ethical issues. There has been significant scientific debate regarding the acceptability of some applications of CRISPR/Cas, with leaders in the field highlighting the need for the lay public's views to shape expert discussion. As such, we sought to determine the factors that influence public opinion on gene editing...
June 21, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29926753/dexmedetomidine-attenuates-cerebral-ischemia-reperfusion-injury-in-neonatal-rats-by-inhibiting-tlr4-signaling
#17
Jiangxia Cheng, Pengfei Zhu, Han Qin, Xia Li, Hai Yu, Hui Yu, Xiaohong Peng
Objective The sedative dexmedetomidine plays a role in multi-organ protection by inhibiting toll-like receptor (TLR) 4 expression in ischemia/reperfusion injury. The present study investigated whether the neuroprotective effects of dexmedetomidine could be blocked by the TLR4 agonist lipopolysaccharide. Methods We established a cerebral ischemia/reperfusion model in neonatal Sprague-Dawley rats through bilateral carotid artery occlusion for 20 minutes followed by a 2-hour reperfusion. Rats were assigned to four groups: Sham operation, ischemia/reperfusion, ischemia/reperfusion preceded by dexmedetomidine treatment (10 µg/kg), and ischemia/reperfusion preceded by dexmedetomidine (10 µg/kg) and lipopolysaccharide (500 µg/kg) treatments...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29926684/-effect-of-yuyin-ruangan-granule-on-tgf-%C3%AE-1-expression-in-hepatic-fibrosis-rats
#18
Zhi-Wang Wang, Xiao-Yan Fu, Xiao-Li Cheng, Xiao-Ying Bao, Xue-Feng Liu, Hai-Jing Duan
OBJECTIVES: To observe the preventive and therapeutic action of Yuyin Ruangan Granule (YRG, Traditional Chinese Medicine) in hepatic fibrosis rats model and its effect on transforming growth factor-β1 (TGF-β1) expression. METHODS: The Wistar rats were randomly divided into 6 group ( n =10), and the model of hepatic fibrosis rats was established by subcutaneous injected with carbon tetrachloride (CCL4), fed on high-fat diet and 20% ethanol for 6 weeks, to survey the effect and mechanism of YRG preventing hypatic fibrosis by detecting liver function (the activity of alanine aminotransferase(ALT), aspartate aminotransferase(AST), etc...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926681/-the-influence-of-benazepril-and-amlodipine-on-the-expression-of-secretin-and-somatostatin-in-spontaneously-hypertensive-rats
#19
Hua Jin, Zhi-Jun Liu, Chun-Lu Yan, Feng-Lin Liu, Li Chen, Qiu-Ju Zhang, Hou-Qian Xu, Ji-Hong Hu, Rong-Hai Dou, Xin-Yang Wen
OBJECTIVES: Investigate the influence of benazepril and amlodipine on the expression of secretin (PZ) and somatostatin (SS) in spontaneously hypertensive rats (SHR). METHODS: Forty-five SHRs (14 weeks old, male) were randomly assigned into 3 groups ( n =15):SHR group, Benazepril group (which was given benazepril 0.90 mg·kg-1 ·d-1 ) and Amlodipine group (SHRs were given amlodipine 0.45 mg· kg-1 ·d-1 ), taking WistarKyoto(WKY) as normal control ( n =15), meanwhile, rats in SHR group and WKY group were given the same volume of distilled water...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926676/-effect-of-two-kinds-of-fermented-food-on-blood-glucose-and-lipids-in-induced-diabetic-mice
#20
Yong-Qiu Yan, Guan-Hai Dai, Shi-Ping Jiang, Yu Lu, Ying-Peng Tong, Ping Wang
OBJECTIVES: To investigate the effect of two kinds of fermented food, noni juice and natto, on blood glucose and lipids in induced diabetic mice. METHODS: Female (ICR) mice were induced into diabetes by an injection of alloxan (55 mg/kg, i. v.). After 72 hours, those mice whose fasting blood glucose levels were over 12.00 mmol/L and urine sugar was strongly positive (+ + +) were regarded as diabetical model and were randomly divided into three groups ( n =10):diabetical model (DM) group, noni juice (NJ) group and natto (NT) group...
February 8, 2018: Chinese Journal of Applied Physiology
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