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Dong-Jie Xie, Hai-Song Shi, Simon S Y Lui, Chuan Shi, Ying Li, Karen K Y Ho, Karen S Y Hung, Wen-Xiu Li, Zheng-Hui Yi, Eric F C Cheung, Ann M Kring, Raymond C K Chan
The Clinical Assessment Interview for Negative Symptoms (CAINS) was designed in accordance with the recent theory and research in social affective neuroscience and to address the psychometric and conceptual limitations of other instruments assessing negative symptoms. The present study aimed to provide a large-scale validation of the CAINS in China and examine its applicability and validity evidence across the schizophrenia spectrum. Using confirmatory factor analysis, our results replicated the original findings in the US development samples that the CAINS possesses a stable 2-factor structure, namely "motivation/pleasure" and "expression"...
February 20, 2018: Schizophrenia Bulletin
Yu Dai, Amanda Li Cheng Tan, Huan Chen, Pei Shi Ong, Xiaoqiang Xiang, Jinzhu Wu, Hai-Shu Lin
Desoxyrhapontigenin (DRG, 4-methoxyresveratrol or trans-3,5-dihydroxy-4'-methoxystilbene) is a naturally occurring resveratrol (RES) derivative with a variety of biological activities. To facilitate its further medicinal exploration, a reliable LC-MS/MS method was developed and validated for the quantification of DRG in rat plasma using heavy isotope labelled RES as an internal standard. The ESI was operated in its negative ion mode while DRG and RES were determined by multiple reaction monitoring (MRM) using precursor-to-product ion transitions of m/z 241...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
Feng Zhu, Xiaofei Li, Jia-Wei Lu, Jing Hai, Jieru Zhang, Bing Xie, Chengyang Hong
Emission characteristics including congener's profile, gas emissions and toxic equivalent concentration (TEQ) indicators of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in 57 stack gas samples from 6 municipal solid waste incinerators (MSWIs) in Northern China were investigated by gas chromatography-high resolution mass spectrometry (HRGC-HRMS). Additionally, PCDD/Fs formation mechanisms from the MSWIs were briefly discussed. Results revealed that the concentrations and equivalent concentrations of PCDD/Fs emissions in stack gas from 6 MSWIs were in the range of 0...
February 16, 2018: Chemosphere
Ning Lyu, Yanan Kong, Luwen Mu, Youen Lin, Jibin Li, Yaru Liu, Zhenfeng Zhang, Lie Zheng, Haijing Deng, Shaolong Li, Qiankun Xie, Rongping Guo, Ming Shi, Li Xu, Xiuyu Cai, Peihong Wu, Ming Zhao
BACKGROUND & AIMS: To compare the overall survival (OS) and disease progression free survival (PFS) in patients with advanced hepatocellular carcinoma (Ad-HCC) who are undergoing hepatic arterial infusion (HAI) of oxaliplatin, fluorouracil/leucovorin (FOLFOX) treatment versus sorafenib. METHODS: This retrospective study was approved by the ethical review committee, and informed consent was obtained from all patients before treatment. HAI of FOLFOX (HAIF) was recommended as an alternative treatment option for patient who refused sorafenib...
February 19, 2018: Journal of Hepatology
Hai H Bui, Phillip E Sanders, Diane Bodenmiller, Ming Shang Kuo, Gregory P Donoho, Anthony S Fischl
Phosphatidylinositol (3,4,5) trisphosphate (PIP3 ) is a biologically active membrane phospholipid that is essential for the growth and survival of all eukaryotic cells. We describe a new method that directly measures PIP3 and describe the HPLC separation and measurement of the positional isomers of phosphatidylinositol bisphosphate, PI(3,5)P2 , PI(3,4)P2 and PI(4,5)P2 . Mass spectrometric analyses were performed online using ultra-high performance liquid chromatography (UHPLC)-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) in the negative multiple-reaction monitoring (MRM) modes...
February 19, 2018: Analytical Biochemistry
Yan Liu, Hai Wang, Wei Zhao, Min Zhang, Hongbo Qin, Yongqiang Xie
Wearable health monitoring systems have gained considerable interest in recent years owing to their tremendous promise for personal portable health watching and remote medical practices. The sensors with excellent flexibility and stretchability are crucial components that can provide health monitoring systems with the capability of continuously tracking physiological signals of human body without conspicuous uncomfortableness and invasiveness. The signals acquired by these sensors, such as body motion, heart rate, breath, skin temperature and metabolism parameter, are closely associated with personal health conditions...
February 22, 2018: Sensors
Wu Yan-Cheng, Liang Cao, Wen-Jie Mei, Han-Qing Wu, Shi-He Luo, Hai-Ying Zhan, Zhao-Yang Wang
New bis-2(5H)-furanone derivatives containing a benzidine core were synthesized via a one-step transition-metal-free reaction of benzidine with 5-substituted 3,4-dihalo-2(5H)- furanones. Their antitumor activities against various tumor cells have been evaluated by MTT assay. Among them, compound 4e exhibits significant inhibitory activity against C6 glioma cells with an IC50 value of 12.1 μM and low toxicity toward HaCaT human normal cells. Studies on the antitumor mechanism reveal that cell cycle arrest at S-phase in C6 cells is induced by compound 4e...
February 22, 2018: Chemical Biology & Drug Design
Yin Jian-Hai, Shen Yu-Juan, Yu Ai-Ping, Cao Jian-Ping
OBJECTIVE: To preliminarily study the pro-angiogenic activity of Echinococcus granulosus hydatid cysts against human umbilical vein endothelial cells in vitro and the transcriptional level of potential pro-angiogenic factors. METHODS: The hydatid cysts and protoscolex derived from experimentally infected mice were collected and cultured in vitro , then the human umbilical vein endothelial cells were stimulated by the supernatant and cyst fluid respectively, and the angiogenesis was observed and analyzed through a microscope and the angiogenesis mode of the software NIH Image J...
May 23, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Chen Wei, Dong Chen, You Lu, Tang Feng, Hua Hai-Yong
OBJECTIVE: To study the expression profiles of circulating microRNAs (miRNAs) in newly-developed advanced schistosomiasis patients. METHODS: Ten healthy controls (Group 1), ten patients with schistosomiasis history (without advanced schistosomiasis, Group 2) and ten patients with newly-developed advanced schistosomiasis (Group 3) were randomly selected from Jiangsu Province. The expression profiles of 570 human related circulatingmiRNAs were measured and analyzed with the Agilent Human microRNAs microarray Rel 12...
December 12, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Jin Yan-Jun, Cai Li, Zhang Yao-Guang, He Yan-Yan, Sun Cai-Ying, Yu Rui-Fang, Fang Wei, Yu Xue-Qin, Zhang Hai-Bing
OBJECTIVE: To understand the risk situation of imported schistosomiasis and its main influencing factors in Shanghai City from 2005 to 2015. METHODS: A retrospective survey was performed, and the database was established based on the data collection of imported schistosomiasis, Oncomelania hupensis snail situation and mobile population in Shanghai City from 2005 to 2015. RESULTS: From 2005 to 2015, the mobile population in Shanghai City increased by 123...
December 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Chen Ying-Dan, Zhu Ting-Jun, Xu Long-Qi, Zhen Bin, Xiong Yan-Hong, Zhou Chang-Hai
Clonorchis sinensis infection is carcinogenic to human, which results in cholangiocarcinoma, confirmed by the World Health Organization. An investigation in 2005 indicated that the standardized C. sinensis infection rate was 0.58%, with 12 490 000 infected people estimated in the clonorchiasis endemic areas in China. In the world, 80% of C. sinensis infected people were distributed in China. Diagnostic Criteria for Clonorchiasis (WS309-2009) was compiled by the ex-Ministry of Health of the People's Republic of China and it was issued and implemented in March 13, 2009...
October 17, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Liu Hui, Xiao Ning, Yang Shi-Jie, Wang Dong, Peng Jia
The Qinghai-Tibet Plateau is known as one of the highest endemic areas of echinococcosis. However, the dog infection rates of Echinococcus granulosus in the plateau regions were similar to other non-Tibetan areas with the high endemic, and most of the rates were below 40%. The infected dogs with E. multilocularis were ubiquitous in Ganzi Prefecture of Sichuan Province and Qinghai Province where many survey data were done and available, which was much different from those in non-Ti-betan areas where the geographical distribution of dogs infected with E...
April 7, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Yan Li, Shu-Xiao Li, Fei Gao, Hai-Ou Li, Gang Xu, Ke Wang, Di Liu, Gang Cao, Ming Xiao, Ting Wang, Jianjun Zhang, Guang-Can Guo, Guo-Ping Guo
Realizing a strong coupling between spin and resonator is an important issue for scalable quantum computation in semiconductor systems. Benefiting from the advantages of strong spin-orbit coupling strength and long coherence time, the Ge hut wire, which is proposed to be site-controlled grown for scalability, is considered as a promising candidate to achieve this goal. Here we present a hybrid architecture in which an on-chip superconducting microwave resonator is coupled to the holes in a Ge quantum dot. The charge stability diagram can be obtained from the amplitude and phase response of the resonator independently from the DC transport measurement...
February 22, 2018: Nano Letters
Dong-Yi Hsieh, Jen-Wen Hung, Ku-Chou Chang, Yu-Ching Huang, Tsong-Hai Lee, Hsiu-Min Chen
BACKGROUND: Stroke results in high mortality with tremendous health care burden. Malnutrition is frequently observed in patients after stroke. This study was designed to explore the nutritional status in the acute stage of stroke aiming at exploring factors related to malnutrition after stroke. METHODS: This was a hospital based, prospective, observational study recruiting cerebrovascular diseases patients hospitalized for acute management. Patients suffered from all kinds of cerebrovascular diseases hospitalized for management within 30 days after onset were consecutively recruited in the study hospitals...
September 15, 2017: Acta Neurologica Taiwanica
Hai-Quyen Tran, Youngho Lee, Eun-Joo Shin, Choon-Gon Jang, Ji Hoon Jeong, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima, Hyoung-Chun Kim
We investigated whether a specific serotonin (5-HT) receptor-mediated mechanism was involved in dextromethorphan (DM)-induced serotonergic behaviors. We firstly observed that the activation of 5-HT1A receptor, but not 5-HT2A receptor, contributed to DM-induced serotonergic behaviors in mice. We aimed to determine whether the upregulation of 5-HT1A receptor induced by DM facilitates the specific induction of certain PKC isoform, because previous reports suggested that 5-HT1A receptor activates protein kinase C (PKC)...
February 22, 2018: Molecular Neurobiology
Xiang-Bin Su, Ying Ding, Ben Ma, Ke-Lu Zhang, Ze-Sheng Chen, Jing-Lun Li, Xiao-Ran Cui, Ying-Qiang Xu, Hai-Qiao Ni, Zhi-Chuan Niu
The device characteristics of semiconductor quantum dot lasers have been improved with progress in active layer structures. Self-assembly formed InAs quantum dots grown on GaAs had been intensively promoted in order to achieve quantum dot lasers with superior device performances. In the process of growing high-density InAs/GaAs quantum dots, bimodal size occurs due to large mismatch and other factors. The bimodal size in the InAs/GaAs quantum dot system is eliminated by the method of high-temperature annealing and optimized the in situ annealing temperature...
February 21, 2018: Nanoscale Research Letters
Rui-Juan Lv, Hai-Tao Ren, Hong-Zhi Guan, Tao Cui, Xiao-Qiu Shao
Objective: The purpose of this study is to analyze the seizure semiologic characteristics of patients with autoimmune epilepsy (AE) and describe the investigation characteristics of AE using a larger sample size. Methods: This observational retrospective case series study was conducted from a tertiary epilepsy center between May 2014 and March 2017. Cases of new-onset seizures were selected based on laboratory evidence of autoimmunity. At the same time, typical mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS) were recruited as the control group from the subjects who underwent presurgical evaluation during the same period...
February 2018: Annals of Clinical and Translational Neurology
Yi-Je Chen, Hai M Nguyen, Izumi Maezawa, Lee-Way Jin, Heike Wulff
Objective: Inhibitors of the voltage-gated K+ channel Kv1.3 are currently in development as immunomodulators for the treatment of autoimmune diseases. As Kv1.3 is also expressed on microglia and has been shown to be specifically up-regulated on "M1-like" microglia, we here tested the therapeutic hypothesis that the brain-penetrant small-molecule Kv1.3-inhibitor PAP-1 reduces secondary inflammatory damage after ischemia/reperfusion. Methods: We studied microglial Kv1...
February 2018: Annals of Clinical and Translational Neurology
Ying Fu, Yi-Na Sun, Ke-Han Yi, Ming-Qiang Li, Hai-Feng Cao, Jia-Zhong Li, Fei Ye
4-Hydroxyphenylpyruvate dioxygenase (EC, HPPD) is a potent new bleaching herbicide target. Therefore, in silico structure-based virtual screening was performed in order to speed up the identification of promising HPPD inhibitors. In this study, an integrated virtual screening protocol by combining 3D-pharmacophore model, molecular docking and molecular dynamics (MD) simulation was established to find novel HPPD inhibitors from four commercial databases. 3D-pharmacophore Hypo1 model was applied to efficiently narrow potential hits...
2018: Frontiers in Chemistry
Rimal H Dossani, Devi P Patra, Hai Sun, Anil Nanda, Federico Ampil
The management of patients with multiple brain metastases, in contrast to those with solitary metastases, continues to evolve. Recent evidence suggests that aggressive microsurgical and radiosurgical management of patients with multiple brain metastases may lead to improved survival and quality of life. The three cases discussed in this report are examples of patients with multiple brain metastases who had excellent outcomes following treatment with microsurgical and radiosurgical approaches. A common feature of each patient is the presence of multiple metastases in the region of the motor cortex...
December 14, 2017: Curēus
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