Long Ma, Chen Zhu, Yun-Fei Wei, Jin-Yong Zhou, Min Chen, Xin Zhang, Ping Zhou, Yan Wang, Jian Wang, Chu Can, Jing-Yuan Tang, Yan Xu
Spinal cord injury often results in chronic loss of micturition control, which is featured by bladder hyperreflexia and detrusor sphincter dyssynergia. Previous studies showed that treatment of capsaicin reduces non-voiding bladder contractions in multiple animal injury models and human patients. However, its underlying neural mechanisms remain largely unknown. Here, by injecting a RetroAAV into the bladder wall, we specifically targeted TRPV1+ , a capsaicin receptor, bladder afferent neurons. Morphometric analysis revealed borderline increase of the soma size and significant spinal axon sprouting of TRPV1+ bladder afferent neurons post a complete T8 spinal cord crush...
January 8, 2024: Experimental Neurology