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Non Linear

Wankun Xie, Min Zhao, Shu-Huai Tsai, William L Burkes, Luke B Potts, Wenjuan Xu, H Ross Payne, Travis W Hein, Lih Kuo, Robert H Rosa
Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo. Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling the human retina, is limited. Herein, we correlated the hypo- and hyper-reflective bands on SD-OCT with histology of the lamellar architecture and cellular constituents of the porcine retina. SD-OCT images were acquired with the Heidelberg Spectralis HRA + OCT. Histological analysis was performed using epoxy resin embedded tissue and transmission electron microscopy...
August 15, 2018: Experimental Eye Research
Jiří Pazourek
Saccharides and their derivatives are typical polar analytes without a suitable UV-chromophore that are nowadays analyzed by HPLC (High-Performance Liquid Chromatography) under HILIC (Hydrophilic Interaction Liquid Chromatography) mode. Usually Evaporative Light Scattering Detector (ELSD) is utilized which, however, gives a non-linear response. A procedure how to overcome the problem of mutarotating (time-varying) analytes recorded with such a non-linear response detector is described. The procedure was applied for determination of glucosamine in two commercially available pharmaceutical formulations containing common inorganic ions the detector gives a response to...
August 17, 2018: Biomedical Chromatography: BMC
Habib Bagheri, Gohar Soofi, Hasan Javanmardi, Majid Karimi
Polyhedral oligomeric silsesquioxanes are 3D nanoscaled materials with large potential in solid phase microextraction (SPME). Here, as a case study, an octaglycidyldimethylsilyl modified polyhedral oligomeric silsesquioxane network is described. It was deposited on a stainless steel wire via a sol-gel method and used as a fiber coating for SPME of aromatic compounds. The uniform pore structure, high surface area, and hydrophobicity of the network make it susceptible toward isolation of non-polar and semi-polar chemical compounds...
August 17, 2018: Mikrochimica Acta
Mehdi Momen, Ahmad Ayatollahi Mehrgardi, Ayyub Sheikhi, Andreas Kranis, Llibertat Tusell, Gota Morota, Guilherme J M Rosa, Daniel Gianola
Recent work has suggested that the performance of prediction models for complex traits may depend on the architecture of the target traits. Here we compared several prediction models with respect to their ability of predicting phenotypes under various statistical architectures of gene action: (1) purely additive, (2) additive and dominance, (3) additive, dominance, and two-locus epistasis, and (4) purely epistatic settings. Simulation and a real chicken dataset were used. Fourteen prediction models were compared: BayesA, BayesB, BayesC, Bayesian LASSO, Bayesian ridge regression, elastic net, genomic best linear unbiased prediction, a Gaussian process, LASSO, random forests, reproducing kernel Hilbert spaces regression, ridge regression (best linear unbiased prediction), relevance vector machines, and support vector machines...
August 17, 2018: Scientific Reports
Nadeem Muhammad, Abdul Rahman, Muhammad Adnan Younis, Qamar Subhani, Khurram Shehzad, Hairong Cui, Yan Zhu
Nowadays, there are rising concerns about the extensive use of the antibiotics such as chloramphenicol (CAP), has threatened the human life in the form of various vicious diseases. The limited selectivity and sensitivity of confirmatory techniques (UV and electrochemical) and non-fluorescence property of CAP make its determination a challenging task in the modern pharmaceutical analysis. In order to redeem the selective, sensitive and cost-effective fluorescence methodology, here by the dual role of synthesized porous SnO2 nanoparticles were exploited; (i) a porous sorbent in a µ-QuEChERS based sample preparation and as (ii) a stimulant for the transformation of non-fluorescent analytes namely CAP and p-nitrophenol (p-NP) into their respective fluorescent product...
August 17, 2018: Scientific Reports
Jing Li, Xiaoxu Huo, Yun-Feng Cao, Sai-Nan Li, Zuo Du, Ping Shao, Junhong Leng, Cuiping Zhang, Xiao-Yu Sun, Ronald C W Ma, Zhong-Ze Fang, XilinYang
BACKGROUND: Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM). METHODS: We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in China: 243 women with GDM were matched with 243 non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline were used to examine full-range associations of bile acid metabolites with GDM...
August 14, 2018: EBioMedicine
Weixia Li, Lin Huang, Dandan Guo, Yonggang Zhao, Yan Zhu
The growing use of non-steroidal anti-inflammatory drugs (NSAIDs) has seriously affected human health and ecosystems, as a result, the World Health Organization (WHO) has regarded them as emerging contaminants. NSAID's polar nature and trace amount present in wastewater make their extraction and determination challenging in modern analytical science. Therefore, regarding the need, we herein report a rapid, sensitive and selective in-syringe solid-phase extraction (SPE) method coupled with ultrahigh performance liquid chromatography and UV detector for the determination of seven NSAIDs in environmental water samples...
August 9, 2018: Journal of Chromatography. A
Chet Preston, Willard S Kasoff, Russell S Witte
We describe a new application of acoustoelectric imaging for non-invasive mapping of the location, magnitude and polarity of current generated by a clinical deep brain stimulation (DBS) device. Ultrasound at 1 MHz was focused near the DBS device as short current pulses were injected across different DBS leads. A recording electrode detected the high-frequency acoustoelectric interaction signal. Linear scans of the US beam produced time-varying images of the magnitude and polarity of the induced current, enabling precise localization of the DBS leads within 0...
August 14, 2018: Ultrasound in Medicine & Biology
Jean de Dieu Habimana, Jian Ji, Fuwei Pi, Eric Karangwa, Jiadi Sun, Wei Guo, Fangchao Cui, Jingdong Shao, Claudine Ntakirutimana, Xiulan Sun
Herein, a novel class-specific artificial receptor-based on molecularly imprinted polymer (MIP)-coated quantum dots (QDs@MIP) was synthesized, characterized, and used for the detection and quantification of the bacterial quorum signaling molecules N-acyl-homoserine lactones (AHLs), a class of autoinducers from Gram-negative bacteria. The QDs@MIP was prepared by surface imprinting technique under controlled conditions using CdSe/ZnS QDs as the signal transducing material. The synthesis of the QDs@MIP was characterized by transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis, and fluorescence spectroscopy...
November 15, 2018: Analytica Chimica Acta
Francesca Solmi, Daniela Melamed, Glyn Lewis, James B Kirkbride
BACKGROUND: Psychotic experiences might represent non-specific markers of poor mental health in adolescence. However, only a few predominantly cross-sectional studies have tested their association with disordered eating behaviours in adolescent and adult populations. The aim of this study was to explore the association between psychotic experiences at age 13 years, and disordered eating behaviours and body-mass index (BMI) at age 18 years. METHODS: We used data from the Avon Longitudinal Study of Parents and Children, a longitudinal birth cohort based in Avon (England, UK) including mothers with an expected delivery date between April 1, 1991, and Dec 31, 1992, and their children...
August 2018: Lancet Child & Adolescent Health
Jian Jia, Yayu Tang, Chong Shen, Ning Zhang, Haixia Ding, Yiyang Zhan
BACKGROUND: The goal of this study was to determine if vitamin D receptor (VDR) gene polymorphisms underlie susceptibility to dyslipidemia in a Chinese Han population. METHODS: Three tag single nucleotide polymorphisms (SNPs) (rs11574129, rs2228570, and rs739837) were genotyped using TaqMan assays to determine VDR SNP associations with dyslipidemia. We genotyped 877 cases of dyslipidemia from a normotensive, non-diabetes mellitus population and 1822 non-dyslipidemia subjects in a stage I study...
August 17, 2018: Lipids in Health and Disease
Zhixiang Deng, Jun Liu, Xianwei Huang, Chujun Zhao, Xinlin Wang
We demonstrate that the optical event horizon can provide an effective technique to actively control the propagation properties of a dark soliton with another weak probe wave. Careful power adjustment of the probe wave enables the black soliton converted into a gray one with varying grayness through the nonlinear interaction, corresponding to a nearly adiabatic variation of the soliton's speed. The sign of the phase angle for the newly formed gray soliton at optical event horizon is significantly dependent on the frequency of the launched probe wave...
June 25, 2018: Optics Express
Zhisheng Yang, Zonglei Li, Simon Zaslawski, Luc Thévenaz, Marcelo A Soto
The performance of unipolar unicolor coded Brillouin optical time-domain analysis (BOTDA) is evaluated based on both Simplex and Golay codes. Four major detrimental factors that limit the system performance, including decoded-gain trace distortion, coding pulse power non-uniformity, polarization pulling and higher-order non-local effects, are thoroughly investigated. Through theoretical analysis and an experimental validations, solutions and optimal design conditions for unipolar unicolor coded BOTDA are clearly established...
June 25, 2018: Optics Express
Sayoob Vadakke-Chanat, Palanisamy Shanmugam, Balasubramanian Sundarabalan
Three-dimensional simulations using the Monte Carlo method are implemented to analyze and quantify the uncertainty and the influence of absorption on the measurement of light backscattering by ECO-BB9 (WET Labs) sensor for a wide variety of optically complex and open ocean waters. The analytical investigation of the geometrical configuration revealed a distinct effective path length which contributes towards an accurate assessment of absorption effect on the backscattering measurement. The present study proposes the application of a non-linear relationship to determine the measured parameter from the detector counts more accurately than the conventional method that applies the scale factor...
August 6, 2018: Optics Express
A Kiet Tran, Achyut Sapkota, Jianming Wen, Jianping Li, Masahiro Takei
We have developed a non-invasive rapid and real-time red blood cell (RBC) hemolysis detection method which is a more accurate for point of care testing of hemolysis in various medical settings. An eight-parameter equivalent circuit is employed to quantify the release of hemoglobin (Hb ) and the cytoplasm from RBC into the blood plasma. RBC hemolysis is induced by adding different volume fractions of distilled water into the blood. The cytoplasm released following RBC hemolysis is estimated from the experimental values...
August 9, 2018: Biosensors & Bioelectronics
Ashley A Wiedemann, Valentina Ivezaj, Carlos M Grilo
Emotional eating has been identified as a predictor of poorer weight loss outcomes in non-bariatric clinical samples. It is unknown, however, whether emotional eating contributes to poorer weight loss outcomes after bariatric surgery or how it might be associated with loss-of-control (LOC) eating, a known predictor of post-surgical outcomes. This study examined the nature and significance of emotional eating among post-bariatric surgery patients with LOC eating. Participants (N = 134) were patients with LOC eating (at least once weekly) seeking treatment to help improve eating approximately 4-9 months following sleeve gastrectomy surgery...
July 26, 2018: Eating Behaviors
Faizan Ahmad, Ra J Prabhu, Jun Liao, Shwe Soe, Michael D Jones, Jonathan Miller, Parker Berthelson, Daniel Enge, Katherine M Copeland, Samar Shaabeth, Richard Johnston, Ian Maconochie, Peter S Theobald
Neonatal heart disorders represent a major clinical challenge, with congenital heart disease alone affecting 36,000 new-borns annually within the European Union. Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of experimental data describing the mechanical behaviour of neonatal cardiac tissue is likely to contribute to the relatively poor short- and long-term outcome of these implants. This study focused on characterising the mechanical behaviour of neonatal cardiac tissue using a porcine model, to enhance the understanding of how this differs to the equivalent mature tissue...
July 29, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Ling-Bing Meng, Ze-Mou Yu, Peng Guo, Qing-Qing Wang, Ruo-Mei Qi, Meng-Jie Shan, Jian Lv, Tao Gong
INTRODUCTION: Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L...
August 3, 2018: Thrombosis Research
Jordi Soler, Bárbara Arias, Jorge Moya, Manuel Ignacio Ibáñez, Generós Ortet, Lourdes Fañanás, Mar Fatjó-Vilas
The ZNF804A gene and cannabis use are risk factors for psychosis and both have also been associated with schizotypal traits. This study aimed to investigate: i) the association of lifetime cannabis use (and its dose effect) with schizotypal personality traits, and ii) whether the genetic variability at ZNF804A gene modulates that association. Our sample consisted of 385 Spanish non-clinical subjects (43.1% males, mean age = 21.11(2.19)). Schizotypy was evaluated using the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (SPQ-CP), Interpersonal (SPQ-I) and Disorganized (SPQ-D)...
August 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Zana A Carver, Alice A Han, Charles Timchalk, Thomas J Weber, Kimberly J Tyrrell, Ryan L Sontag, Teresa Luders, William B Chrisler, Karl K Weitz, Jordan N Smith
The objective of this study was to evaluate the potential for non-invasive biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D) in saliva. Using an in vitro rat salivary gland epithelial cell (SGEC) system, a collection of experiments investigating chemical protein binding, temporal and directional transport, as well as competitive transport with para-aminohippuric acid (PAH), a substrate for renal organic anion transporters, was conducted to identify cellular transport parameters required to computationally model salivary transport of 2,4-D...
August 14, 2018: Toxicology
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