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https://www.readbyqxmd.com/read/30516825/histone-demethylase-utx-is-a-therapeutic-target-for-diabetic-kidney-disease
#1
Hong Chen, Yixue Huang, Xiuqin Zhu, Chong Liu, Yangmian Yuan, Hua Su, Chun Zhang, Chengyu Liu, Mingrui Xiong, Yannan Qu, Peng Yun, Ling Zheng, Kun Huang
KEY POINTS: Diabetic kidney disease (DKD) is a major complication of diabetes. We found that UTX, a histone demethylase, was upregulated in the renal mesangial and tubular cells of diabetic mice and DKD patients. In cultured renal mesangial and tubular cells, UTX overexpression promoted palmitic acid-induced elevation of inflammation and DNA damage; while UTX knockdown or GSK-J4 treatment showed the opposite effects. We found that UTX demethylase activity-dependently regulated the transcription of inflammatory genes and apoptosis; moreover, UTX bound with p53 and p53-dependently exacerbated DNA damage...
December 5, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/30516253/the-diagnostic-value-of-irisin-in-patients-with-acute-abdominal-pain-a-preliminary-study
#2
Selman Yeniocak, Özgür Karcıoğlu, Asım Kalkan, Fatma Saraç, Gökçe Akgül Karadana, Zehra Zeynep Keklikkıran, Alper Gümüş, Macit Koldaş, Semih Korkut
BACKGROUND: The aim of this study was to investigate the prognostic value of irisin by examining the serum level of this smooth muscle protein in patients presenting at the emergency department (ED) with acute abdominal pain. METHODS: This research was performed as a single-center, prospective, cross-sectional study. In all, 213 adult patients presenting at the ED with acute abdominal pain and 140 healthy controls were enrolled. The serum irisin level was correlated with the leukocyte, C-reactive protein, amylase, and creatine kinase values...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/30514440/5-aminolaevulinic-acid-ala-enhances-heme-oxygenase-ho-1-expression-and-attenuates-tubulointerstitial-fibrosis-and-renal-apoptosis-in-chronic-cyclosporine-nephropathy
#3
Chi Liu, Ping Zhu, Masayuki Fujino, Yoshitaka Isaka, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Jian Zhuang, Xiao-Kang Li
BACKGROUND: Cyclosporine-A (CsA) is an immunosuppressant indicated for various immunological diseases; however, it can induce chronic kidney injury. Oxidative stress and apoptosis play a crucial role in CsA-induced nephrotoxicity. The present study evaluated the protective effect of combining 5-aminolaevulinic acid with iron (5-ALA/SFC), a precursor of heme synthesis, to enhance HO-1 activity against CsA-induced chronic nephrotoxicity. METHODS: Mice were divided into three groups: the control group (using olive oil as a vehicle), CsA-only group, and CsA+5-ALA/SFC group...
December 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30513528/the-tubular-damage-markers-neutrophil-gelatinase-associated-lipocalin-and-kidney-injury-molecule-1-in-newborns-with-intrauterine-growth-restriction
#4
Monika Kamianowska, Marek Szczepański, Elżbieta Ewa Kulikowska, Barbara Bebko, Anna Wasilewska
BACKGROUND: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. OBJECTIVES: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1)...
December 4, 2018: Neonatology
https://www.readbyqxmd.com/read/30511718/the-surrounding-tissue-contributes-to-smooth-muscle-cells-regeneration-and-vascularization-of-small-diameter-vascular-grafts
#5
Jing Liu, Yibo Qin, Yifan Wu, Zhiting Sun, Binhan Li, Huimin Jing, Chuangnian Zhang, Chen Li, Xigang Leng, Zhihong Wang, Deling Kong
Small diameter vascular grafts have been promising substitutes for bypass surgery to treat cardiovascular disease. However, no ideal product is available in the clinic. In order to design improved, next generation vascular grafts, it is essential to understand the cellular and molecular mechanisms underlying tissue regeneration after vascular graft implantation. Two diverse microenvironments, circulating blood and the surrounding tissue, are involved in the regeneration process after vascular graft implantation in situ...
December 4, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30511139/bortezomib-based-chemotherapy-can-improve-renal-and-tubular-functions-in-patients-with-light-chain-associated-fanconi-syndrome
#6
Xia Wu, Lu Zhang, Jun Feng, Yue-Ying Mao, Xin-Xin Cao, Dao-Bin Zhou, Jian Li
Light chain-associated Fanconi syndrome (LCFS) is a disorder of renal proximal tubule due to immunoglobulin light chains. Cases of LCFS are rare and mostly sporadically reported, and treatment of this entity is still controversial. This single-center retrospective study included 22 patients diagnosed with LCFS in Peking Union Medical College Hospital. Monoclonal gammopathy of undetermined significance was diagnosed in 13 patients, and overt multiple myeloma in six patients, with two smoldering myeloma and one Waldenstrom macroglobulinemia...
December 4, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30510761/rates-of-colorectal-cancer-detection-in-screening-colonoscopy-post-appendicectomy-in-patients-50-years-and-over
#7
Sunny Dhadlie, Daniel Mehanna
Introduction: Acute appendicitis in older adults is relatively uncommon and could be the first presentation of an underlying colorectal carcinoma. Colonoscopy in these individuals affords the opportunity for earlier diagnosis and treatment. The finding of increased rates of colorectal cancer (CRC) with older patients who have had appendicitis was supported by a number of small studies and case reports in the early 1980s.With the advent of CT scanning and laparoscopic appendicectomy, increased ability to visualize the caecum has been achieved...
December 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30508897/primary-biliary-cirrhosis-with-refractory-hypokalemia-a-case-report
#8
Kai-Hui Dong, Yi-Na Fang, Xiao-Yu Wen, Qing-Long Jin
RATIONALE: Renal tubular acidosis (RTA) represents a class of metabolic disorders characterized by metabolic acidosis with a normal plasma anion gap. As a rare complication of primary biliary cirrhosis (PBC), RTA is easily overlooked, likely leading to misdiagnosis. PATIENT CONCERNS: A 32-year-old woman who had been diagnosed with PBC at our hospital was found to have hypokalemia due to repeated fatigue for 2 years, and the etiology was unknown. DIAGNOSES: Due to the laboratory test results, radiographic findings, and pathologic results, she was diagnosed with PBC associated with RTA...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30507918/ldl-cholesterol-uptake-assay-using-live-cell-imaging-analysis-with-cell-health-monitoring
#9
Portia Ritter, Keyvan Yousefi, Juliana Ramirez, Derek M Dykxhoorn, Armando J Mendez, Lina A Shehadeh
The regulation of LDL cholesterol uptake through LDLR-mediated endocytosis is an important area of study in various major pathologies including metabolic disorder, cardiovascular disease, and kidney disease. Currently, there is no available method to assess LDL uptake while simultaneously monitoring for health of the cells. The current study presents a protocol, using a live cell imaging analysis system, to acquire serial measurements of LDL influx with concurrent monitoring for cell health. This novel technique is tested in three human cell lines (hepatic, renal tubular epithelial, and coronary artery endothelial cells) over a four-hour time course...
November 17, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30506859/deciphering-the-sumo-code-in-the-kidney
#10
REVIEW
Zhen Yang, Yuming Zhang, Shiren Sun
SUMOylation of proteins is an important regulatory element in modulating protein function and has been implicated in the pathogenesis of numerous human diseases such as cancers, neurodegenerative diseases, brain injuries, diabetes, and familial dilated cardiomyopathy. Growing evidence has pointed to a significant role of SUMO in kidney diseases such as DN, RCC, nephritis, AKI, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that SUMO might have a protective role against podocyte apoptosis...
December 1, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30505626/dna-origami-nanostructures-can-exhibit-preferential-renal-uptake-and-alleviate-acute-kidney-injury
#11
Dawei Jiang, Zhilei Ge, Hyung-Jun Im, Christopher G England, Dalong Ni, Junjun Hou, Luhao Zhang, Christopher J Kutyreff, Yongjun Yan, Yan Liu, Steve Y Cho, Jonathan W Engle, Jiye Shi, Peng Huang, Chunhai Fan, Hao Yan, Weibo Cai
Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructures (DONs) with rectangular, triangular and tubular shapes accumulate preferentially in the kidneys of healthy mice and mice with rhabdomyolysis-induced AKI, and that rectangular DONs have renal-protective properties, with efficacy similar to the antioxidant N -acetylcysteine-a clinically used drug that ameliorates contrast-induced AKI and protects kidney function from nephrotoxic agents...
November 2018: Nature biomedical engineering
https://www.readbyqxmd.com/read/30504713/the-kidney-specific-protein-myo-inositol-oxygenase-a-potential-biomarker-for-diabetic-nephropathy
#12
Peng Gao, Bo Xu, Panai Song, Xuejing Zhu, Shuguang Yuan, Yashipal S Kanwar, Lin Sun
BACKGROUND/AIMS: Renal tubular injury plays an important role in the progression of diabetic nephropathy (DN). However, there is a lack of specific biomarkers for tubular damage in incipient DN. We have evaluated the role of myo-inositol oxygenase (MIOX) in the tubular injury of DN, but whether it could serve as a new biomarker for the early diagnosis of DN is unclear. METHODS: Ninety patients with type 2 diabetes mellitus (T2DM) were divided into normoalbuminuria, microalbuminuria and macroalbuminuria groups...
November 30, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30503577/histopathological-findings-in-the-viscera-of-malformed-neotropical-viperids
#13
M P N Carvalho, S S Sant'Anna, J Díaz-Delgado, K F Grego, I C V P Gogone, N G T Queiroz-Hazarbassanov, J L Catão-Dias
Congenital malformations (CMs) or developmental abnormalities are pathological processes defined as morphological defects that originate during embryonic stages. A wide variety of CMs is observed in reptiles, most of which are incompatible with normal life. Characterization of CMs and their pathogenesis are of great importance for the conservation of reptiles, including neotropical viperids (NVs). External CMs are often reported in these species, but little is known about concomitant microscopical findings in the viscera of malformed individuals...
November 28, 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30501003/tauroursodeoxycholic-acid-tudca-abolishes-chronic-high-salt-induced-renal-injury-and-inflammation
#14
C De Miguel, R Sedaka, M Kasztan, J M Lever, M Sonnenberger, A Abad, C Jin, P K Carmines, D M Pollock, J S Pollock
AIM: Chronic high salt intake exaggerates renal injury and inflammation, especially with the loss of functional ETB receptors. Tauroursodeoxycholic acid (TUDCA) is a chemical chaperone and bile salt that is approved for the treatment of hepatic diseases. Our aim was to determine whether TUDCA is reno-protective in a model of ETB receptor deficiency with chronic high salt-induced renal injury and inflammation. METHODS: ETB -deficient and transgenic control rats were placed on normal (0...
November 30, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/30496037/hypermethylated-in-cancer-1-hic1-mediates-high-glucose-induced-ros-accumulation-in-renal-tubular-epithelial-cells-by-epigenetically-repressing-sirt1-transcription
#15
Sheng Zeng, Xiaoyan Wu, Xuyang Chen, Huihui Xu, Tao Zhang, Yong Xu
Reactive oxygen species (ROS) is a key regulator of an array of physiological and pathological processes. While essential for the host defense mechanism, excessive ROS generation and/or deficient clearance is blamed for the pathogenesis of human diseases. In the present study, we investigated the regulatory role of hypermethylated in cancer 1 (HIC1), a transcription factor, in high glucose-induced ROS accumulation in renal tubular epithelial cells (HK-2). Treatment with high glucose (HG) not only markedly up-regulated HIC1 expression but prompted its translocation into the nucleus...
October 2018: Biochimica et biophysica acta. Gene regulatory mechanisms
https://www.readbyqxmd.com/read/30485646/protease-activated-receptor-1-contributes-to-renal-injury-and-interstitial-fibrosis-during-chronic-obstructive-nephropathy
#16
Maaike Waasdorp, Dennis M de Rooij, Sandrine Florquin, JanWillem Duitman, C Arnold Spek
End-stage renal disease, the final stage of all chronic kidney disorders, is associated with renal fibrosis and inevitably leads to renal failure and death. Transition of tubular epithelial cells (TECs) into mesenchymal fibroblasts constitutes a proposed mechanism underlying the progression of renal fibrosis and here we assessed whether protease-activated receptor (PAR)-1, which recently emerged as an inducer of epithelial-to-mesenchymal transition (EMT), aggravates renal fibrosis. We show that PAR-1 activation on TECs reduces the expression of epithelial markers and simultaneously induces mesenchymal marker expression reminiscent of EMT...
November 28, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30484583/-renal-involvement-during-monoclonal-gammopathies-at-the-teaching-hospital-of-yopougon-in-abidjan-from-2000-to-2016
#17
Mélanie Tia Weu, Cyr Guei Monlet, Amidou Sawadogo, Albert Coulibaly Pessa, Amelie Lagou Delphine, Apollinaire Gnionsahé Daze
BACKGROUND: Renal involvement is common during monoclonal gammopathies and their occurrence impacts the survival of the patients. Our objective was to describe the renal features during monoclonal gammopathies from 2004 to 2016 at the University Hospital of Yopougon in Abidjan. METHODS: Renal failure was defined as blood creatinine level > 20 mg/L and/or proteinuria > 500 mg/24 hours. RESULTS: We identified 42 cases of monoclonal gammopathiesincluding multiple myeloma (n=40) and monoclonal gammopathy of underdetermined significance (n=2)...
2018: Le Mali Médical
https://www.readbyqxmd.com/read/30483741/establishment-of-microrna-transcript-and-protein-regulatory-networks-in-alport-syndrome-induced-pluripotent-stem-cells
#18
Wenbiao Chen, Donge Tang, Yong Dai, Hongyan Diao
Alport syndrome (AS) is an inherited progressive disease caused by mutations in genes encoding for the α3, α4 and α5 chains, which are an essential component of type IV collagen and are required for formation of the glomerular basement membrane. However, the underlying etiology of AS remains largely unknown, and the aim of the present study was to examine the genetic mechanisms in AS. Induced pluripotent stem cells (iPSCs) were generated from renal tubular cells. The Illumina HiSeq™ 2000 system and iTRAQ‑coupled 2D liquid chromatography‑tandem mass spectrometry were used to generate the sequences of microRNAs (miRNAs), transcripts and proteins from AS‑iPSCs...
November 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30483252/inflammasome-independent-role-of-nlrp3-mediates-mitochondrial-regulation-in-renal-injury
#19
Su-Mi Kim, Yang Gyun Kim, Dong-Jin Kim, Seon Hwa Park, Kyung-Hwan Jeong, Yu Ho Lee, Sung Jig Lim, Sang-Ho Lee, Ju-Young Moon
The NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome has been implicated in renal inflammation and fibrosis. However, the biological function of inflammasome-independent NLRP3 in non-immune cells is still unclear. We evaluated the role of inflammasome-independent NLRP3 in renal tubular cells and assessed the value of NLRP3 as a therapeutic target for acute kidney injury (AKI). Various renal tubular cell lines and primary cultured tubular cells from NLRP3 knockout (KO) mice were used for in vitro studies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30479321/findings-during-screening-colonoscopies-in-a-middle-eastern-cohort
#20
Majid A Almadi, Abed Allehibi, Mohammad A Aljebreen, Othman R Alharbi, Nahla Azzam, Abdulrahman M Aljebreen
Background/Aims: Colorectal cancer is the most common cancer in males and the third most common cancer in females. We aim to determine the polyp and adenoma prevalence in a cohort of patients who underwent opportunistic screening colonoscopies. Patients and Methods: A retrospective cohort study was conducted using an endoscopic reporting database of individuals seen at three tertiary care hospitals (two public hospitals and one private) in Riyadh, Saudi Arabia. Consecutive patients who were 45 years of age and older and underwent opportunistic screening colonoscopies between November 2016 and October 2017 were included...
November 27, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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