Andrew M Brunner, Traci M Blonquist, Daniel J DeAngelo, Malgorzata McMasters, Geoffrey Fell, Nicole M Hermance, Eric S Winer, R Coleman Lindsley, Gabriela S Hobbs, Philip C Amrein, Hanno R Hock, David P Steensma, Jacqueline S Garcia, Marlise R Luskin, Richard M Stone, Karen K Ballen, Jacalyn Rosenblatt, David Avigan, Myrna R Nahas, Lourdes M Mendez, Steven L McAfee, Jenna A Moran, Meghan Bergeron, Julia Foster, Christina Bertoli, Amity L Manning, Kristin L McGregor, Kaitlyn M Fishman, Frank C Kuo, Michele T Baltay, Molly Macrae, Meghan Burke, Tanya Behnan, Margaret C Wey, Tina T Som, Aura Y Ramos, Jessica Rae, Jennifer Lombardi Story, Nicole Nelson, Emma Logan, Christine Connolly, Donna S Neuberg, Yi-Bin Chen, Timothy A Graubert, Amir T Fathi
BACKGROUND: Increased aurora A kinase (AAK) expression occurs in acute myeloid leukaemia; AAK inhibition is a promising therapeutic target in this disease. We therefore aimed to assess the activity of alisertib combined with 7 + 3 induction chemotherapy in previously untreated patients with high-risk acute myeloid leukaemia. METHODS: We did a single-arm, phase 2 trial of patients recruited from the Dana-Farber/Harvard Cancer Center in the USA. Eligible patients had previously untreated acute myeloid leukaemia, an Eastern Cooperative Oncology Group performance status of 0-2, and were at high risk of disease as defined by the presence of an adverse-risk karyotype, the presence of secondary acute myeloid leukaemia arising from previous myelodysplastic syndrome or myeloproliferative neoplasm, the presence of therapy-related acute myeloid leukaemia, or being 65 years or older...
February 2020: Lancet Haematology