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https://www.readbyqxmd.com/read/30336519/assessment-of-plasma-amino-acid-dynamics-in-response-to-acth-stimulation-by-liquid-chromatography-tandem-mass-spectrometry
#1
Michael Paal, Johanna M Lindner, Philipp Schmoeckel, Anna C Suhr, Simon Schafferer, Therese Koal, Josef Briegel, Michael Vogeser
BACKGROUND: The adrenocorticotropic hormone (ACTH) stimulation test is a widely used diagnostic tool to assess the adrenal gland function. Beyond that the ACTH test can be used in stress research to induce a biochemical stress response under standardized conditions. To study the impact of the stress response on protein metabolism, time-course plasma amino acid profiling in healthy individuals was performed with high performance liquid chromatography tandem-mass spectrometry (HPLC-MS/MS)...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336512/impact-of-interfacial-composition-on-emulsion-digestion-using-in-vitro-and-in-vivo-models
#2
Ernesta Malinauskytė, Jovita Ramanauskaitė, Milda Keršienė, Ina Jasutienė, Daiva Leskauskaitė, Tove G Devold, Gerd E Vegarud
This study explored the influence of different emulsification layers as mono- and bilayers on lipid digestion by using in vitro and in vivo digestion methods. The monolayer emulsion of rapeseed oil contained whey proteins and the bilayer emulsion, whey proteins and carboxymethyl cellulose. The in vitro digestion using human gastrointestinal enzymes showed that the lipid digestion as free fatty acids was slowed down in the bilayer emulsion compared with the monolayer. Droplet size was still low in the gastric phase and pseudoplasticity was well preserved (even though viscosity decreased) during in vitro gastrointestinal digestion...
October 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/30336511/establishing-a-diagnostic-technique-for-coelomocentesis-in-the-long-spined-sea-urchin-diadema-antillarum
#3
Molly Martony, Deborah Pouder, Roy Yanong, Yasunari Kiryu, Jan H Landsberg, Ramiro Isaza, Thomas Waltzek, Nicole I Stacy, Robson Giglio, Shirley Baker, Ruth Francis-Floyd
Coelomic fluid aspiration has been utilized in echinoderms in research and clinical settings. Detailed procedural descriptions for coelomic fluid sampling in sea urchins (class Echinoidea) are lacking, and samples are prone to contamination. The objectives of this study were to (1) standardize a technique for coelomic fluid collection in long-spined sea urchin Diadema antillarum that optimizes the diagnostic quality of the sample utilizing diagnostic imaging, (2) identify coelomic fluid bacterial isolates (using Biolog GEN III MicroLog and 16s rDNA sequencing), and (3) compare positive cultures to animal weight, holding time prior to sampling, water temperature, and gross fluid appearance...
October 18, 2018: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/30336493/type-1-interferon-inducible-gene-expression-in-quantiferon-gold-tb-positive-uveitis-a-tool-to-stratify-a-high-versus-low-risk-of-active-tuberculosis
#4
Rina La Distia Nora, Ratna Sitompul, Marleen Bakker, Marjan A Versnel, Sigrid M A Swagemakers, Peter J van der Spek, Made Susiyanti, Lukman Edwar, Soedarman Sjamsoe, Gurmeet Singh, Rr Diah Handayani, Aniki Rothova, P Martin van Hagen, Willem A Dik
QuantiFERON-Gold TB (QFT)-positive patients with undetermined cause of uveitis are problematic in terms of whether to diagnose and treat them for tuberculosis (TB). Here, we investigated whether peripheral blood expression of type 1 interferon (IFN)-inducible genes may be of use to stratify QFT-positive patients with uveitis into groups of high versus low risk of having active TB-associated uveitis. We recruited all new uveitis patients in Cipto Mangunkusumo Hospital, Jakarta, Indonesia for one year. We included 12 patients with uveitis and clinically diagnosed active pulmonary TB, 58 QFT-positive patients with uveitis of unknown cause, 10 newly diagnosed sputum-positive active pulmonary TB patients without uveitis and 23 QFT-negative healthy controls...
2018: PloS One
https://www.readbyqxmd.com/read/30336480/c-jun-n-terminal-kinase-inhibition-induces-mitochondrial-oxidative-stress-and-decreases-survival-in-human-neural-stem-progenitors
#5
Neha Sharma, Lisamarie Moore, Shravanthi Chidambaram, Nicholas W Colangelo, Sonia M de Toledo, Edouard I Azzam
Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for homeostatic cellular functions. The redox-modulated c-Jun N-terminal kinases (JNK) are a molecular switch in stress signal transduction and are involved in numerous brain functions. Using a selective but broad-spectrum inhibitor of JNK 1/2/3, we investigated the role of JNK in regulating the levels of reactive oxygen species in mitochondria, mitochondrial membrane potential, viability, proliferation and lineage alterations in human H9-derived neural stem/progenitor cells (NSPs)...
October 18, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/30336452/a-fast-approximate-algorithm-for-determining-bond-orders-in-large-polycyclic-structures
#6
Sergey Trepalin, Sasha Gurke, Mikhail Akhukov, Andrey Knizhnik, Boris Potapkin
Novel logarithmic time algorithm is proposed for determining the order of chemical bonds from known valences of the atoms. The algorithm has the order of complexity N · log(N) and is applicable to polycyclic compounds containing a combination of the cycles of any size and the atoms with the valences ≤4 in cycle nodes. The algorithm is applicable to structures containing triple and cumulene bonds in the cycles. It was tested for graphene, C[12,12] nanotubes, graphyne-GY1, graphyne-GY7, graphyne-like nanotube, fullerenes C20, C60, C70, C80, C82 and their aza-analogs, polypentadienes, as well as for porphine...
October 11, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/30336451/structural-analysis-of-a-novel-n-carbamoyl-d-amino-acid-amidohydrolase-from-a-brazilian-bradyrhizobium-japonicum-strain-in-silico-insights-by-molecular-modelling-docking-and-molecular-dynamics
#7
Reinaldo G Bellini, Mônika Aparecida Coronado, Alexandre Rossi Paschoal, Thaís Gaudencio do Rêgo, Mariangela Hungria, Ana Tereza Ribeiro de Vasconcelos, Marisa Fabiana Nicolás
In this work we performed several in silico analyses to describe the relevant structural aspects of an enzyme N-Carbamoyl-d-amino acid amidohydrolase (d-NCAase) encoded on the genome of the Brazilian strain CPAC 15 (=SEMIA 5079) of Bradyrhizobium japonicum, a nonpathogenic species belonging to the order Rhizobiales. d-NCAase has wide applications particularly in the pharmaceutical industry, since it catalyzes the production of d-amino acids such as D-p-hydroxyphenylglycine (D-HPG), an intermediate in the synthesis of β-lactam antibiotics...
October 9, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/30336433/protected-area-management-fusion-and-confusion-with-the-ecosystem-services-approach
#8
Christiaan Hummel, Dimitris Poursanidis, Daniel Orenstein, Michael Elliott, Mihai Cristian Adamescu, Constantin Cazacu, Guy Ziv, Nektarios Chrysoulakis, Jaap van der Meer, Herman Hummel
For many years, Protected Areas (PA) have been an important tool for conserving nature. Recently, also societal aspects have been introduced into PA management via the introduction of the Ecosystem Services (ES) approach. This review discusses the historical background of PAs, PA management, and the ES approach. We then discuss the relevance and applicability of the ES approach for PA management, including the different definitions of ES, different classification methods, and the ways in which ES are measured...
October 6, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336432/evaluation-of-the-estrogen-receptor-alpha-as-a-possible-target-of-bifenthrin-effects-in-the-estrogenic-and-dopaminergic-signaling-pathways-in-zebrafish-embryos
#9
Luísa Becker Bertotto, Subham Dasgupta, Sara Vliet, Stacia Dudley, Jay Gan, David C Volz, Daniel Schlenk
Bifenthrin (BF) is a pyrethroid insecticide widely used in urban and agricultural applications. Previous studies in embryos of zebrafish have shown that BF can affect estradiol biosynthesis and the dopaminergic system. To examine the role of the estrogen receptor (ER) in the endocrine effects of BF, embryos were exposed for 96 h to a mixture of 0.15 and 1.5 μg/L BF and an ER agonist (17α-ethynylestradiol - EE2) at 0.09 μg/L. Transcripts related to estrogenic (vitellogenin VTG) and dopaminergic (tyrosine hydroxylase (TH), dopamine receptor 1 (DR1), monoamine oxidase (MAO), and catechol-O-methyltransferase b (COMTb)) signaling pathways were investigated by qRT-PCR...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336423/influence-of-triazole-pesticides-on-tillage-soil-microbial-populations-and-metabolic-changes
#10
Praveen Satapute, Milan V Kamble, Shivakantkumar S Adhikari, Sudisha Jogaiah
Pesticides are generally applied to agricultural soil to control crop diseases, with the critical goal of preventing yield loss and optimizing economic returns. However, the excessive utilization of pesticides in agriculture is a severe environmental and human health problem. In the present study, effect of triazole based fungicide, propiconazole on soil physicochemical properties, stimulatory impact of propiconazole residue on soil microbial communities and soil enzyme activities (phosphatise and urease) in contaminated red sandy loam and deep black soils of paddy (Oryza sativa L...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336417/poly-vinyl-alcohol-hydrogels-integrated-with-cuprous-oxide-tannic-acid-submicroparticles-for-enhanced-mechanical-properties-and-synergetic-antibiofouling
#11
Xiankun Lin, Xiaodi Huang, Chenggen Zeng, Wei Wang, Chaogang Ding, Jie Xu, Qiang He, Bin Guo
Highly hydrophilic hydrogels are able to potentially act as fouling-resistant coatings to prevent the settlement of marine organisms, due to the inherent surface properties. It is highly desired to improve mechanical and antifouling (AF) performance of hydrogels for durable and effective usage. Herein, a kind of composite hydrogels with enhanced mechanical properties and synergetic AF activity is prepared in a simple and low-cost way. The cooperation of biocidal copper release and non-fouling interfaces is realized, resulting in improved AF performance...
October 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30336403/radiological-assessment-of-congenital-talipes-equinovarus-clubfoot-is-it-worthwhile
#12
Surendra U Kamath, Jose Austine
The lack in consensus with regard to qualitative use of standard radiographs and their predictive value in evaluating congenital talipes equinovarus among infants continues to be apparent in clinical practice. Since standard radiographs continue to play a role in the assessment of clubfoot it is essential to ensure that the values measured are reliable and reproducible keeping in mind acceptable tolerances for clinical application. This study was undertaken to assess the inter-observer and the intra-observer reliability in estimation of talocalcaneal and talo-first metatarsal angles on standard radiographs done according to Simon's method...
June 8, 2018: Foot
https://www.readbyqxmd.com/read/30336396/autotrophic-nitrogen-removal-in-combined-nitritation-and-anammox-systems-through-intermittent-aeration-and-possible-microbial-interactions-by-quorum-sensing-analysis
#13
Yuepeng Sun, Yuntao Guan, Hongyang Wang, Guangxue Wu
Nitrogen removal and microbial interactions in two combined nitritation and Anammox systems with or without the addition of organics were examined. Two systems were successfully started up by adopting intermittent aeration. Organics addition deteriorated nitrogen removal, and total inorganic nitrogen and ammonium removal percentages decreased by 16.4% and 26.3%, respectively. Organics addition promoted the growth of Chloroflexi and Proteobacteria while suppressed the growth of Candidatus Kuenenia. Organics addition decreased activities of fatty acid biosynthesis and metabolism, amino acid metabolism and biofilm formation, while increased activities of steroid metabolism and glycosaminoglycan biosynthesis...
October 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/30336379/reliability-of-palatal-rugoscopy-for-sexual-dimorphism-in-forensic-dentistry-a-systematic-literature-review-and-meta-analysis
#14
REVIEW
Ramon Nazareno Menezes Andrade, Walbert de Andrade Vieira, Ítalo de Macedo Bernardino, Ademir Franco, Luiz Renato Paranhos
OBJECTIVE: This study aimed to assess the validity of palatal rugoscopy for sexual dimorphism in the casework routine of forensic dentistry. DESIGN: A systematic literature reviews was established following the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) and Cochrane guidelines. Six electronic databases were searched as the primary source of information. "Grey literature" was included to avoid selection and publication bias...
October 11, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30336375/combination-of-phenolic-profiles-pharmacological-properties-and-in-silico-studies-to-provide-new-insights-on-silene-salsuginea-from-turkey
#15
Gokhan Zengin, Maria João Rodrigues, Hassan H Abdallah, Luisa Custodio, Azzurra Stefanucci, Muhammad Zakariyyah Aumeeruddy, Adriano Mollica, Kannan R R Rengasamy, Mohamad Fawzi Mahomoodally
The genus Silene is renowned in Turkey for its traditional use as food and medicine. Currently, there are 138 species of Silene in Turkey, amongst which have been several studies for possible pharmacological potential and application in food industry. However, there is currently a paucity of data on Silene salsuginea Hub.-Mor. This study endeavours to access its antioxidant, enzyme inhibitory, and anti-inflammatory properties. Besides, reversed-phase high-performance liquid chromatography-diode array detector (RP-HPLC-DAD) was used to detect phenolic compounds, and molecular docking was performed to provide new insights for tested enzymes and phenolics...
October 9, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30336369/enhancement-in-median-nerve-mobility-during-radioulnar-wrist-compression-in-carpal-tunnel-syndrome-patients
#16
Yifei Yao, Emily Grandy, Peter J Evans, William H Seitz, Zong-Ming Li
BACKGROUND: Carpal tunnel syndrome is a compression neuropathy at the wrist associated with compromised median nerve mobility. The purpose of this study was to investigate the effects of radioulnar wrist compression on median nerve longitudinal mobility within the carpal tunnel in carpal tunnel syndrome patients as well as healthy subjects. METHODS: Dynamic ultrasound images captured longitudinal median nerve motion in the carpal tunnel during radioulnar wrist compression force application in 11 healthy subjects and 11 carpal tunnel syndrome patients...
October 12, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/30336364/a-designer-bow-tie-combination-therapeutic-platform-an-approach-to-resistant-cancer-treatment-by-simultaneous-delivery-of-cytotoxic-and-anti-inflammatory-agents-and-radiation
#17
Rakesh K Pathak, Uttara Basu, Anis Ahmad, Shrita Sarkar, Anil Kumar, Bapurao Surnar, Saba Ansari, Katarzyna Wilczek, Michael E Ivan, Brian Marples, Nagesh Kolishetti, Shanta Dhar
Multimodal therapies are used to treat advanced cancers including castration-resistant prostate cancer to manage the biological characteristics of the tumors like inflammation, bone metastases, and participation of metabolically altered cancer stem cells (CSCs) that have integral roles in disease dissemination and progression. We developed a multifunctional polymer-based self-assembled technology to deliver a predefined stoichiometric combination of a chemotherapy and an anti-inflammatory agent in a stimuli responsive manner, to complement and improve the currently established treatment methods of prostate cancer...
September 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/30336344/a-novel-prototype-of-integrated-anaerobic-filter-condenser-anco-system-for-application-of-waste-heat-from-office-building-to-improve-performances-of-both-air-conditioner-and-wastewater-treatment-system
#18
Chalearn Bouted, Chavalit Ratanatamskul
The prototype system of integrated anaerobic filter with condenser of air conditioner (anaerobic filter-condenser; ANCO) was developed for sustainable water-energy management model in green office building. The ANCO consists of an insulated anaerobic filter (IAF) and condenser that are connected to an existing refrigerant of air conditioner. The system applied waste heat energy from an air conditioner to improve wastewater treatment efficiency. While the performance of air conditioner also could be enhanced by decreasing refrigerant temperature from transferring waste heat through the IAF system for increasing wastewater temperature...
October 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/30336334/single-sheet-iron-oxide-an-efficient-heterogeneous-electro-fenton-catalyst-at-neutral-ph
#19
Li-Zhi Huang, Mingtao Zhu, Zizheng Liu, Zongping Wang, Hans Christian B Hansen
In order to overcome the inefficiency of heterogeneous electro-Fenton process for water treatment at neutral pH, single sheet iron oxide (SSI) derived from layered Fe(II)-Fe(III) double hydroxides (green rusts) was fabricated on an indium tin oxide electrode via layer by layer assembly and used in an undivided electrolysis cell. Use of radical scavengers demonstrated the formation of oxygen radicals by electrochemical reduction of oxygen at the SSI electrode, and the key role of hydroxyl radicals (OH) and superoxide anion (O2 - ) radicals in degradation of the azo dye orange II...
October 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30336333/carboxymethyl-cellulose-polyacrylamide-composite-hydrogel-for-cascaded-treatment-reuse-of-heavy-metal-ions-in-wastewater
#20
Chirag B Godiya, Xiao Cheng, Dawei Li, Zhan Chen, Xiaolin Lu
A new bio-based bilateral hydrogel containing carboxymethyl cellulose (CMC) and polyacrylamide (PAM) was prepared for the wastewater remediation. The obtained CMC/PAM composite hydrogel reveals a strong single-ion affinity for copper (CuII ), lead (PbII ) and cadmium (CdII ) ions, as well as multi-ion absorbability with its equilibrium data following the Langmuir adsorption model and its adsorption process abiding by a pseudo-second-order kinetics. To demonstrate its recycled use for the metal ions, the adsorbed CuII ions in the hydrogel were reduced in situ to form homogeneously dispersed Cu nanoparticles (NPs), leading to the Cu NPs-loaded CMC/PAM hydrogel...
October 6, 2018: Journal of Hazardous Materials
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