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Karine Beaugelin-Seiller, Brenda J Howard, Jacqueline Garnier-Laplace
There is a need to prioritise the requirements for data to assess the radiological risk for fauna and flora, as inevitable large data gaps occur due to the large number of combinations of radionuclides and organisms for which doses need to be assessed. The potentially most important dose-forming radionuclide-pathways combinations need to be identified to optimize filling these gaps. Few attempts have been made to classify the importance of isotopes with regard to radiation protection of the environment. A hierarchical approach is described here for radionuclides that are potentially present in generic ecosystems (freshwater, marine or terrestrial) and is applied for scenarios considering ecologically relevant chronic exposure...
December 12, 2018: Journal of Environmental Radioactivity
Ying Wang, Bin Zhong, Mohammad Shafi, Jiawei Ma, Jia Guo, Jiasen Wu, Zhengqian Ye, Dan Liu, Hexian Jin
Pot experiment was conducted to investigate the effects of wood biochar (5%), bamboo biochar (5%), rice straw biochar (5%) and Chinese walnut shell biochar (5%) on growth, accumulation of heavy metals in moso bamboo, soil physical properties, and solubility of heavy metals in soil. The results revealed that dry weight of moso bamboo was significantly increased in treatments of wood biochar (5%), rice straw biochar (5%) and Chinese walnut shell biochar (5%) except bamboo biochar (5%). Application of straw biochar (5%) was most effective in enhancing plants biomass, with increase of 157%, 113% and 111% in leaves, roots and stems of moso bamboo...
November 26, 2018: Chemosphere
N Antolino, C Muhlstein, G Hayes, J Adair, R Bermejo
Micro-surgical instruments are a new application for mesoscale ceramics formed using the lost mold-rapid infiltration forming (LM-RIF) process. Instrument strength and reliability are the foremost concerns for this sensitive application. It is hypothesized that increasing grain size can improve the damage tolerance of the parts associated with the transformation toughening in the 3Y-TZP material, while retaining high strength. In this work, mesoscale bend bars (314 × 22 × 18 µm) of 3Y-TZP fabricated using the LM-RIF process were heat treated at 1400 °C for 1 h, 8 h, or 16 h, respectively, to obtain samples with different grain sizes...
December 4, 2018: Journal of the Mechanical Behavior of Biomedical Materials
P Kubiak, P Mierzejewska, M Krukowski
The article presents research on the methods of crash velocity determination based on the Compact car class. The database used in the research is provided by the NHTSA (National Highway Traffic Safety Administration) and includes numerous frontal crash tests, which allowed the determination of the mathematical model parameters. Two methods are presented that enable the determination of vehicle velocity before the collision. The first researched method is the so-called inversed system method and is based on the assumption that the relationship between bk coefficient Cs is an inverse function...
December 4, 2018: Forensic Science International
Bruna Zucchetti, Andrea Kazumi Shimada, Artur Katz, Giuseppe Curigliano
Histone deacetylase inhibitors (HDACi) are a relatively new class of drug that plays an important role in the epigenetic and non-epigenetic regulation in cancer, inducing death, apoptosis and cell cycle arrest in cancer cells. Although HDACi are approved only for hematologic malignancies, there are several trials in the breast cancer setting with promising results. In this review, we summarize the latest studies with HDACi in breast cancer from the emerging data in the translational research until its possible applicability in the clinical practice...
December 6, 2018: Breast: Official Journal of the European Society of Mastology
Lin Lin, Xuefang Mao, Yanhui Sun, Govindan Rajivgandhi, Haiying Cui
This study was aimed to develop novel antibacterial packaging materials in order to reduce the microbial contamination of food surface. Chrysanthemum essential oil (CHEO) was successfully incorporated into chitosan nanofibers (CS/NF) through electrospinning which was demonstrated by SEM and AFM analysis. The antibacterial mechanism of CHEO against Listeria monocytogenes (L. monocytogenes) was explored as well. The cell membrane permeability of L. monocytogenes appeared to be increased by CHEO. In addition, respiratory metabolism of L...
December 8, 2018: International Journal of Food Microbiology
Jasmina Petrova, Gergana Gocheva, Nikoleta Ivanova, Stoyan Iliev, Boyana Atanasova, Galia Madjarova, Anela Ivanova
The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modelled in saline by atomistic molecular dynamics simulations and characterized in detail. In addition, quantum chemical calculations are used for determining the electronic structure of the six compounds. All molecules are highly flexible and have similar interactions with water...
December 4, 2018: Journal of Molecular Graphics & Modelling
Zeinab Masoudyfar, Shahla Elhami
This study reports a colorimetric sensor with excellent sensitivity to detect Cefixime base on gold nanoparticles. Cefixime is an antibiotic which has a wide range of applications in medicine. Cefixime did not change the surface plasmon resonance bond in gold nanoparticles solution; therefore, there was no change in the color solution of gold nanoparticles. The presence of Alizarin Red S in the system was necessary for the degradation of Cefixime, resulting in the aggregation of gold nanoparticles and a color change from red to blue...
December 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Srikanth Dasari, Swati Singh, Priyaranjan Kumar, Sri Sivakumar, Ashis K Patra
Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)2 Cl3 ] (1), [Yb(dppz)(DMF)2 Cl3 ] (2), [Yb(dpq)(ttfa)3 ] (3) and [Yb(dppz)(ttfa)3 ] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined...
December 5, 2018: European Journal of Medicinal Chemistry
Kohei Watanabe
INTRODUCTION: The present study investigated the effect of stretchable characteristics of elastic therapeutic tape and its elongation on surface electromyography (EMG) of knee extensor muscles during knee extension movements. METHODS: Nine healthy men performed knee extension movement with the application of normal elastic tape or highly stretchable tape and without the tapes (control). Tapes were applied on the anterior thigh to cross the knee joint with no elongation and elongation of 50 and 75% of the maximum stretchability...
December 12, 2018: Human Movement Science
Lorenzo Rossi, Lauren N Fedenia, Hamidreza Sharifan, Xingmao Ma, Leonardo Lombardini
A greenhouse study comparing the physiological responses and uptake of coffee (Coffea arabica L.) plants to foliar applications of zinc sulfate (ZnSO4 ) and zinc nano-fertilizer (ZnO NPs) was conducted with the aim to understand their effects on plant physiology. One-year old coffee plants were grown in greenhouse conditions and treated with two foliar applications of 10 mg/L of Zn as either zinc sulfate monohydrate (ZnSO4 ‧ H2 O) or zinc oxide nanoparticle (ZnO NPs 20% w/t) and compared to untreated control plants over the course of 45 days...
December 10, 2018: Plant Physiology and Biochemistry: PPB
(no author information available yet)
OBJECTIVES: SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure. METHODS AND RESULTS: The study was designed as a 2-armed partially blinded parallel randomized controlled trial. Seven sites in the United Kingdom (UK) recruited a total of 202 adults with heart failure at high risk of adverse outcomes and with potential to benefit from remote management (mean age 73 years, 28% female, median left ventricular ejection fraction 37%)...
September 25, 2018: American Heart Journal
Kkotchorong Park, Min Seong Kim, Mijeong Kang, Taejoon Kang, Bongsoo Kim, Seung Tae Lee
Transgenic pigs are quite useful in many biomedical fields, such as xenotransplantation research and the production of biopharmaceutical materials. The genetic transformation of porcine spermatogonial stem cells (pSSCs) followed by differentiation into mature spermatozoa enables the effective production of transgenic pigs. Improving the transfection efficiency of pSSCs, however, has been much desired. Herein, we report the efficient genetic modification of pSSCs by using an electrically responsive Au nanowire injector (E-R Au NWI)...
December 10, 2018: Biomaterials
Peng Zhang, Jing Zhu, Xiao-Yan Xu, Tai-Ping Qing, You-Zhi Dai, Bo Feng
Microbial extracellular proteins serve as important functions in wastewater treatment process. Analysis of their compositions and properties is crucial to probe their specific functions. However, conventional analytical techniques cannot obtain interest protein information from complex proteins. Recently, the extracellular proteomics method has been applied to resolve the composition of extracellular proteins. In order to better understand the roles of extracellular protein in wastewater treatment process, this review provides the information on the proteomics methods and their application in investigating extracellular proteins involved in microbial attachment/aggregation, biodegradation of pollutants, and response to environmental stresses...
December 12, 2018: Journal of Environmental Management
Hai-Fang Chen, Chen Zhang, Yun Yao, Jun-Mao Li, Wen-di Du, Mu-Lan Li, Bei Wu, Shi-Lin Yang, Yu-Lin Feng, Wu-Gang Zhang
TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)...
November 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
Long Yuan, Christine Huang, Peggy Liu-Kreyche, Kimberly Voronin, R Marcus Fancher, Alban Allentoff, Naiyu Zheng, Ramaswamy Iyer, Li Zhu, Renuka Pillutla, Qin C Ji
Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography-mass spectrometry (LC-MS) bioanalytical assays. Recently, the application of SIL drugs and LC-MS assays to microdose absolute bioavailability (BA) studies has gained increasing attention. This approach can provide significant cost and time saving, and higher data quality compared to the accelerator mass spectrometry (AMS)-based method, since it avoids the use of radioactive drug, high-cost AMS instrumentation and complex measurement processes...
December 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
Jialiang Guo, Hang Lin, Jincai Wang, Yuanjing Lin, Tingting Zhang, Zhengjin Jiang
Natural products are one of the most important sources of leading compounds in drug discovery. Until now, rapid screening and identification of biologically active components from natural products remain a technical challenge. Bio-affinity chromatography (BAC) based approaches hold great promise in screening potential bioactive ligands from complex samples. In this review, we summarized recent development of BAC in natural products screening, with a particular emphasis on the reported bio-affinity stationary phases and chromatographic supports as well as the applications of BAC coupled with GC-MS or LC-MS...
December 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
Seunguk Kim, Youngjin Lee, Jae Yeon Kim, Jae Hoon Yang, Hyuk-Jun Kwon, Jae Youn Hwang, Cheil Moon, Jae Eun Jang
A color-sensitive and spectrometer-free sensing method using plasmonic nanohole arrays and the color components, L* , a* , and b* , of the CIELAB defined by the international commission on illumination (CIE) is introduced for the analysis of optically transparent materials in the visible range. Spectral analysis based on plasmonic nanoparticles or nanostructures can be applied to real-time bio-detection, but complex optical instrumentations and low spatial resolution have limited the sensing ability. Therefore, we take an advantage of color image processing instead of spectral analysis which induces the distinctive color information of plasmonic nanohole arrays with different transparent materials...
December 7, 2018: Biosensors & Bioelectronics
Xu Yan, Yingpan Song, Jiameng Liu, Nan Zhou, Chunlin Zhang, Linghao He, Zhihong Zhang, Zhongyi Liu
A porphyrin-based covalent organic framework (denoted as p-COF) was synthesized by a simple oil-bath method and exploited as a novel sensing layer for immobilizing epidermal growth factor receptor (EGFR)-targeting aptamer strands to detect trace EGFR and living michigan cancer foundation-7 (MCF-7) cells for the first time. p-COF presented a nanosheet-like structure, large cavities, rich nitrogen-bearing groups, high electrochemical activity, excellent bioaffinity, low toxicity, and good stability in aqueous solution; the microstructural features of this material enabled strong immobilization of the aptamer strands...
December 7, 2018: Biosensors & Bioelectronics
Ahmed Galal, Hagar K Hassan, Nada F Atta, Timo Jacob
Nano-Ru-based perovskites RGO are prepared simultaneously in presence of various A-metal salts (A = Sr, Ba or Ca salts) using two different methods for reaction initiation. No further calcination step is needed for the formation of well-defined perovskite structure. Graphene oxide (GO) is used as a fuel to prepare various Ru-based perovskites for the first time. The resulted low-Ru content nanocomposites are used as supercapacitor electrodes in a neutral electrolyte (1.0 M NaNO3 ). The results show that the specific capacitance of the resulted nanocomposites strongly depends on the method of their preparation as well as the type of A-site of the nanocomposites...
December 5, 2018: Journal of Colloid and Interface Science
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