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A V Aleshkin, E R Zulkarneev, I A Kiseleva, K A Emelyanenko, A M Emelyanenko, L B Boinovich
A new approach to prevention of STEC infection is based on the synergic effect of combined bactericidal activity of bacteriophages and organic-inorganic hybrid coating of metals. The coatings are characterized by superhydrophilic or superhydrophobic properties and multimodal granularity with the texture incorporating metal oxide nanoparticles and bacteriophages. Superhydrophilic surfaces are characterized by significantly higher bactericidal activity than superhydrophobic ones. The cytotoxicity of superhydrophobic surfaces can be increased due to antibacterial activity of bacteriophages combined with the superhydrophobic characteristics of the materials...
August 18, 2018: Bulletin of Experimental Biology and Medicine
A V Razygraev, A D Yushina, I A Titovich
A method of measuring of glutathione peroxidase activity using H2 O2 was adapted for homogenates of murine brains.
August 18, 2018: Bulletin of Experimental Biology and Medicine
Lucas Eduardo de Oliveira Aparecido, José Reinaldo da Silva Cabral de Moraes, Glauco de Souza Rolim, Lucieta Guerreiro Martorano, Sabrina Dos Santos Soares, Kamila Cunha de Meneses, Cicero Teixeira Silva Costa, Daniel Zimmermann Mesquita, Aline Michelle da Silva Barbosa, Eufran Ferreira do Amaral, Nilson Gomes Bardales
Bamboo has an important role in international commerce due to its diverse uses, but few studies have been conducted to evaluate its climatic adaptability. Thus, the objective of this study was to construct an agricultural zoning for climate risk (ZARC) for bamboo using meteorological elements spatialized by neural networks. Climate data included air temperature (TAIR , °C) and rainfall (P) from 4947 meteorological stations in Brazil from the years 1950 to 2016. Regions were considered climatically apt for bamboo cultivation when TAIR varied between 18 and 35 °C, and P was between 500 and 2800 mm year-1 , or PWINTER was between 90 and 180 mm year-1 ...
August 18, 2018: International Journal of Biometeorology
Lindsay Clark, Igor Dikiy, Daniel M Rosenbaum, Kevin H Gardner
NMR studies of human integral membrane proteins provide unique opportunities to probe structure and dynamics at specific locations and on multiple timescales, often with significant implications for disease mechanism and drug development. Since membrane proteins such as G protein-coupled receptors (GPCRs) are highly dynamic and regulated by ligands or other perturbations, NMR methods are potentially well suited to answer basic functional questions (such as addressing the biophysical basis of ligand efficacy) as well as guiding applications (such as novel ligand design)...
August 18, 2018: Journal of Biomolecular NMR
Marina Carbone, Vincenzo Ferrari, Michele Marconi, Roberta Piazza, Andrea Del Corso, Daniele Adami, Quintilia Lucchesi, Valeria Pagni, Raffaella Berchiolli
In non-urban scenarios: rural areas or small cities, there is often a limited access to specialistic healthcare due to the inherent challenges associated with recruitment, retention, and access to healthcare professionals. Telemedicine is an economical and effective way to address this problem. In this research, we developed a framework for real-time communication during ultrasound examination that combines interaction via standard video conference protocols and basic AR functionalities (commercial) and a custom-developed application...
August 18, 2018: Updates in Surgery
M Kargar, F Khashei Varnamkhasti, A Lohrasebi
Multilayer graphene membranes could be considered as an efficient membrane in water desalination processes based on the reverse osmosis (RO) method. In this study, we designed multilayer graphene channels using the molecular dynamics (MD) simulation approach. The effects of different parameters, such as channel width and length, and the pressure on the operation of the designed channels were examined, in the absence and presence of electric fields with various amplitudes and directions. The results indicated that the ion separation and water flow through the channels were modified under the application of the electric fields...
August 18, 2018: Journal of Molecular Modeling
Samuel J Galgano, Mark E Lockhart, Ghaneh Fananapazir, Rupan Sanyal
Doppler ultrasound is routinely used for the post-operative evaluation of renal transplant patients. Knowledge of the surgical anatomy and application of a robust technique are important for appropriate evaluation of a transplanted kidney. In this review article, we discuss the surgical anatomy of renal transplantation, techniques to optimize image acquisition, as well as commonly associated pitfalls with Doppler ultrasound evaluation of renal grafts.
August 18, 2018: Abdominal Radiology
Muhammad Kamran, Irshad Ahmad, Xiaorong Wu, Tiening Liu, Ruixia Ding, Qingfang Han
Lodging is a major constraint contributing to poor grain yield and quality of wheat (Triticum aestivum L.) worldwide. The use of plant growth regulators is becoming a foremost agro-chemical approach for minimizing the risk of lodging in cereal crops. The present study was conducted to examine the effects of the paclobutrazol application on culm physical strength, lignin content, and lodging resistance of wheat. Wheat seeds were soaked in paclobutrazol at the concentrations of 0 (CK, as control), 200 (PB1), 300 (PB2), and 400 (PB3) mg L-1 ...
August 18, 2018: Environmental Science and Pollution Research International
Hui Wang, Chao Xu, Zun-Chang Luo, Han-Hua Zhu, Shuai Wang, Qi-Hong Zhu, Dao-You Huang, Yang-Zhu Zhang, Jie Xiong, Yan-Bing He
Cadmium (Cd) pollution in rice and its transfer to food chain are cause of global concern. Application of zinc (Zn) can reduce Cd uptake by plants, as both these metals are generally antagonistic in soil-plant systems. In a field experiment on Cd-contaminated acid soil, we investigated the effectiveness of foliar application of Zn in minimizing Cd accumulation and its effect on the content of mineral nutrient elements in rice. The treatment was done at an early grain filling stag using 0.3 and 0.5% w/v ZnSO4 ·7H2 O solution...
August 18, 2018: Environmental Science and Pollution Research International
Soo-Jung Kim, Jung-Eun Lee, Do Yup Lee, Haeseong Park, Kyoung Heon Kim, Yong-Cheol Park
In this study, an evolved Saccharomyces cerevisiae HJ7-14 with high ability of algae-based ethanol production was characterized by multi-omic approaches. Genome sequencing of the HJ7-14 revealed a point mutation in the GAL83 gene (G703A) involved in the catabolite repression as well as the galactose metabolism. Cultural and transcriptional analyses of a S. cerevisiae mutant with chromosomal GAL83(G703A) indicated that the catabolite repression onto the galactose metabolism was considerably relieved in all cell growth stages...
August 18, 2018: Applied Microbiology and Biotechnology
Caroline M Ruminski, Matthew T Clark, Douglas E Lake, Rebecca R Kitzmiller, Jessica Keim-Malpass, Matthew P Robertson, Theresa R Simons, J Randall Moorman, J Forrest Calland
Predictive analytics monitoring, the use of patient data to provide continuous risk estimation of deterioration, is a promising new application of big data analytical techniques to the care of individual patients. We tested the hypothesis that continuous display of novel electronic risk visualization of respiratory and cardiovascular events would impact intensive care unit (ICU) patient outcomes. In an adult tertiary care surgical trauma ICU, we displayed risk estimation visualizations on a large monitor, but in the medical ICU in the same institution we did not...
August 18, 2018: Journal of Clinical Monitoring and Computing
Qian Peter Su, Lining Arnold Ju
The focus of the cell biology field is now shifting from characterizing cellular activities to organelle and molecular behaviors. This process accompanies the development of new biophysical visualization techniques that offer high spatial and temporal resolutions with ultra-sensitivity and low cell toxicity. They allow the biology research community to observe dynamic behaviors from scales of single molecules, organelles, cells to organoids, and even live animal tissues. In this review, we summarize these biophysical techniques into two major classes: the mechanical nanotools like dynamic force spectroscopy (DFS) and the optical nanotools like single-molecule and super-resolution microscopy...
August 18, 2018: Biophysical Reviews
K Anslinger, B Bayer
The interpretation and statistical evaluation of mixed DNA profiles often presents a particular challenge in forensic DNA investigations. Only in specific combinations can single cellular components of a mixture be assigned to one contributor. In this study, the DEPArray™ technology, which enables image-assisted immunofluorescent-sorting of rare single cells using dielectrophoretic (DEP) forces, was applied together with different preliminary tests to identify the individual/s who contributed blood to a given mixture...
August 18, 2018: International Journal of Legal Medicine
Oula Yassin, Hussam Milly
OBJECTIVES: To evaluate CPP-ACP effect on colour change and tooth sensitivity (TS) associated with at-home vital tooth bleaching using 20% carbamide peroxide (CP). METHODS: A randomised double-blind placebo-controlled clinical trial was conducted to measure the TS and tooth colour change of 24 patients at 3-day, 7-day, 14-day and 30-day periods. The participants were instructed to apply 20% CP (7 days-04 h each) followed by the application of either CPP-ACP or non-active placebo paste, delivered by the bleaching custom tray (7 days-30 min each)...
August 18, 2018: Clinical Oral Investigations
Meytal Radzinski, Dana Reichmann
Cellular heterogeneity is a widespread phenomenon, existing across organisms and serving a crucial role in evolution and cell survival. Genetically identical cells may as a result present in a variety of forms with different gene and protein expressions, as well as oxidation level. As a result, a wide range of methodologies and techniques for dissecting different types of genetic, proteomic, and phenotypic heterogeneous traits have emerged in recent years in an effort to better understand how diversity exists within a single population and its effects therein...
August 18, 2018: Current Genetics
Soumya Nayak, C S K Mishra, B C Guru, Suryasikha Samal
Phosphogypsum (PG) is the major solid waste generated by phosphate fertilizer plants and is used worldwide as sulfur and calcium supplement in agricultural soil. Considering the probability of elevated doses of PG during agricultural applications, this study was carried out to assess its impact on the connective tissue, tissue cholinesterase (ChE) activity, lactate dehydrogenase (LDH) activity, and lipid peroxidation (LPX) level of the tropical earthworm Glyphidrillus tuberosus (Stephenson) found in abundance in the rice fields in India...
August 18, 2018: Environmental Monitoring and Assessment
Christina Schug, Sarah Urnauer, Carsten Jäckel, Kathrin Alexandra Schmohl, Mariella Tutter, Katja Steiger, Nathalie Schwenk, Markus Schwaiger, Ernst Wagner, Peter Jon Nelson, Christine Spitzweg
Based on their excellent tumor-homing capacity, genetically engineered mesenchymal stem cells (MSCs) are under investigation as tumor-selective gene delivery vehicles. Transgenic expression of the sodium iodide symporter ( NIS ) in genetically engineered MSCs allows noninvasive tracking of MSC homing by imaging of functional NIS expression as well as therapeutic application of 131 I. The use of tumor-stroma activated promoters can improve tumor-specific MSC-mediated transgene delivery. The essential role of transforming growth factor B1 (TGFB1) and the SMAD downstream target in the signaling between tumor and the surrounding stroma makes the biology of this pathway a potential option to better control NIS expression within the tumor milieu...
August 18, 2018: Endocrine-related Cancer
Michelle Helena Van Velthoven, James Smith, Glenn Wells, David Brindley
INTRODUCTION: There is currently a lack of clear and accepted standards for the development (planning, requirement analysis and research, design and application testing) of apps for medical and healthcare use which poses different risks to developers, providers, patients and the public. The aim of this work is to provide an overview of the current standards, frameworks, best practices and guidelines for the development of digital health apps. This review is a critical 'stepping stone' for further work on producing appropriate standards that can help mitigate risks (eg, clinical, privacy and economic risks)...
August 17, 2018: BMJ Open
Ane Berger Bungum, Clara Helene Glazer, Jens Peter Bonde, Peter M Nilsson, Aleksander Giwercman, Sandra Søgaard Tøttenborg
OBJECTIVE: To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. DESIGN: A population-based cohort study. SETTING: Not applicable. PARTICIPANTS: 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. INTERVENTIONS: None. MAIN OUTCOME MEASURES: From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men...
August 17, 2018: BMJ Open
Maryam Maddineshat, Mohammad Reza Yousefzadeh, Mahdi Mohseni, Zahra Maghsoudi, Mohammad Ebrahim Ghaffari
This study seeks to develop a method of teaching ethics to nursing students using games. We used the one-group pretest-posttest design with 30 undergraduate nursing students as participants. Professional ethics education was provided for 17 weeks in 90-minute sessions. The Lutzen ethical sensitivity questionnaire and a checklist of the satisfaction levels of games used measured the effects of training. Repeated-measures ANOVA and the Greenhouse-Geisser correction were used to measure ethics game satisfaction...
July 14, 2018: Indian Journal of Medical Ethics
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