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JOURNAL ARTICLE
Sam Wilson Cole, Jennifer L Glick, Nicola B Campoamor, Travis H Sanchez, Supriya Sarkar, Vani Vannappagari, Alex Rinehart, Keith Rawlings, Patrick S Sullivan, John F P Bridges
INTRODUCTION: Cabotegravir long-acting injectable HIV pre-exposure prophylaxis (LA-PrEP) was shown to be safe and effective in multiple clinical trials. Increasing uptake and persistence among populations with elevated risk for HIV acquisition, especially among men who have sex with men (MSM), is critical to HIV prevention. OBJECTIVE: This analysis aims to understand potential users' preferences for LA-PrEP, with audience segmentation. DESIGN: Willingness to use and preferences for LA-PrEP were measured in HIV-negative, sexually active MSM in the 2020 American Men's Internet Survey...
April 22, 2024: BMJ Open
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JOURNAL ARTICLE
Nigel B Wilding, Robert Evans, Francesco Turci
Measurements of local density fluctuations are crucial to characterizing the interfacial properties of equilibrium fluids. A specific case that has been well-explored involves the heightened compressibility of water near hydrophobic entities. Commonly, a spatial profile of local fluctuation strength is constructed from the measurements of the mean and variance of solvent particle number fluctuations in a set of contiguous subvolumes of the system adjacent to the solvo-/hydrophobe. An alternative measure proposed by Evans and Stewart [J...
April 28, 2024: Journal of Chemical Physics
#3
JOURNAL ARTICLE
Seung Hee Choi, Thomas Templin
No abstract text is available yet for this article.
March 2024: Womens Health Nurs
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JOURNAL ARTICLE
Yaqin Zhong, Xiaojun Guo, Yitong Liu, Yaning Wang, Yanan Wang, Yan Song, Rujian Lu
BACKGROUND: The aged people who live in nursing home are predicted to keep growing in the following decades. There are both quantitative imbalance and structural imbalance in the utilization of nursing homes in China. This study aimed to analyze old people's preference for nursing homes and help the government optimize resource allocation. METHODS: A discrete choice experiment (DCE) was conducted and six attributes of nursing homes including monthly fee, distance from home, geographical location, medical facilities, environment of nursing homes and nursing staff were determined...
April 22, 2024: BMC Nursing
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JOURNAL ARTICLE
Carol Mansfield, Marco Boeri, Josh Coulter, Eileen Baranowski, Susan Sparks, Kristina An Haack, Alaa Hamed
BACKGROUND: Genetic testing can offer early diagnosis and subsequent treatment of rare neuromuscular diseases. Options for these tests could be improved by understanding the preferences of patients for the features of different genetic tests, especially features that increase information available to patients. METHODS: We developed an online discrete-choice experiment using key attributes of currently available tests for Pompe disease with six test attributes: number of rare muscle diseases tested for with corresponding probability of diagnosis, treatment availability, time from testing to results, inclusion of secondary findings, necessity of a muscle biopsy, and average time until final diagnosis if the first test is negative...
April 22, 2024: Orphanet Journal of Rare Diseases
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JOURNAL ARTICLE
Vasileios J Kontsiotis, Foteini Emmanouilidou, Vasilios Liordos
Red foxes (Vulpes vulpes) have interacted with humans during their common history. We used a contingent valuation method to assess the economic value of the management of this mesocarnivore's negative impacts. We carried out face-to-face interviews with 746 Greek residents, using a multiple-bounded discrete choice approach to estimate willingness to pay (WTP) for red fox management under three impact situations: attack domestic animals, reduce game, carry disease. About 51.9%, 33.0%, and 81.1% of the respondents stated a mean WTP of €34...
April 22, 2024: Environmental Science and Pollution Research International
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JOURNAL ARTICLE
Giuseppe Di Vita, Raffaele Zanchini, Daniela Spina, Antonella Vastola, Mario D'Amico, Francesco Caracciolo
The purpose of this paper is to thoroughly assess the value of colours in consumers' preferences for sweet peppers, and the association with more sustainable methods of production in the consumers' minds. Furthermore, this study provides novel insights into the influence of colours on the willingness to pay (WTP) for vegetables. It explores the interplay between colours, food attributes, and socio-demographic characteristics among consumers, marking the first attempt to examine this relationship comprehensively...
April 30, 2024: Heliyon
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JOURNAL ARTICLE
Sylvia Martin, Emanuele Angolini, Jennifer Audi, Dr Enrico Bertini, Lucia Pia Bruno, Joshua Coulter, Alessandra Ferlini, Fernanda Fortunato, Vera Frankova, Nicolas Garnier, Åsa Grauman, Edith Gross, Brett Hauber, Mats Hansson, Janbernd Kirschner, Ferdinand Knieling, Gergana Kyosovksa, Silvia Ottombrino, Antonio Novelli, Roman Raming, Stefaan Sansen, Christina Saier, Jorien Veldwijk
INTRODUCTION: Rare diseases (RDs) collectively impact over 30 million people in Europe. Most individual conditions have a low prevalence which has resulted in a lack of research and expertise in this field, especially regarding genetic newborn screening (gNBS). There is increasing recognition of the importance of incorporating patients' needs and general public perspectives into the shared decision-making process regarding gNBS. This study is part of the Innovative Medicine Initiative project Screen4Care which aims at shortening the diagnostic journey for RDs by accelerating diagnosis for patients living with RDs through gNBS and the use of digital technologies, such as artificial intelligence and machine learning...
April 19, 2024: BMJ Open
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JOURNAL ARTICLE
Ling-Hsiang Chuang, Huanlan Zhang, Tianqi Hong, Shitong Xie
PURPOSE: To quantify the preferences for an oral antidiabetic drug (OAD) among patients with type 2 diabetes mellitus (T2DM) in China. METHODS: A discrete choice experiment (DCE) with hypothetical OAD profiles was performed among patients with T2DM recruited from both online and offline sources. Each patient completed 12 DCE choice tasks. The attributes, elicited through mixed methods, include blood glucose level decrease, blood glucose level stability, frequency of medication, gastrointestinal side effects, dose adjustment and out-of-pocket expense...
April 20, 2024: Patient
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JOURNAL ARTICLE
Gabriela Manco Machado, Ana Clara Falabello Luca, Renata Paz Leal Pereira, Ana Yne Fernandez, Lucas Gabriel Santini Rodrigues, Isabella Petroline Leite, Maximiliano Sergio Cenci, Tatiana Pereira Cenci, Ana Paula Pires Santos, Branca Heloisa Oliveira, Paulo Nadanovsky, Marina Deus Moura Lima, Marcoeli Silva Moura, Edson Hilan Gomes Lucena, Tathiane Larissa Lenzi, Ana Carla Crispim, Fernanda Campos Almeida Carrer, Mariana Gabriel, Claudia Cazal Lira, Carla Vecchione Gurgel, Helder Henrique Costa Pinheiro, Gilberto Alfredo Pucca, Fábio Carneiro Martins, Paola Gondim Calvasina, Maria Fernanda Montezuma Tricoli, Camila Menezes Costa Castelo Branco, Raiza Dias Freitas, José Carlos Pettorossi Imparato, Daniela Prócida Raggio, Tamara Kerber Tedesco, Fausto Medeiros Mendes, Mariana Minatel Braga
BACKGROUND: Important evidence has been constantly produced and needs to be converted into practice. Professional consumption of such evidence may be a barrier to its implementation. Then, effective implementation of evidence-based interventions in clinical practice leans on the understanding of how professionals value attributes when choosing between options for dental care, permitting to guide this implementation process by maximizing strengthens and minimizing barriers related to that...
April 19, 2024: BMC Oral Health
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JOURNAL ARTICLE
Stefan Baumann, Janne Lorenzen
In this exploratory study, we investigate the influence of several semantic-pragmatic and syntactic factors on prosodic prominence production in German, namely referential and lexical newness/givenness, grammatical role, and position of a referential target word within a sentence. Especially in terms of the probabilistic distribution of accent status (nuclear, prenuclear, deaccentuation) we find evidence for an additive influence of the discourse-related and syntactic cues, with lexical newness and initial sentence position showing the strongest boosting effects on a target word's prosodic prominence...
2024: PloS One
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JOURNAL ARTICLE
Harrison J Hansford, Matthew D Jones, Aidan G Cashin, Raymond Wjg Ostelo, Alessandro Chiarotto, Sam A Williams, Saurab Sharma, John M Rose, Jack J Devonshire, Michael C Ferraro, Michael A Wewege, James H McAuley
OBJECTIVE: To identify the smallest worthwhile effect (SWE) of exercise therapy for people with non-specific chronic low back pain (CLBP). DESIGN: Discrete choice experiment. METHODS: The SWE was estimated as the lowest reduction in pain that participants would consider exercising worthwhile, compared to not exercising i.e., effects due to natural history and other components (e.g., regression to the mean). We recruited English-speaking adults in Australia with non-specific CLBP to our online survey via email obtained from a registry of previous participants and advertisements on social media...
April 17, 2024: Journal of Orthopaedic and Sports Physical Therapy
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JOURNAL ARTICLE
Rajabali Daroudi, Hojjat Zeraati, Thomas G Poder, Richard Norman, Alireza Olyaeemanesh, Ali Akbari Sari, Hosein Ameri
BACKGROUND: The second version of the Short-Form 6-Dimension (SF-6Dv2) classification system has recently been developed. The objective of this study was to develop a value set for SF-6Dv2 based on the societal preferences of a general population in the capital of Iran. METHODS: A representative sample of the capital of Iran (n = 3061) was recruited using a stratified multistage quota sampling technique. Face-to-face interviews were conducted using binary choice sets from the international valuation protocol of the discrete choice experiment with duration...
April 17, 2024: Quality of Life Research
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JOURNAL ARTICLE
Xinyu Li, Louise A Donnelly, Roderick C Slieker, Joline W J Beulens, Leen M 't Hart, Petra J M Elders, Ewan R Pearson, Anoukh van Giessen, Jose Leal, Talitha Feenstra
AIMS/HYPOTHESIS: This study aimed to explore the added value of subgroups that categorise individuals with type 2 diabetes by k-means clustering for two primary care registries (the Netherlands and Scotland), inspired by Ahlqvist's novel diabetes subgroups and previously analysed by Slieker et al. METHODS: We used two Dutch and Scottish diabetes cohorts (N=3054 and 6145; median follow-up=11.2 and 12.3 years, respectively) and defined five subgroups by k-means clustering with age at baseline, BMI, HbA1c , HDL-cholesterol and C-peptide...
April 16, 2024: Diabetologia
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JOURNAL ARTICLE
Carla Rauseo, M Samuel Cheng
As health care moves away from volume-based to value-based delivery, the role of the patient in determining value in health care is now paramount. Thus, health care should be aligned with what matters most to patients. Ascertaining patient preferences is therefore critical if we are to provide patients with care that is meaningful to them. However, preferences are difficult to measure and traditional methods of preference measurement in physical therapy face challenges when attempting to measure such. This perspective makes a case for greater use of the discrete choice experiment (DCE) in physical therapy as a research method to measure patient preferences...
April 16, 2024: Physical Therapy
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REVIEW
Giulio Laino Chiavegatti, Stan B Floresco
Acute stress has various effects on cognition, executive function and certain forms of cost/benefit decision making. Recent studies in rodents indicate that acute stress differentially alters reward-related decisions involving particular types of costs and slows choice latencies. Yet, how stress alters decisions where rewards are linked to punishment is less clear. We examined how 1 h restraint stress, followed by behavioral testing 10 min later altered action-selection on two tasks involving reward-seeking under threat of punishment in well-trained male and female rats...
May 2024: Neurobiology of Stress
#17
Gavin M Bidelman, Fallon Bernard, Kimberly Skubic
Our perceptual system bins elements of the speech signal into categories to make speech perception manageable. Here, we aimed to test whether hearing speech in categories (as opposed to a continuous/gradient fashion) affords yet another benefit to speech recognition: parsing noisy speech at the "cocktail party." We measured speech recognition in a simulated 3D cocktail party environment. We manipulated task difficulty by varying the number of additional maskers presented at other spatial locations in the horizontal soundfield (1-4 talkers) and via forward vs...
April 5, 2024: bioRxiv
#18
JOURNAL ARTICLE
John H McDermott, Videha Sharma, William G Newman, Paul Wilson, Katherine Payne, Stuart Wright
AIMS: Genetic testing can be used to improve the safety and effectiveness of commonly prescribed medicines-a concept known as pharmacogenetics. This study aimed to quantify members of the UK public's preferences for a pharmacogenetic service to be delivered in primary care in the National Health Service. METHODS: Members of the UK population were surveyed via an online panel company. Respondents completed 1 of 2 survey versions, asking respondents to select their preferred pharmacogenetic testing service in the context of a presentation of low mood or pain...
April 14, 2024: British Journal of Clinical Pharmacology
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REVIEW
Samer H Sharkiya, Anat M Hag
INTRODUCTION: E-health services offer potential benefits for healthcare delivery, especially for older adults, yet their adoption remains suboptimal due to various barriers. Understanding the environmental and contextual factors influencing e-health use among this demographic is crucial for enhancing their health outcomes. AIM: This rapid review aims to explore the various environmental and contextual factors affecting the use of e-health among older adults, focusing on identifying strategies to enhance acceptance and usefulness...
April 12, 2024: International Journal of Medical Informatics
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JOURNAL ARTICLE
Emily Holmes, Pete Dixon, Amy Mathieson, Leone Ridsdale, Myfanwy Morgan, Alison McKinlay, Jon Dickson, Steve Goodacre, Mike Jackson, Deborah Foster, Kristy Hardman, Steve Bell, Anthony Marson, Dyfrig Hughes, Adam J Noble
INTRODUCTION: To identify service users' preferences for an alternative care pathway for adults with epilepsy presenting to the ambulance service. METHODS: Extensive formative work (qualitative, survey and knowledge exchange) informed the design of a stated preference discrete choice experiment (DCE). This hypothetical survey was hosted online and consisted of 12 binary choices of alternative care pathways described in terms of: the paramedic's access to medical records/ 'care plan', what happens next (described in terms of conveyance), time, availability of epilepsy specialists today, general practitioner (GP) notification and future contact with epilepsy specialists...
April 10, 2024: Seizure: the Journal of the British Epilepsy Association
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