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https://www.readbyqxmd.com/read/28227934/effect-of-embedding-dimension-on-complexity-measures-in-identifying-arrhythmia
#1
Radhagayathri K Udhayakumar, Chandan Karmakar, Peng Li, Marimuthu Palaniswami, Radhagayathri K Udhayakumar, Chandan Karmakar, Peng Li, Marimuthu Palaniswami, Marimuthu Palaniswami, Radhagayathri K U Udhayakumar, Peng Li, Chandan Karmakar
Entropy measures like Approximate entropy (ApEn) and Sample entropy (SampEn) are well established tools to analyze Heart Rate Variability (HRV) data. Critical parameters involved in these computations namely embedding dimension m and tolerance r are in most cases assumed to be 2 and 0.2*signal SD (standard devaition) respectively. Such assumptions do not work fairly across data sets and thus create misleading results in many cases. Problems with r have been addressed with the advent of newer entropy measures like Permutation entropy (PE), Fuzzy entropy (FuzzyEn) and Distribution entropy (DistEn) that simply eliminate, modify or replace r from calculations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227886/development-of-an-open-source-cosimulation-method-of-the-knee
#2
Anne Schmitz, Davide Piovesan, Anne Schmitz, Davide Piovesan, Anne Schmitz, Davide Piovesan
Rigid body dynamics and soft tissue loads are solved simultaneously in a cosimulation framework to couple musculoskeletal dynamics and tissue mechanics. The goal of this work was to implement a validated, open-source cosimulation framework of the knee to determine how this coupling affects computed cartilage loads. The kinematic knee joint of a generic whole body model in the open-source software OpenSim was replaced by a previously developed discrete element knee model that consisted of a six degree of freedom (dof) tibiofemoral joint and one dof patellofemoral joint...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227130/verification-of-a-research-prototype-for-hemodynamic-analysis-of-cerebral-aneurysms
#3
Takashi Suzuki, Cosmin Ioan Nita, Saikiran Rapaka, Hiroyuki Takao, Viorel Mihalef, Soichiro Fujimura, Chihebeddine Dahmani, Puneet Sharma, Hiroya Mamori, Toshihiro Ishibashi, Thomas Redel, Makoto Yamamoto, Yuichi Murayama, Takashi Suzuki, Cosmin Ioan Nita, Saikiran Rapaka, Hiroyuki Takao, Viorel Mihalef, Soichiro Fujimura, Chihebeddine Dahmani, Puneet Sharma, Hiroya Mamori, Toshihiro Ishibashi, Thomas Redel, Makoto Yamamoto, Yuichi Murayama, Cosmin Ioan Nita, Puneet Sharma, Hiroya Mamori, Soichiro Fujimura, Thomas Redel, Saikiran Rapaka, Chihebeddine Dahmani, Toshihiro Ishibashi, Makoto Yamamoto, Viorel Mihalef, Takashi Suzuki, Hiroyuki Takao, Yuichi Murayama
Owing to its clinical importance, there has been a growing body of research on understanding the hemodynamics of cerebral aneurysms. Traditionally, this work has been performed using general-purpose, state-of-the-art commercial solvers. This has meant requiring engineering expertise for making appropriate choices on the geometric discretization, time-step selection, choice of boundary conditions etc. Recently, a CFD research prototype has been developed (Siemens Healthcare GmbH, Prototype - not for diagnostic use) for end-to-end analysis of aneurysm hemodynamics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221188/treatment-of-cervical-intraepithelial-neoplasia-patients-preferences-for-surgery-or-immunotherapy-with-imiquimod
#4
Margot M Koeneman, Brigitte A Essers, Cornelis G Gerestein, Anna J M van de Sande, Rogier J N T M Litjens, Dieuwke Boskamp, Medi F J Goossens, Heleen J Beekhuizen, Roy F P M Kruitwagen, Arnold J Kruse, Carmen D Dirksen
OBJECTIVE: Imiquimod has been studied as a noninvasive pharmacological treatment alternative to large loop excision of the transformation zone (LLETZ) for high-grade cervical intraepithelial neoplasia (CIN), to prevent long-term obstetric complications from surgical treatment. This study aims to investigate womens' preferences for treatment of high-grade CIN with imiquimod or LLETZ. METHODS: A labeled discrete choice experiment was conducted among 100 women with abnormal cervical cytology in 5 hospitals in the Netherlands between March 2014 and December 2015...
February 17, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28217847/do-financial-incentives-influence-gps-decisions-to-do-after-hours-work-a-discrete-choice-labour-supply-model
#5
Barbara Broadway, Guyonne Kalb, Jinhu Li, Anthony Scott
This paper analyses doctors' supply of after-hours care (AHC), and how it is affected by personal and family circumstances as well as the earnings structure. We use detailed survey data from a large sample of Australian General Practitioners (GPs) to estimate a structural, discrete choice model of labour supply and AHC. This allows us to jointly model GPs' decisions on the number of daytime-weekday working hours and the probability of providing AHC. We simulate GPs' labour supply responses to an increase in hourly earnings, both in a daytime-weekday setting and for AHC...
February 20, 2017: Health Economics
https://www.readbyqxmd.com/read/28213678/unifying-differential-item-functioning-in-factor-analysis-for-categorical-data-under-a-discretization-of-a-normal-variant
#6
Yu-Wei Chang, Nan-Jung Hsu, Rung-Ching Tsai
The multiple-group categorical factor analysis (FA) model and the graded response model (GRM) are commonly used to examine polytomous items for differential item functioning to detect possible measurement bias in educational testing. In this study, the multiple-group categorical factor analysis model (MC-FA) and multiple-group normal-ogive GRM models are unified under the common framework of discretization of a normal variant. We rigorously justify a set of identified parameters and determine possible identifiability constraints necessary to make the parameters just-identified and estimable in the common framework of MC-FA...
February 17, 2017: Psychometrika
https://www.readbyqxmd.com/read/28212966/estimating-preferences-for-complex-health-technologies-lessons-learned-and-implications-for-personalized-medicine
#7
Deborah A Marshall, Juan Marcos Gonzalez, Karen V MacDonald, F Reed Johnson
We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example of genomic testing. Assessing the value of WGS is complex because WGS provides multiple findings, some of which can be incidental in nature and unrelated to the specific health concerns that motivated the test. In addition, WGS results can include actionable findings (variants considered to be clinically useful and can be acted on), findings for which evidence for best clinical action is not available (variants considered clinically valid but do not meet as high of a standard for clinical usefulness), and findings of unknown significance...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212952/the-challenge-of-conditional-reimbursement-stopping-reimbursement-can-be-more-difficult-than-not-starting-in-the-first-place
#8
E J van de Wetering, Job van Exel, Werner B F Brouwer
BACKGROUND: Conditional reimbursement of new health technologies is increasingly considered as a useful policy instrument. It allows gathering more robust evidence regarding effectiveness and cost-effectiveness of new technologies without delaying market access. Nevertheless, the literature suggests that ending reimbursement and provision of a technology when it proves not to be effective or cost-effective in practice may be difficult. OBJECTIVES: To investigate how policymakers and the general public in the Netherlands value removing a previously reimbursed treatment from the basic benefits package relative to not including a new treatment...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28211729/stochastic-dynamics-through-hierarchically-embedded-markov-chains
#9
Vítor V Vasconcelos, Fernando P Santos, Francisco C Santos, Jorge M Pacheco
Studying dynamical phenomena in finite populations often involves Markov processes of significant mathematical and/or computational complexity, which rapidly becomes prohibitive with increasing population size or an increasing number of individual configuration states. Here, we develop a framework that allows us to define a hierarchy of approximations to the stationary distribution of general systems that can be described as discrete Markov processes with time invariant transition probabilities and (possibly) a large number of states...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28208379/prediction-of-the-moments-in-advection-diffusion-lattice-boltzmann-method-i-truncation-dispersion-skewness-and-kurtosis
#10
Irina Ginzburg
The effect of the heterogeneity in the soil structure or the nonuniformity of the velocity field on the modeled resident time distribution (RTD) and breakthrough curves is quantified by their moments. While the first moment provides the effective velocity, the second moment is related to the longitudinal dispersion coefficient (k_{T}) in the developed Taylor regime; the third and fourth moments are characterized by their normalized values skewness (Sk) and kurtosis (Ku), respectively. The purpose of this investigation is to examine the role of the truncation corrections of the numerical scheme in k_{T}, Sk, and Ku because of their interference with the second moment, in the form of the numerical dispersion, and in the higher-order moments, by their definition...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207968/mri-vs-ultrasound-as-the-initial-imaging-modality-for-pediatric-and-young-adult-patients-with-suspected-appendicitis
#11
Daniel Imler, Christine Keller, Shyam Sivasankar, Nancy Ewen Wang, Shreyas Vasanawala, Matias Bruzoni, James Quinn
BACKGROUND: While ultrasound (US), given its lack of ionizing radiation is currently the recommended initial imaging study of choice for the diagnosis of appendicitis in pediatric and young adult patients, it does have significant shortcomings. US is time intensive, operator dependent, and results in frequent inconclusive studies, thus necessitating further imaging, and admission for observation or repeat clinical visits. A rapid focused Magnetic Resonance Imaging (MRI) for appendicitis has been shown to have definitive sensitivity and specificity, similar to Computed tomography (CT) but without radiation and offers a potential alternative to US...
February 16, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28192688/bidirectional-relationship-between-time-preference-and-adolescent-smoking-and-alcohol-use-evidence-from-longitudinal-data
#12
Young Kyung Do, Eunhae Shin
INTRODUCTION: Scholarly interest in time preference as a potential predictor of risky health behaviors in adolescents has increased in recent years. However, most of the existing literature is limited due to the exclusive reliance on cross-sectional data, precluding the possibility of establishing the direction of causality. Using longitudinal data from the Korea Youth Panel Survey (2003-7), which followed up a nationally representative sample of 3449 adolescents aged 14years for five years, this study examines a bidirectional relationship between time preference and smoking and drinking behaviors among adolescents...
February 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28183069/a-dynamic-model-of-the-piezoelectric-traveling-wave-rotary-ultrasonic-motor-stator-with-the-finite-volume-method
#13
I A Renteria Marquez, V Bolborici
This manuscript presents a method to model in detail the piezoelectric traveling wave rotary ultrasonic motor (PTRUSM) stator response under the action of DC and AC voltages. The stator is modeled with a discrete two dimensional system of equations using the finite volume method (FVM). In order to obtain accurate results, a model of the stator bridge is included into the stator model. The model of the stator under the action of DC voltage is presented first, and the results of the model are compared versus a similar model using the commercial finite element software COMSOL Multiphysics...
January 31, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28182131/getting-patients-in-the-door-medical-appointment-reminder-preferences
#14
Trisha M Crutchfield, Christine E Kistler
PURPOSE: Between 23% and 34% of outpatient appointments are missed annually. Patients who frequently miss medical appointments have poorer health outcomes and are less likely to use preventive health care services. Missed appointments result in unnecessary costs and organizational inefficiencies. Appointment reminders may help reduce missed appointments; particular types may be more effective than other types. We used a survey with a discrete choice experiment (DCE) to learn why individuals miss appointments and to assess appointment reminder preferences...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28181651/preferences-for-the-emergency-department-or-alternatives-for-older-people-in-aged-care-a-discrete-choice-experiment
#15
Glenn Arendts, Stephen Jan, Matthew J Beck, Kirsten Howard
No abstract text is available yet for this article.
January 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28181330/discrete-and-morphometric-traits-reveal-contrasting-patterns-and-processes-in-the-macroevolutionary-history-of-a-clade-of-scorpions
#16
Nicolas Mongiardino Koch, F Sara Ceccarelli, Andrés A Ojanguren-Affilastro, Martín J Ramírez
Many paleontological studies have investigated the evolution of entire body plans, generally relying on discrete character-taxon matrices. In contrast, macroevolutionary studies performed by neontologists have mostly focused on morphometric traits. Although these data types are very different, some studies have suggested that they capture common patterns. Nonetheless, the tests employed to support this claim have not explicitly incorporated a phylogenetic framework, and may therefore be susceptible to confounding effects due to the presence of common phylogenetic structure...
February 9, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28173806/ecg-signal-performance-de-noising-assessment-based-on-threshold-tuning-of-dual-tree-wavelet-transform
#17
Oussama El B'charri, Rachid Latif, Khalifa Elmansouri, Abdenbi Abenaou, Wissam Jenkal
BACKGROUND: Since the electrocardiogram (ECG) signal has a low frequency and a weak amplitude, it is sensitive to miscellaneous mixed noises, which may reduce the diagnostic accuracy and hinder the physician's correct decision on patients. METHODS: The dual tree wavelet transform (DT-WT) is one of the most recent enhanced versions of discrete wavelet transform. However, threshold tuning on this method for noise removal from ECG signal has not been investigated yet...
February 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28168926/stimulation-of-nicotinic-acetylcholine-alpha7-receptors-rescue-schizophrenia-like-cognitive-impairments-in-rats
#18
Agnieszka Potasiewicz, Agnieszka Nikiforuk, Małgorzata Hołuj, Piotr Popik
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) dysfunction plays an important role in schizophrenia. Positive allosteric modulators of α7 nAChR have emerged as a promising therapeutic approach to manage cognitive deficits that are inadequately treated in schizophrenic patients. The aim of the present study was to evaluate the ability of type I (CCMI) and type II (PNU120596) α7 nAChR positive allosteric modulators to counteract MK-801-induced cognitive and sensorimotor gating deficits. The activity of these compounds was compared with the action of the α7 nAChR agonist A582941...
February 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28168448/the-impact-of-health-insurance-expansion-on-physician-treatment-choice-medicare-part-d-and-physician-prescribing
#19
Tianyan Hu, Sandra L Decker, Shin-Yi Chou
We test the effect of the introduction of Medicare Part D on physician prescribing behavior by using data on physician visits from the National Ambulatory Medical Care Survey (NAMCS) 2002-2004 and 2006-2009 for patients aged 60-69. We use regression discontinuity designs to estimate the effect of part D around the age of 65 before and after 2006 and then compare the discrete jump in outcomes at age 65 before and after Part D. We find a 32% increase in the number of prescription drugs prescribed or continued per visit and a 46% increase in the number of generic drugs prescribed or continued for the elderly after the introduction of Medicare Part D...
February 6, 2017: Int J Health Econ Manag
https://www.readbyqxmd.com/read/28166413/dutch-consumers-willingness-to-pay-for-broiler-welfare
#20
Machiel Mulder, Sigourney Zomer
This article analyzes Dutch consumers' willingness to pay (WTP) for the welfare of broiler chickens and the consequences for nonhuman animal welfare policies. Using data from a discrete-choice experiment and a random parameter logit model, this study showed that consumers particularly value opportunities for outdoor access and the method used for anesthesia before slaughter. The WTP was also positively related to the number of consumers buying the same product, indicating that they experience the public-good dilemma...
February 6, 2017: Journal of Applied Animal Welfare Science: JAAWS
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