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https://www.readbyqxmd.com/read/27920834/trends-and-determinant-factors-in-the-use-of-cardiac-resynchronization-therapy-devices-in-japan-analysis-of-the-japan-cardiac-device-treatment-registry-database
#1
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Takashi Nitta, Ken Okumura
BACKGROUND: The choice of cardiac resynchronization therapy device, with (CRT-D) or without (CRT-P) a defibrillator, in patients with heart failure largely depends on the physician׳s discretion, because it has not been established which subjects benefit most from a defibrillator. METHODS: We examined the annual trend of CRT device implantations between 2006 and 2014, and evaluated the factors related to the device selection (CRT-D or CRT-P) for primary prevention of sudden cardiac death in patients with heart failure by analyzing the Japan Cardiac Device Treatment Registry (JCDTR) database from January 2011 and August 2015 (CRT-D, n=2714; CRT-P, n=555)...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27920507/men-s-preferences-for-the-treatment-of-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-a-discrete-choice-experiment
#2
Colette Mankowski, Divine Ikenwilo, Sebastian Heidenreich, Mandy Ryan, Jameel Nazir, Cathy Newman, Verity Watson
OBJECTIVE: To explore and quantify men's preferences and willingness to pay (WTP) for attributes of medications for lower urinary tract symptoms associated with benign prostatic hyperplasia using a discrete choice experiment. SUBJECTS AND METHODS: Men in the UK aged ≥45 years with moderate-to-severe lower urinary tract symptoms/benign prostatic hyperplasia (based on self-reported International Prostate Symptom Score ≥8) were recruited. An online discrete choice experiment survey was administered...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27917560/is-best-worst-scaling-suitable-for-health-state-valuation-a-comparison-with-discrete-choice-experiments
#3
Nicolas Krucien, Verity Watson, Mandy Ryan
Health utility indices (HUIs) are widely used in economic evaluation. The best-worst scaling (BWS) method is being used to value dimensions of HUIs. However, little is known about the properties of this method. This paper investigates the validity of the BWS method to develop HUI, comparing it to another ordinal valuation method, the discrete choice experiment (DCE). Using a parametric approach, we find a low level of concordance between the two methods, with evidence of preference reversals. BWS responses are subject to decision biases, with significant effects on individuals' preferences...
December 4, 2016: Health Economics
https://www.readbyqxmd.com/read/27905819/mothers-preferences-regarding-new-combination-vaccines-for-their-children-in-japan-2014
#4
Aiko Shono, Masahide Kondo
A number of new vaccines to prevent childhood diseases have been introduced globally over the last few decades. Only four combination vaccines are currently available in Japan, DTaP/sIPV, DTaP, DT, and MR, leading to complex infant vaccine scheduling. This study aims to investigate mothers' preferences with respect to combination vaccines for their children, should new combination vaccines become available that have not yet been launched in Japan or that will be developed in the future. We conducted a web-based, cross-sectional survey of 1,243 mothers who had at least one child between 2 months and 3 years of age...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27887202/serological-markers-in-diagnosis-of-pediatric-inflammatory-bowel-disease-and-as-predictors-for-early-tumor-necrosis-factor-blocker-therapy
#5
Christine Olbjørn, Milada Cvancarova Småstuen, Espen Thiis-Evensen, Britt Nakstad, Morten Harald Vatn, Gøri Perminow
OBJECTIVE: To describe the prevalence of serological markers in newly diagnosed treatment-naïve pediatric inflammatory bowel disease (IBD), their utility in differentiating Crohn's disease (CD), ulcerative colitis (UC) and symptomatic non-IBD patients and whether serological markers are associated with early TNF blocker treatment. MATERIAL AND METHODS: Ninety-six children and adolescents <18 years, 58 with IBD and 38 symptomatic non-IBD controls were included...
November 25, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27884193/reorganising-specialist-cancer-surgery-for-the-twenty-first-century-a-mixed-methods-evaluation-respect-21
#6
Naomi J Fulop, Angus I G Ramsay, Cecilia Vindrola-Padros, Michael Aitchison, Ruth J Boaden, Veronica Brinton, Caroline S Clarke, John Hines, Rachael M Hunter, Claire Levermore, Satish B Maddineni, Mariya Melnychuk, Caroline M Moore, Muntzer M Mughal, Catherine Perry, Kathy Pritchard-Jones, David C Shackley, Jonathan Vickers, Stephen Morris
BACKGROUND: There are longstanding recommendations to centralise specialist healthcare services, citing the potential to reduce variations in care and improve patient outcomes. Current activity to centralise specialist cancer surgical services in two areas of England provides an opportunity to study the planning, implementation and outcomes of such changes. London Cancer and Manchester Cancer are centralising specialist surgical pathways for prostate, bladder, renal, and oesophago-gastric cancers, so that these services are provided in fewer hospitals...
November 25, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27881284/perceived-risks-contra-benefits-of-using-biosimilar-drugs-in-ulcerative-colitis-discrete-choice-experiment-among-gastroenterologists
#7
Petra Baji, László Gulácsi, Petra A Golovics, Barbara D Lovász, Márta Péntek, Valentin Brodszky, Fanni Rencz, Péter L Lakatos
BACKGROUND: In middle-income countries, access to biological therapy is limited in ulcerative colitis in terms of the number of patients and the length of therapy. Because of their cost advantages, biosimilars have the potential to improve access to therapy, but physicians have concerns toward their use because of the lack of evidence from randomized clinical trials. OBJECTIVES: To explore the preferences of gastroenterologists for biosimilar drugs in ulcerative colitis as well as to compare our results with results of previous studies on gastroenterologists' preferences toward biosimilars...
September 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27878548/contemporary-use-of-arterial-and-venous-conduits-in-coronary-artery-bypass-grafting-anatomical-functional-and-clinical-aspects
#8
REVIEW
G Cuminetti, S Gelsomino, S Curello, R Lorusso, J G Maessen, J C A Hoorntje
Although the benefits of using the left internal mammary artery to bypass the left anterior descending artery (LAD) have been extensively ascertained, freedom from major cardiovascular events and survival after coronary artery bypass grafting (CABG) also correlate with the completeness of revascularisation. Hence, careful selection of the second-best graft conduit is crucial for CABG success. The more widespread use of saphenous vein grafts contrasts with the well-known long-term efficacy of multiple arterial grafting, which struggles to emerge as the procedure of choice due to concerns over increased technical difficulties and higher risk of postoperative complications...
November 22, 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27873226/is-dimension-order-important-when-valuing-health-states-using-discrete-choice-experiments-including-duration
#9
Brendan Mulhern, Richard Norman, Paula Lorgelly, Emily Lancsar, Julie Ratcliffe, John Brazier, Rosalie Viney
BACKGROUND: Discrete choice experiments with duration (DCETTO) can be used to estimate utility values for preference-based measures, such as the EQ-5D-5L. For self-completion, the health dimensions are presented in a standard order. However, for valuation, this may result in order effects. Thus, it is important to understand whether health state dimension ordering affects values. The aim of this study was to examine the importance of dimension ordering on DCE values using EQ-5D-5L. METHODS: A choice experiment presenting two health profiles and a third immediate death option was developed...
November 21, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27859513/recognition-decisions-from-visual-working-memory-are-mediated-by-continuous-latent-strengths
#10
Timothy J Ricker, Jonathan E Thiele, April R Swagman, Jeffrey N Rouder
Making recognition decisions often requires us to reference the contents of working memory, the information available for ongoing cognitive processing. As such, understanding how recognition decisions are made when based on the contents of working memory is of critical importance. In this work we examine whether recognition decisions based on the contents of visual working memory follow a continuous decision process of graded information about the correct choice or a discrete decision process reflecting only knowing and guessing...
November 17, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27856356/percutaneous-nephrolithotomy-pcnl-a-critical-review
#11
REVIEW
Arvind P Ganpule, Mohankumar Vijayakumar, Ankur Malpani, Mahesh R Desai
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is the preferred treatment of choice for renal calculi. PCNL has evolved remarkably since the eighties when it was first described. APPROACH: Approach might be by either supine or prone and the access is made with the help of either fluoroscopy or ultrasound. Recently endoscopy guided puncture has also been described. MINIATURIZATION: Traditionally the tract size for PCNL used to be 30Fr. Even though the stone clearance rate was good there were complications such as bleeding With the advent of excellent optics and advances in stone fragmentation the tract size has reduced to a great extent which has reduced the complications without compromising the stone clearance...
November 14, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27853894/determining-preferences-related-to-hiv-counselling-and-testing-services-among-high-school-learners-in-kwazulu-natal-a-discrete-choice-experiment
#12
Michael Strauss, Gavin L George, Bruce D Rhodes
A key strategy of the South African national response to HIV is the scale-up of HIV counselling and testing (HCT) in the 15-49 years age group. The integrated school health policy aims to guide the roll out of youth-friendly health services including the provision of HCT in schools. Using a discrete choice experiment to examine preferences regarding the attributes of HCT service packages, this study identifies barriers to and facilitators of HCT among high school learners. Monetary considerations were found to have the strongest effect of any attribute on choice, whilst confidentiality was found to be a primary concern for learners considering HCT...
November 16, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27849124/people-with-dementia-and-carer-preferences-for-home-support-services-in-early-stage-dementia
#13
Helen Chester, Paul Clarkson, Linda Davies, Caroline Sutcliffe, Sue Davies, Alexandra Feast, Jane Hughes, David Challis
OBJECTIVES: To examine people with dementia and carer preferences for home support attributes in early-stage dementia, building on the paucity of evidence in this area. METHOD: Preferences from 44 people with dementia and 103 carers, recruited through memory clinics and an online questionnaire, were assessed with a Discrete Choice Experiment survey, with attributes informed by an evidence synthesis and lay consultation. A conditional logit model was used to estimate preference weights for the attributes within a home support 'package'...
November 16, 2016: Aging & Mental Health
https://www.readbyqxmd.com/read/27846242/understanding-health-workers-job-preferences-to-improve-rural-retention-in-timor-leste-findings-from-a-discrete-choice-experiment
#14
Marc-Francois Smitz, Sophie Witter, Christophe Lemiere, Patrick Hoang-Vu Eozenou, Tomas Lievens, Rashid U Zaman, Kay Engelhardt, Xiaohui Hou
BACKGROUND: Timor-Leste built its health workforce up from extremely low levels after its war of independence, with the assistance of Cuban training, but faces challenges as the first cohorts of doctors will shortly be freed from their contracts with government. Retaining doctors, nurses and midwives in remote areas requires a good understanding of health worker preferences. METHODS: The article reports on a discrete choice experiment (DCE) carried out amongst 441 health workers, including 173 doctors, 150 nurses and 118 midwives...
2016: PloS One
https://www.readbyqxmd.com/read/27843301/examining-patient-preferences-in-the-treatment-of-rheumatoid-arthritis-using-a-discrete-choice-approach
#15
Rieke Alten, Klaus Krüger, Julian Rellecke, Julia Schiffner-Rohe, Olaf Behmer, Guido Schiffhorst, Hans-Dieter Nolting
BACKGROUND: Biological disease-modifying antirheumatic drugs (bDMARDs) used in second-line treatment of rheumatoid arthritis (RA) are administered parenterally. However, so-called targeted synthetic DMARDs (tsDMARDs) - developed more recently - offer alternative (ie, oral) administration forms in second-line treatment. Since bDMARDs and tsDMARDs can be regarded as equal in terms of efficacy, the present study examines whether such characteristics as route of administration drive RA patients' treatment choice...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27836037/factors-affecting-chinese-broiler-farmers-main-preventive-practices-in-response-to-highly-pathogenic-avian-influenza
#16
Zeying Huang, Di Zeng, Jimin Wang
Preventive practices are highly important in response to highly pathogenic avian influenza (HPAI). As biosecurity guidelines, HPAI vaccination, antiviral medication, farm cleaning and disinfection jointly focus on mitigating the risk of infectious pathogen spread, yet much less is known about the association between broiler farmer's socio-economic characteristics and their adoption decision of these preventive practices. The current study aims to bridge this gap using a nationally representative household survey of 331 Chinese chicken farm owners, among whom the practices are far from fully adopted (only 58% of the farmers adopt all four types)...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27814714/patient-preferences-for-treatment-of-castration-resistant-prostate-cancer-in-japan-a-discrete-choice-experiment
#17
Hiroji Uemura, Nobuaki Matsubara, Go Kimura, Akito Yamaguchi, Dianne Athene Ledesma, Marco DiBonaventura, Ateesha F Mohamed, Enrique Basurto, Ian McKinnon, Ed Wang, Kristen Concialdi, Aya Narimatsu, Yasuko Aitoku
BACKGROUND: Up to a fifth of patients diagnosed with prostate cancer (PC) will develop castration-resistant prostate cancer (CRPC), which has been associated with a poor prognosis. The aim of this study was to consider the patient perspective as part of the overall treatment decision-making process for CRPC, given that an alignment between patient preference and prescribing has been shown to benefit patient outcomes. This study examines preferences of patients with CRPC in Japan for treatment features associated with treatments like RA-223, abiraterone, and docetaxel and to examine the extent to which treatment preferences may vary between symptomatic and asymptomatic patients...
November 4, 2016: BMC Urology
https://www.readbyqxmd.com/read/27812746/junior-doctors-medical-specialty-and-practice-location-choice-simulating-policies-to-overcome-regional-inequalities
#18
Pedro Ramos, Hélio Alves, Paulo Guimarães, Maria A Ferreira
There are nowadays over 1 million Portuguese who lack a primary care physician. By applying a discrete choice experiment to a large representative sample of Portuguese junior doctors (N = 503) in 2014, we provide an indication that this shortage may be addressed with a careful policy design that mixes pecuniary and non-pecuniary incentives for these junior physicians. According to our simulations, a policy that includes such incentives may increase uptake of general practitioners (GPs) in rural areas from 18% to 30%...
November 3, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27807631/head-to-head-comparison-of-health-state-values-derived-by-a-probabilistic-choice-model-and-scores-on-a-visual-analogue-scale
#19
Paul F M Krabbe, Elly A Stolk, Nancy J Devlin, Feng Xie, Elise H Quik, A Simon Pickard
BACKGROUND: Health states were quantified based on discrete choice (DC) modeling and visual analogue scale (VAS) values using the five-level version of the EQ-5D (EQ-5D-5L). The aim of this study was to determine the extent of the relationship between DC derived values (indirect method) and VAS values (direct method). METHODS: Data were collected in Canada, the United Kingdom, the Netherlands, and the United States. Respondents were asked to perform paired comparisons between two EQ-5D-5L health states for DC...
November 2, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27807165/rule-encoding-in-orbitofrontal-cortex-and-striatum-guides-selection
#20
Brianna J Sleezer, Meghan D Castagno, Benjamin Y Hayden
: Active maintenance of rules, like other executive functions, is often thought to be the domain of a discrete executive system. An alternative view is that rule maintenance is a broadly distributed function relying on widespread cortical and subcortical circuits. Tentative evidence supporting this view comes from research showing some rule selectivity in the orbitofrontal cortex and dorsal striatum. We recorded in these regions and in the ventral striatum, which has not been associated previously with rule representation, as macaques performed a Wisconsin Card Sorting Task...
November 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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