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https://www.readbyqxmd.com/read/29145686/-the-use-of-partial-nephrectomy-in-the-treatment-of-patients-with-pt1-pt2-renal-cell-carcinoma-a-trend-analysis-from-a-tertiary-referral-centre
#1
Bernhard Ralla, Stephanie Buhl, Irena Goranova, Margit Pohle, Andreas Maxeiner, Frank Friedersdorff, Ahmed Magheli, Stefan Hinz, Tom F Fuller, Kurt Miller, Jonas Busch
Introduction In patients with localised renal cell carcinoma, the only curative treatment option is surgical tumour excision. Current national and European guidelines recommend partial nephrectomy in the form of an open or minimally-invasive procedure in case of small tumours. The aim of this study was to examine the use of radical (RN) or partial (PN) nephrectomy performed as open or minimally-invasive procedures in patients with pT1 /pT2 renal cell carcinoma at a tertiary referral centre. Patients and Methods This retrospective study included a total of 758 patients with localised renal cell carcinoma (pT1/pT2), who underwent PN or RN between 01/2008 and 10/2014...
November 16, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/29124406/selective-lateral-pelvic-lymph-node-dissection-a-comparative-study-of-the-robotic-versus-laparoscopic-approach
#2
Hye Jin Kim, Gyu-Seog Choi, Jun Seok Park, Soo Yeun Park, Hee Jae Lee, In Taek Woo, In Kyu Park
BACKGROUND: Lateral pelvic lymph node dissection (LPND) is a challenging procedure due to its technical difficulty and higher incidence of surgical morbidity. We compared short-term outcomes between laparoscopic and robotic LPND in patients with rectal cancer. METHODS: Between May 2006 and December 2014, prospectively collected data from consecutive patients undergoing robotic or laparoscopic total mesorectal excision (TME) with LPND were retrospectively compared...
November 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29113345/combined-targeting-of-raf-and-mek-synergistically-inhibits-tumorigenesis-in-triple-negative-breast-cancer-model-systems
#3
Teddy S Nagaria, Changnian Shi, Charles Leduc, Victoria Hoskin, Soma Sikdar, Waheed Sangrar, Peter A Greer
Aberrant Ras-MAPK signaling from receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2), is a hallmark of triple negative breast cancer (TNBC); thus providing rationale for targeting the Ras-MAPK pathway. Components of this EGFR/HER2-Ras-Raf-Mek-Erk pathway were co-targeted in the MDA-MB-231 and MDA-MB-468 human TNBC cell lines, and in vitro effects on signaling and cytotoxicity, as well as in vivo effects on xenograft tumor growth and metastasis were assessed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29062446/the-effect-of-zero-ischaemia-laparoscopic-minimally-invasive-partial-nephrectomy-using-the-modified-sequential-preplaced-suture-renorrhaphy-technique-on-long-term-renal-functions
#4
Mehmet Giray Sönmez, Cengiz Kara
INTRODUCTION: Laparoscopic minimally invasive partial nephrectomy (MIPN) is the preferred technique in renal surgery, especially T1 phase kidney tumours, and it is recommended for the protection of renal functions in methods that do not involve ischaemia. AIM: To evaluate long-term renal functions of zero-ischaemia laparoscopic MIPN patients who underwent a modified sequential preplaced suture renorrhaphy technique. MATERIAL AND METHODS: In a total of 17 renal units in 16 patients with kidney tumours that were determined incidentally and did not cause any complaints, the masses were extracted via laparoscopic partial nephrectomy (LPN) using the modified sequential preplaced suture renorrhaphy technique...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28963260/improved-utilization-of-preventive-services-among-patients-following-team-based-annual-wellness-visits
#5
Shelley L Galvin, Rebecca Grandy, Tasha Woodall, Anna Beth Parlier, Sarah Thach, Suzanne E Landis
BACKGROUND The Annual Wellness Visit was designed to enhance preventive services utilization among Medicare beneficiaries; Annual Wellness Visits are underutilized with sparse documented effectiveness. Patients of 3 community-based and 2 retirement community outpatient clinics in western North Carolina had team-based Annual Wellness Visits over a 20-month program, with the goal of improving the uptake and delivery of the Annual Wellness Visit. A clinical pharmacist saw high-complexity patients (≥5 medications) and a licensed practical nurse saw low-complexity patients...
September 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28943598/the-piezo-actuator-driven-pulsed-water-jet-system-for-minimizing-renal-damage-after-off-clamp-laparoscopic-partial-nephrectomy
#6
Yoshihiro Kamiyama, Shinichi Yamashita, Atsuhiro Nakagawa, Shinji Fujii, Koji Mitsuzuka, Yasuhiro Kaiho, Akihiro Ito, Takaaki Abe, Teiji Tominaga, Yoichi Arai
In the setting of partial nephrectomy (PN) for renal cell carcinoma, postoperative renal dysfunction might be caused by surgical procedure. The aim of this study was to clarify the technical safety and renal damage after off-clamp laparoscopic PN (LPN) with a piezo actuator-driven pulsed water jet (ADPJ) system. Eight swine underwent off-clamp LPN with this surgical device, while off-clamp open PN was also performed with radio knife or soft coagulation. The length of the removed kidney was 40 mm, and the renal parenchyma was dissected until the renal calyx became clearly visible...
September 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28937805/laparoscopic-partial-nephrectomy-a-narrative-review-and-comparison-with-open-and-robotic-partial-nephrectomy
#7
Andrew M Ng, Paras H Shah, Louis R Kavoussi
INTRODUCTION: Kidney cancer ranks among the top 10 most prevalent cancers in Western society, ∼90% of which are renal cell carcinomas. There has been a paradigm shift in the management of small renal masses with strong emphasis now placed on nephron-sparing surgery and increased utilization of laparoscopic approaches to partial nephrectomy. In this review, the current state of laparoscopic partial nephrectomy (LPN) is discussed. EVIDENCE ACQUISITION: The PubMed database was queried using the MeSH terms "laparoscopy" and "nephrectomy," as well as the search term "partial...
October 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28892872/polymer-lipid-hybrid-nanoparticles-based-paclitaxel-and-etoposide-combinations-for-the-synergistic-anticancer-efficacy-in-osteosarcoma
#8
Rui Duan, Caiyan Li, Fan Wang, Jin-Chu Yangi
In this study, paclitaxel and etoposide-loaded lipid-polymer hybrid nanoparticles (PE-LPN) was successful prepared and evaluated for physicochemical and anticancer effect. Nanosized PE-LPN was obtained with a perfect spherical morphology. PE-LPN exhibited a controlled release of two drugs in a sequential manner. The nanoparticles exhibited a typical endocytosis-mediated cellular uptake in cancer cells. The ratiometric combination of paclitaxel (PTX) and etoposide (ETP) were significantly more cytotoxic than individual drugs...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28875952/role-of-r-e-n-a-l-nephrometry-score-in-laparoscopic-partial-nephrectomy
#9
Hai-Jiang Zhou, Yong Yan, Jian-Zhong Zhang, Li-Rong Liang, Shu-Bin Guo
Background: Preoperative anatomical scoring system is conducive to comparison between treatment options and evaluation of postoperative outcomes in patients with small renal tumors. This study aimed to evaluate the clinical application efficacy of the R.E.N.A.L. nephrometry score (RNS) in predicting perioperative outcomes in patients with renal tumor who underwent laparoscopic partial nephrectomy (LPN). Methods: The clinical data of 139 patients with renal tumors who underwent LPN between 2009 and 2015 were collected and analyzed...
September 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28847667/engineering-of-budesonide-loaded-lipid-polymer-hybrid-nanoparticles-using-a-quality-by-design-approach
#10
Donglei Leng, Kaushik Thanki, Elias Fattal, Camilla Foged, Mingshi Yang
Chronic obstructive pulmonary disease (COPD) is a complex disease, characterized by persistent airflow limitation and chronic inflammation. The purpose of this study was to design lipid-polymer hybrid nanoparticles loaded with the corticosteroid budesonide, which could potentially be combined with small interfering RNA (siRNA) for COPD management. Lipid-modified PLGA nanoparticles (LPNs) based on biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) and the cationic lipid dioleyltrimethylammonium propane (DOTAP) were prepared using a double emulsion solvent evaporation method...
August 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28843996/neural-correlates-of-visuo-tactile-crossmodal-paired-associate-learning-and-memory-in-humans
#11
Peng Gui, Yixuan Ku, Lei Li, Xiaojin Li, Mark Bodner, Fred A Lenz, Liping Wang, Yong-Di Zhou
Studies have indicated that a cortical sensory system is capable of processing information from different sensory modalities. However, it still remains unclear when and how a cortical system integrates and retains information across sensory modalities during learning. Here we investigated the neural dynamics underlying crossmodal associations and memory by recording event-related potentials (ERPs) when human participants performed visuo-tactile (crossmodal) and visuo-visual (unimodal) paired-associate (PA) learning tasks...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28802596/effects-of-differential-phase-remote-ischemic-preconditioning-intervention-in-laparoscopic-partial-nephrectomy-a-single-blinded-randomized-controlled-trial-in-a-parallel-group-design
#12
Yuan-Yuan Hou, Yun Li, Shu-Fang He, Jie Song, De-Xin Yu, Gordon T C Wong, Ye Zhang
STUDY OBJECTIVE: There are two windows of protection for remote ischemic preconditioning (RIPC), an early (ERIPC) and a late-phase (LRIPC). While ERIPC has been well studied, works on LRIPC are relatively scarce, especially for the kidneys. We aimed to compare the effects of early-phase versus late-phase RIPC in patients with laparoscopic partial nephrectomy (LPN). DESIGN: A randomized controlled study SETTING: The Second Affiliated Hospital of Anhui Medical University, 1 May 2012 to 30 October 2013 PATIENTS: Sixty-five ASA 1 to 2 patients scheduled for LPN were located randomly to ERIPC group, LRIPC group and CON group (control)...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28792194/laparoscopic-partial-nephrectomy-for-tumors-7cm-and-above-perioperative-outcomes
#13
Matvey Tsivian, Efrat Tsivian, Yury Stanevsky, Roman Bass, A Ami Sidi, Alexander Tsivian
PURPOSE: To assess and report the outcomes of laparoscopic partial nephrectomy )LPN) for T2 renal masses. MATERIALS AND METHODS: Retrospective review of patients undergoing LPN for clinically localized renal masses ≥7cm between the years 2005-2016. Descriptive analyses were generated for demographics, lesion characteristics, perioperative variables (operative time, warm ischemia time (WIT), estimated blood loss (EBL), intra-operative and post-operative complications (IOC and POC) and pathologic variables (pathology, subtype and Fuhrman grade)...
September 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28747994/lignin-valorization-lignin-nanoparticles-as-high-value-bio-additive-for-multifunctional-nanocomposites
#14
Dong Tian, Jinguang Hu, Jie Bao, Richard P Chandra, Jack N Saddler, Canhui Lu
BACKGROUND: Although conversion of low value but high-volume lignin by-product to its usable form is one of the determinant factors for building an economically feasible integrated lignocellulose biorefinery, it has been challenged by its structural complexity and inhomogeneity. We and others have shown that uniform lignin nanoparticles can be produced from a wide range of technical lignins, despite the varied lignocellulosic biomass and the pretreatment methods/conditions applied. This value-added nanostructure lignin enriched with multifunctional groups can be a promising versatile material platform for various downstream utilizations especially in the emerging nanocomposite fields...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28739404/laparoscopic-partial-nephrectomy-with-sequential-precise-tumor-specific-segmental-renal-artery-clamping-for-multiple-ipsilateral-renal-tumors-a-new-treatment-approach-and-initial-experience
#15
Mingyue Tan, Yongzhi Xu, Dongliang Xu, Juntao Jiang, Wei Zhao, Di Cui, Yuan Ruan, Shujie Xia
OBJECTIVE: To present our surgical approach and initial experience of laparoscopic partial nephrectomy (LPN) with sequential precise tumor-specific segmental renal artery clamping in patients with multiple ipsilateral renal tumors. MATERIALS AND METHODS: Six patients with multiple ipsilateral renal tumors having imperative indications for nephron-sparing surgery underwent LPN with sequential precise tumor-specific segmental renal artery clamping from May 2012 to September 2015...
July 21, 2017: Urology
https://www.readbyqxmd.com/read/28727369/comparison-of-two-different-suture-techniques-in-laparoscopic-partial-nephrectomy
#16
COMPARATIVE STUDY
Onur Kaygisiz, Sinan Çelen, Berna Aytac Vuruşkan, Hakan Vuruşkan
OBJECTIVE: To comparatively evaluate the traditional interrupted knot-tying and running suture renorrhaphy with Monocryl® in laparoscopic partial nephrectomy (LPN). MATERIALS AND METHODS: A retrospective analysis of 62 consecutive patients undergoing LPN using traditional interrupted knot-tying suture renorrhaphy (Group 1; n=31) or running suture technique renorrhaphy with 2-0 monofilament polyglecaprone (Monocryl®, Ethicon) (Group 2; n=31) from December 2011 to October 2015 at the University...
September 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28725203/retrieval-and-monitoring-processes-during-visual-working-memory-an-erp-study-of-the-benefit-of-visual-semantics
#17
Elizabeth Orme, Louise A Brown, Leigh M Riby
In this study, we examined electrophysiological indices of episodic remembering whilst participants recalled novel shapes, with and without semantic content, within a visual working memory paradigm. The components of interest were the parietal episodic (PE; 400-800 ms) and late posterior negativity (LPN; 500-900 ms), as these have previously been identified as reliable markers of recollection and post-retrieval monitoring, respectively. Fifteen young adults completed a visual matrix patterns task, assessing memory for low and high semantic visual representations...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28723795/comparison-of-postoperative-pain-between-laparoscopic-and-robot-assisted-partial-nephrectomies-for-renal-tumors-a-propensity-score-matching-analysis
#18
COMPARATIVE STUDY
Seok-Joon Jin, Jun-Young Park, Doo-Hwan Kim, Syn-Hae Yoon, Eunkyul Kim, Jai-Hyun Hwang, Cheryn Song, Young-Kug Kim
Robot-assisted partial nephrectomy (RAPN) has emerged as an alternative to laparoscopic partial nephrectomy (LPN) for removal of renal tumors. Several advantages of robotic surgery have been reported, but there is no comparative study on postoperative pain between the 2 techniques. Therefore, we compared the postoperative numerical rating scale (NRS) of pain intensity between patients who underwent LPN and those who underwent RAPN.We included 705 patients who underwent either LPN (n = 200) or RAPN (n = 505) for renal tumors between January 2000 and September 2016...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28679176/comparison-of-robotic-and-laparoscopic-partial-nephrectomy-for-small-renal-tumours
#19
Abdulmuttalip Simsek, Abdullah Hizir Yavuzsan, Yunus Colakoglu, Arda Atar, Selcuk Sahin, Volkan Tugcu
OBJECTIVE: To evaluate a single surgeon oncological and functional outcomes of laparoscopic partial nephrectomy (LPN) compared to robotic partial nephrectomy (RPN) for pT1a renal tumours. MATERIALS AND METHODS: Between 2006 and 2016, a retrospective review of 42 patients who underwent LPN (n = 20) or RPN (n = 22) by same surgeon was performed. Patients were matched for gender, age, body mass index (BMI), American Society of Anaesthesiologists (ASA) score, tumour side, RENAL and PADUA scores, peri-operative and post-operative outcomes...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28637282/the-effect-of-predisposing-atheroembolic-risk-factors-on-renal-functional-recovery-between-laparoscopy-and-open-technique-in-patients-with-t1-stage-renal-cell-carcinoma-who-underwent-partial-nephrectomy-a-retrospective-comparison-study
#20
Sung Han Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
Objective: The present study aimed to determine the effect of an increasing number of predisposing atheroembolic risk factors on the development of chronic kidney disease (CKD) after partial nephrectomy (PN) in patients with T1-stage renal cell carcinoma (RCC). Methods: The study included 147 patients with T1-stage RCC with a normal contralateral kidney and without preoperative CKD, who underwent open (OPN, N = 83, 56.5%) or laparoscopic PN (LPN, N = 64, 43.5%) between 2003 and 2014...
September 1, 2017: Japanese Journal of Clinical Oncology
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