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Masahiro Sugiura, Takahito Suyama, Manato Kanesaka, Ayumi Fujimoto, Kyokushin Hou, Kazuhiro Araki, Hiroshi Masuda, Satoko Kojima, Yukio Naya
OBJECTIVES: The aim of this study was to investigate the clinical usefulness for prediction of outcome of laparoscopic partial nephrectomy (LPN) using the R.E.N.A.L nephrometry scoring system (RNS) and centrality index score (C-index). MATERIALS AND METHODS: We retrospectively reviewed 64 patients who underwent LPN from 2010 to 2014 in our institution. The RNS and C-index scores were assigned according to the described protocols for their systems. The relationships between the patients' scores before surgery and the outcomes of LPN, warm ischemia time (WIT), operative time (ORT), estimated blood loss (EBL), and percent change in estimated glomerular filtration rate (eGFR) were analyzed retrospectively...
October 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Shota Takenaka, Yukitaka Nagamoto, Hiroyuki Aono, Takashi Kaito, Noboru Hosono
BACKGROUND CONTEXT: The time of onset of postoperative upper limb palsy (ULP), also referred to as C5 palsy, varies among patients. Although some studies addressed the relationship between the time of onset of ULP and potential etiologies, no meta-analysis has been conducted regarding the association between the time of onset of ULP and other factors such as surgical procedure type and treated diseases. PURPOSE: To elucidate differences in the time of onset of ULP among spinal surgical procedures and treated diseases to understand its etiology...
October 7, 2016: Spine Journal: Official Journal of the North American Spine Society
Faruk Ozgor, Abdulmuttalip Simsek, Ozgu Aydogdu, Onur Kucuktopcu, Omer Sarilar, Ahmet Yalcin Berberoglu, Mehmet Fatih Ahbulut, Murat Binbay
OBJECTIVES: To evaluate the possible role of an hemostatic matrix on hemostasis, perioperative outcomes and complications in patients who underwent laparoscopic partial nephrectomy (LPN). MATERIALS AND METHODS: Patients charts were analyzed retrospectively and their demographic characteristics, operative parameters and follow-up results were recorded. Patients were divided into two groups, according to those who used an hemostatic matrix as Group 1 (n = 41) and those who did not used as Group 2 (n = 44)...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
X B Wu, G T Zhang, F Zhang, W D Gan, G X Liu, X G Li, S W Zhang, H Q Guo
Objective: To explore the safety and clinical efficacy of partial nephrectomy for solitary kidney tumor. Methods: Twenty patients with a functional or anatomic solitary kidney who underwent nephron-sparing surgery for one or more renal masses were retrospectively analyzed. There were 15 male and 5 female patients with mean age of 63 years.Patients were divided into open partial nephrectomy(OPN) group and laparoscopic partial nephrectomy(LPN) group, the two groups were followed up.Demographic and clinical characteristics were analyzed using student t-test for continuous variables, and the χ(2) test for categorical variables...
October 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Longfei Liu, Lin Qi, Yangle Li, Minfeng Chen, Chao Li, Xu Cheng, Peihua Liu, Xiongbing Zu
OBJECTIVES: T1 ventral renal hilar tumors (VRHTs) represent a very special type of tumor, for which laparoscopic partial nephrectomy (LPN) by the retroperitoneal approach is challenging. In this study, we report our surgical technique and Trifecta results. METHODS: Renal rotation technique has been established for retroperitoneal laparoscopic partial nephrectomy (RLPN) for VRHTs in our institution. Trifecta was used as a composite outcome measure for assessing quality of PLPN using this technique...
September 26, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Wasiluk Alicja, Polewko Agnieszka, Laudanski Piotr, Redzko Slawomir, Kicel-Wesolowska Barbara, Dabrowska Milena, Milewski Robert
BACKGROUND: The current study objective was to compare blood platelet indices in late preterm newborns (LPN) and full term newborns (FTN). MATERIALS AND METHODS: We recruited 58 LPN and 71 FTN. Platelet indices were estimated in blood samples collected from the umbilical artery. RESULTS: LPN demonstrated a decreased count of blood platelets (249 × 10³/μL) as compared to FTN (295 × 10³/μL), p < 0.001. Platelet hematocrit (PCT) also showed substantial differences in both groups (LPN = 0...
October 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
Divya Suares, Bala Prabhakar
The present work aimed to develop and characterize sustained release cuboidal lipid polymeric nanoparticles (LPN) of rosuvastatin calcium (ROS) by solvent emulsification-evaporation process. A three factor, two level (2(3)) full-factorial design was applied to study the effect of independent variables, i.e. amount of lipid, surfactant and polymer on dependent variables, i.e. percent entrapment efficiency and particle size. Optimized formulations were further studied for zeta potential, TEM, in-vitro drug release and ex-vivo intestinal permeability...
September 5, 2016: Drug Development and Industrial Pharmacy
Hui Yi Xue, Ngoc Tran, Ho Lun Wong
Solid lipid-polymer hybrid nanocarrier (LPN) was previously reported to achieve high siRNA transfection efficiency and induce sustained RNAi-based chemosensitizing effect at cellular level. In this study, our objectives are to evaluate the in vivo biodistribution of LPNs in a prostate cancer model and determine the factors that potentially affect tumor penetration by LPNs. The LPN formulation with the highest transfection efficiency (64%) and stability was selected for the study. Mice bearing tumors of PC-3M cells were treated with LPNs labeled with IR780 or AF647-siRNA...
August 25, 2016: European Journal of Pharmaceutics and Biopharmaceutics
Byung-Kwang Yoo, Minchul Kim, Tzu-Chun Lin, Tomoko Sasaki, Debbie Ward, Joanne Spetz
BACKGROUND: The proportion of registered nurses (RNs) with employment in health-related positions before their initial RN education has increased in the past two decades. Previous research found that prior health-related employment is positively associated with RN workforce supply, potentially due to the wage differences based on different career paths. This study's objective is to test the hypotheses that prior health-related employment is associated with differences in starting wages and with different rates of wage growth for experience as an RN...
2016: BMC Health Services Research
Tobias Simpfendörfer, Claudia Gasch, Gencay Hatiboglu, Michael Müller, Lena Maier-Hein, Markus Hohenfellner, Dogu Teber
INTRODUCTION: Laparoscopic partial nephrectomy (LPN) remains challenging in endophytic and complex kidney tumors as the clear understanding of tumor location and spreading depends on a precise analysis of available imaging. The purpose of this study was to investigate navigated kidney surgery using intraoperative cone-beam computed tomography (CBCT) images in conjunction with a previously proposed method for augmented reality (AR) guidance for safe LPN. MATERIALS AND METHODS: The concept proposed is based on using an intraoperative CBCT scan for (1) marker-based AR guidance for fast and reliable tumor access and (2) enhancement of real-time fluoroscopy images for accurate tumor resection...
October 2016: Journal of Endourology
Jens J Rassweiler, Jan Klein, Alexandra Tschada, Ali Serdar Gözen
OBJECTIVES: To present technique and long-term results of retroperitoneal laparoscopic partial nephrectomy (LPN) focussing on the impact of an ergonomic platform. PATIENTS AND METHODS: Between January 2000 and May 2016, 287 patients (193 male, 94 female) underwent LPN by four surgeons. Median age was 59 (19-85) years. Mean tumour size was 3.1 (1-9) cm. Mean PADUA-score was 7.3 (6-12). Access was retroperitoneal in 235 (82%) cases. Since October 2010, we used ETHOS(TM) -chair during excision of the tumour in 130 (45...
August 12, 2016: BJU International
Gonzalo Vitagliano, Francisco Lopez, Juan Manuel Guglielmi, Mauro Mieggi, Leandro Blas, Luis Rico, Carlos Ameri
BACKGROUND: Multiple factors can account for surgical complexity during laparoscopic partial nephrectomy (LPN); severe adhesion of perirenal fat (PRF) is a crucial one. Consequent renal decapsulation can deem renorrhaphy a very challenging task. We propose a novel technique (synthetic renal capsule tailoring [SYRCT]) to facilitate renorrhaphy in decapsulated kidneys and suggest early decapsulation as a safe option in cases with severe PRF. MATERIALS AND METHODS: We retrospectively analyzed perioperative results of this novel technique performed in cases with severe PRF...
July 25, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Changwei Ji, Yang Yang, Xiaozhi Zhao, Gutian Zhang, Shiwei Zhang, Guangxiang Liu, Xiaogong Li, Hongqian Guo
OBJECTIVE: The study aimed to report our experiences of laparoscopic and open partial nephrectomies on patients with peripelvic cystic renal cell carcinoma (cRCC). METHODS: From July 2003 and October 2014, 18 patients with suspected peripelvic cRCCs underwent partial nephrectomies via an open or laparoscopic approach at Nanjing Drum Tower Hospital. Patients' perioperative and oncological outcomes were analyzed and compared between the open partial nephrectomy (OPN) and the laparoscopic partial nephrectomy (LPN) groups...
2016: Urologia Internationalis
Axel Mecklinger, Timm Rosburg, Mikael Johansson
The late posterior negativity (LPN) is an ERP effect frequently reported in episodic memory tasks. In 2003, we proposed that both non-mnemonic action monitoring processes and reconstructive mnemonic processes contribute to the LPN. Here, we review more recent studies and provide additional evidence that the LPN reflects dissociable (though not mutually exclusive) mnemonic and non-mnemonic processes. The idea that the LPN is related to the modality-specific reactivation of brain regions activated during encoding is critically evaluated...
September 2016: Neuroscience and Biobehavioral Reviews
Hong-Kai Wang, Xiao-Jian Qin, Chun-Guang Ma, Guo-Hai Shi, Hai-Liang Zhang, Ding-Wei Ye
BACKGROUND: Laparoscopic partial nephrectomy (LPN) is not a novel but a relatively technically challenging surgical procedure. Off-clamp LPN with zero ischemia can completely eliminate ischemic reperfusion injury to the kidney. The purpose of this study was to evaluate the safety and functional outcome of nephrometry score-guided off-clamp technique in LPN. METHODS: A total of 44 patients underwent LPN between January 2015 and July 2015 for renal mass with radius, exophytic/endophytic, nearness to sinus, anterior/posterior location (RENAL) score 4 were enrolled...
2016: World Journal of Surgical Oncology
Paolo Verze, Paolo Fedelini, Francesco Chiancone, Vito Cucchiara, Roberto La Rocca, Maurizio Fedelini, Clemente Meccariello, Alessandro Palmieri, Vincenzo Mirone
PURPOSE: In recent times there has been a trend in mininvasive renal tumour surgery. Very limited evidence can be found in literature of the outcomes of laparoscopic partial nephrectomy (LPN) for highly complex renal tumours. The aim of the present study was to assess the feasibility and safety of LPN for renal tumours of high surgical complexity in our single-institutional experience, comparing perioperative and functional data between clampless and clamped procedures. MATERIALS AND METHODS: We enrolled 68 patient who underwent a clampless LPN (Group A) and 41 patients who underwent a clamped LPN (Group B) for a renal tumour with a R...
June 20, 2016: World Journal of Urology
Taek Sang Kim, Jeoung Gu Park, Hee Kang, Su Hwan Kang, Hyun Yul Rhew, Pil Moon Kang
PURPOSE: Urologists and radiologists should be aware of the CT scan appearance of laparoscopic partial nephrectomy (LPN) with the various hemostatic agents since they may confound the interpretation of these radiographic findings. We report the various postoperative CT scan appearance and changes after LPN. MATERIALS AND METHODS: We reviewed CT scans retrospectively (within 3 months) of 86 patients who underwent LPN using various hemostatic agents between March 2008 and July 2014...
September 2016: Journal of Endourology
Jeffrey J Leow, Nathaniel H Heah, Steven L Chang, Yew Lam Chong, Keng Siang Png
PURPOSE: We evaluate the current literature comparing outcomes of robotic vs laparoscopic partial nephrectomy. MATERIALS AND METHODS: We performed a literature search according to Cochrane guidelines up to December 2015 including studies comparing robotic and laparoscopic partial nephrectomy, and we compared baseline patient and tumor characteristics. We performed a meta-analysis to evaluate safety, effectiveness and functional outcomes of robotic vs laparoscopic partial nephrectomy using weighted mean difference and inverse variance pooled risk ratios, respectively...
June 10, 2016: Journal of Urology
Soichiro Ishihara, Yukihide Kanemitsu, Koji Murono, Kensuke Otani, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hioaki Nozawa, Shinsuke Kazama, Hironori Yamaguchi, Eiji Sunami, Kenichi Sugihara, Toshiaki Watanabe
PURPOSE: We aimed to clarify the prognostic impact of lateral pelvic lymph node (LPN) dissection (LPND) for rectal cancer through a multicenter retrospective study using propensity score analysis. METHODS: A total of 1238 patients with pathological T2-4, M0 rectal cancer who had undergone curative operation between 2007 and 2008 were examined. Majority of the patients (96 %) were treated without preoperative chemoradiotherapy (CRT). Clinical background data of the patients treated with LPND and those treated without LPND were matched using propensity scores, and hazard ratios (HRs) for cancer-specific mortality were compared...
July 2016: International Journal of Colorectal Disease
Pu Li, Chao Qin, Qiang Cao, Jie Li, Qiang Lv, Xiaoxin Meng, Xiaobing Ju, Lijun Tang, Pengfei Shao
OBJECTIVE: To evaluate the feasibility and efficiency of laparoscopic partial nephrectomy (LPN) with segmental renal artery clamping, and to analyse the factors affecting postoperative renal function. PATIENTS AND METHODS: We conducted a retrospective analysis of 466 consecutive patients undergoing LPN using main renal artery clamping (group A, n = 152) or segmental artery clamping (group B, n = 314) between September 2007 and July 2015 in our department. Blood loss, operating time, warm ischaemia time (WIT) and renal function were compared between groups...
October 2016: BJU International
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