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https://www.readbyqxmd.com/read/29330499/three-dimensional-physical-model-assisted-planning-and-navigation-for-laparoscopic-partial-nephrectomy-in-patients-with-endophytic-renal-tumors
#1
Gang Fan, Jun Li, Mingfeng Li, Mingji Ye, Xiaming Pei, Feiping Li, Shuai Zhu, Han Weiqin, Xiao Zhou, Yu Xie
Resection of completely endophytic renal tumors is a huge challenge for surgeons due to a lack of definite visual clues, especially in the laparoscopic approach. Three-dimensional (3D) kidney models, which can illustrate the clear relationship between renal masses and surrounding health tissues, were considered as reliable tools for understanding renal tumor characteristics in previous studies. We hypothesized that 3D kidney models can be used not only for planning but also for navigating laparoscopic partial nephrectomy (LPN) in patients with completely endophytic renal tumors...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314751/emergency-airway-and-ventilator-procedures-for-community-based-home-care-staff-validation-of-an-educational-program
#2
Ann Marie Ramsey, Sarah Brennan, Adam Stricker, Kurt Riek, Dana Brown, Rachel Gurtowsky, Julie Sturza, Amy Goldstein Filbrun
BACKGROUND: Children discharged home with tracheostomy and chronic mechanical ventilator support are at high risk for complications and adverse events. Private duty nursing and home respiratory care services are a critical support necessary for successful discharge. The literature suggests that there are opportunities for home care staff (HCS) to improve upon the skills necessary to assess and intervene in an emergency thereby increasing the likelihood of improving long-term outcomes...
January 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29306576/an-untapped-resource-in-the-nursing-workforce-licensed-practical-nurses-who-transition-to-become-registered-nurses
#3
Cheryl B Jones, Mark Toles, George J Knafl, Anna S Beeber
BACKGROUND: A more diverse registered nurse (RN) workforce is needed to provide health care in North Carolina (NC) and nationally. Studies describing licensed practical nurse (LPN) career transitions to RNs are lacking. PURPOSE: To characterize the occurrence of LPN-to-RN professional transitions; compare key characteristics of LPNs who do and do not make such a transition; and compare key characteristics of LPNs who do transition in the years prior to and following their transition...
July 20, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/29278581/oncologic-outcomes-after-minimally-invasive-surgery-for-ct1-renal-masses-a-comprehensive-review
#4
Mihai Dorin Vartolomei, Beat Foerster, Shoji Kimura, Riccardo Autorino, Shahrokh F Shariat, Christian Seitz
PURPOSE OF REVIEW: To evaluate current literature reporting oncologic outcomes after robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN). RECENT FINDINGS: Recently, there have been published first mid-term results after RAPN (5 years). To date, there are no randomized trials to guide decision-making regarding LPN or robotic partial nephrectomy (RPN), and such trials are unlikely to be forthcoming, given the rapid adoption of RAPN worldwide...
December 22, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29246016/optimal-treatment-strategies-for-clinically-suspicious-lateral-pelvic-lymph-node-metastasis-in-rectal-cancer
#5
Hye Jin Kim, Gyu-Seog Choi, Jun Seok Park, Soo Yeun Park, Seung Hyun Cho, Soo Jung Lee, Byung Woog Kang, Jong Gwang Kim
Background: Although lateral pelvic lymph node (LPN) metastasis is a major cause of local recurrence in patients with rectal cancer, controversy still remains on the treatment of suspected LPN metastasis, "suspicious LPN". We aimed to determine the optimal treatment strategies for suspicious LPN, in patients with locally advanced rectal cancer who underwent preoperative chemoradiotherapy (CRT). Materials and Methods: Of 377 patients who received preoperative CRT for rectal cancer between 2006 and 2013, 84 (22...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29241312/selective-clamping-during-laparoscopic-partial-nefrectomy-the-use-of-near-infrared-fluorescence-guidance
#6
Francesco Porpiglia, Cristian Fiori, Enrico Checcucci, Angela Pecoraro, Michele DI Dio, Riccardo Bertolo
BACKGROUND: Near infrared fluorescence (NIRF) is being investigated as a helpful tool to enhance segmental arterial clamping in robotics. Available experiences with NIRF during standard laparoscopy are anecdotal. The aim of the study was to perform a single-center feasibility and results analysis of laparoscopic partial nephrectomy (LPN) performed using NIRF-guided selective clamping. METHODS: May 2016-December 2016: 15 patients diagnosed with a renal mass suitable for nephron-sparing approach consecutively underwent LPN with NIRF-guidance technique...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29217176/a-strong-adjuvant-based-on-glycol-chitosan-coated-lipid-polymer-hybrid-nanoparticles-potentiates-mucosal-immune-responses-against-the-recombinant-chlamydia-trachomatis-fusion-antigen-cth522
#7
Fabrice Rose, Jeanette Erbo Wern, Francesca Gavins, Peter Andersen, Frank Follmann, Camilla Foged
Induction of mucosal immunity with vaccines is attractive for the immunological protection against pathogen entrance directly at the site of infection. An example is infection with Chlamydia trachomatis (Ct), which is the most common sexually transmitted infection in the world, and there is an unmet medical need for an effective vaccine. A vaccine against Ct should elicit protective humoral and cell-mediated immune (CMI) responses in the genital tract mucosa. We previously designed an antibody- and CMI-inducing adjuvant based on poly(dl-lactic-co-glycolic acid) (PLGA) nanoparticles modified with the cationic surfactant dimethyldioctadecylammonium bromide and the immunopotentiator trehalose-6,6'-dibehenate...
December 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29165245/computational-modeling-of-spinal-circuits-controlling-limb-coordination-and-gaits-in-quadrupeds
#8
Simon M Danner, Natalia A Shevtsova, Alain Frigon, Ilya A Rybak
Interactions between cervical and lumbar spinal circuits are mediated by long propriospinal neurons (LPNs). Ablation of descending LPNs in mice disturbs left-right coordination at high speeds without affecting fore-hind alternation. We developed a computational model of spinal circuits consisting of four rhythm generators coupled by commissural interneurons (CINs), providing left-right interactions, and LPNs, mediating homolateral and diagonal interactions. The proposed CIN and diagonal LPN connections contribute to speed-dependent gait transition from walk, to trot, and then to gallop and bound; the homolateral LPN connections ensure fore-hind alternation in all gaits...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29145686/-the-use-of-partial-nephrectomy-in-the-treatment-of-patients-with-pt1-pt2-renal-cell-carcinoma-a-trend-analysis-from-a-tertiary-referral-centre
#9
Bernhard Ralla, Stephanie Buhl, Irena Goranova, Margit Pohle, Andreas Maxeiner, Frank Friedersdorff, Ahmed Magheli, Stefan Hinz, Tom F Fuller, Kurt Miller, Jonas Busch
Introduction In patients with localised renal cell carcinoma, the only curative treatment option is surgical tumour excision. Current national and European guidelines recommend partial nephrectomy in the form of an open or minimally-invasive procedure in case of small tumours. The aim of this study was to examine the use of radical (RN) or partial (PN) nephrectomy performed as open or minimally-invasive procedures in patients with pT1 /pT2 renal cell carcinoma at a tertiary referral centre. Patients and Methods This retrospective study included a total of 758 patients with localised renal cell carcinoma (pT1/pT2), who underwent PN or RN between 01/2008 and 10/2014...
November 16, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/29124406/selective-lateral-pelvic-lymph-node-dissection-a-comparative-study-of-the-robotic-versus-laparoscopic-approach
#10
Hye Jin Kim, Gyu-Seog Choi, Jun Seok Park, Soo Yeun Park, Hee Jae Lee, In Taek Woo, In Kyu Park
BACKGROUND: Lateral pelvic lymph node dissection (LPND) is a challenging procedure due to its technical difficulty and higher incidence of surgical morbidity. We compared short-term outcomes between laparoscopic and robotic LPND in patients with rectal cancer. METHODS: Between May 2006 and December 2014, prospectively collected data from consecutive patients undergoing robotic or laparoscopic total mesorectal excision (TME) with LPND were retrospectively compared...
November 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29113345/combined-targeting-of-raf-and-mek-synergistically-inhibits-tumorigenesis-in-triple-negative-breast-cancer-model-systems
#11
Teddy S Nagaria, Changnian Shi, Charles Leduc, Victoria Hoskin, Soma Sikdar, Waheed Sangrar, Peter A Greer
Aberrant Ras-MAPK signaling from receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2), is a hallmark of triple negative breast cancer (TNBC); thus providing rationale for targeting the Ras-MAPK pathway. Components of this EGFR/HER2-Ras-Raf-Mek-Erk pathway were co-targeted in the MDA-MB-231 and MDA-MB-468 human TNBC cell lines, and in vitro effects on signaling and cytotoxicity, as well as in vivo effects on xenograft tumor growth and metastasis were assessed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29062446/the-effect-of-zero-ischaemia-laparoscopic-minimally-invasive-partial-nephrectomy-using-the-modified-sequential-preplaced-suture-renorrhaphy-technique-on-long-term-renal-functions
#12
Mehmet Giray Sönmez, Cengiz Kara
INTRODUCTION: Laparoscopic minimally invasive partial nephrectomy (MIPN) is the preferred technique in renal surgery, especially T1 phase kidney tumours, and it is recommended for the protection of renal functions in methods that do not involve ischaemia. AIM: To evaluate long-term renal functions of zero-ischaemia laparoscopic MIPN patients who underwent a modified sequential preplaced suture renorrhaphy technique. MATERIAL AND METHODS: In a total of 17 renal units in 16 patients with kidney tumours that were determined incidentally and did not cause any complaints, the masses were extracted via laparoscopic partial nephrectomy (LPN) using the modified sequential preplaced suture renorrhaphy technique...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28963260/improved-utilization-of-preventive-services-among-patients-following-team-based-annual-wellness-visits
#13
Shelley L Galvin, Rebecca Grandy, Tasha Woodall, Anna Beth Parlier, Sarah Thach, Suzanne E Landis
BACKGROUND The Annual Wellness Visit was designed to enhance preventive services utilization among Medicare beneficiaries; Annual Wellness Visits are underutilized with sparse documented effectiveness. Patients of 3 community-based and 2 retirement community outpatient clinics in western North Carolina had team-based Annual Wellness Visits over a 20-month program, with the goal of improving the uptake and delivery of the Annual Wellness Visit. A clinical pharmacist saw high-complexity patients (≥5 medications) and a licensed practical nurse saw low-complexity patients...
September 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28943598/the-piezo-actuator-driven-pulsed-water-jet-system-for-minimizing-renal-damage-after-off-clamp-laparoscopic-partial-nephrectomy
#14
Yoshihiro Kamiyama, Shinichi Yamashita, Atsuhiro Nakagawa, Shinji Fujii, Koji Mitsuzuka, Yasuhiro Kaiho, Akihiro Ito, Takaaki Abe, Teiji Tominaga, Yoichi Arai
In the setting of partial nephrectomy (PN) for renal cell carcinoma, postoperative renal dysfunction might be caused by surgical procedure. The aim of this study was to clarify the technical safety and renal damage after off-clamp laparoscopic PN (LPN) with a piezo actuator-driven pulsed water jet (ADPJ) system. Eight swine underwent off-clamp LPN with this surgical device, while off-clamp open PN was also performed with radio knife or soft coagulation. The length of the removed kidney was 40 mm, and the renal parenchyma was dissected until the renal calyx became clearly visible...
September 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28937805/laparoscopic-partial-nephrectomy-a-narrative-review-and-comparison-with-open-and-robotic-partial-nephrectomy
#15
Andrew M Ng, Paras H Shah, Louis R Kavoussi
INTRODUCTION: Kidney cancer ranks among the top 10 most prevalent cancers in Western society, ∼90% of which are renal cell carcinomas. There has been a paradigm shift in the management of small renal masses with strong emphasis now placed on nephron-sparing surgery and increased utilization of laparoscopic approaches to partial nephrectomy. In this review, the current state of laparoscopic partial nephrectomy (LPN) is discussed. EVIDENCE ACQUISITION: The PubMed database was queried using the MeSH terms "laparoscopy" and "nephrectomy," as well as the search term "partial...
October 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28892872/polymer-lipid-hybrid-nanoparticles-based-paclitaxel-and-etoposide-combinations-for-the-synergistic-anticancer-efficacy-in-osteosarcoma
#16
Rui Duan, Caiyan Li, Fan Wang, Jin-Chu Yangi
In this study, paclitaxel and etoposide-loaded lipid-polymer hybrid nanoparticles (PE-LPN) was successful prepared and evaluated for physicochemical and anticancer effect. Nanosized PE-LPN was obtained with a perfect spherical morphology. PE-LPN exhibited a controlled release of two drugs in a sequential manner. The nanoparticles exhibited a typical endocytosis-mediated cellular uptake in cancer cells. The ratiometric combination of paclitaxel (PTX) and etoposide (ETP) were significantly more cytotoxic than individual drugs...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28875952/role-of-r-e-n-a-l-nephrometry-score-in-laparoscopic-partial-nephrectomy
#17
Hai-Jiang Zhou, Yong Yan, Jian-Zhong Zhang, Li-Rong Liang, Shu-Bin Guo
Background: Preoperative anatomical scoring system is conducive to comparison between treatment options and evaluation of postoperative outcomes in patients with small renal tumors. This study aimed to evaluate the clinical application efficacy of the R.E.N.A.L. nephrometry score (RNS) in predicting perioperative outcomes in patients with renal tumor who underwent laparoscopic partial nephrectomy (LPN). Methods: The clinical data of 139 patients with renal tumors who underwent LPN between 2009 and 2015 were collected and analyzed...
September 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28847667/engineering-of-budesonide-loaded-lipid-polymer-hybrid-nanoparticles-using-a-quality-by-design-approach
#18
Donglei Leng, Kaushik Thanki, Elias Fattal, Camilla Foged, Mingshi Yang
Chronic obstructive pulmonary disease (COPD) is a complex disease, characterized by persistent airflow limitation and chronic inflammation. The purpose of this study was to design lipid-polymer hybrid nanoparticles loaded with the corticosteroid budesonide, which could potentially be combined with small interfering RNA (siRNA) for COPD management. Lipid-modified PLGA nanoparticles (LPNs) based on biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) and the cationic lipid dioleyltrimethylammonium propane (DOTAP) were prepared using a double emulsion solvent evaporation method...
August 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28843996/neural-correlates-of-visuo-tactile-crossmodal-paired-associate-learning-and-memory-in-humans
#19
Peng Gui, Yixuan Ku, Lei Li, Xiaojin Li, Mark Bodner, Fred A Lenz, Liping Wang, Yong-Di Zhou
Studies have indicated that a cortical sensory system is capable of processing information from different sensory modalities. However, it still remains unclear when and how a cortical system integrates and retains information across sensory modalities during learning. Here we investigated the neural dynamics underlying crossmodal associations and memory by recording event-related potentials (ERPs) when human participants performed visuo-tactile (crossmodal) and visuo-visual (unimodal) paired-associate (PA) learning tasks...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28802596/effects-of-differential-phase-remote-ischemic-preconditioning-intervention-in-laparoscopic-partial-nephrectomy-a-single-blinded-randomized-controlled-trial-in-a-parallel-group-design
#20
Yuan-Yuan Hou, Yun Li, Shu-Fang He, Jie Song, De-Xin Yu, Gordon T C Wong, Ye Zhang
STUDY OBJECTIVE: There are two windows of protection for remote ischemic preconditioning (RIPC), an early (ERIPC) and a late-phase (LRIPC). While ERIPC has been well studied, works on LRIPC are relatively scarce, especially for the kidneys. We aimed to compare the effects of early-phase versus late-phase RIPC in patients with laparoscopic partial nephrectomy (LPN). DESIGN: A randomized controlled study SETTING: The Second Affiliated Hospital of Anhui Medical University, 1 May 2012 to 30 October 2013 PATIENTS: Sixty-five ASA 1 to 2 patients scheduled for LPN were located randomly to ERIPC group, LRIPC group and CON group (control)...
September 2017: Journal of Clinical Anesthesia
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