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Cholangiocarcinoma AND imaging

Dongli Shi, Liang Ma, Dawei Zhao, Jing Chang, Chen Shao, Shi Qi, Feng Chen, Yunfang Li, Xing Wang, Yanyan Zhang, Jing Zhao, Hongjun Li
BACKGROUND: Primary hepatic sarcomatous carcinoma (PHSC) is a rare malignancy composed of both carcinomatous (either hepatocellular or cholangiocellular) and sarcomatous components. The purpose of our study was to evaluate the imaging and clinical findings of PHSCs, improving the understanding and diagnosis of tumors. METHODS: We retrospectively reviewed the imaging and clinical findings of ten patients with pathologically proven PHSCs, including two cases of sarcomatous intrahepatic cholangiocarcinoma (S-ICC), seven cases of sarcomatous hepatocellular carcinoma (S-HCC) and one case of sarcomatous combined hepatocellular and cholangiocarcinoma (S-HCC-CC)...
October 12, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Edward C Lo, Adam N Rucker, Michael P Federle
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) comprise the majority of primary liver cancers. Both HCC and ICC have characteristic imaging appearances on multiphase computed tomography (CT) and magnetic resonance imaging (MRI). Several locoregional therapies, including radiation therapy, are used to treat unresectable disease and residual or recurrent tumor. The tumor response following locoregional therapies has variable imaging manifestations. Focal liver reaction, the imaging changes of the liver following radiation treatment, should be recognized and not mistaken for tumor...
October 2018: Seminars in Radiation Oncology
Nicholas Bird, Adrian McKenna, Declan Dunne, Ben Francis, Stephen Fenwick, Graeme Poston, Robert Jones, Hassan Malik
AIMS: Cholangiocarcinoma is a rare cancer arising from the biliary tree. Case series indicate that 25-40% of all borderline resectable primary tumours are potentially resectable. The Memorial Sloane Kettering System (MSKCC) stratifies patients for resectability by longitudinal and radial extension of the hilar tumour. The Bismuth-Corlette system describes the longitudinal extension of the tumour within the biliary duct system. We sought to validate and, if possible, augment these two scores within an independent validation cohort...
September 11, 2018: European Journal of Surgical Oncology
Ning Zhang, Yatong Li, Mengyun Zhao, Xiaoyan Chang, Feng Tian, Qiang Qu, Xiaodong He
RATIONALE: Sarcomatous intrahepatic cholangiocarcinoma is a rare histological variant of cholangiocarcinoma (ICC). Previous medical literature has not mentioned the prevalence of this kind of disease, but a poorer prognosis than that of ordinary ICC was indicated. The diagnosis of the sarcomatous ICC is established on histopathological and immunohistochemical examinations. In this article, we present a new case of a patient with sarcomatous ICC who had no radiographic sign of intrahepatic tumor preoperatively...
September 2018: Medicine (Baltimore)
Xianlun Zou, Yan Luo, Zhen Li, Yao Hu, Haojie Li, Hao Tang, Yaqi Shen, Daoyu Hu, Ihab R Kamel
BACKGROUND: Accurate differentiation between intrahepatic mass-forming cholangiocarcinoma (IMCC) and hepatocellular carcinoma (HCC) is needed because treatment and prognosis differ significantly. PURPOSE: To explore whether volumetric apparent diffusion coefficient (ADC) histogram analysis can provide additional value to dynamic enhanced MRI in differentiating IMCC from HCC. STUDY TYPE: Retrospective. POPULATION: In all, 131 patients with pathologically proven IMCC (n = 33) or HCC (n = 98)...
September 12, 2018: Journal of Magnetic Resonance Imaging: JMRI
Koichiro Sakata, Daiki Kijima, Taizo Yamaguchi, Takashi Furuhashi, Toshihiko Abe, Haruki Iwamoto, Katsuhiko Morita
INTRODUCTION: Although curative resection is an outstanding prognostic factor of intrahepatic cholangiocarcinoma (ICC), certain segments remain unresectable. The standard therapy for initially unresectable ICC is uncertain. In this case report, we reported the feasibility of multimodal chemotherapy and curative resection. CASE: A 59-year-old Asian woman with back pain was referred to the hospital by her family physician regarding liver mass visible on ultrasonography...
September 15, 2018: International Journal of Surgery Case Reports
Nian-Mei Gong
PURPOSE: To retrospectively evaluate the role of intraoperative ultrasonography (IOUS) and contrast-enhanced IOUS (CE-IOUS) for the patients with hepatocellular carcinoma (HCC) undergoing hepatic resection (HR). METHODS: Twenty-one consecutive patients who had undergone HR for HCC were included in this study. The patients were subject to preoperative imaging modalities including preoperative ultrasonography (Pre-US) and preoperative contrast-enhanced ultrasonography (Pre-CEUS)...
September 19, 2018: Clinical Hemorheology and Microcirculation
Toshifumi Wakai, Jun Sakata, Tomohiro Katada, Yuki Hirose, Daiki Soma, Pankaj Prasoon, Kohei Miura, Takashi Kobayashi
Recent advances in dimensional imaging, surgical technique, and perioperative patient care have resulted in increased rates of complete resection with histopathologically negative margins and improved surgical outcomes in patients with extrahepatic cholangiocarcinoma. However, achieving cancer-free resection margins at ductal stumps in surgery for this disease remains challenging because of longitudinal extension, which is one of the hallmarks of extrahepatic cholangiocarcinoma. When the ductal resection margins are shown to be positive on examination of frozen sections, discrimination between carcinoma in situ and invasive carcinoma is clinically important because residual carcinoma in situ may lead to late local recurrence whereas residual invasive carcinoma is associated with early local recurrence...
September 2018: Annals of gastroenterological surgery
Wenjie Liang, Lei Xu, Pengfei Yang, Lele Zhang, Dalong Wan, Qiang Huang, Tianye Niu, Feng Chen
Introduction: The emerging field of "radiomics" has considerable potential in disease diagnosis, pathologic grading, prognosis evaluation, and prediction of treatment response. We aimed to develop a novel radiomics nomogram based on radiomics features and clinical characteristics that could preoperatively predict early recurrence (ER) of intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy. Methods: A predictive model was developed from a training cohort comprising 139 ICC patients diagnosed between January 2010 and June 2014...
2018: Frontiers in Oncology
Nozha Toumi, Hanene Abid, Salah Henchir, Houssem Harbi, Nejmeddine Affes, Khaireddine Ben Mahfoudh
Magnetic resonance cholangiopancreatography is a non-invasive imaging, highly performant in detecting and locating biliary stenosis and in predicting its malignancy. The combination of two and three-dimensional MRI sequences is recommended to assess a biliary obstacle. Cholangiopathies are the main differential diagnosis of cholangiocarcinomas. In addition to bile duct abnormalities beyond the stenosis, the predictive signs of malignancy are: asymmetric irregular luminal narrowing (longer than 3mm and thicker than 13mm), abrupt discontinuation of stenosis, and enhancement superior to that of the adjacent hepatic parenchyma during arterial and portal acquisitions...
September 14, 2018: La Presse Médicale
Hong-Xia Zhang, Xiu-Shi Zhang, Zi-Xiang Kuai, Yang Zhou, Yun-Feng Sun, Zhi-Chang Ba, Kuang-Bang He, Xi-Qiao Sang, Yuan-Fei Yao, Chun-Yu Chu, Yue-Min Zhu
PURPOSE: To distinguish hepatocellular carcinoma (HCC) from other types of hepatic lesions with the adaptive multi-exponential IVIM model. METHODS: 94 hepatic focal lesions, including 38 HCC, 16 metastasis, 12 focal nodular hyperplasia, 13 cholangiocarcinoma, and 15 hemangioma, were examined in this study. Diffusion-weighted images were acquired with 13 b values (b = 0, 3, …, 500 s/mm2 ) to measure the adaptive multi-exponential IVIM parameters, namely, pure diffusion coefficient (D), diffusion fraction (fd ), pseudo-diffusion coefficient (Di *) and perfusion-related diffusion fraction (fi ) of the ith perfusion component...
September 11, 2018: Translational Oncology
Adianto Nugroho, Kwang-Woong Lee, Kyung-Bun Lee, Hyo-Shin Kim, Hyeyoung Kim, Nam-Joon Yi, Kyung-Suk Suh
The incidence of combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CC) in a single patient accounts for only 0.4 to 14% of all primary liver cancer. However, the prognosis of its intrahepatic cholangiocarcinoma (ICC) component is poor. We experienced a unique case of a sequentially developed cHCC-CC with adrenal metastasis as the primary presentation and a hidden primary hepatocellular carcinoma. A 65-year-old female with a history of jaundice and abdominal discomfort was diagnosed with S4 ICC measuring 5 cm in diameter, and characterized histologically as papillary adenocarcinoma with intraductal growth, but without any evidence of malignant hepatocyte...
August 2018: Annals of Hepato-Biliary-Pancreatic Surgery
Xing-Hui Li, Qi Liang, Tian-Wu Chen, Jian Wang, Xiao-Ming Zhang
Primary hepatocellular carcinoma (PHC) includes hepatocellular carcinoma, intrahepatic cholangiocarcinoma and other pathological types and is characterized by rapid progression. Most of the clinical diagnoses are made at late stage or when distant metastasis occurs, increasing the difficulty of treatment and resulting in a poor prognosis. Therefore, the early diagnosis of PHC plays an important role in timely treatment and the improvement of prognosis. The gold standard for the diagnosis of primary liver cancer is liver biopsy, but it has limitations as an invasive examination...
September 6, 2018: World Journal of Clinical Cases
Jingfeng Luo, Jiali Zhou, Fengnan Xie, Yali Zhu, Fei Zhou, Shuanglin Zhang, Shaojie Jiang, Jie He, Jiaxin Liu, Xia Wu, Yanhua Zhang, Jihong Sun, Xiaoming Yang
Cholangiocarcinoma is a most lethal malignancy frequently resistant to chemotherapy. Herpes simplex virus thymidine kinase/Ganciclovir (HSV-TK/GCV) suicide gene therapy is a promising approach to treat different cancers, including cholangiocarcinoma. However drawbacks including low therapeutic gene expression and lack of precise targeted gene delivery limit the wide clinical utilization of the suicide gene therapy. We attempted to overcome these obstacles. We established the "proof-of-principle" of this concept via serial in-vitro experiments using human cholangiocarcinoma cells and then validated the new interventional oncology technique in vivo using mice harboring the same patient derived cholangiocarcinomas...
2018: American Journal of Cancer Research
Li-Da Chen, Si-Min Ruan, Jin-Yu Liang, Zheng Yang, Shun-Li Shen, Yang Huang, Wei Li, Zhu Wang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Wei Wang
AIM: To develop a contrast-enhanced ultrasound (CEUS) predictive model for distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC) in high-risk patients. METHODS: This retrospective study consisted of 88 consecutive high-risk patients with ICC and 88 high-risk patients with HCC selected by propensity score matching between May 2004 and July 2016. Patients were assigned to two groups, namely, a training set and validation set, at a 1:1 ratio...
September 7, 2018: World Journal of Gastroenterology: WJG
Peter Jiang, Lin Gu, Yihua Zhou, Yulin Zhao, Jinping Lai
Concurrent laryngeal squamous cell carcinoma and intrahepatic cholangiocarcinoma is rare and no prior report has been found through a PubMed search. Here we report such a case of a 51-year old obese male presenting with hoarseness and trouble swallowing for 2 to 3 months. Imaging findings of computer tomography (CT) and magnetic resonance imaging (MRI) with and without contrast were suspicious for a T3N2 supraglottic laryngeal cancer. Laryngeal biopsy showed a well differentiated squamous cell carcinoma (SCC)...
September 2018: Anticancer Research
Masayuki Akita, Keitaro Sofue, Kohei Fujikura, Kyoko Otani, Tomoo Itoh, Tetsuo Ajiki, Takumi Fukumoto, Yoh Zen
BACKGROUND: Growing evidence has suggested that intrahepatic cholangiocarcinoma (iCCA) can be classified into small- and large-duct types. The present study aimed to elucidate how large-duct iCCA is similar and dissimilar to perihilar cholangiocarcinoma (pCCA). METHODS: The study cohort consisted of iCCA (n = 58) and pCCA (n = 44). After iCCA tumors were separated into small- (n = 36) and large-duct (n = 22) types based on our histologic criteria, genetic statuses of the three types of neoplasms were compared...
August 28, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Dietmar Tamandl, Ahmed Ba-Ssalamah, Gernot Böhm, Klaus Emmanuel, Rosemarie Forstner, Reinhold Függer, Benjamin Henninger, Oliver Koch, Claus Kölblinger, Hans-Jörg Mischinger, Wolfgang Schima, Helmut Schöllnast, Stefan Stättner, Klaus Kaczirek
Rapid advances in imaging technology have improved the detection, characterization and staging of colorectal liver metastases, hepatocellular carcinoma and cholangiocarcinoma. A variety of imaging modalities are available and play a pivotal role in the work-up of patients, particularly as imaging findings determine resectability. Surgery often represents the only measure that can render long-term survival possible. Imaging is also indispensable for the assessment of responses to neoadjuvant treatment and for the detection of recurrence...
August 30, 2018: Wiener Klinische Wochenschrift
Julaluck Promsorn, Wannaporn Soontrapa, Kulyada Somsap, Nittaya Chamadol, Panita Limpawattana, Mukesh Harisinghani
INTRODUCTION: Cholangiocarcinoma (CCA) is the primary tumor found in the bile duct and is associated with a high incidence of lymph node (LN) metastases and poor outcomes. The presence of metastatic lymph nodes, when shown by imaging, can influence patient treatment and prognosis. DWI is a promising, non-invasive imaging technique for differentiating between benign and malignant LNs. Many studies have shown that LN metastases have a lower apparent diffusion coefficient (ADC) value when compared to benign nodes...
August 27, 2018: Abdominal Radiology
Marcia P Gaspersz, Stefan Buettner, Eva Roos, Jeroen L A van Vugt, Robert J S Coelen, Jaynee Vugts, Jimme K Wiggers, Peter J Allen, Marc G Besselink, Olivier R C Busch, Eric J Belt, Michael I D'Angelica, Ronald P DeMatteo, Jeroen de Jonge, T Peter Kingham, Wojciech G Polak, François E J A Willemssen, Thomas M van Gulik, William R Jarnagin, Jan N M Ijzermans, Bas Groot Koerkamp
BACKGROUND: Patients with resectable perihilar cholangiocarcinoma (PHC) on imaging have a substantial risk of metastatic or locally advanced disease, incomplete (R1) resection, and 90-day mortality. Our aim was to develop a preoperative prognostic model to predict surgical success, defined as a complete (R0) resection without 90-day mortality, in patients with resectable PHC on imaging. STUDY DESIGN: Patients with PHC who underwent exploratory laparotomy in three tertiary referral centers were identified...
September 2018: Journal of Surgical Oncology
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