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Md Faruque Ahmad
Ganoderma lucidum comprises probably 400 different biologically active constituents principally polysaccharides, triterpenoids, proteins, enzymes, steroids, sterols, nucleotides, fatty acids, vitamins and minerals which have been proved to have several therapeutical properties to control various diseases. Broad spectrum of its pharmacological actions have been established which include immunomodulation, anticancer, antidiabetic, antioxidant, antiatherosclerotic, antifibrotic, chemopreventive, antitumor, anticancer drug toxicity prevention, analgesic, anti inflammatory, antinociceptive, antimicrobial, hypolipidemic, hepatoprotective, antiandrogenic, antiangiogenic, antiherpetic, antiarthritic, antiosteoporotic, antiaging, antiulcer properties and estrogenic activity...
August 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jin-Ge Zhao, Jian-Dong Liu, Peng-Fei Shen, Xin Tang, Guang-Xi Sun, Xing-Ming Zhang, Jun-Ru Chen, Kun-Peng Shu, Ming Shi, Hao Zeng
Even in the era of novel targeted agents, switching to a second-line nonsteroidal antiandrogen (NSAA) is still widely used in treating metastatic castration-resistant prostate cancer (mCRPC), especially in undeveloped countries. However, whether prior treatment with a second-line NSAA would impact the efficacy of abiraterone acetate (Abi) remains uncertain. In the current study, 87 mCRPC patients treated with Abi were analyzed. Among them, 21 were treated with a second-line NSAA (from bicalutamide to flutamide) before receiving abiraterone, while the remaining 66 received Abi directly...
August 14, 2018: Asian Journal of Andrology
Dana E Rathkopf, Howard I Scher
Five new agents have been shown to prolong survival in patients with metastatic castration-resistant prostate cancer, including two targeting androgen receptor signaling (abiraterone acetate plus prednisone; enzalutamide). Recognition that these tumors remain driven by androgen receptor signaling has prompted clinical evaluation of these agents at earlier states in the prostate cancer disease continuum, along with the continued development of new agents targeting this pathway. Areas covered: This article focuses on apalutamide, a next-generation nonsteroidal antiandrogen, with current literature queried in PubMed/Medline...
September 2018: Expert Review of Anticancer Therapy
Iwona J Stanisławska, Jakub P Piwowarski, Sebastian Granica, Anna K Kiss
BACKGROUND: Urolithins are bioavailable products of gut microbiota metabolism of ellagitannins. Their biological activity includes anti-cancer effects. PURPOSE: The aim of this study was to explore the effects of urolithins on prostate cancer cells and activity of clinically used anti-androgen, bicalutamide. METHODS: Prostate cancer cells were treated with urolithin A, urolithin B, urolithin C or their combinations with bicalutamide. Cell proliferation was determined by DNA fluorescence with Hoechst 33258...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Ecem Özdemir, Nurhayat Barlas, Mehmet Alper Çetinkaya
Propyl paraben is a widely used preservative in pharmaceuticals, cosmetics, and foods preventing microbial and fungal contamination. This study was designed to investigate antiandrogenic profiles of propyl paraben following oral doses at 10, 250, and 750 mg kg-1 day to immature male rats using the Hershberger Bioassay. Rats were divided into six groups including solvent control, negative control (0.4 mg kg-1 day testosterone propionate = TP), positive control (3 mg kg-1 day flutamide = FLU) and treatment groups (10, 250, and 750 mg kg-1 day testosterone propionate + Propyl paraben)...
March 1, 2018: Toxicology Research
Yifan Kong, Lijun Cheng, Fengyi Mao, Zhuangzhuang Zhang, Yanquan Zhang, Elia Farah, Jacob Bosler, Yunfeng Bai, Nihal Ahmad, Shihuan Kuang, Lang Li, Xiaoqi Liu
Enzalutamide, a nonsteroidal second-generation antiandrogen, has been recently approved for the management of castration-resistant prostate cancer (CRPC). Although patients can benefit from enzalutamide at the beginning of this therapy, acquired enzalutamide resistance usually occurs within a short period. This motivated us to investigate the mechanism involved and possible approaches for overcoming enzalutamide resistance in CRPC. In the present study, we found that HMG-CoA reductase (HMGCR), a crucial enzyme in the mevalonate pathway for sterol biosynthesis, is elevated in enzalutamide-resistant prostate cancer cell lines...
August 8, 2018: Journal of Biological Chemistry
Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano
Importance: Women are at higher risk of drug-induced torsade de pointes (TdP) than men. Androgens are protective. Influence of oral contraception on drug-induced TdP and QT prolongation is controversial. Objective: To determine if the extent of sotalol-induced corrected QT (QTc) prolongation and specific T-wave morphological changes, which are biomarkers for the risk of drug-induced TdP, differ in patients according to the androgenic activity of the type of oral contraceptive (OCs) they take compared with patients who took no pills...
August 1, 2018: JAMA Cardiology
Erkin Pekmezci, Murat Türkoğlu
Although more than three decades have passed since the first use of minoxidil in androgenetic alopecia (AGA), its mechanisms of action have still not been comprehensively understood. 5α-reductase (5α-R) has an active role as the predominant enzyme in both AGA and female pattern hair loss (FPHL), which are also the main therapeutic indications of topical minoxidil. But there is insufficient literature data regarding the interaction of minoxidil and the enzyme 5α-R. Herein, we studied the in vitro expression levels of 5α-R type 2 (5α-R2) in a minoxidil-treated human keratinocyte cell line (HaCaT) in order to elucidate the relation of these two parameters...
December 2017: Acta Dermatovenerologica Croatica: ADC
Li Zhang, Jiabin Guo, Qiang Zhang, Wei Zhou, Jin Li, Jian Yin, Lan Cui, Tingfen Zhang, Jun Zhao, Paul L Carmichael, Alistair Middleton, Shuangqing Peng
Flutamide is a widely used nonsteroidal antiandrogen for prostate cancer therapy, but its clinical application is restricted by the concurrent liver injury. Increasing evidence suggests that flutamide-induced liver injury is associated with oxidative stress, though the precise mechanism is poorly understood. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcription factor regulating endogenous antioxidants including heme oxygenase-1 (HO-1). This study was designed to delineate the role of Nrf2/HO-1 in flutamide-induced hepatic cell injury...
2018: Oxidative Medicine and Cellular Longevity
Michele Bertoncello Souza, Marcella Tapias Passoni, Claudia Pälmke, Katlyn Barp Meyer, Amanda Caroline Venturelli, Giulia Araújo, Bruno Sanches de Castilhos, Rosana Nogueira Morais, Paulo Roberto Dalsenter, Shanna Helen Swan, Holger Martin Koch, Anderson Joel Martino-Andrade
BACKGROUND: Human exposure to phthalates and other non-persistent chemicals in developing countries is largely unknown. A preliminary analysis of urinary samples from pregnant Brazilian women revealed the presence of metabolites of Diisopentyl phthalate (DiPeP). OBJECTIVES: Reliably quantify DiPeP metabolites in human urine and investigate the potential antiandrogenic activity of this phthalate in rats. METHODS: We initiated a pilot pregnancy cohort in Curitiba, Brazil, to examine phthalate exposure in urine samples collected in early pregnancy (n = 50) or pooled samples from early, mid and late pregnancy (n = 44)...
July 18, 2018: Environment International
Samer L Traboulsi, Fred Saad
PURPOSE OF REVIEW: The widespread use of prostate-specific antigen (PSA) resulted in stage migration of prostate cancer where androgen deprivation therapy (ADT) is administered for biochemical recurrence in patients following primary treatment. A proportion of these patients progress to a disease state termed nonmetastatic castration-resistant prostate cancer (nmCRPC), with a rising PSA despite ADT and without evidence of metastases on conventional imaging. We will review the treatment options in nmCRPC, especially in light of recent trials showing significant improvement in metastasis-free survival with newer agents...
September 2018: Current Opinion in Supportive and Palliative Care
Kok-Yong Chin, Kok-Lun Pang, Wun Fui Mark-Lee
Bisphenol A (BPA) is an endocrine disruptor which can bind to the oestrogen receptor. It also possesses oestrogenic, antiandrogenic, inflammatory and oxidative properties. Since bone responds to changes in sex hormones, inflammatory and oxidative status, BPA exposure could influence bone health in humans. This review aimed to summarize the current evidence on the relationship between BPA and bone health derived from cellular, animal and human studies. Exposure to BPA (0.5-12.5 µM) decreased the proliferation of osteoblast and osteoclast precursor cells and induce their apoptosis...
2018: International Journal of Medical Sciences
Nicole M Golbari, Martina L Porter, Alexa B Kimball
BACKGROUND: Hormonal therapy is a potential treatment for hidradenitis suppurativa (HS). However, little data exists describing the efficacy of spironolactone in HS treatment. OBJECTIVE: To assess whether spironolactone treatment improves HS disease severity and patient reported pain. METHODS: We performed a single center chart review of female HS patients treated with spironolactone between 2000 and 2017. Primary outcome measurements included the HS Physician Global Assessment (HSPGA), Hurley Staging, inflammatory lesion count, fistula count, and a numeric rating scale for pain...
July 9, 2018: Journal of the American Academy of Dermatology
Nina-Sophie Schmidt-Hegemann, Christian Stief, Tak-Hyun Kim, Chukwuka Eze, Simon Kirste, Iosif Strouthos, Minglun Li, Wolfgang Schultze-Seemann, Harun Ilhan, Wolfgang Peter Fendler, Peter Bartenstein, Anca-Ligia Grosu, Ute Ganswindt, Claus Belka, Philipp T Meyer, Constantinos Zamboglou
Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) detects prostate cancer recurrence at low PSA levels. Radiotherapy with dose escalation to the former prostate bed has been associated with improved biochemical recurrence-free survival (BRFS). Thus, we hypothesized that PSMA PET/CT-guided salvage radiotherapy leads to improved BRFS. Methods: A total of 204 consecutive patients were referred for salvage radiotherapy following radical prostatectomy. PSMA PET/CT scans were performed and patients with PSA persistence (109 patients) or evidence of distant metastases (5 patients) were excluded from this analysis...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Zhenlang Guo, Yiyu Huang, Leiliang Gong, Shu Gan, Franky Leung Chan, Chiming Gu, Songtao Xiang, Shusheng Wang
BACKGROUND: Whether androgen deprivation therapy (ADT) causes excess thromboembolic events (TEs) in men with prostate cancer (PCa) remains controversial and is the subject of the US Food and Drug Administration safety warning. This study aims to perform a systematic review and meta-analysis on previous studies to determine whether ADT is associated with TEs in men with PCa. METHODS: Medline, Embase, and Cochrane Library databases were searched for relevant studies...
July 9, 2018: Prostate Cancer and Prostatic Diseases
Jack L Turban, Alex S Keuroghlian
The following clinical scenarios are composite cases that illustrate clinically important phenomena based on several patients. Jamie is a 19-year-old who was assigned a female gender at birth and had a history of major depressive disorder in remission. She presented to her primary care physician, psychiatrist, and psychotherapist reporting dysphoria related to gender and requesting gender-affirming hormone therapy. Jamie had symptoms for at least 6 months consistent with DSM-5 criteria for gender dysphoria...
July 2018: Journal of the American Academy of Child and Adolescent Psychiatry
I Huhtaniemi
The two pituitary gonadotrophins, luteinising hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular (IT) testosterone (T) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the LH receptor (R) knockout mouse (LuRKO), the other a transgenic mouse expressing in Sertoli cells a highly constitutively active mutated Fshr (Fshr-CAM). It was found that full spermatogenesis was induced by exogenous T treatment in LuRKO mice at doses that restored ITT concentration to a level corresponding to normal circulating T levels in wild-type (WT) mice, ≈ 5 nmol/L, which is 1...
June 29, 2018: European Journal of Endocrinology
(no author information available yet)
Recent findings from a phase II trial suggest that combining the antiandrogen abiraterone and the PARP inhibitor olaparib significantly improves progression-free survival among patients with metastatic castration-resistant prostate cancer, regardless of their homologous recombination repair-mutation status.
June 28, 2018: Cancer Discovery
Erkin Pekmezci, Cihat Dündar, Murat Türkoğlu
INTRODUCTION: Currently there are only a limited number of drugs available for treatment of androgenetic alopecia and telogen effluvium. However, certain plants and their standardized extracts may provide some clinical benefits against hair loss. We formulated a herbal shampoo and a solution to evaluate their efficacy, safety, and synergy in hair loss. METHODS: We conducted a randomized, placebo-controlled, single-blind, clinical and instrumental study for 6 months on 120 subjects with androgenetic alopecia and telogen effluvium, confirmed by pull test and phototricogram...
June 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Justin M Conley, Christy S Lambright, Nicola Evans, Mary Cardon, Johnathan Furr, Vickie S Wilson, Leon Earl Gray
Biomonitoring efforts have clearly shown that all humans are exposed to chemical mixtures. Of concern is whether or not exposure to mixtures during pregnancy contributes to congenital abnormalities in children even when each chemical is at an individual dose that does not affect the fetus. Here, we hypothesized that in utero exposure to a mixture of chemicals covering multiple "antiandrogenic" mechanisms of action at doses that individually have no adverse effect would result in permanent reproductive tract alterations in the male rat after birth...
July 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
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