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pancreatic cancer h pylori

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https://www.readbyqxmd.com/read/29786110/multi%C3%A2-layered-prevention-and-treatment-of-chronic-inflammation-organ-fibrosis-and-cancer-associated-with-canonical-wnt-%C3%AE-%C3%A2-catenin-signaling-activation-review
#1
Masaru Katoh
β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulators (BCL9, BCL9L, CREBBP/CBP, EP300/p300, FOXM1, MED12, SMARCA4/BRG1 and TCF/LEF). Gain‑of‑function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss‑of‑function CTNNB1 mutations are also detected in human cancer...
August 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29740203/olfactomedin-4-in-digestive-diseases-a-mini-review
#2
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29658052/reduced-%C3%AE-glcnac-glycosylation-on-gastric-gland-mucin-is-a-biomarker-of-malignant-potential-for-gastric-cancer-barrett-s-adenocarcinoma-and-pancreatic-cancer
#3
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
June 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28032715/helicobacter-pylori-infection-chronic-corpus-atrophic-gastritis-and-pancreatic-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort-a-nested-case-control-study
#4
Jiaqi Huang, Ulrika Zagai, Göran Hallmans, Olof Nyrén, Lars Engstrand, Rachael Stolzenberg-Solomon, Eric J Duell, Kim Overvad, Verena A Katzke, Rudolf Kaaks, Mazda Jenab, Jin Young Park, Raul Murillo, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kathryn E Bradbury, Elio Riboli, Dagfinn Aune, Konstantinos K Tsilidis, Gabriel Capellá, Antonio Agudo, Vittorio Krogh, Domenico Palli, Salvatore Panico, Elisabete Weiderpass, Anne Tjønneland, Anja Olsen, Begoña Martínez, Daniel Redondo-Sanchez, Maria-Dolores Chirlaque, Petra Hm Peeters, Sara Regnér, Björn Lindkvist, Alessio Naccarati, Eva Ardanaz, Nerea Larrañaga, Marie-Christine Boutron-Ruault, Vinciane Rebours, Amélie Barré, H B As Bueno-de-Mesquita, Weimin Ye
The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27825384/inhibiting-the-proton-pump-mechanisms-benefits-harms-and-questions
#5
COMMENT
Jeffrey K Aronson
Inhibition of the H+ /K+ -adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27573783/helicobacter-pylori-and-gastric-cancer-timing-and-impact-of-preventive-measures
#6
REVIEW
Marino Venerito, Riccardo Vasapolli, Peter Malfertheiner
Helicobacter pylori (H. pylori) is a Gram negative spiraliform bacterium that is commonly found in the stomach. H. pylori infection is still one of the world's most frequent infections, present in the stomachs of approximately one-half of the world's people. H. pylori infection is etiologically linked to histologic chronic active gastritis, peptic ulcer disease, and primary B-cell gastric lymphoma (gastric MALT lymphoma) and represents the major risk factor for the development of sporadic non-cardia gastric cancer (GC) of both intestinal and diffuse type...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27325222/testing-for-anti-pbp-antibody-is-not-useful-in-diagnosing-autoimmune-pancreatitis
#7
Jorie Buijs, Djuna L Cahen, Marianne J van Heerde, Bettina E Hansen, Henk R van Buuren, Maikel P Peppelenbosch, Gwenny M Fuhler, Marco J Bruno
OBJECTIVES: Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis, clinically mimicking pancreatic cancer. In 2009, a serological diagnostic test detecting antibodies against plasminogen-binding protein (PBP) of Helicobacter pylori was reported with outstanding test performances (NEJM 361:135). We aimed to validate these findings. METHODS: Between March 2007 and May 2011, sera were collected from consecutive patients presenting with type 1 AIP, pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), primary sclerosing cholangitis (PSC), and healthy controls (HC) with or without antibodies against H...
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27320723/helicobacter-pylori-is-undetectable-in-intraductal-papillary-mucinous-neoplasm
#8
Birol Baysal, Ali Tüzün İnce, Bilge Gültepe, Zuhal Gücin, Fatma Ümit Malya, Mukaddes Tozlu, Hakan Şentürk, Pelin Bağcı, Çiğdem Ataizi Çelikel, Fügen Aker, Selvinaz Özkara, Esra Paşaoğlu, Nevra Dursun, Banu Yılmaz Özgüven, Deniz Tunçel
BACKGROUND: About half of the world population is infected with Helicobacter pylori (H. pylori), a bacterium associated with gastric cancer and considered to be a risk factor for pancreatic ductal adenocarcinoma. Whether the bacterium is associated with intraductal papillary mucinous neoplasm, believed to be a precursor of pancreatic ductal adenocarcinoma, is unknown. The aim of this study was to investigate the presence of H. pylori DNA in tissue sections of intraductal papillary mucinous neoplasm...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27239140/characteristics-of-upper-digestive-tract-diseases-in-bohai-bay-fishermen
#9
Y B Wang, Y P Wang, J Zou, B J Bai, G C Ren, B Q Cai
AIM: To study the characteristics of upper digestive tract diseases (UDTDs) in fishermen who live in Bohai Bay. METHODS: An investigation was carried out in 1488 fishermen with symptoms of UDTDs (aside from liver, biliary and pancreatic diseases) during the time period between December 1991 and February 1995. This investigation included medical history evaluations, physical, gastroscopic and pathological examinations, tests for Helicobacter pylori (H. pylori) infection, and analysis of the nitrate content in their drinking water...
September 15, 1997: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26987137/-diffuse-neuroendocrine-system-of-the-stomach-and-characteristics-of-proliferation-in-realization-of-correa-s-cascade-in-diseases-associated-with-helicobacter-pylori
#10
A A Svistunov, N V Kireeva, M A Osadchuk, I M Kvetnoy
AIM: To study the role of the vascular endothelial growth factor (VEGF), Ki-67, BCL-2, and endocrine cells (EC) of gastric mucosa producing somatostatin (SS), glucagon (GL), and pancreatic polypeptide (PP) in diseases associated with Helicobacter pylori. To use the data obtained to develop early diagnostic criteria for the progress of structural changes in gastric mucosa of the patients with stomach ulcer disease [SUD), chronic atrophic gastritis (CAG), gastric adenomatous polyps (GAP), and gastric cancer (GC) before and after surgical intervention and eradication of H...
2015: Klinicheskaia Meditsina
https://www.readbyqxmd.com/read/26958813/association-of-helicobacter-pylori-infection-and-chronic-atrophic-gastritis-with-risk-of-colonic-pancreatic-and-gastric-cancer-a-ten-year-follow-up-of-the-esther-cohort-study
#11
Xin-Zu Chen, Ben Schöttker, Felipe Andres Castro, Hongda Chen, Yan Zhang, Bernd Holleczek, Hermann Brenner
OBJECTIVES: To assess the association of H. pylori and chronic atrophic gastritis (AG) with colonic, pancreatic and gastric cancer in a population-based prospective cohort. METHODS: Serum antibodies against H. pylori in general and specific to cytotoxin-associated gene A (CagA), as well as serum pepsinogen I and II were analyzed in 9,506 men and women, aged 50-75 years in a cohort study from Saarland, Germany. Incident cases of colonic, pancreatic and gastric cancer were ascertained by record linkage with data from the Saarland Cancer Registry...
March 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/26730276/extragastric-manifestations-of-helicobacter-pylori-infection-possible-role-of-bacterium-in-liver-and-pancreas-diseases
#12
REVIEW
Elizabeth Ma Rabelo-Gonçalves, Bruna M Roesler, José Mr Zeitune
Helicobacter pylori (H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases...
December 28, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/26372823/helicobacter-pylori-and-gastrointestinal-malignancies
#13
REVIEW
Marino Venerito, Riccardo Vasapolli, Theodoros Rokkas, Peter Malfertheiner
Helicobacter pylori infection is the principal trigger of gastric carcinogenesis and gastric cancer (GC) and remains the third leading cause of cancer-related death in both sexes worldwide. In a big Japanese study, the risk of developing GC in patients with peptic ulcer disease who received H. pylori eradication therapy and annual endoscopic surveillance for a mean of 9.9 years was significantly lower after successful eradication therapy compared to the group with persistent infection (0.21%/year and 0.45%/year, respectively, p = ...
September 2015: Helicobacter
https://www.readbyqxmd.com/read/26198377/helicobacter-pylori-eradication-for-the-prevention-of-gastric-neoplasia
#14
REVIEW
Alexander C Ford, David Forman, Richard Hunt, Yuhong Yuan, Paul Moayyedi
BACKGROUND: Gastric cancer is the third most common cause of cancer death worldwide. Individuals infected with Helicobacter pylori have a higher likelihood of developing gastric cancer than individuals who are not infected. Eradication of H. pylori in healthy asymptomatic individuals in the general population may reduce the incidence of gastric cancer, but the magnitude of this effect is unclear. OBJECTIVES: To assess the effectiveness of eradication of H. pylori in healthy asymptomatic individuals in the general population in reducing the incidence of gastric cancer...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25951801/association-between-helicobacter-pylori-and-pancreatic-cancer-risk-a-meta-analysis
#15
Annaka Schulte, Nirmala Pandeya, Jonathan Fawcett, Lin Fritschi, Harvey A Risch, Penelope M Webb, David C Whiteman, Rachel E Neale
PURPOSE: Gastric colonization with Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of pancreatic cancer, but results of epidemiological studies have been inconclusive. We analyzed data from the Queensland Pancreatic Cancer Study, an Australian population-based case-control study, and incorporated our findings into an updated meta-analysis. METHODS: Blood samples were obtained from 580 patients and 626 controls, and enzyme-linked immunosorbent assay kits were used to determine seropositivity to H...
July 2015: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/25805956/rare-case-of-helicobacter-pylori-positive-multiorgan-igg4-related-disease-and-gastric-cancer
#16
Min Li, Qiang Zhou, Kun Yang, David R Brigstock, Lu Zhang, Ming Xiu, Li Sun, Run-Ping Gao
A 61-year-old male from Northeast China presented with a 2-mo history of abdominal distension, pruritus and jaundice. Laboratory testing revealed an elevated serum IgG4 level. A computed tomography scan showed a typical feature of autoimmune pancreatitis (AIP) and cholecystocholangitis. Early gastric cancer was incidentally discovered when endoscopic untrasound-guided fine needle aspiration (EUS-FNA) of the pancreas was carried out. The patient underwent radical subtotal gastrectomy for gastric cancer combined with cholecystectomy...
March 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25584172/burden-of-gastrointestinal-cancer-in-asia-an-overview
#17
REVIEW
Mohamad Amin Pourhoseingholi, Mohsen Vahedi, Ahmad Reza Baghestani
The cancers in the digestive system including gastric cancer, colorectal cancer, liver cancer, esophageal cancer and pancreatic cancer are one of the most common cancers in Asia. The burden of GI cancer is increasing in Asia because of aging, growth of the population and the risk factors including smoking, obesity, changing lifestyle and high prevalence of H pylori, HBV and HCV. In most Asian countries, cancer control programs or early detection and treatment services are limited despite this increase. There are many people in the developing countries inside Asia who have no health insurance and many of them are too poor to go for screening tests, early detection or medical treatments...
2015: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/25400980/helicobacter-pylori-and-pancreatic-diseases
#18
REVIEW
Milutin Bulajic, Nikola Panic, Johannes Matthias Löhr
A possible role for Helicobacter pylori (H. pylori) infection in pancreatic diseases remains controversial. H. pylori infection with antral predomination leading to an increase in pancreatic bicarbonate output and inducing ductal epithelial cell proliferation could contribute to the development of pancreatic cancer via complex interactions with the ABO genotype, dietary and smoking habits and N-nitrosamine exposure of the host. Although the individual study data available so far is inconsistent, several meta-analyses have reported an increased risk for pancreatic cancer among H...
November 15, 2014: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/25167946/helicobacter-pylori-and-extragastric-diseases
#19
REVIEW
Francesco Franceschi, Annalisa Tortora, Giovanni Gasbarrini, Antonio Gasbarrini
While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer...
September 2014: Helicobacter
https://www.readbyqxmd.com/read/25146335/preliminary-study-of-pancreatic-cancer-associated-with-helicobacter-pylori-infection
#20
Fulu Ai, Xiangdong Hua, Yefu Liu, Jie Lin, Zhaoqiang Feng
Little is known about the relationship about Helicobacter pylori (H. pylori) infection and pancreatic, and this study was set to investigate how H. pylori infection is correlated with pancreatic cancer and provide references for the clinical prevention and treatment of pancreatic cancer. 56 cases of pancreatic cancer patients admitted to the hospital from August 2012 to August 2013 were collected as the observation group. The anti-Hp IgG (H. pylori-specific antibodies), Hp IgM (H. pylori antibodies), and CagA-Hp-IgG (H...
January 2015: Cell Biochemistry and Biophysics
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