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Fungal sinusitis

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https://www.readbyqxmd.com/read/27888473/nasal-mucosa-healing-after-endoscopic-sinus-surgery-in-chronic-rhinosinusitis-of-elderly-patients-role-of-topic-alpha-tocopherol-acetate
#1
Domenico Testa, Giuseppina Marcuccio, Giorgio Panin, Andrea Bianco, Domenico Tafuri, Francesco Zappoli Thyrion, Michele Nunziata, Pasquale Piombino, Germano Guerra, Gaetano Motta
BACKGROUND: Chronic rhinosinusitis (CRS) in European country ranges in elderly patients from 4.5 to 12% of population and has a significant effect on quality of life. In these patients, rhinosinusitis is linked to immune functions changes with age and to mucosal paraphysiological alterations such as crusting formations with atrophic epithelium, variations of nasal airflow and modifications of the mucociliary clearance. Failure of medical treatments leads to surgery in patients with persistent symptoms and radiographic signs of CRS...
November 25, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27852812/a-retrospective-study-of-the-prevalence-of-calcium-oxalate-crystals-in-veterinary-aspergillus-cases
#2
Courtney L Payne, Michael J Dark, Julia A Conway, Lisa L Farina
Fungi in the genus Aspergillus are some of the most common fungal pathogens in veterinary species, primarily affecting the respiratory tract. In both human and veterinary cases, calcium oxalate crystals have been documented in sites of Aspergillus infection. Cases in multiple species (16 birds, 15 horses, 5 dogs, 1 ox, and 1 dolphin) were identified that had either positive cultures for Aspergillus sp., or had conidiophores present that could be identified as belonging to the genus Aspergillus Histologic slides were examined to confirm the presence of oxalate crystals and how often they were identified on the original report...
November 15, 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27832748/invasive-mucormycosis-in-children-an-epidemiologic-study-in-european-and-non-european-countries-based-on-two-registries
#3
Zoi Dorothea Pana, Danila Seidel, Anna Skiada, Andreas H Groll, Georgios Petrikkos, Oliver A Cornely, Emmanuel Roilides
BACKGROUND: Mucormycosis has emerged as a rare but frequently fatal invasive fungal disease. Current knowledge on paediatric mucormycosis is based on case reports and small series reported over several decades. Contemporary data on a large cohort of patients is lacking. METHODS: Two large international registries (Zygomyco.net and FungiScope™) were searched for mucormycosis cases in ≤19 year-old patients. Cases enrolled between 2005 and 2014 were extracted, and dual entries in the two databases merged...
November 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27816878/invasive-granulomatous-cryptococcal-sinusitis-in-an-adult-with-multiple-myeloma
#4
Richard A Ferraro, Jana Ivanidze, Elizabeth Margolskee, Hamilton Tsang, Theresa Sconomiglio, Yuliya S Jhanwar
We report a case of cryptococcal sinusitis, a rare presentation of Cryptococcus neoformans infection in a patient with multiple myeloma. The objective of this case report is to highlight the utility of structural and functional imaging modalities in the differential diagnosis of sinonasal soft tissue masses in the immunocompromised patient population. PET-CT was the first imaging modality in this patient, who presented for routine follow-up staging of multiple myeloma, and was asymptomatic at the time of his presentation...
October 17, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27799071/evaluation-of-coldzyme%C3%A2-mouth-spray-on-prevention-of-upper-respiratory-tract-infections-in-a-boy-with-primary-immunodeficiency-a-case-report
#5
Mats Clarsund, Ulf Blom, Ann Gardulf
BACKGROUND: Primary immunodeficiencies include a variety of disorders that render patients more susceptible to infections. If left untreated, these infections may be fatal. Patients with primary antibody deficiencies are therefore given prophylactic immunoglobulin G replacement therapy. ColdZyme® Mouth Spray is a medical device intended to reduce the probability of catching a cold and/or can help shorten the duration of a cold, if used at an early stage of the infection, by forming a thin protective barrier on the pharyngeal mucous membrane...
October 31, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27751781/epico-3-0-empirical-antifungal-therapy-in-critically-ill-hematology-patients
#6
Pedro Llinares, Isabel Ruiz, Rafael Zaragoza, Ricard Ferrer, Alejandro H Rodríguez, Emilio Maseda, Santiago Grau
BACKGROUND: Although in the past decade the management of invasive fungal infections has improved, a number of controversies persist regarding empirical antifungal treatment in critically-ill hematology patients. AIMS: To identify key clinical knowledge to elaborate a set of recommendations, with a high level of consensus, necessary for the approach to fungal infections in critically-ill hematology patients. METHODS: A Spanish prospective questionnaire, which measures consensus through the Delphi technique, was anonymously answered and e-mailed by 30 multidisciplinary national experts, all specialists in fungal invasive infections from six scientific national societies; intensivists, anesthesiologists, microbiologists, pharmacologists and specialists in infectious diseases...
October 14, 2016: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/27730655/secondary-free-flap-reconstruction-following-ablation-for-acute-invasive-fungal-sinusitis
#7
Jordan J Allensworth, Scott H Troob, Tyler S Weaver, Javier D Gonzalez, Daniel Petrisor, Mark K Wax
OBJECTIVE: Acute invasive fungal sinusitis (AIFS) is a frequently fatal infection for which extensive and debilitating surgical debridement is a mainstay of therapy. Resulting defects are often composite in nature, mandating free tissue-transfer reconstruction. Outcomes data for free flap reconstruction are limited. The purpose of this study was to examine surgical outcomes and survival in patients undergoing free flap transfer following invasive fungal sinusitis. STUDY DESIGN: Retrospective case series...
October 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27729140/invasive-fungal-sinusitis-in-the-pediatric-population-systematic-review-with-quantitative-synthesis-of-the-literature
#8
Aaron Smith, Vikrum Thimmappa, Brandon Shepherd, Meredith Ray, Anthony Sheyn, Jerome Thompson
BACKGROUND: Invasive fungal sinusitis (IFS) represents an often fatal condition within the pediatric population. In an effort to characterize demographics, treatment modalities, and prognostic factors, we performed a systematic review. METHODS: We systematically reviewed EMBASE, Medline, TRIPdatabase, SCOPUS and the Cochrane database for invasive fungal nasal and sinus infections limited to individuals <18 years of age. Case series including 3 or more patients were included...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27703827/chronic-invasive-nongranulomatous-fungal-rhinosinusitis-in-immunocompetent-individuals
#9
Ozge Turhan, Asli Bostanci, Irem Hicran Ozbudak, Murat Turhan
Chronic invasive nongranulomatous fungal rhinosinusitis is a well-described but uncommon type of fungal rhinosinusitis (FRS). While the prevalence of chronic FRS is 0.11% in healthy individuals, only 1.3% of them are in nongranulomatous invasive nature. The majority of the cases in the literature have been reported from developing countries mostly located in the tropical regions, as typically occurring in the background of diabetes mellitus or corticosteroid treatment. The current paper reports four consecutive cases, who were diagnosed within a short period of six months at a single center of a country located outside the tropical climate zone...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27698695/rare-case-of-disseminated-fusariosis-in-a-young-patient-with-graft-vs-host-disease-following-an-allogeneic-transplant
#10
Alina Tanase, Anca Colita, Gabriel Ianosi, Daniela Neagoe, Daciana Elena Branisteanu, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Simona Laura Ianosi
Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft-vs.-host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27650099/invasive-fungal-sinusitis-by-lasiodiplodia-theobromae-in-an-patient-with-aplastic-anemia-an-extremely-rare-case-report-and-literature-review
#11
Hyun Jung Gu, Young Jin Kim, Hee Joo Lee, Sung Hwa Dong, Sung Wan Kim, Hee Jae Huh, Chang-Seok Ki
Human Lasiodiplodia theobromae infection has not been reported frequently. We report the first case of invasive L. theobromae nasal and neck infection. A 66-year-old male visited our hospital with anemia and general weakness. He showed pancytopenia, and his bone marrow examination revealed markedly decreased hematopoietic cells. The patient was presumed to have iatrogenic aplastic anemia due to mushroom toxicity. He began treatment for multiple organ infections with broad-spectrum antibiotics and antifungal agents...
September 20, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27625124/-managements-and-prognostic-analyses-in-patients-with-invasive-fungal-rhinosinusitis
#12
W Zhou, Q Liu, W D Zhao, H P Yu, X C Sun, J J Wang, Z F Liu, H Y Li, C Q Zheng, S Y Wang, D H Wang
OBJECTIVE: To evaluate the survival outcomes of invasive fungal rhinosinusitis by analyzing the clinical features. METHODS: A retrospective analysis was performed for cases of invasive fungal sinusitis proved by histological analysis between March 2006 and November 2015. All relevant factors including interval from the onset of symptoms to initiation of diagnosis, clinical characteristics, features of CT and MRI, treatment and prognosis were collected. A total of 18 patients (10 males; 8 females) were identified...
August 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27601608/are-allergic-fungal-rhinosinusitis-and-allergic-bronchopulmonary-aspergillosis-lifelong-conditions
#13
Ritesh Agarwal, Sandeep Bansal, Arunaloke Chakrabarti
Aspergillus fumigatus can cause several allergic disorders including Aspergillus-sensitized asthma, allergic bronchopulmonary aspergillosis (ABPA), and allergic fungal rhinosinusitis (AFRS). ABPA is an immunological pulmonary disorder caused by allergic reactions mounted against antigens of A. fumigatus colonizing the airways of patients with asthma (and cystic fibrosis). Allergic bronchopulmonary mycosis is an allergic fungal airway disease caused by thermotolerant fungi other than A. fumigatus On the other hand, AFRS is a type of chronic rhinosinusitis that is also a result of hypersensitivity reactions to the presence of fungi that become resident in the sinuses...
September 6, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27577717/predicting-revision-sinus-surgery-in-allergic-fungal-and-eosinophilic-mucin-chronic-rhinosinusitis
#14
Ramzi T Younis, Jamal Ahmed
BACKGROUND: Chronic rhinosinusitis consists of several disease processes. Eosinophilic mucin is found in the subtypes of allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS). These entities frequently require surgical intervention and have high recurrence rates. OBJECTIVE: We aimed to determine factors in patients with AFS and EMCRS that may be associated with a higher rate of revision surgeries. Our hypothesis is that patients who have polyps, high Lund-Mackay score (LMS), and fungus may have higher revision rates...
August 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27563478/orbital-metastasis-of-breast-cancer-mimicking-invasive-fungal-rhinosinusitis
#15
Mayara Tabai, Igor Moreira Hazboun, Emerson Taro Inoue Sakuma, Marcelo Hamilton Sampaio, Eulalia Sakano
Introduction. A range of traumatic, vascular, inflammatory, infectious, and neoplastic processes can affect the orbit and its structures. In the area of otolaryngology, the rhino-orbital-cerebral involvement of invasive fungal rhinosinusitis can affect the orbit, which may look like initially a rhinosinusitis or even mimic malignancy. Case Presentation. Female patient, 32 years old, with headache and ocular proptosis. She was using prednisone in immunosuppressive doses for a year and had breast cancer treated three years earlier...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27560920/-cross-reactivity-in-allergic-fungal-sinusitis-case-report
#16
Sandra Nora González-Díaz, Alfredo Arias-Cruz, Dulce María Rivero-Arias, Alma Belén Partida-Ortega, Bárbara Elizondo-Villarreal, Jesús Arturo Ibarra-Chávez, Lissette Ramos-Valencia, Olga Patricia Monge-Ortega, Carlos Macouzet-Sánchez, María Rocío Salinas-Díaz
BACKGROUND: The presence of allergic mucin in allergic fungal sinusitis (AFS) is a manifestation that identifies it as a hypersensitivity process. AFS has a phenomenon of cross-reactivity to IgE-bound proteins having at least two shared epitopes. CLINICAL REPORT: A 13-year-old male with nasal obstructive symptoms of three years of evolution. An obstructive mass was identified in the sinuses through physical examination and CT. In endoscopic surgery, the left nostril polyp was identified with the macroscopic appearance of allergic mucin; the polyp was resected...
July 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27536497/mucormycosis-of-the-forehead-and-sinuses-in-a-trauma-patient
#17
Pallavi A Kumbla, Nathan Lee, Mary K Kimbrough
Mucormycosis is a rare fungal infection in immunocompetent patients. It is not commonly seen in trauma patients who sustain multisystem injuries and are often exposed to numerous infectious sources. A multidisciplinary approach between medical and surgical specialties is crucial to ensuring timely diagnosis and treatment as morbidity and mortality can be high once acquired. In addition to antifungal therapy, radical debridement and reconstruction by plastic surgery is often necessary. Review of the literature shows that there is no definitive reconstructive technique for mucormycosis of the forehead and sinuses because the amount of tissue destruction may be varied in location and depth, therefore requiring varying extents of debridement...
July 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27487469/migratory-and-adhesive-cues-controlling-innate-like-lymphocyte-surveillance-of-the-pathogen-exposed-surface-of-the-lymph-node
#18
Yang Zhang, Theodore L Roth, Elizabeth E Gray, Hsin Chen, Lauren B Rodda, Yin Liang, Patrick Ventura, Saul Villeda, Paul R Crocker, Jason G Cyster
Lymph nodes (LNs) contain innate-like lymphocytes that survey the subcapsular sinus (SCS) and associated macrophages for pathogen entry. The factors promoting this surveillance behavior have not been defined. Here, we report that IL7R(hi)Ccr6(+) lymphocytes in mouse LNs rapidly produce IL17 upon bacterial and fungal challenge. We show that these innate-like lymphocytes are mostly LN resident. Ccr6 is required for their accumulation near the SCS and for efficient IL17 induction. Migration into the SCS intrinsically requires S1pr1, whereas movement from the sinus into the parenchyma involves the integrin LFA1 and its ligand ICAM1...
August 3, 2016: ELife
https://www.readbyqxmd.com/read/27475007/-sinonasal-fungal-infections-are-not-exclusively-due-to-mucorales-and-aspergillus
#19
Arnault Tauziède-Espariat, Michel Wassef, Homa Adle-Biassette, Alexandre Alanio, Stéphane Bretagne, Fanny Lanternier, Mohammed Boui, Olivier Bouchaud, Pierre Vironneau, Romain Kania, Grégory Jouvion, Fabrice Chrétien, Marion Classe
Rhino-sinusal infections are serious diseases and possibly lethal. When they are invasive, we easily discuss apergilloses and mucormycoses. The confirmation of the diagnosis of mucormycosis need an extensive surgery for precise histopathological and mycological evaluation. The pathologist may be faced to other rare mycoses such as phaeohyphomycoses, which present different morphological features than mucormycoses and Aspergillus. Once the diagnosis is established, an appropriate antifungal treatment is quickly started...
August 2016: Annales de Pathologie
https://www.readbyqxmd.com/read/27466842/allergic-fungal-rhinosinusitis-the-latest-in-diagnosis-and-management
#20
Patricia A Loftus, Sarah K Wise
Allergic fungal rhinosinusitis (AFRS) is the most common form of fungal sinusitis in the United States. Its pathophysiological basis is associated with a predisposed person's type I IgE-mediated allergic response to inhaled mold spores that are ubiquitous in the environment. AFRS is a well-recognized type of chronic, recurrent, and non-invasive hypertrophic sinus disease that affects immunocompetent hosts, most commonly young African American males. There are 5 main criteria used for the diagnosis of AFRS, one being the presence of nasal polyposis...
2016: Advances in Oto-rhino-laryngology
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