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https://www.readbyqxmd.com/read/30059027/quantitative-micro-ct-analysis-of-aortopathy-in-a-mouse-model-of-%C3%AE-aminopropionitrile-induced-aortic-aneurysm-and-dissection
#1
Brittany O Aicher, Subhradip Mukhopadhyay, Xin Lu, Selen C Muratoglu, Dudley K Strickland, Areck A Ucuzian
Aortic aneurysm and dissection is associated with significant morbidity and mortality in the population and can be highly lethal. While animal models of aortic disease exist, in vivo imaging of the vasculature has been limited. In recent years, micro-computerized tomography (micro-CT) has emerged as a preferred modality for imaging both large and small vessels both in vivo and ex vivo. In conjunction with a method of vascular casting, we have successfully used micro-CT to characterize the frequency and distribution of aortic pathology in β-aminopropionitrile-treated C57/Bl6 mice...
July 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29799729/absence-of-nanostructuring-in-napb-m-sbte-m-2-solid-solutions-with-high-thermoelectric-performance-in-the-intermediate-temperature-regime
#2
Tyler J Slade, Jann A Grovogui, Shiqiang Hao, Trevor P Bailey, Runchu Ma, Xia Hua, Aurélie Guéguen, Ctirad Uher, Chris Wolverton, Vinayak P Dravid, Mercouri G Kanatzidis
Thermoelectric devices directly convert heat into electrical energy and are highly desired for emerging applications in waste heat recovery. Currently, PbTe based compounds are the leading thermoelectric materials in the intermediate temperature regime (∼800 K); however, integration into commercial devices has been limited. This is largely because the performance of PbTe, which is maximized ∼900 K, is too low over the temperatures of interest for most potential commercial applications (generally under 600 K)...
June 6, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29727455/assessing-the-public-health-impact-of-tolerance-based-therapies-with-mathematical-models
#3
Nathanaël Hozé, Sebastian Bonhoeffer, Roland Regoes
Disease tolerance is a defense strategy against infections that aims at maintaining host health even at high pathogen replication or load. Tolerance mechanisms are currently intensively studied with the long-term goal of exploiting them therapeutically. Because tolerance-based treatment imposes less selective pressure on the pathogen it has been hypothesised to be "evolution-proof". However, the primary public health goal is to reduce the incidence and mortality associated with a disease. From this perspective, tolerance-based treatment bears the risk of increasing the prevalence of the disease, which may lead to increased mortality...
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29708242/co-delivery-of-timolol-and-hyaluronic-acid-from-semi-circular-ring-implanted-contact-lenses-for-the-treatment-of-glaucoma-in-vitro-and-in-vivo-evaluation
#4
Ankita R Desai, Furqan A Maulvi, Mihir M Pandya, Ketan M Ranch, Bhavin A Vyas, Shailesh A Shah, Dinesh O Shah
Glaucoma is a chronic disease, which is currently treated using frequent high dose applications of an eye drop solution; this method is tedious, and most of patients are non-compliant to it. Contact lenses are emerging as a convenient option to sustain the release of ophthalmic drugs. However, the incorporation of a drug/formulation changes the optical and physical properties of contact lenses. Contact lens users have also reported pink eye syndrome; this makes contact lenses unsuitable to be accepted as a medical device...
May 29, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29707870/polypeptides-with-high-zwitterion-density-for-safe-and-effective-therapeutics
#5
Peng Zhang, Priyesh Jain, Caroline Tsao, Zhefan Yuan, Wenchen Li, Bowen Li, Kan Wu, Hsiang-Chieh Hung, Xiaojie Lin, Shaoyi Jiang
The commonly used "stealth material" poly(ethylene glycol) (PEG) effectively promotes the pharmacokinetics of therapeutic cargos while reducing their immune response. However, recent studies have suggested that PEG could induce adverse reactions, including the emergence of anti-PEG antibodies and tissue histologic changes. An alternative stealth material with no or less immunogenicity and organ toxicity is thus urgently needed. We designed a polypeptide with high zwitterion density (PepCB) as a stealth material for therapeutics...
June 25, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29688487/circulating-non-coding-rnas-in-biomarker-guided-cardiovascular-therapy-a-novel-tool-for-personalized-medicine
#6
David de Gonzalo-Calvo, Angela Vea, Christian Bär, Jan Fiedler, Liam S Couch, Carlos Brotons, Vicenta Llorente-Cortes, Thomas Thum
Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. However, results from previous publications cast some doubts about the clinical applicability of biomarkers to direct individualized treatment. In recent years, the non-coding human transcriptome has emerged as a new opportunity for the development of novel therapeutic strategies and biomarker discovery...
April 24, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29499347/is-oval-window-transport-a-royal-gate-for-nanoparticle-delivery-to-vestibule-in-the-inner-ear
#7
Shan Ding, Shibao Xie, Weiquan Chen, Lu Wen, Junyi Wang, Fan Yang, Gang Chen
Drug delivery to the inner ear by nanomedicine strategies has emerged as an effective therapeutic approach for the management of inner ear diseases including hearing and balance disorders. It is well accepted that substance enters the perilymph from the middle ear through the round window membrane (RWM), but the passage through the oval window (OW) has long been neglected. Up to now, researchers still know little about the pathway via which nanoparticles (NPs) enter the inner ear or how they reach the inner ear following local applications...
February 28, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29468161/big-data-and-dementia-charting-the-route-ahead-for-research-ethics-and-policy
#8
Marcello Ienca, Effy Vayena, Alessandro Blasimme
Emerging trends in pervasive computing and medical informatics are creating the possibility for large-scale collection, sharing, aggregation and analysis of unprecedented volumes of data, a phenomenon commonly known as big data. In this contribution, we review the existing scientific literature on big data approaches to dementia, as well as commercially available mobile-based applications in this domain. Our analysis suggests that big data approaches to dementia research and care hold promise for improving current preventive and predictive models, casting light on the etiology of the disease, enabling earlier diagnosis, optimizing resource allocation, and delivering more tailored treatments to patients with specific disease trajectories...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29354847/dopamine-functionalization-of-batio-3-an-effective-strategy-for-the-enhancement-of-electrical-magnetoelectric-and-thermal-properties-of-batio-3-pvdf-trfe-nanocomposites
#9
Anshida Mayeen, Kala M S, M S Jayalakshmy, Sabu Thomas, Didier Rouxel, Jacob Philip, R N Bhowmik, Nandakumar Kalarikkal
Electro-active polymer-ceramic composite systems are emerging materials in the fields of nanoelectronic, microelectromechanical and macroelectronic device applications. Still more precise and concise research studies have yet to come in the areas of energy storage, harvesting, energy conversion, etc. In line with this, we have synthesized and analyzed PVDF-TrFE based nanocomposites of both functionalized and non-functionalized BaTiO3 (BTO). All the samples were prepared as free standing films by employing a solvent cast method...
February 6, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29178335/a-general-synthesis-of-porous-carbon-nitride-films-with-tunable-surface-area-and-photophysical-properties
#10
Guiming Peng, Lidan Xing, Jesús Barrio, Michael Volokh, Menny Shalom
Graphitic carbon nitride (g-CN) has emerged as a promising material for energy-related applications. However, exploitation of g-CN in practical devices is still limited owing to difficulties in fabricating g-CN films with adjustable properties and high surface area. A general and simple pathway is reported to grow highly porous and large-scale g-CN films with controllable chemical and photophysical properties on various substrates using the doctor blade technique. The growth of g-CN films, ascribed to the formation of a supramolecular paste, comprises g-CN monomers in ethylene glycol, which can be cast on different substrates...
January 26, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29075440/efficient-isolation-method-for-high-quality-genomic-dna-from-cicada-exuviae
#11
Hoa Quynh Nguyen, Ye Inn Kim, Amaël Borzée, Yikweon Jang
In recent years, animal ethics issues have led researchers to explore nondestructive methods to access materials for genetic studies. Cicada exuviae are among those materials because they are cast skins that individuals left after molt and are easily collected. In this study, we aim to identify the most efficient extraction method to obtain high quantity and quality of DNA from cicada exuviae. We compared relative DNA yield and purity of six extraction protocols, including both manual protocols and available commercial kits, extracting from four different exoskeleton parts...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29049268/patient-and-parent-satisfaction-with-sling-use-after-pediatric-upper-extremity-fractures-a-randomized-controlled-trial-of-a-customized-cast-sling-versus-standard-cast-and-sling
#12
Aristides I Cruz, Steven F DeFroda, Joseph A Gil, Heather Hansen, Alexandre Bolous, Michaela Procaccini, Mark R Zonfrillo
BACKGROUND: Long arm cast immobilization after operative and nonoperative treatment of pediatric upper extremity fractures is common. The use of a sling to aid in carrying the casted extremity as well as provide further immobilization is also common practice. Off-the-shelf slings vary in quality and fit, can be confusing for parents/patients to apply, and lead to frustration and dissatisfaction with its use. The purpose of this investigation was to compare patient/parent centered outcomes after the use of a customized sling compared with a standard sling by utilizing a prospective, randomized-controlled trial...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28811117/bilayered-buccal-films-as-child-appropriate-dosage-form-for-systemic-administration-of-propranolol
#13
Angela Abruzzo, Fiore Pasquale Nicoletta, Francesco Dalena, Teresa Cerchiara, Barbara Luppi, Federica Bigucci
Buccal mucosa has emerged as an attractive site for systemic administration of drug in paediatric patients. This route is simple and non-invasive, even if the saliva wash-out effect and the relative permeability of the mucosa can reduce drug absorption. Mucoadhesive polymers represent a common employed strategy to increase the contact time of the formulation at the application site and to improve drug absorption. Among the different mucoadhesive dosage forms, buccal films are particularly addressed for paediatric population since they are thin, adaptable to the mucosal surface and able to offer an exact and flexible dose...
October 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28804733/3d-printed-tissue-mimicking-phantoms-for-medical-imaging-and-computational-validation-applications
#14
Aidan J Cloonan, Danial Shahmirzadi, Ronny X Li, Barry J Doyle, Elisa E Konofagou, Tim M McGloughlin
Abdominal aortic aneurysm (AAA) is a permanent, irreversible dilation of the distal region of the aorta. Recent efforts have focused on improved AAA screening and biomechanics-based failure prediction. Idealized and patient-specific AAA phantoms are often employed to validate numerical models and imaging modalities. To produce such phantoms, the investment casting process is frequently used, reconstructing the 3D vessel geometry from computed tomography patient scans. In this study the alternative use of 3D printing to produce phantoms is investigated...
March 1, 2014: 3D Printing and Additive Manufacturing
https://www.readbyqxmd.com/read/28785093/magnetic-quantum-phase-transition-in-cr-doped-bi2-sexte1-x-3-driven-by-the-stark-effect
#15
Zuocheng Zhang, Xiao Feng, Jing Wang, Biao Lian, Jinsong Zhang, Cuizu Chang, Minghua Guo, Yunbo Ou, Yang Feng, Shou-Cheng Zhang, Ke He, Xucun Ma, Qi-Kun Xue, Yayu Wang
The recent experimental observation of the quantum anomalous Hall effect has cast significant attention on magnetic topological insulators. In these magnetic counterparts of conventional topological insulators such as Bi2Te3, a long-range ferromagnetic state can be established by chemical doping with transition-metal elements. However, a much richer electronic phase diagram can emerge and, in the specific case of Cr-doped Bi2(SexTe1-x)3, a magnetic quantum phase transition tuned by the actual chemical composition has been reported...
October 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28692801/uv-curable-antismudge-coatings
#16
Chao Zheng, Guojun Liu, Heng Hu
Current antismudge coatings that bear nano-pools of a grafted liquid ingredient for dewetting enablement (NP-GLIDE) are cured at high temperatures, which are undesirable for application on heat-sensitive substrates. Reported herein is the development of a NP-GLIDE coating that can be photocured at room temperature. Of the various formulations that have been tested, robust coatings were obtained from one recipe consisting of a photoinitiator, a trifunctional monomer that bears three double bonds, and a graft copolymer...
August 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28629097/emerging-bone-tissue-engineering-via-polyhydroxyalkanoate-pha-based-scaffolds
#17
REVIEW
Janice Lim, Mingliang You, Jian Li, Zibiao Li
Polyhydroxyalkanoates (PHAs) are a class of biodegradable polymers derived from microorganisms. On top of their biodegradability and biocompatibility, different PHA types can contribute to varying mechanical and chemical properties. This has led to increasing attention to the use of PHAs in numerous biomedical applications over the past few decades. Bone tissue engineering refers to the regeneration of new bone through providing mechanical support while inducing cell growth on the PHA scaffolds having a porous structure for tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28060178/assessment-of-splints-applied-for-pediatric-fractures-in-an-emergency-department-urgent-care-environment
#18
Joshua M Abzug, Brandon S Schwartz, Aaron J Johnson
BACKGROUND: Fractures are common in the pediatric population. The initial evaluation is rarely by an orthopaedic surgeon, but commonly an emergency room or urgent care center physician/extender. This typically involves splint application by a nonorthopaedist to immobilize the extremity and provide stabilization. Iatrogenic injuries from inappropriate splint placement are a potential public health and legal concern that can lead to complications. The primary purpose of this study was to prospectively evaluate the adequacy of all splints placed on patients who presented to a pediatric orthopaedic office; secondary outcomes included assessing prevalence and types of complications that were associated with inadequate splints...
January 5, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27813012/confined-growth-of-metal-nanoparticles-within-3d-dna-origami-molds
#19
Wei Sun, Jie Shen
Manufacturing prescribed shaped metal nanoparticles promises emerging applications in plasmonics, energy, and disease diagnosis. The key to the shape-controllable synthesis is generating local environments encoded with prescribed geometrical information. Here, we describe a general strategy that uses 3D self-assembled DNA origami as mold to confine the casting growth of metal nanoparticle. By transferring the shape information from DNA cavities to metal nanoparticles, metal nanoparticles with prescribed shapes, dimensions, and surface binding features could be rationally designed and synthesized...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27749671/effect-of-a-computerized-reminder-on-splinting-of-pediatric-upper-limb-fractures-in-the-emergency-department
#20
Erin Mills, Simon Craig, Ed Oakley
OBJECTIVE: The primary objective was to assess if a computerized pop-up reminder increased splint application before X-ray in pediatric emergency department patients with deformed upper limb fractures. The secondary objective was to evaluate whether this same reminder improved pharmaceutical analgesia provision in this population. METHODOLOGY: This was a prospective study of 518 pediatric emergency department patients with upper limb fractures after the implementation of a computerized pop-up reminder to give analgesia and apply a splint...
October 2016: Pediatric Emergency Care
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