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Intensive AND Care

Amanda C Kentner, Stephanie Scalia, Junyoung Shin, Mattia M Migliore, Alejandro N Rondón-Ortiz
Both basic and clinical research support the use of tactile stimulation to rescue several neurobiobehavioral consequences that follow early life stress including. Here, using a translational rodent model of the neonatal intensive care unit (NICU), we tested the individual prophylactic potential of a variety of sensory interventions including tactile (brushing pups with a paint brush to mimic maternal licking), auditory (a simulated lactating rat dam heart beat), and olfactory (a series of aroma therapy scents) stimulation...
July 30, 2018: Psychoneuroendocrinology
Hazem Akkad, Nicola Cacciani, Monica Llano-Diez, Rebeca Corpeno Kalamgi, Tamara Tchkonia, James L Kirkland, Lars Larsson
AIM: Critical illness myopathy (CIM) is a consequence of modern critical care, leading to skeletal muscle atrophy/paralysis with negative consequences for mortality/morbidity and health care costs. Glucocorticoids (GCs) have been proposed to trigger CIM. Here, we compare outcomes of two GCs, the commonly used prednisolone and the newly developed dissociative vamorolone in response to the intensive care unit (ICU) condition for 5 days, i.e., sedation, immobilization, and mechanical ventilation...
August 18, 2018: Acta Physiologica
F Rosso, S Rodríguez, J A Cedano, B L Mora, P A Moncada, J D Velez
Chikungunya virus is a recent emerging arbovirus in Latin America, and the clinical manifestations can vary from fever and rash to severe chronic inflammatory arthritis. Few reports have been published regarding this infection in immunocompromised patients, including solid organ transplant recipients. We report a case series of solid organ transplant recipients with confirmed Chikungunya infection by positive reverse transcription polymerase chain reaction (RT-PCR), identified between January 2014 and December 2016...
August 17, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
A L van Melle, Y Voskes, H C W de Vet, J van der Meijs, C L Mulder, G A M Widdershoven
This study aims to validate the HIC monitor as a model-fidelity scale to the High and Intensive Care (HIC) model, a recently developed model for acute psychiatric wards. To assess the psychometric properties of the HIC monitor, 37 audits were held on closed inpatient wards at 20 psychiatric hospitals in the Netherlands. Interrater reliability, construct validity and content validity were examined. Our results suggest that the HIC monitor has good psychometric properties. It can be used as a tool for assessing the implementation of the HIC model on acute psychiatric wards in the Netherlands, and for quality assessment and improvement...
August 17, 2018: Administration and Policy in Mental Health
W Druml
The central role of the organ system "gut" for critically ill patients has not been acknowledged until the last decade. The gut is a crucial immunologic, metabolic and neurologic organ system and impairment of its functions is associated with morbidity and mortality. The gut has a central position in the cross-talk between organs and dysfunction of the gut may result in impairment of other intra-abdominal and extra-abdominal organ systems. The intestinal tract is the most important source of endogenous infections and determines the inflammatory status of the organism...
August 17, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Dilip R Bhatt, Alexandria I Kristensen-Cabrera, Henry C Lee, Sunjeeve Weerasinghe, David K Stevenson, Vinod K Bhutani, M Jeffrey Maisels, Rangasamy Ramanathan
OBJECTIVES: Transcutaneous bilirubin measurements (TcBs) provide a noninvasive method for screening infants for hyperbilirubinemia and have been used extensively in term and late preterm newborns in well baby nurseries, offices, and outpatient clinics. Several studies have also demonstrated the utility of TcBs as a screening tool for infants > 28 weeks' gestation and their ability to reduce the need for blood sampling. The objectives of this study are to identify how often TcBs are used among California Newborn Intensive Care Units (NICUs) in preterm, late preterm and term infants, and other aspects of jaundice management...
August 17, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Melissa Scala, Suna Seo, Juniper Lee-Park, Christina McClure, Maria Scala, Judith Jones Palafoutas, Kabir Abubakar
OBJECTIVE: To evaluate the impact of parental bedside reading (PR) on cardio-respiratory (CR) stability of preterm infants. METHODS/STUDY DESIGN: Prospective examination of the impact of PR on CR stability in preterm NICU infants. CR data from 3 time points: pre-reading (3 and 1 h before reading), during PR, and post-reading (1 h after reading) were compared. RESULTS: Eighteen infants born at 23-31wks gestation, and 8 to 56 days old, were enrolled...
August 17, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Wojciech Rudno-Rudziński, Marcin Syperek, Janusz Andrzejewski, Ernest Rogowicz, Gadi Eisenstein, Sven Bauer, Vitalii I Sichkovskyi, Johann P Reithmaier, Grzegorz Sęk
We investigate a hybrid system containing an In0.53 Ga0.47 As quantum well (QW), separated by a thin 2 nm In0.53 Ga0.23 Al0.24 As barrier from 1.55 µm emitting InAs quantum dots (QDs), grown by molecular beam epitaxy on an InP substrate. Photoreflectance and photoluminescence (PL) spectroscopies are used to identify optical transitions in the system, with support of 8-band kp modelling. The main part of the work constitute the measurements and analysis of thermal quenching of PL for a set of samples with different QW widths (3-6 nm)...
August 17, 2018: Scientific Reports
Courtney P Williams, Kelly M Kenzik, Andres Azuero, Grant R Williams, Maria Pisu, Karina I Halilova, Stacey A Ingram, Supriya K Yagnik, Andres Forero, Smita Bhatia, Gabrielle B Rocque
BACKGROUND: National Comprehensive Cancer Network (NCCN) guideline-based treatment is a marker of high-quality care. The impact of guideline discordance on cost and health care utilization is unclear. MATERIALS AND METHODS: This retrospective cohort study of Medicare claims data from 2012 to 2015 included women age ≥65 with stage I-III breast cancer receiving care within the University of Alabama at Birmingham Cancer Community Network. Concordance with NCCN guidelines was assessed for treatment regimens...
August 17, 2018: Oncologist
Colleen A Hughes Driscoll, Samuel Gurmu, Ahad Azeem, Dina El Metwally
No abstract text is available yet for this article.
August 14, 2018: Healthcare
Quirine M J van der Vliet, Oscar E C van Maarseveen, Diederik P J Smeeing, Roderick M Houwert, Karlijn J P van Wessem, Rogier K J Simmermacher, Geertje A M Govaert, Mirjam B de Jong, Ivar G J de Bruin, Luke P H Leenen, Falco Hietbrink
INTRODUCTION: There is continuous drive to optimize healthcare for the most severely injured patients. Although still under debate, a possible measure is to provide 24/7 in-house (IH) coverage by trauma surgeons. The aim of this study was to compare process-related outcomes for severely injured patients before and after transition of attendance policy from an out-of-hospital (OH) on-call attending trauma surgeon to an in-house attending trauma surgeon. METHODS: Retrospective before-and-after study using prospectively gathered data in a Level 1 Trauma Center in the Netherlands...
August 10, 2018: Injury
Hiroyuki Naruse, Junnichi Ishii, Hiroshi Takahashi, Fumihiko Kitagawa, Hideto Nishimura, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Akira Yamada, Sadako Motoyama, Shigeru Matsui, Mutsuharu Hayashi, Masayoshi Sarai, Eiichi Watanabe, Hideo Izawa, Yukio Ozaki
BACKGROUND: The early prediction of acute kidney injury (AKI) can facilitate timely intervention and prevent complications. We aimed to understand the predictive value of urinary liver-type fatty-acid binding protein (L-FABP) levels on admission to medical (non-surgical) cardiac intensive care units (CICUs) for AKI, both independently and in combination with serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. METHODS: We prospectively investigated the predictive value of L-FABP and NT-proBNP for AKI in a large, heterogeneous cohort of patients treated in medical CICUs...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
Kay Choong See, Venetia Ong, Yi Lin Tan, Juliet Sahagun, Juvel Taculod
BACKGROUND: Lung ultrasound may be a reasonable alternative to chest radiography for the identification of acute respiratory distress syndrome (ARDS), but the diagnostic performance of lung ultrasound for ARDS is uncertain. We therefore analyzed the clinical outcomes of ARDS diagnosed according to the Berlin Definition, using either chest radiography (Berlin-CXR) or lung ultrasound (Berlin-LUS) as an alternative imaging method. METHODS: This was a retrospective observational study in a 20-bed medical intensive care unit (ICU)...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
Marie Cantier, Adeline Morisot, Emmanuel Guérot, Bruno Megarbane, Keyvan Razazi, Damien Contou, Eric Mariotte, Emmanuel Canet, Etienne De Montmollin, Vincent Dubée, Eric Boulet, Stéphane Gaudry, Guillaume Voiriot, Julien Mayaux, Frédéric Pène, Mathilde Neuville, Bruno Mourvillier, Stéphane Ruckly, Lila Bouadma, Michel Wolff, Jean-François Timsit, Romain Sonneville
BACKGROUND: Tuberculous meningitis (TBM) is a devastating infection in tuberculosis endemic areas with limited access to intensive care. Functional outcomes of severe adult TBM patients admitted to the ICU in nonendemic areas are not known. METHODS: We conducted a retrospective multicenter cohort study (2004-2016) of consecutive TBM patients admitted to 12 ICUs in the Paris area, France. Clinical, biological, and brain magnetic resonance imaging (MRI) findings at admission associated with a poor functional outcome (i...
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
Anis Hasnaoui, Raja Jouini, Dhafer Haddad, Haithem Zaafouri, Ahmed Bouhafa, Anis Ben Maamer, Ehsen Ben Brahim
BACKGROUND: Since the advent of immunohistochemistry for the diagnosis of stromal tumours, the incidence of leiomyosarcomas has significantly decreased. Nowadays, gastric leiomyosarcoma is an exceptionally rare tumour. We report the second case in the English literature of gastric leiomyosarcoma revealed with massive bleeding and hemodynamic instability and diagnostic pitfalls that we encountered. CASE PRESENTATION: A 63-year-old woman, with 2 years' history of dizziness and weakness probably related to an anaemic syndrome, presented to the emergency room with hematemesis, melena and hemodynamic instability...
August 17, 2018: BMC Surgery
E A J M Spaans, P R van Dijk, K H Groenier, P L P Brand, N Kleefstra, H J G Bilo
BACKGROUND: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children. Studies on costs related to T1DM are scarce and focused primarily on the costs directly related to diabetes. We aimed to investigate both the overall healthcare costs and the more specific costs related to the management of diabetes. METHODS: This is a retrospective and observational, nationwide cohort study of all Dutch children (aged 0-18 years) with T1DM. Data were collected from the national registry for healthcare reimbursement, in which all Dutch insurance companies combine their reimbursement data...
August 17, 2018: BMC Endocrine Disorders
Sachin Talwar, Amolkumar Bhoje, Rajesh Khadagawat, Pradeep Chaturvedi, Vishnubhatla Sreenivas, Neeti Makhija, Manoj Sahu, Shiv Kumar Choudhary, Balram Airan
BACKGROUND: Decreases in serum total thyroxin and total triiodothyronine occurs after cardiopulmonary bypass, and is reflected as poor immediate outcome. We studied effects of oral thyroxin supplementation in infants who underwent open-heart surgery. METHODS: In this prospective study, 100 patients were randomized into 2 groups: 50 in the thyroxin group (TH) and 50 in the placebo group (PL). Patients in the TH group received oral thyroxin (5 μg/kg) 12 hours before surgery and once daily for the remainder of their intensive care unit (ICU) stay...
September 2018: Journal of Thoracic and Cardiovascular Surgery
Özlem Ediboğlu, Sami Cenk Kıraklı, Özlem Yazıcıoğlu Moçin, Gökay Güngör, Ceyda Anar, Pınar Çimen, Nalan Adıgüzel, Cüneyt Saltürk, Merih Kalamanoğlu Balcı, Zühal Karakurt, Dursun Alizoroğlu
Background/aim: Cancer patients frequently need intensive care support due to respiratory failure. We aimed to evaluate the predictors of mortality in cancer patients who were admitted to the intensive care unit (ICU). Materials and methods: This study was performed in the ICUs of two centers between 1 January 2008 and 31 December 2015. Demographic data, cancer type, causes of respiratory failure, comorbidities, APACHE II scores, treatments, and mortality rates were recorded...
August 16, 2018: Turkish Journal of Medical Sciences
Giuseppe Berton, Rocco Cordiano, Fiorella Cavuto, Francesco Bagato, Beatrice Segafredo, Mattia Pasquinucci
AIM: To investigate the clinical features and incidence of malignant neoplasia during 17 years of follow-up in an unselected sample of patients with acute coronary syndrome (ACS). METHODS: The Adria, Bassano, Conegliano, and Padova Hospital-4 Study on Heart Disease is an ongoing, prospective study of an unbiased population of patients with ACS. Baseline clinical and laboratory data were obtained during the first 7 days of hospitalization at three different intensive coronary care units...
August 14, 2018: Journal of Cardiovascular Medicine
Aline B Maddux, Matthew Cox-Martin, Michael Dichiaro, Tellen D Bennett
OBJECTIVES: To determine the association between the Functional Status Scale and Pediatric Functional Independence Measure scores during the rehabilitation stay in children who survive traumatic brain injury. DESIGN: Secondary analysis of a prospective observational cohort study. SETTING: Tertiary care children's hospital with a level 1 trauma center and inpatient rehabilitation service. PATIENTS: Sixty-five children less than 18 years old admitted to an ICU with acute traumatic brain injury and subsequently transferred to the inpatient rehabilitation service...
August 16, 2018: Pediatric Critical Care Medicine
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