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"Untargeted metabolomics"

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https://www.readbyqxmd.com/read/29022978/freeze-dried-strawberry-and-blueberry-attenuates-diet-induced-obesity-and-insulin-resistance-in-rats-by-inhibiting-adipogenesis-and-lipogenesis
#1
Paula Aranaz, Ana Romo-Hualde, María Zabala, David Navarro-Herrera, Marina Ruiz de Galarreta, Ana Gloria Gil, J Alfredo Martinez, Fermín I Milagro, Carlos J González-Navarro
Obesity and type 2-diabetes are becoming a worldwide health problem, reiterating the importance of alternative therapies to tackle their progression. Here, we hypothesized that supplementation of diet with 6% w/w of a freeze-dried strawberry-blueberry (5 : 1) powder (FDSB) could exert beneficial metabolic effects on Wistar rats. FDSB-supplemented animals experienced significantly reduced body weight gain, food efficiency and visceral adiposity accumulation in two independent experiments. FDSB supplementation also contributed to lower area under the curve after an intraperitoneal GTT and reduced serum insulin levels and an insulin resistance index (IR-HOMA) in HFS diet-fed animals, together with reduced plasma MCP-1 inflammation marker concentrations...
October 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29018346/comparative-analysis-of-compatibility-effects-on-invigorating-blood-circulation-for-cyperi-rhizoma-series-of-herb-pairs-using-untargeted-metabolomics
#2
Pei Liu, Er-Xin Shang, Yue Zhu, Jin-Gao Yu, Da-Wei Qian, Jin-Ao Duan
The mutual-assistance compatibility of Cyperi Rhizoma (Xiangfu, XF) and Angelicae Sinensis Radix (Danggui, DG), Chuanxiong Rhizoma (Chuanxiong, CX), Paeoniae Radix Alba (Baishao, BS), or Corydalis Rhizoma (Yanhusuo, YH), found in a traditional Chinese medicine (TCM) named Xiang-Fu-Si-Wu Decoction (XFSWD), can produce synergistic and promoting blood effects. Nowadays, XFSWD has been proved to be effective in activating blood circulation and dissipating blood stasis. However, the role of the herb pairs synergistic effects in the formula were poorly understood...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29018323/cerebrospinal-fluid-amino-acid-profiling-of-pediatric-cases-with-tuberculous-meningitis
#3
Shayne Mason, Carolus J Reinecke, Regan Solomons
Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of tuberculous meningitis (TBM) being the most severe manifestation. TBM is often difficult to diagnose in its early stages because of its non-specific clinical presentation. Of particular concern is that late diagnosis, and subsequent delayed treatment, leads to high risk of long-term neurological sequelae, and even death...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28992663/metabolic-analysis-of-the-anti-depressive-effects-of-yangxinshi-tablet-in-a-vascular-depression-model-in-mice
#4
Hongli Du, Hai Zhang, Yahong Zhao, Min Liu, Anni Chen, Shiyu Liu, Dan Xue, Yanjun Liu, Guoqing Zhang
In recent years, vascular depression has become the focus of international attention. Yangxinshi Tablet (YXST) is usually used in clinic for treatment of arrhythmia and heart failure, but we found that it also has anti-depressive effect in this study. The objective of the study was to identify biomarkers related to vascular depression in hippocampus and explore the anti-depressive effects of YXST on the mice model. Untargeted metabolomics based on UHPLC-Q-TOF/MS was applied to identify significant differential biomarkers between model group and control group...
October 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28990522/untargeted-metabolomics-provides-insight-into-mechanisms-underlying-resistant-hypertension
#5
Renata Bujak, Arlette Yumba-Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndle, Marzena Chrostowska, Michał Hoffmann, Ryszard T Smoleński, Roman Kaliszan, Krzysztof Narkiewicz, Michał J Markuszewski
BACKGROUND: Resistant hypertension (RH) affects about 15-20% of treated hypertensive patients worldwide. RH increases the risk of cardiovascular events such as myocardial infarction and stroke by 50%. The pathological mechanisms underlying resistance to treatment are still poorly understood. OBJECTIVE: The main goal of this pilot study was to determine and compare plasma metabolomic profiles in resistant and non-resistant hypertensive patients. METHOD: We applied untargeted metabolomic profiling in plasma samples collected from 69 subjects with RH and 81 subjects with controlled hypertension...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28990281/mass-spectrometry-in-untargeted-lc-ms-metabolomics-esi-parameters-and-global-coverage-of-the-metabolome
#6
Fidele Tugizimana, Paul A Steenkamp, Lizelle A Piater, Ian A Dubery
RATIONALE: Liquid chromatography coupled to mass spectrometry (LC-MS) is a dominant analytical platform in metabolomics, because of high sensitivity and resolution, thus enabling large-scale coverage of metabolomes. Correspondingly, electrospray ionisation (ESI) is the favoured ionisation method in untargeted LC-MS metabolomics given the ability to produce large numbers of ions. In the workflow of LC-ESI-MS metabolomics, maximising the ionisation efficiency over a wide mass range is inevitably an essential and determining step, subsequently defining the extent of coverage of the metabolome under investigation...
October 9, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28983290/studying-the-differences-of-bacterial-metabolome-and-microbiome-in-the-colon-between-landrace-and-meihua-piglets
#7
Shijuan Yan, Cui Zhu, Ting Yu, Wenjie Huang, Jianfeng Huang, Qian Kong, Jingfang Shi, Zhongjian Chen, Qinjian Liu, Shaolei Wang, Zongyong Jiang, Zhuang Chen
This study was conducted to compare the microbiome and metabolome differences in the colon lumen from two pig breeds with different genetic backgrounds. Fourteen weaned piglets at 30 days of age, including seven Landrace piglets (a lean-type pig breed with a fast growth rate) and seven Meihua piglets (a fatty-type Chinese local pig breed with a slow growth rate), were fed the same diets for 35 days. Untargeted metabolomics analyses showed that a total of 401 metabolites differed between Landrace and Meihua...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28982093/nmr-based-untargeted-metabolomic-study-of-hydrogen-peroxide-induced-development-and-diapause-termination-in-brine-shrimp
#8
Ming-Chang Hong, Shangwu Ding, Cheng-Chi Lin, Tah-Wei Chu, Kuo-Hsun Chiu
Artemia diapause has been extensively studied in embryonic biology for a long time. It has been demonstrated that hydrogen peroxide (H2O2) can increase the hatching rate in the development and diapause termination of Artemia cysts. This study used an untargeted (1)H NMR-based metabolomic approach to explore the physiological regulation of H2O2 in initiating the development and terminating the diapause of Artemia cysts. This experiment was divided into two parts. In the first part, we analyzed three groups with or without H2O2 as control-0h, control-5h and H2O2 (180μM)-5h; in the second part, after 7-d incubation, the non-hatching cysts were treated with different H2O2 concentrations as low as 180μM and as high 1800μM...
September 21, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28982054/urinary-metabolic-phenotyping-of-mucopolysaccharidosis-type-i-combining-untargeted-and-targeted-strategies-with-data-modeling
#9
Abdellah Tebani, Isabelle Schmitz-Afonso, Lenaig Abily-Donval, Bénédicte Héron, Monique Piraud, Jérôme Ausseil, Anais Brassier, Pascale De Lonlay, Farid Zerimech, Frédéric M Vaz, Bruno J Gonzalez, Stephane Marret, Carlos Afonso, Soumeya Bekri
BACKGROUND: Application of metabolic phenotyping could expand the pathophysiological knowledge of mucopolysaccharidoses (MPS) and may reveal the comprehensive metabolic impairments in MPS. However, few studies applied this approach to MPS. METHODS: We applied targeted and untargeted metabolic profiling in urine samples obtained from a French cohort comprising 19 MPS I and 15 MPS I treated patients along with 66 controls. For that purpose, we used ultra-high-performance liquid chromatography combined with ion mobility and high-resolution mass spectrometry following a protocol designed for large-scale metabolomics studies regarding robustness and reproducibility...
October 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28978801/metabolic-alterations-in-multiple-sclerosis-and-the-impact-of-vitamin-d-supplementation
#10
Pavan Bhargava, Kathryn C Fitzgerald, Peter A Calabresi, Ellen M Mowry
BACKGROUND: Our goal was to identify changes in the metabolome in multiple sclerosis (MS) and how vitamin D supplementation alters metabolic profiles in MS patients and healthy controls. METHODS: We applied global untargeted metabolomics to plasma from a cross-sectional cohort of age- and sex-matched MS patients and controls and a second longitudinal cohort of MS patients and healthy controls who received 5,000 IU cholecalciferol daily for 90 days. We applied partial least squares discriminant analysis, weighted correlation network analysis (WGCNA), and pathway analysis to the metabolomics data...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28965405/metabolic-characterization-of-dairy-cows-treated-with-gossypol-by-blood-biochemistry-and-body-fluid-untargeted-metabolome-analyses
#11
Chaohua Tang, Kai Zhang, Tengfei Zhan, Qingyu Zhao, Junmin Zhang
To characterize the metabolic disorders of dairy cows treated with gossypol, 12 dairy cows were assigned to either a control group or a treatment group that was fed 1000 mg of gossypol per kilogram of dry matter feed for 28 days. Milk quality was adversely affected, as both milk protein and lactose levels were significantly decreased in the gossypol-treated group (3.40% vs. 3.16%, P = 0.044; 5.15% vs. 4.91%, P = 0.027; respectively). Plasma samples revealed increases in alanine aminotransferase (P = 0.092), choline esterase (P = 0...
September 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28948040/phenotype-driven-identification-of-modules-in-a-hierarchical-map-of-multifluid-metabolic-correlations
#12
Kieu Trinh Do, Maik Pietzner, David Jnp Rasp, Nele Friedrich, Matthias Nauck, Thomas Kocher, Karsten Suhre, Dennis O Mook-Kanamori, Gabi Kastenmüller, Jan Krumsiek
The identification of phenotype-driven network modules in complex, multifluid metabolomics data poses a considerable challenge for statistical analysis and result interpretation. This is the case for phenotypes with only few associations ('sparse' effects), but, in particular, for phenotypes with a large number of metabolite associations ('dense' effects). Herein, we postulate that examining the data at different layers of resolution, from metabolites to pathways, will facilitate the interpretation of modules for both the sparse and the dense cases...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28947825/untargeted-metabolomics-identifies-a-plasma-sphingolipid-related-signature-associated-with-lifestyle-intervention-in-prepubertal-children-with-obesity
#13
M J Leal-Witt, M Ramon-Krauel, S Samino, M Llobet, D Cuadras, J C Jimenez-Chillaron, O Yanes, C Lerin
OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metabolic signatures associated with lifestyle intervention in prepubertal children with obesity. METHODS: Thirty-five prepubertal children (7-10 years) with obesity (body mass index (BMI)>2 standard deviations) were enrolled in the study and participated in a 6-month-long lifestyle intervention program...
August 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28946342/a-novel-approach-based-on-untargeted-lipidomics-reveals-differences-in-the-lipid-pattern-among-durum-and-common-wheat
#14
Laura Righetti, Josep Rubert, Gianni Galaverna, Kamila Hurkova, Chiara Dall'Asta, Jana Hajslova, Milena Stranska-Zachariasova
In the present work the possibility of using an untargeted metabolomic strategy to discriminate between common and durum wheat lipidome for an authenticity purpose was explored. A first study was conducted by analyzing 52 samples from two durum and common wheat varieties. Afterwards, an extended and independent sample set (173 samples and five varieties) was used as a confirmatory study to verify the stability and consistency of the models obtained. Putatively identified markers were evaluated applying ROC curves resulting in individual marker AUC >90% both in preliminary and confirmatory study...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28934963/metabolic-status-of-csf-distinguishes-rats-with-tauopathy-from-controls
#15
Radana Karlíková, Kateřina Mičová, Lukáš Najdekr, Alžběta Gardlo, Tomáš Adam, Petra Majerová, David Friedecký, Andrej Kováč
BACKGROUND: Tauopathies represent heterogeneous groups of neurodegenerative diseases that are characterised by abnormal deposition of the microtubule-associated protein tau. Alzheimer's disease is the most prevalent tauopathy, affecting more than 35 million people worldwide. In this study we investigated changes in metabolic pathways associated with tau-induced neurodegeneration. METHODS: Cerebrospinal fluid (CSF), plasma and brain tissue were collected from a transgenic rat model for tauopathies and from age-matched control animals...
September 21, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28924163/large-scale-metabolomic-analysis-reveals-potential-biomarkers-for-early-stage-coronary-atherosclerosis
#16
Xueqin Gao, Chaofu Ke, Haixia Liu, Wei Liu, Kang Li, Bo Yu, Meng Sun
Coronary atherosclerosis (CAS) is the pathogenesis of coronary heart disease, which is a prevalent and chronic life-threatening disease. Initially, this disease is not always detected until a patient presents with seriously vascular occlusion. Therefore, new biomarkers for appropriate and timely diagnosis of early CAS is needed for screening to initiate therapy on time. In this study, we used an untargeted metabolomics approach to identify potential biomarkers that could enable highly sensitive and specific CAS detection...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922389/comprehensive-metabolic-characterization-of-serum-osteocalcin-action-in-a-large-non-diabetic-sample
#17
Lukas Entenmann, Maik Pietzner, Anna Artati, Anke Hannemann, Ann-Kristin Henning, Gabi Kastenmüller, Henry Völzke, Matthias Nauck, Jerzy Adamski, Henri Wallaschofski, Nele Friedrich
Recent research suggested a metabolic implication of osteocalcin (OCN) in e.g. insulin sensitivity or steroid production. We used an untargeted metabolomics approach by analyzing plasma and urine samples of 931 participants using mass spectrometry to reveal further metabolic actions of OCN. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism...
2017: PloS One
https://www.readbyqxmd.com/read/28916823/digging-into-the-low-molecular-weight-peptidome-with-the-oligonet-web-server
#18
Youzhong Liu, Sara Forcisi, Marianna Lucio, Mourad Harir, Florian Bahut, Magali Deleris-Bou, Sibylle Krieger-Weber, Régis D Gougeon, Hervé Alexandre, Philippe Schmitt-Kopplin
Bioactive peptides play critical roles in regulating many biological processes. Recently, natural short peptides biomarkers are drawing significant attention and are considered as "hidden treasure" of drug candidates. High resolution and high mass accuracy provided by mass spectrometry (MS)-based untargeted metabolomics would enable the rapid detection and wide coverage of the low-molecular-weight peptidome. However, translating unknown masses (<1 500 Da) into putative peptides is often limited due to the lack of automatic data processing tools and to the limit of peptide databases...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915313/a-metabolomic-approach-applied-to-a-liquid-chromatography-coupled-to-high-resolution-tandem-mass-spectrometry-method-hplc-esi-hrms-ms-towards-the-comprehensive-evaluation-of-the-chemical-composition-of-cannabis-medicinal-extracts
#19
Cinzia Citti, Umberto Maria Battisti, Daniela Braghiroli, Giuseppe Ciccarella, Martin Schmid, Maria Angela Vandelli, Giuseppe Cannazza
INTRODUCTION: Cannabis sativa L. is a powerful medicinal plant and its use has recently increased for the treatment of several pathologies. Nonetheless, side effects, like dizziness and hallucinations, and long-term effects concerning memory and cognition, can occur. Most alarming is the lack of a standardised procedure to extract medicinal cannabis. Indeed, each galenical preparation has an unknown chemical composition in terms of cannabinoids and other active principles that depends on the extraction procedure...
September 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28914531/systems-level-annotation-of-a-metabolomics-data-set-reduces-25%C3%A2-000-features-to-fewer-than-1000-unique-metabolites
#20
Nathaniel G Mahieu, Gary J Patti
When using liquid chromatography/mass spectrometry (LC/MS) to perform untargeted metabolomics, it is now routine to detect tens of thousands of features from biological samples. Poor understanding of the data, however, has complicated interpretation and masked the number of unique metabolites actually being measured in an experiment. Here we place an upper bound on the number of unique metabolites detected in Escherichia coli samples analyzed with one untargeted metabolomics method. We first group multiple features arising from the same analyte, which we call "degenerate features", using a context-driven annotation approach...
September 15, 2017: Analytical Chemistry
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