Panan Suntornsaratoon, Jayson M Antonio, Juan Flores, Ravij Upadhyay, John Veltri, Sheila Bandyopadhyay, Rhema Dadala, Michael Kim, Yue Liu, Iyshwarya Balasubramanian, Jerrold R Turner, Xiaoyang Su, Wei Vivian Li, Nan Gao, Ronaldo P Ferraris
BACKGROUND & AIMS: Lacticaseibacillus rhamnosus GG (LGG) is the world's most consumed probiotic but its mechanism of action on intestinal permeability and differentiation along with its interactions with an essential source of signaling metabolites, dietary tryptophan, are unclear. METHODS: Untargeted metabolomic and transcriptomic analyses were performed in LGG mono-colonized germ-free (GF) mice fed tryptophan (trp)-free or -sufficient diets. LGG-derived metabolites were profiled in vitro under anaerobic and aerobic conditions...
April 17, 2024: Cellular and Molecular Gastroenterology and Hepatology