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https://www.readbyqxmd.com/read/30342411/higher-mortality-and-years-of-potential-life-lost-of-suicide-in-patients-with-schizophrenia
#1
Yu Shun Ko, Hsin-Chun Tsai, Mei Hung Chi, Chien-Chou Su, I Hui Lee, Po See Chen, Kao Chin Chen, Yen Kuang Yang
Patients with schizophrenia could have a higher risk of mortality. We compared the risk of mortality and the years of potential life lost (YPLL) associated with various causes of death between patients with schizophrenia and the general population. A total of 4,298 patients with schizophrenia were included. The cohort was linked to the Taiwan Death Register between 1998 and 2010 using personal identification numbers, which showed 367 patients with schizophrenia had died by the end of 2010. The standard mortality ratios (SMRs) and YPLL were analyzed by age, sex and cause of death...
September 18, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30342401/fast-empirical-lab-method-for-performance-projections-of-large-scale-powdered-activated-carbon-re-circulation-plants
#2
Frederik Zietzschmann, Stefan Dittmar, Lydia Splettstößer, Jonas Hunsicker, Daniel Dittmann, Felix Meinel, Annette Rößler, Steffen Metzger, Martin Jekel, Aki Sebastian Ruhl
Powdered activated carbon (PAC) for organic micro-pollutant (OMP) removal can be applied effectively on wastewater treatment plant (WWTP) effluents by using re-circulation schemes, accumulating the PAC in the system. This technique is complex because several factors are unknown: (i) the PAC concentration in the system, (ii) specific and average contact times of PAC particles, and (iii) PAC particle loadings with target compounds/competing water constituents. Thus, performance projections (e.g. in the lab) are very challenging...
October 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/30342395/prenatal-ethanol-exposure-potentiates-isolation-induced-ethanol-consumption-in-young-adult-rats
#3
Macarena Soledad Fernández, Jorge Carrizo, Wladimir Plaza, Paola Haeger, Ricardo Marcos Pautassi
Prenatal and/or early postnatal ethanol exposure (PEE) is associated with significant behavioral and physiological deficits in offspring, including alterations in stress response systems and a greater likelihood of alcohol use disorders. Stress-induced ethanol drinking after PEE, however, has been largely unexplored. The present study analyzed ethanol intake in male Sprague-Dawley rats after protracted prenatal and early postnatal ethanol exposure and tested whether social isolation during the sensitive period of adolescence modulates the effects of PEE on ethanol drinking...
October 17, 2018: Alcohol
https://www.readbyqxmd.com/read/30342394/simultaneous-determination-of-flz-and-its-metabolite-m1-in-human-plasma-and-urine-by-uhplc-ms-ms-application-to-a-pharmacokinetic-study
#4
Cheng Cui, Rui Chen, Ji Jiang, Rui Liu, Wei Wang, Qian Zhao, Pei Hu
FLZ is a novel anti-Parkinson's disease candidate drug. The main active metabolite is FLZ O-dealkylation (M1) in preclinical studies. A reliable ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) quantitation method was developed for the simultaneous determination of FLZ and M1 with low limits of quantitation in human plasma (0.1 ng/mL) and urine (0.5 ng/mL). The plasma and urine samples were both purified by full-automatic solid phase extraction (SPE) method with ensured high extraction recovery and little matrix effect for both analytes, and then separated on a BEH C18 column (2...
October 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30342336/utilization-of-shale-cuttings-in-production-of-lightweight-aggregates
#5
K Piszcz-Karaś, M Klein, J Hupka, J Łuczak
The development of technologies for unconventional hydrocarbon exploration requires designing procedures to manage drilling waste that are consistent with the waste management hierarchy. In view of this, the possibility to apply shale drill cuttings as a prospective additive (replacing bentonite) to fly ash used for the production of lightweight aggregates (LWAs) was investigated. Moreover, a facile, waste-free method of LWAs production with using shales was proposed. Cuttings were characterized in terms of their mineralogical and elemental composition (XRD and XRF) as well as thermophysical behavior (TG-DTA and fusibility test)...
October 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/30342307/photoprotective-potential-of-medicinal-plants-from-cerrado-biome-brazil-in-relation-to-phenolic-content-and-antioxidant-activity
#6
Alesandra Ricardo Nunes, Ana Livya Moreira Rodrigues, Dinalva Brito de Queiróz, Icaro Gusmão Pinto Vieira, João Francisco Câmara Neto, João Tavares Calixto Junior, Saulo Relison Tintino, Selene Maia de Morais, Henrique Douglas Melo Coutinho
Photooxidative damage affects cellular lipids, proteins and DNA in addition to being involved in the pathobiochemistry of erythema formation, premature skin aging, photodermatoses development and skin cancer. Phenolic compounds, flavonoids and hydroxycinnamic acid esters protect plant tissues against harmful UV-radiation. This study aimed to evaluate the sun protection factor of several Brazilian plant extracts in relation to UVB radiation absorption, which causes skin cancer, and to correlate the findings with their antioxidant activity, as well as with total phenol and flavonoid content...
October 13, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30342300/the-effectiveness-of-interventions-to-improve-resilience-among-health-professionals-a-systematic-review
#7
REVIEW
Michelle Cleary, Rachel Kornhaber, Deependra Kaji Thapa, Sancia West, Denis Visentin
OBJECTIVE: To assess the effectiveness of resilience interventions in improving resilience outcome among health professionals. BACKGROUND: The nature of health professionals' work is physically and emotionally demanding, with trauma a common consequence with the act of providing health care. DESIGN: A systematic review. DATA SOURCE: A comprehensive search of the literature was conducted in February 2018 using PubMed, PsychInfo, Cumulative Index of Nursing and Allied Health Literature (CIHAHL) and Scopus...
October 11, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/30342237/lateral-geniculate-nucleus-volumetry-at-3t-and-7t-four-different-optimized-magnetic-resonance-imaging-sequences-evaluated-against-a-7t-reference-acquisition
#8
Njoud Aldusary, Lars Michels, Ghislaine L Traber, Birgit Hartog-Keisker, Michael Wyss, Arwa Baeshen, Karen Huebel, Yassir Edrees Almalki, David Otto Brunner, Klaas Paul Pruessmann, Klara Landau, Spyridon Kollias, Marco Piccirelli
PURPOSE: The lateral geniculate nucleus (LGN) is an essential nucleus of the visual pathway, occupying a small volume (60-160 mm3 ) among the other thalamic nuclei. The reported LGN volumes vary greatly across studies due to technical limitations and due to methodological differences of volume assessment. Yet, structural and anatomical alterations in ophthalmologic and neurodegenerative pathologies can only be revealed by a precise and reliable LGN representation. To improve LGN volume assessment, we first implemented a reference acquisition for LGN volume determination with optimized Contrast to Noise Ratio (CNR) and high spatial resolution...
October 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/30342219/abdominal-aortic-aneurysm-associated-with-polycystic-kidney-disease-endovascular-aortic-repair-and-renal-embolization
#9
Pascual Lozano-Vilardell, Raúl Lara-Hernández, Noé Benabarre-Castany, David García-García
A 79-year old patient with an asymptomatic 63-mm infrarenal abdominal aortic aneurysm, confirmed on computed tomography, was admitted in our unit. The patient had undergone kidney transplantation years before, due to renal failure secondary to polycystic kidney disease. Renal function at admission was normal. The aneurysm had a very short neck, and a standard endovascular aortic repair procedure was not feasible. So, the two renal arteries were embolized with coils and endovascular repair of the aneurysm, covering the ostia of the renal arteries, was achieved placing the endoprosthesis up to the level of superior mesenteric artery...
October 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30342205/creation-of-a-transposed-mature-arteriovenous-fistula-autograft-a-novel-approach-to-treating-steal-syndrome
#10
Matthew G Brown, Nicholas Dugan, Laura C Lamb
INTRODUCTION: Autogenous arteriovenous fistula (AVF) creation is the gold standard of hemodialysis access. However, autologous upper extremity arteriovenous fistulae continue to present significant clinical challenges including failure to mature and steal syndrome. We describe treating a patient with dialysis-associated steal syndrome (DASS) by ligating and then transposing a well-developed, mature upper arm cephalic vein AVF into the contralateral arm. CASE DESCRIPTION: Our patient is a 76 year old female with end stage renal disease (ESRD) secondary to glomerulonephritis, who had a left arm brachiocephalic AVF created in 2007...
October 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30342202/chronic-sound-induced-tinnitus-and-auditory-attention-in-animals
#11
Thomas Brozoski, Kurt Wisner, Marc Randall, Donald Caspary
Attention may be an important factor in tinnitus. Individuals most disturbed by their tinnitus differ from those who are not in terms of attention allocation. This study used an operant conditioning animal model to examine the interaction between tinnitus and auditory vigilant attention as well as auditory selective attention. Tinnitus was induced in 90-day-old rats by a unilateral exposure to band-limited noise (120 dB, SPL). Tinnitus testing began 90 days following exposure; afterward animals were divided into 3 groups: Unexposed controls without tinnitus, Exposed without tinnitus, and Exposed with tinnitus...
October 17, 2018: Neuroscience
https://www.readbyqxmd.com/read/30342115/outcomes-of-liver-transplantations-from-donation-after-circulatory-death-dcd-treated-by-hypothermic-oxygenated-perfusion-hope-before-implantation
#12
A Schlegel, X Muller, M Kalisvaart, B Muellhaupt, Mtpr Perera, J Isaac, P-A Clavien, P Muiesan, P Dutkowski
OBJECTIVES: To provide 5-year outcome in human livers donated after circulatory death (DCD), treated by hypothermic oxygenated perfusion (HOPE). BACKGROUND: DCD liver transplantation is known for potential worse outcome due to higher rates of graft non-function or irreversible cholangiopathy. The impact of machine liver perfusion techniques on these complications remains elusive. METHODS: Fifty HOPE treated DCD liver transplants in Zurich between 2012 and 3/2017 were matched with 50 primary DBD liver transplants, and also with 50 un-treated DCD livers in Birmingham...
October 17, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30342092/structure-and-function-of-mycobacterium-specific-components-of-f-atp-synthase-subunits-%C3%AE-and-%C3%AE%C2%B5
#13
Nebojša Bogdanović, Lavanya Sundararaman, Neelagandan Kamariah, Anu Tyagi, Shashi Bhushan, Priya Ragunathan, Joon Shin, Thomas Dick, Gerhard Grüber
The Mycobacterium tuberculosis (Mtb) F1 FO -ATP synthase (α3 :β3 :γ:δ:ε:a:b:b':c9 ) is an essential enzyme that supplies energy for both the aerobic growing and the hypoxic dormant stage of the mycobacterial life cycle. Employing the heterologous F-ATP synthase model system αchi 3 :β3 :γ we showed previously, that transfer of the C-terminal domain (CTD) of Mtb subunit α (Mtα514-549 ) to a standard F-ATP synthase α subunit suppresses ATPase activity. Here we determined the 3D reconstruction from electron micrographs of the αchi 3 :β3 :γ complex reconstituted with the Mtb subunit ε (Mtε), which has been shown to crosstalk with the CTD of Mtα...
October 17, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/30342072/blockade-of-il-6-signaling-in-neuromyelitis-optica
#14
REVIEW
Manabu Araki
Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune diseases associated with a disease-specific autoantibody directed against the water channel protein aquaporin-4. Standard immunotherapy, immunosuppressive agents, and corticosteroids can prevent acute attacks and maintain remission in most patients with NMOSD. However, there is a strong need for additional options for patients who are refractory to standard treatments. Emerging therapies targeting specific molecules related to the pathogenicity of NMOSD are currently being developed...
October 17, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/30342063/estimating-minimally-important-differences-for-the-bladder-cancer-index-using-distribution-and-anchor-based-approaches
#15
Charles C Peyton, Carl Henriksen, Richard R Reich, Mounsif Azizi, Scott M Gilbert
PURPOSE: The Bladder Cancer Index is a validated condition-specific health questionnaire assessing urinary, bowel and sexual function and quality of life among bladder cancer patients. We aimed to establish minimally important difference score thresholds that signal clinical importance. METHODS: A prospective cohort of 150 patients who underwent radical cystectomy between 2013 and 2016 were followed for one year after surgery. Usable data from 138 patients was analyzed...
October 17, 2018: Journal of Urology
https://www.readbyqxmd.com/read/30342044/real-age-red-blood-cell-aging-during-storage
#16
REVIEW
Colleen G Koch, Andra I Duncan, Priscilla Figueroa, Lu Dai, Daniel I Sessler, Steven M Frank, Paul M Ness, Tomislav Mihaljevic, Eugene H Blackstone
BACKGROUND: During cold storage, some red blood cell (RBC) units age more rapidly than others. Yet, the FDA has set a uniform storage limit of 42 days. Objectives of this review are to present evidence for an RBC storage lesion and suggest that functional measures of stored RBC quality-which we call real age-may be more appropriate than calendar age. METHODS/RESULTS: During RBC storage, biochemical substances and byproducts accumulate and RBC shape alters. Factors influencing the rate of degradation include donor characteristics, bio-preservation conditions, and vesiculation...
October 17, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30342029/automated-polyp-detection-in-the-colorectum-a-prospective-study-with-videos
#17
Peter Klare, Christoph Sander, Martin Prinzen, Bernhard Haller, Sebastian Nowack, Mohamed Abdelhafez, Alexander Poszler, Hayley Brown, Dirk Wilhelm, Roland M Schmid, Stefan von Delius, Thomas Wittenberg
BACKGROUND AND AIMS: Adenoma detection is a highly personalized task that differs markedly between endoscopists. Technical advances are therefore desirable for the improvement of the adenoma detection rate (ADR). An automated computer driven technology would offer the chance to objectively assess the presence of colorectal polyps during colonoscopy. We present here the application of a real-time automatic polyp detection software (APDS) under routine colonoscopy conditions. METHODS: This was a prospective study at a university hospital in Germany...
October 17, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30342026/the-comparison-of-monopolar-hemostatic-forceps-with-soft-coagulation-versus-hemoclip-for-peptic-ulcer-bleeding-a-randomized-trial-with-video
#18
Bilal Toka, Ahmet Tarik Eminler, Cengiz Karacaer, Mustafa Ihsan Uslan, Aydin Seref Koksal, Erkan Parlak
BACKGROUND AND AIMS: Although various methods are used in the treatment of peptic ulcer bleeding, there is not a standard recommended approach. The choice depends on multiple factors such as location of the ulcer, clinical experience of endoscopist and local facilities of the clinic. We aimed to compare the efficacy of monopolar hemostatic forceps soft coagulation (MHFSC) and hemoclips (HC) in the treatment of peptic ulcer related upper GI bleeding. PATIENTS AND METHODS: The study group included patients who had GI bleeding due to Forrest 1a, 1b, 2a gastric or duodenal ulcers within 1 year...
October 17, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30342017/weight-loss-achieved-by-bariatric-surgery-modifies-high-density-lipoprotein-subfractions-and-low-density-lipoprotein-oxidation-towards-atheroprotection
#19
Susana Coimbra, Flávio Reis, Cátia Ferreira, Sara Nunes, Sofia Viana, Alice Catarino, Petronila Rocha-Pereira, Luís Belo, Luís Monteiro, Cristina Catarino, Alice Santos-Silva
OBJECTIVES: Weight loss achieved by laparoscopic adjustable gastric banding (LAGB) induces an increase in high-density lipoprotein cholesterol (HDLc) but a small effect on low-density lipoprotein (LDL), although changes in their quality (size and composition) are uncertain. Our aim was to study the impact of weight loss, achieved 13-months after LAGB, on inflammation and dyslipidemia, focusing on HDL and LDL subfractions, and oxidized LDL (oxLDL). DESIGN & METHODS: We evaluated standard lipid profile, HDL and LDL subfractions, oxLDL, interleukin (IL)-6 and C-reactive protein (CRP), in twenty obese patients, before (T0) and 13-months after LAGB (T1), and in seventeen healthy controls...
October 17, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/30342009/analytical-validation-of-an-alternative-method-to-quantify-specific-antibodies-in-3-applications
#20
Marie Senant, Pauline Bordereau, Eric Tartour, Marie-Agnès Dragon-Durey
The detection and the quantification of specific antibodies represent essential tools for the diagnosis and for the biological monitoring of immune humoral response in many clinical situations in particular in autoimmune diseases or in the context of immunotherapy using monoclonal antibodies. This article focuses on the development of a specific antibody measuring method (Patent n°PCT/IB2014/064437). The principle of this method is based on the combined use of a monoclonal antibody as standard and the protein G as immunoglobulins detecting agent...
October 17, 2018: Journal of Immunological Methods
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