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Volker Schöffl, Olaf Pöppelmeier, Julia Emmler, Isabelle Schöffl, Thomas Küpper, Christoph Lutter
Ski mountaineering (skimo) has recently gained popularity and established itself as a competition sport. It requires a specific training with a high hypoxic load. Although a variety of sport specific performance test protocols have been developed, a specific method for ski mountaineering (skimo) is pending. After the development of a sport specific ergometric protocol with recreational athletes in pre-tests a standard sport specific protocol was defined, concerning treadmill speed, slope and step test variables...
December 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
Yue Song, Jing-Shi Wang, Yi-Ni Wang, Zhao Wang
Haemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome that can be classified as either primary or secondary. Secondary HLH can be triggered by a variety of diseases. Pregnancy-related HLH has already been observed clinically. However, most of these cases occur during pregnancy. Considering that the periods before and after delivery have different clinical features, we presented the first case series of HLH that presented during the postpartum stage of pregnancy. From these cases, we concluded that postpartum HLH is a common form of pregnancy-related HLH...
December 7, 2018: Acta Haematologica
Mika Saigusa, Kazuhiro Asada, Taisuke Akamatsu, Yuko Tanaka, Yoshinari Endo, Akito Yamamoto, Satoru Morita, Toshihiro Shirai
BACKGROUND: There are no standard cytotoxic treatments for non-small-cell lung cancer (NSCLC) patients beyond third-line therapy. The purpose of this study was to evaluate the efficacy and safety of amrubicin in pretreated NSCLC patients. METHODS: The records of NSCLC patients who received amrubicin monotherapy as a third or later line of chemotherapy at Shizuoka General Hospital between April 2007 and March 2015 were retrospectively reviewed. Tumor response was evaluated according to the Response Evaluation Criteria in Solid Tumors version 1...
December 12, 2018: Oncology Research and Treatment
Filippo Montevecchi, Alberto Caranti, Giovanni Cammaroto, Giuseppe Meccariello, Claudio Vicini
Eagle syndrome is a rare and poorly understood clinical condition caused by an elongated or disfigured styloid process. The possible managements of Eagle syndrome include conservative medical treatment or surgical intervention. The surgical removal of the elongated styloid process may be efficiently achieved either by an intraoral or a transcervical approach. An effective styloidectomy may be either total or partial, provided the bony residue's length is within the range of normality. Here, we report our experience with a bilateral robotic-assisted styloidectomy in a young female patient...
December 11, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Izael S Costa, Amanda F Medeiros, Fabiana M C Carvalho, Vanessa C O Lima, Raphael P Serquiz, Alexandre C Serquiz, Vivian N Silbiger, Raul H Bortolin, Bruna L L Maciel, Elizeu A Santos, Ana H A Morais
OBJECTIVE: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. METHODS: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed...
December 11, 2018: Obesity Facts
Ane Etxebeste, John Barrio, José Bernabéu Alberola, Carlos Lacasta, Gabriela Llosa, Enrique Muñoz, Ana Ros, Josep Francisco Oliver
Sensitivity and spatial resolution are the main parameters to
 maximize in the performance of a PET scanner. For this purpose, detectors
 consisting of a combination of continuous crystals optically coupled to segmented
 photodetectors have been employed. With the use of continuous crystals the
 sensitivity is increased with respect to the pixelated crystals. In addition, spatial
 resolution is no longer limited to the crystal size. The main drawback is the
 difficulty in determining the interaction position...
December 11, 2018: Physics in Medicine and Biology
Gokhan Ariturk, Yusuf Ziya Ider
Non-quadrature radio frequency (RF) excitation has been widely studied in the fields of RF shimming, local SAR estimation, and MR-EPT with the use of multi-channel transceiver arrays. These studies generally require the retrieval of the complex transmit field B<sub>1</sub><sup>+</sup>, which can be accomplished by acquiring its magnitude and phase in different steps. Magnitude of the transmit field is acquired with the conventional methods which give accurate results for both quadrature and non-quadrature excitations...
December 11, 2018: Physics in Medicine and Biology
Nicholas Chartres, Lisa A Bero, Susan L Norris
BACKGROUND: Approximately one quarter of all deaths globally are attributed to living or working in an unhealthy environment, with household and ambient air pollution, along with exposures to ultraviolet radiation and chemicals amongst the leading causes. At present there are no international standards for assessing the risks of these environmental hazards. The use of heterogeneous methods to identify health risks from environmental hazards may reduce the level of confidence the public has in the conclusions that are made...
December 8, 2018: Environment International
Juan Qi, Yaping Lai, Chunmei Liang, Shuangqin Yan, Kun Huang, Weijun Pan, Lanlan Feng, Liu Jiang, Peng Zhu, Jiahu Hao, Shilu Tong, Fangbiao Tao
BACKGROUND: Thallium (Tl) exposure remains a public health problem with potential impacts on humans. Studies have suggested that prenatal exposure to thallium may be associated with fetal growth, but no studies are known have explored its association with early childhood anthropometry. OBJECTIVE: To investigate the effects of prenatal Tl exposures on early child growth and development aged 0-2 years in a prospective birth cohort study. METHODS: 3080 pregnant women and their children participated in the study, which were recruited from a birth cohort in China...
December 8, 2018: Environment International
Patrick Caron, Véronique Turcotte, Eric Lévesque, Chantal Guillemette
Abiraterone acetate (AA) is a prodrug of abiraterone, a selective and potent steroidal cytochrome P450 17alpha- hydroxylase-17,20-lyase (CYP17A1) blocking androgen synthesis in the treatment of advanced prostate cancer. Abiraterone (Abi) is metabolized to D(4)-abiraterone (D4A) directly blocking CYP17A1 and other steroidogenic enzymes and antagonizing the androgen receptor (AR). D4A is converted by 5α-reductase to 3-keto-5α-abiraterone (5α-Abi), an AR agonist. Our recent work suggests phase II biotransformation of Abi, D4A and 5α-Abi conjugated to glucuronic acid in vitro leading to four glucuronides (G)...
December 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Jitka Vanderpol, Leon Jonker
OBJECTIVE: Greater occipital nerve (GON) block is a treatment option applied for a variety of primary headache disorders. Although a patient's body position is known to have an impact on the effect of local anaesthetics, this has not before been investigated for patients undergoing GON block. Therefore, the clinical effectiveness of either a sitting or supine position was assessed. PATIENTS AND METHODS: This evaluative prospective study took place in a single neurology department in the UK...
December 3, 2018: Clinical Neurology and Neurosurgery
Patrick Alan Hagen, Patrick Stiff
Multiple myeloma (MM) is a malignant disorder of plasma cells primarily affecting elderly patients and is the second most commonly diagnosed hematological neoplasm. With the recent influx of effective new agents available including proteasome inhibitors, immunomodulators, targeted monoclonal antibodies, and now chimeric antigen receptor t-cell therapy (CAR-T), the treatment landscape is evolving rapidly. While the role of consolidative autologous stem cell transplantation (ASCT) in first remission is well established, in the relapsed setting following up front ASCT, the role of a second ASCT (SAT) following reinduction is less clear and understudied...
December 8, 2018: Biology of Blood and Marrow Transplantation
Yu-Juan Xue, Yi-Fei Cheng, Ai-Dong Lu, Yu Wang, Ying-Xi Zuo, Chen-Hua Yan, Jun Wu, Yu-Qian Sun, Pan Suo, Yu-Hong Chen, Huan Chen, Yue-Ping Jia, Kai-Yan Liu, Wei Han, Lan-Ping Xu, Le-Ping Zhang, Xiao-Jun Huang
BACKGROUND: The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly haploidentical (haplo)-HSCT, in pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) in the tyrosine kinase inhibitor (TKI) era is unclear. This study aimed to identify prognostic factors and explore the role of haplo-HSCT in the treatment of Ph+ALL in the TKI era. METHODS: We analyzed clinical data of Ph+ALL patients aged 1-18 years who received imatinib added to intensive chemotherapy at the start of induction therapy...
December 8, 2018: Biology of Blood and Marrow Transplantation
Robert A F de Lind van Wijngaarden, Sabrina Siregar, Juno Legué, Aafke Fraaije, Araz Abbas, Jenny Dankelman, Robert J M Klautz
OBJECTIVE: Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The goal of this study was to improve communication during CABG by identifying critical items in verbal interaction between surgeons, anesthetists and perfusionists. METHODS: Based on 6 video recordings, a list was assembled containing items of communication in CABG procedures...
December 8, 2018: Seminars in Thoracic and Cardiovascular Surgery
Salam Abbara, Aurélia Pitsch, Sébastien Jochmans, Kyann Hodjat, Dr Pascale Cherrier, Mehran Monchi, Christophe Vinsonneau, Sylvain Diamantis
OBJECTIVES: To assess if the postprescription review and feedback (PPRF) of all antibiotics with restriction of carbapenems, fluoroquinolones and third generation cephalosporins, along with a change of medical standard of care, impacted the consumption of antibiotics and bacterial resistance in a medical/surgical intensive care unit (MSICU). METHODS: A four years before (2007-2010) and after (2011-2014) retrospective comparative study. Antibiotics consumption was evaluated in Defined Daily Doses per 1000 patient days...
December 8, 2018: International Journal of Antimicrobial Agents
John F Butzer, Allan J Kozlowski, Roberta Virva
The value of post-acute care is unclear. While experienced clinicians understand the appropriateness of each specific site of post-acute care, clear evidence-based guidelines are not available, and many referrals to post-acute care today are made based on bed availability rather than patient need. Measuring value (value = outcomes / cost) for the entire episode of care has been proposed as an effective method to both evaluate and enable faster innovation in care. Instituting value-based care will increase patient engagement, improve quality and reduce cost with the potential of unifying the goals for all stakeholders-patients/families, providers, and payers...
December 8, 2018: Archives of Physical Medicine and Rehabilitation
Ida T Fonkoue, Seth D Norrholm, Paul J Marvar, Yunxiao Li, Melanie L Kankam, Barbara O Rothbaum, Jeanie Park
Posttraumatic stress disorder (PTSD) is characterized by increased sympathetic nervous system (SNS) activity, blunted parasympathetic nervous system (PNS) activity, and impaired baroreflex sensitivity (BRS), which contribute to accelerated cardiovascular disease. Patients with PTSD also have chronic stress-related elevations in resting blood pressure (BP), often in the prehypertensive range; yet, it is unclear if elevated resting blood pressure (ERBP) augments these autonomic derangements in PTSD. We hypothesized that compared with normotensive PTSD (N-PTSD), those with ERBP (E-PTSD) have further increased SNS, decreased PNS activity, and impaired BRS at rest and exaggerated SNS reactivity, PNS withdrawal, and pressor responses during stress...
December 1, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Anne C Chiang, Jessica Lake, Naralys Sinanis, Debra Brandt, Jane Kanowitz, Wajih Kidwai, Jeremy Kortmansky, Johanna LaSala, Jeffrey Orell, Kert Sabbath, Harold Tara, Constance Engelking, Lisa Shomsky, Monica Fradkin, Kerin Adelson, Kathleen Uscinski, Kevin Vest, Catherine Lyons, Arthur Lemay, Abe Lopman, Charles S Fuchs, Rogerio Lilenbaum
PURPOSE: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was to determine whether the acquisition and integration of community oncology practices by Yale/Smilow Cancer Hospital improved outcomes in quality of care, disease team integration, clinical trial accrual, and patient satisfaction at network practice sites. METHODS: We evaluated quality of care by testing the hypothesis that core Quality Oncology Practice Initiative measures at network sites that were acquired in 2012 were significantly different after their 2016 integration into the network...
December 2018: Journal of Oncology Practice
Dina Thompson, Kimberly Cox, James Loudon, Ivan Yeung, Woodrow Wells
PURPOSE: Peer review of a proposed treatment plan is increasingly recognized as an important quality activity in radiation medicine. Although peer review has been emphasized in the curative setting, applying peer review for treatment plans that have palliative intent is receiving increased attention. This study reports peer review outcomes for a regional cancer center that applied routine interprofessional peer review as a standard practice for palliative radiotherapy. METHODS AND MATERIALS: Peer review outcomes for palliative radiotherapy plans were recorded prospectively for patients who began radiotherapy between October 1, 2015, and September 30, 2017...
December 2018: Journal of Oncology Practice
Jessica A Zerillo, Victoria Carballo, Carole K Tremonti, Orinta Kalibatas, Brian M Cummings, Joseph O Jacobson
PURPOSE: Training clinical and supportive staff in quality improvement (QI) theory and use of QI tools has the potential to improve oncology care delivery. We report our combined experience of providing training to oncologists in a variety of local settings and assess the effect of the training on individual participants and for institutions. METHODS: Multidisciplinary oncology teams at a comprehensive cancer center, an academic medical center, and community practices were led through experiential QI training that spanned several months...
December 2018: Journal of Oncology Practice
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