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Hipec Gastric Cancer

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https://www.readbyqxmd.com/read/30276006/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-as-treatment-options-for-peritoneal-metastasis-of-advanced-gastric-cancer
#1
Dong-Wook Kim, Dong-Guk Park, Sanghyun Song, Ye Seob Jee
Purpose: This study aimed to examine the outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC). Materials and Methods: Between May 2015 and June 2017, 38 CRS and HIPEC procedures were performed in patients with PM of AGC at the Dankook University Hospital. We prospectively collected and analyzed data regarding PM grade, morbidity and mortality rates, and short-term follow-up results (median, 13...
September 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/30228253/drainage-of-a-subphrenic-abscess-followed-by-two-stage-gastrectomy-and-adjuvant-hyperthermic-intraperitoneal-chemotherapy-hipec-for-perforated-gastric-carcinoma-a-case-report
#2
Daniele Bernardi, Emanuele Asti, Davide Ferrari, Luigi Bonavina
BACKGROUND Perforated gastric cancer accounts for less than 1% of patients who present with an acute abdomen and for up to 16% of all gastric perforations. A two-stage laparoscopic procedure may be the therapeutic strategy of choice in selected patients, and adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) can reduce the incidence of peritoneal recurrence. A rare case of subphrenic abscess and gastric perforation due to carcinoma of the gastric fundus, followed by two-stage gastrectomy and adjuvant HIPEC is presented...
September 19, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/30113499/comparative-effectiveness-of-hyperthermic-intraperitoneal-chemotherapy-for-gastric-cancer-a-systematic-review-and-network-meta-analysis-protocol
#3
REVIEW
Zhaolun Cai, Zhaohui Cai, Tao He, Zhou Zhao, Yuan Yin, Chaoyong Shen, Xiaonan Yin, Zhixin Chen, Cao Dan, Bo Zhang
BACKGROUND: Comparative efficacy and safety of different hyperthermic intraperitoneal chemotherapies (HIPEC) in patients with advanced gastric cancer who underwent gastrectomy is unclear. To investigate this question, we conduct a systematic review and network meta-analysis. METHODS: The protocol followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. PubMed, Embase, and the Cochrane Library will be searched systematically for eligible randomized controlled trials without language restriction...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30094567/hyperthermic-intraperitoneal-chemotherapy-hipec-for-peritoneal-malignancies-using-new-hybrid-co-2-system-preliminary-experience-in-referral-center
#4
Stefano Cianci, Carlo Abatini, Anna Fagotti, Benito Chiofalo, Alessandro Tropea, Antonio Biondi, Giovanni Scambia, Fabio Pacelli
The most frequent peritoneal surface malignancies originate principally by gastric cancer, colorectal cancer and ovarian cancer. Apart from the origin, peritoneal carcinosis (PC) is considered a negative prognostic factor. The hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal malignancies is considered an attractive method to deliver chemotherapy with enhanced effect directly at the tumor site. The use of such loco-regional approach has proved to improve prognosis of peritoneal carcinomatosis from different origins...
August 9, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/30087071/cytoreductive-surgery-combined-with-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-with-gastric-cancer-and-peritoneal-carcinomatosis
#5
Cristina Rihuete Caro, Israel Manzanedo, Fernando Pereira, Lucía Carrion-Alvarez, Ángel Serrano, Estíbalitz Pérez-Viejo
BACKGROUND: Gastric Cancer (GC) with Peritoneal Carcinomatosis (PC) has long been regarded as a terminal disease. Over the past two decades, cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has changed the traditional concept of peritoneal metastases from being a systemic disease, to being considered a locoregional dissemination. PATIENTS AND METHODS: A prospective study was performed at a high-volume Carcinomatosis Center to evaluate survival, morbi-mortality and prognostic factors for survival in a cohort of patients with GC and PC treated with CRS + HIPEC between June 2006 and December 2016...
July 26, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30059861/case-report-of-combined-surgical-oncologic-and-bariatric-procedures
#6
Salaam Sadi, Paul H Sugarbaker, Timothy Shope
INTRODUCTION: Morbidly obese patients may require a laparotomy to resect a malignancy. In some patients the cancer resection can be combined with the bariatric procedure to concomitantly treat both diseases. PRESENTATION OF CASE: A morbidly obese patient with peritoneal metastases from an appendiceal mucinous neoplasm was evaluated and definitively treated with Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC), at the same time the patient was treated for morbid obesity with sleeve gastrectomy and removal of a previous laparoscopic adjustable gastric banding (LAGB)...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30039281/is-there-a-role-for-treatment-oriented-surgery-in-stage-iv-gastric-cancer-a-systematic-review
#7
Sarah Molfino, Zeno Ballarini, Federico Gheza, Nazario Portolani, Gian Luca Baiocchi
To analyze the available evidence on the role of treatment-oriented surgery in stage IV gastric cancer (metastatic disease), a systematic literature search was undertaken using Medline, Embase, Cochrane, and Web-of-Science libraries. The search was not restricted to articles published within a given year range. Articles written in English language (or with abstracts written in English) were considered. All references in the chosen articles were further screened to find additional relevant publications. Both clinical series and literature reviews were included...
July 23, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/30037640/current-practice-of-latin-american-centers-in-the-treatment-of-peritoneal-diseases-with-cytoreductive-surgery-with-hipec
#8
(no author information available yet)
INTRODUCTION: A combination therapy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been proposed as a treatment option in patients with peritoneal metastasis of colorectal, ovarian, gastric cancers and sarcomas and as a current standard treatment for pseudomyxoma peritonei and peritoneal mesothelioma. There is a need to standardize its indication, drugs selection along with their concentrations and ways to deliver peritoneal chemotherapy solutions for best outcomes...
July 11, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30019100/chemosensitivity-of-various-peritoneal-cancer-cell-lines-to-hipec-and-pipac-comparison-of-an-experimental-duplex-drug-to-standard-drug-regimens-in-vitro
#9
Jürgen Weinreich, Florian Struller, Iaroslav Sautkin, Shalva Giuashvili, Marc Reymond, Alfred Königsrainer, Timm C Schott
We performed an in-vitro study testing the chemosensitivity of peritoneal cancer cell lines (SW620, HCT116, MKN45, 23,132/87, OAW42) to various cytostatic drug regimens. A duplex drug, characterized by reversible linking of the antimetabolites 2'-deoxy-5-fluorouridine (5-FdU) and 3'-C-ethynylcytidine (ECyd), was compared to oxaliplatin or to cisplatin plus doxorubicin. The experiments were designed to reflect the conditions of intraperitoneal chemotherapy. CASY® (Cell Analysis System) technology was used to compare the impact of incubation temperature/duration and drug concentration on the viability of the cancer cell lines versus normal human dermal fibroblasts...
July 18, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29950734/role-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-treatment-of-gastric-cancer
#10
Horacio N López-Basave, Osvaldo A Quiroz-Sandoval, Alejandro E Padilla-Rosciano, Alberto M León-Takahashi, Gerardo Miranda-Devora, Araceli Arrollo-Monroy
Patients with peritoneal carcinomatosis (PC) of gastric origin have a poor prognosis of life with an average survival of 1-3 months. Systemic chemotherapy has improved the survival of those patients with gastric metastatic cancer at 7-10 months. However, this benefit could not be reproduced in those patients with PC. The current literature for the use of hyperthermic intraperitoneal chemotherapy (HIPEC) for gastric PC has significant variation related to patient selection, treatment intent (palliative vs. attempt at curative treatment), surgical technique, intraperitoneal chemotherapy agent utilized, and systemic chemotherapy administered adjuvantly...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29946371/clinical-significance-of-heat-shock-proteins-in-gastric-cancer-following-hyperthermia-stress-indications-for-hyperthermic-intraperitoneal-chemoperfusion-therapy
#11
Yinuo Tu, Yunhong Tian, Yinbing Wu, Shuzhong Cui
Heat shock proteins (HSPs) are important factors in the response of cancer cells to thermo- and chemotherapy. Transient hyperthermic intraperitoneal chemoperfusion (HIPEC) therapy results in the upregulation of HSP expression, which may compromise the efficacy of additional anticancer treatments. The aim of the present study was to monitor the kinetics of HSP expression in tumor cells and patients with gastric cancer following HIPEC. Thus, in vitro and in vivo experiments were conducted to investigate the expression of two HSP family members, HSP70 and HSP90...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29943164/different-mitochondrial-response-to-cisplatin-and-hyperthermia-treatment-in-human-ags-caco-2-and-t3m4-cancer-cell-lines
#12
Sonata Trumbeckaite, Vaidotas Cesna, Aldona Jasukaitiene, Rasa Baniene, Antanas Gulbinas
Gastrointestinal cancers (gastric, pancreatic and colorectal) are life-threatening diseases, which easily spread to peritoneal cavity (Juhl et al. in Int J Cancer 57:330-335, 1994; Schneider et al. in Gastroenterology 128:1606-1625, 2005; Geer and Brennan in Am J Surg 165:68-72 1993). Application of hyperthermal intraperitoneal chemotherapy (HIPEC) is one of the choices treating these malignancies and prolonging patient survival time. Despite numbers of clinical trials showing positive effects of HIPEC against various types of cancer, the question whether hyperthermia significantly potentiate the cytotoxicity of cisplatin remains unanswered...
June 25, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29928208/complete-response-for-more-than-4-years-following-neoadjuvant-folfox-and-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-a-patient-with-advanced-gastric-cancer-with-extensive-peritoneal-carcinomatosis
#13
Renata D'Alpino Peixoto, Tercia Tarciane de Sousa, Pedro Alexandre Ismael Amaral Silva, Luciana Rodrigues de Meirelles, Carlos Henrique Andrade Teixeira
Background: Peritoneal carcinomatosis is usually a terminal disease with short median survival in patients with gastric cancer. Systemic FOLFOX is one of the most used regimens in the first-line treatment of metastatic gastric cancer. However, there is scarce evidence that cytoreductive surgery (CRS) and intraperitoneal heated chemotherapy (HIPEC) improves oncological outcomes of patients with advanced gastric cancer. Methods: Herein we present a case of a young woman with advanced gastric cancer with omental and peritoneal metastases who achieved an excellent response after 6 months of FOLFOX followed by CRS and HIPEC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29863151/treatment-of-patients-with-peritoneal-metastases-from-gastric-cancer
#14
REVIEW
Joji Kitayama, Hironori Ishigami, Hironori Yamaguchi, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata
Despite recent advances in chemotherapy, outcomes of patients with peritoneal metastases (PM) from gastric cancer are still very poor and standard treatment has not been established. Although oral S-1 appears to be effective for patients with PM, the effects of systemic chemotherapy are limited. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) yield fewer benefits in patients with PM from gastric cancer than in patients with PM from other malignancies. In comparison, repeated intraperitoneal chemotherapy (RIPEC) with taxanes using an implantable peritoneal access port has a pharmacokinetic advantage for the control of peritoneal lesions and in combination with systemic chemotherapy can result in surprisingly long-term survival in patients with PM from gastric cancer...
March 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29796937/clinical-impact-of-molecular-classifications-in-gastric-cancer
#15
REVIEW
Daniele Marrelli, Karol Polom, Alessandro Neri, Franco Roviello
Treatment options to gastric cancer (GC) have been changing in recent years from a standard to a tailored approach. Different individualized procedures can range from endoscopic resection, D2 with open or minimally invasive approach, to neo-adjuvant therapy followed by extended surgery. In more advanced stages, a combined approach with the inclusion of intraperitoneal chemo-hyperthermia (HIPEC) may represent a new advanced option. The inclusion of histological type according to Laurén classification in the flowchart of treatment could increase both accuracy and effectiveness of such tailored approach...
June 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29774943/-progress-in-prophylatic-hyperthermic-intraperitoneal-chemotherapy-for-advanced-gastric-carcinoma
#16
Xinhua Chen, Jun Luo, Hao Liu, Yuehong Chen, Yanfeng Hu, Tuanjie Li, Tian Lin, Yu Zhu, Mingli Zhao, Hao Chen, Guoxin Li, Jiang Yu
Advanced gastric cancer (AGC) has a high recurrence rate (especially peritoneal relapse) and a poor prognosis. Systematic chemotherapy or targeted therapy have not been able to significantly reduce the major cause of an unfavorable prognosis, namely the high peritoneal AGC recurrence rate post-surgery. Further studies concerning the application of hyperthermic intraperitoneal chemotherapy (HIPEC) post curative surgery for AGC patients, namely the prophylactic HIPEC (P-HIPEC), have involved a prophylactic approach to prevent peritoneal relapse following curative gastrectomy in high-risk patients...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29755762/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-ovarian-and-gastrointestinal-peritoneal-carcinomatosis-results-from-a-7-year-experience
#17
Giulia Montori, Federico Coccolini, Paola Fugazzola, Marco Ceresoli, Matteo Tomasoni, Carolina Rubicondo, Stefano Raimondo, Domenico Pinelli, Michele Colledan, Luigi Frigerio, Luca Ansaloni
Background: An increasing promising evidence and increasing long-term oncologic outcomes support the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as locoregional treatment for peritoneal carcinosis (PC) especially from ovarian and gastrointestinal tumors, but also for others cancers. Methods: A prospective monocentric study was performed in Papa Giovanni XXIII Hospital, Bergamo (Italy). Patients and tumor characteristics were analyzed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29616280/-surgical-treatment-of-peritoneal-metastases-of-gastric-cancer
#18
REVIEW
A Brandl, E Pachmayr, S Gül-Klein, M Alberto, P Thuss-Patience, B Rau
BACKGROUND: Up to 17% of all patients with gastric cancer are diagnosed with the presence of peritoneal metastases, which is associated with a poor prognosis. The most promising results were shown with multimodal treatment regimens including systemic chemotherapy and cytoreductive surgery (CRS). A subsequent hyperthermic intraperitoneal chemotherapy (HIPEC).possibly has a positive effect and is currently being tested. OBJECTIVES: This manuscript highlights the key role of CRS and HIPEC in patients with peritoneal metastases of gastric cancer and illustrates which patients benefit from this intensive therapy...
September 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29568842/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-gastrointestinal-cancers-fad-or-standard-of-care
#19
Melissa Ching Ching Teo, Grace Hwei Ching Tan
Peritoneal metastases (PM) are the common endpoint for patients with advanced gastrointestinal cancers. PM from these cancers are often managed in a similar fashion to other sites of systemic metastases, but the following must be taken into consideration. (a) PM do not respond to systemic chemotherapy in the same fashion as liver and lung metastases. (b) PM cause local problems, resulting in disruption of chemotherapy. (c) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) actually work for PM...
March 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29566715/neoadjuvant-intraperitoneal-chemotherapy-followed-by-radical-surgery-and-hipec-in-patients-with-very-advanced-gastric-cancer-and-peritoneal-metastases-report-of-an-initial-experience-in-a-western-single-center
#20
Bianca Escorel Costa Fava, Wilson Luiz da Costa, Maria Luiza L Medeiros, Marina Sonagli, Héber Salvador de Castro Ribeiro, Alessandro L Diniz, André L Godoy, Igor C de Farias, Victor Hugo Fonseca de Jesus, Maria Dirlei F S Begnami, Felipe J F Coimbra
BACKGROUND: The association of preoperative systemic and intraperitoneal chemotherapy has been described in Eastern patients with very good outcomes in treatment responders. The aim of this paper is to describe the initial results of this multidisciplinary regimen in gastric cancer patients with very advanced peritoneal metastases. CASE PRESENTATION: We present here the first four cases who received the treatment protocol. They had a baseline PCI between 19 and 33...
March 22, 2018: World Journal of Surgical Oncology
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