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peripheral vascular intervention

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https://www.readbyqxmd.com/read/30114505/quantification-of-daily-physical-activity-and-sedentary-behavior-of-claudicating-patients
#1
Hernan Hernandez, Sara A Myers, Molly Schieber, Duy M Ha, Sarah Baker, Panagiotis Koutakis, Kyung-Soo Kim, Constance Mietus, George P Casale, Iraklis I Pipinos
OBJECTIVES: Claudication is the most common manifestation of peripheral artery disease (PAD), producing significant ambulatory compromise. Limited information exists on the routine physical activity of claudicating patients. Our objective was to record the intensity/time profiles of physical activity and the timing and duration of sedentary behavior of a sample of community-dwelling claudicating patients. METHODS: Forty-four claudicating patients referred to our vascular clinic were recruited...
August 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30113652/vascular-endothelial-fsh-receptor-a-target-of-interest-for-cancer-therapy
#2
Nicolae Ghinea
Improved molecular understanding of tumor microenvironment has resulted in the identification of various cancer cell targets for diagnostic and therapeutic interventions, including the receptor for the follicle-stimulating hormone (FSH), a glycoprotein hormone responsible for growth, maturation and function of human reproductive system. The expression and localization of the FSHR-protein were associated with the tumor epithelial cells and/or with the peripheral tumor blood vessels. The available evidence indicates that in ovarian cancer, prostate cancer, and breast cancer, the tumor epithelial FSHR promotes proliferation, migration and invasion of cancer cells...
August 2, 2018: Endocrinology
https://www.readbyqxmd.com/read/30095992/multilayer-flow-modulator-enhances-vital-organ-perfusion-in-type-b-aortic-dissection-patients
#3
Farhad Rikhtegar Nezami, Lambros S Athanasiou, Junedh M Amrute, Elazer R Edelman
Management of aortic dissections (AD) is still challenging, with no universally-approved guideline among possible surgical, endovascular or medical therapies. Approximately 25% of AD patients suffer post-intervention malperfusion syndrome or hemodynamic instability, with the risk of sudden death if left untreated. Part of the issue is that vascular implants may themselves induce flow disturbances that critically impact vital organs. A multilayer mesh construct might obviate the induced flow disturbances and it is this concept we investigated...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30095170/surgery-versus-thrombolysis-for-initial-management-of-acute-limb-ischaemia
#4
REVIEW
Rosemary Darwood, David C Berridge, David O Kessel, Iain Robertson, Rachel Forster
BACKGROUND: Both peripheral arterial thrombolysis and surgery can be used in the management of peripheral arterial ischaemia. Much is known about the indications, risks, and benefits of thrombolysis. However, whether thrombolysis works better than surgery for initial management of acute limb ischaemia remains unknown. This is the second update of the review first published in 2002. OBJECTIVES: To determine whether thrombolysis or surgery is the more effective technique in the initial management of acute limb ischaemia due to thromboembolism...
August 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30094656/a-versatile-hybrid-agent-based-particle-and-partial-differential-equations-method-to-analyze-vascular-adaptation
#5
Marc Garbey, Stefano Casarin, Scott A Berceli
Peripheral arterial occlusive disease is a chronic pathology affecting at least 8-12 million people in the USA, typically treated with a vein graft bypass or through the deployment of a stent in order to restore the physiological circulation. Failure of peripheral endovascular interventions occurs at the intersection of vascular biology, biomechanics, and clinical decision making. It is our hypothesis that the majority of endovascular treatment approaches share the same driving mechanisms and that a deep understanding of the adaptation process is pivotal in order to improve the current outcome of the procedure...
August 9, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/30094480/-aortic-bifurcation-reconstruction-endovascular-repair-and-alternatives
#6
REVIEW
K Schürmann
CLINICAL ISSUE: Aortic bifurcation disease is a manifestation of arteriosclerosis in about 95% of cases. Stenotic disease of the aortic bifurcation is a special form of peripheral arterial occlusive disease (PAOD). Men older than 60 years are particularly affected. STANDARD TREATMENT: The potential of endovascular therapy has continued to increase. Hereby, the increased availability of hybrid operating suites which allow for a combined use of endovascular techniques and open surgery plays an important role...
August 9, 2018: Der Radiologe
https://www.readbyqxmd.com/read/30091513/nanoentrapped-polyphenol-coating-for-sustained-drug-release-from-a-balloon-catheter
#7
Tammy R Dugas, Gabrielle Brewer, Madison Longwell, Taylor Fradella, Jacob Braun, Carlos E Astete, Merilyn H Jennings, Cristina M Sabliov
Peripheral artery disease is a cardiovascular disease characterized by a narrowing of arteries that supply blood to the extremities, particularly, the legs. When surgical intervention is warranted, the primary approach is balloon angioplasty. Drug coated balloons (DCB) designed to release antimitogenic agents to the site of the blockage are a relatively new product aimed at reducing artery re-narrowing, or restenosis, after intervention. However, first generation DCB utilize mainly direct application of the chemotherapy drug paclitaxel, along with hydrophilic excipients to facilitate uptake into the tissue, and the majority of drug is released from the DCB systemically...
August 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30078377/cardiovascular-magnetic-resonance-imaging-of-aorto-iliac-and-ilio-femoral-vascular-calcifications-using-proton-density-weighted-in-phase-stack-of-stars
#8
Ali Serhal, Ioannis Koktzoglou, Pascale Aouad, James C Carr, Shivraman Giri, Omar Morcos, Robert R Edelman
BACKGROUND: Comparing cardiovascular magnetic resonance (CMR) angiography with computed tomography angiography (CTA), a major deficiency has been its inability to reliably image peripheral vascular calcifications that may impact the choice of interventional strategy and influence patient prognosis. Recently, MRI using a proton density-weighted, in-phase stack of stars (PDIP-SOS) technique has proved capable of detecting these calcifications. The goal of the present study was two-fold: (1) to determine whether magnetic field strength impacts the apparent size and conspicuity of ilio-femoral arterial calcifications; and (2) to determine whether the technique can be accurately applied to image aorto-iliac arterial calcifications...
August 6, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/30058959/rationale-design-and-baseline-participant-characteristics-in-the-mri-and-cognitive-substudy-of-the-cardiovascular-outcomes-for-people-using-anticoagulation-strategies-trial
#9
Mukul Sharma, Robert G Hart, Eric E Smith, Jackie Bosch, Fei Yuan, Amparo Casanova, John W Eikelboom, Stuart J Connolly, Gloria Wong, Rafael Diaz, Patricio Lopez-Jaramillo, Georg Ertl, Stefan Störk, Gilles R Dagenais, Eva M Lonn, Lars Ryden, Andrew M Tonkin, John D Varigos, Deepak L Bhatt, Kelley Rh Branch, Jeffrey L Probstfield, Jae-Hyung Kim, Jong-Won Ha, Martin O'Donnell, Dragos Vinereanu, Keith Aa Fox, Yan Liang, Lisheng Liu, Jun Zhu, Nana Pogosova, Aldo P Maggioni, Alvaro Avezum, Leopoldo S Piegas, Katalin Keltai, Matyas Keltai, Nancy Cook Bruns, Scott Berkowitz, Salim Yusuf
Background Covert vascular disease of the brain manifests as infarcts, white matter hyperintensities, and microbleeds on MRI. Their cumulative effect is often a decline in cognition, motor impairment, and psychiatric disorders. Preventive therapies for covert brain ischemia have not been established but represent a huge unmet clinical need. Aims The MRI substudy examines the effects of the antithrombotic regimens in COMPASS on incident covert brain infarcts (the primary outcome), white matter hyperintensities, and cognitive and functional status in a sample of consenting COMPASS participants without contraindications to MRI...
July 30, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30046448/interventional-repair-of-a-vascular-aneurysm-in-a-patient-with-marfan-syndrome
#10
Mohammed E Ghonem, Xun Yuan, Andreas Mitsis, Christoph A Nienaber
Marfan syndrome is a heritable connective tissue disorder affecting skeletal, ocular and cardiovascular systems. Cardiovascular manifestations comprise aneurysmal dilatation of aortic root, aortic dissection and rupture; peripheral arterial aneurysms have been reported in femoral, iliac and subclavian arteries with surgical reconstruction as the first-line therapeutic option. We report a Marfan patient with a symptomatic aneurysm of left subclavian artery in the intrathoracic retro-clavicular space; instead of open surgical resection, an endovascular solution was successfully applied by use of a flexible self-expanding stent-graft (W...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/30045811/influence-of-perioperative-serum-magnesium-for-cardiac-and-noncardiac-morbidity-and-mortality-following-emergency-peripheral-vascular-surgery
#11
Joshua D Whittaker, Frederick Downes, Helga Becker, Andrew Garnham, Michael Wall
OBJECTIVES: To examine the influence of serum magnesium on 30-day mortality and cardiac and noncardiac morbidity. DESIGN: Retrospective cross-sectional observational study of routinely collected prospective data. SETTING: Single-center tertiary vascular center in the United Kingdom. PARTICIPANTS: All patients undergoing arterial peripheral vascular surgery during an unplanned admission. INTERVENTIONS: Observational, no interventions implemented...
May 28, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/30045083/cardiovascular-disease-in-williams-syndrome
#12
R Thomas Collins
PURPOSE OF REVIEW: Williams syndrome is a multisystem disorder seen with some regularity at most pediatric centers and usually fairly often at larger centers. Cardiovascular abnormalities, because of elastin deficiency, are the leading cause of morbidity and mortality in patients with Williams syndrome. The present article presents a review of the most recent developments regarding the cardiovascular issues in Williams syndrome. RECENT FINDINGS: Cardiovascular abnormalities occur in 80% of patients with Williams syndrome, the majority of which are arterial stenoses...
July 23, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/30044331/actual-impact-of-screening-for-myocardial-ischemia-with-single-photon-emission-tomography-among-patients-undergoing-peripheral-vascular-interventions
#13
Mariana Corneli, Osvaldo Masoli, Gabriel Perea, Alejandro Meretta, Gustavo Daquarti, Daniel Rosa, Fernando Belcastro, Ruth Henquin, Néstor Perez Baliño
The present study provides actual data with regard to the prevalence of myocardial ischemia among patients under contemporary cardiovascular prevention strategies undergoing peripheral vascular interventions. We included a total of 200 consecutive patients who underwent gated single-photon emission computed tomography myocardial perfusion study between January 2012 and January 2014 as preoperative evaluation for peripheral vascular interventions at our institution. The baseline medical treatment comprised aspirin (81%), statins (79%), and β-blockers (54%)...
September 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30041526/the-effects-of-probiotic-supplementation-on-gene-expression-related-to-inflammation-insulin-and-lipid-in-patients-with-parkinson-s-disease-a-randomized-double-blind-placebocontrolled-trial
#14
Shokoofeh Borzabadi, Shahrbanoo Oryan, Akram Eidi, Esmat Aghadavod, Reza Daneshvar Kakhaki, Omid Reza Tamtaji, Mohsen Taghizadeh, Zatollah Asemi
BACKGROUND: This study was conducted to evaluate the effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson's disease (PD). METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted in 50 patients with PD as a pilot study. Participants were randomly allocated into two groups to take either 8×109 CFU/day probiotic supplements or placebo (n = 25 each group, one capsule daily) for 12 weeks...
July 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/30029719/the-effect-of-oral-hydration-and-localised-heat-on-peripheral-vein-diameter-and-depth-a-randomised-controlled-trial
#15
Rebecca Sharp, Jessie Childs, Andrew C Bulmer, Adrian Esterman
BACKGROUND: Accessing the peripheral veins for blood sampling and short-term peripheral intravenous catheter insertion is common in contemporary healthcare. Clinicians may apply heat or promote oral hydration to increase vein diameter and reveal veins to improve success rates. However, there is limited research that has examined the effect of these interventions on vein diameter and depth. OBJECTIVES: To determine the effect of localised heat and oral hydration on vein diameter and depth...
August 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/30028313/glaucomatous-optic-neuropathy-treatment-options-the-promise-of-novel-therapeutics-techniques-and-tools-to-help-preserve-vision
#16
REVIEW
Najam A Sharif
Peripheral vision loss followed by "tunnel vision" and eventual irreversible blindness is the fate of patients afflicted by various forms of glaucoma including primary open-angle glaucoma (POAG) and normotensive glaucoma (NTG). These complex and heterogeneous diseases are characterized by extensive death of retinal ganglion cells (RGCs) accompanied by retraction and severance of their axonal connections to the brain and thus damage to and thinning of the optic nerve. Since patients suffering from this glaucomatous optic neuropathy (GON) first notice visual impairment when they have lost > 40% of their RGCs, early diagnosis is the key to retard the progression of glaucoma...
July 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30028182/patient-doses-in-endovascular-and-hybrid-revascularization-of-the-lower-extremities
#17
Desislava D Kostova-Lefterova, Nadelin N Nikolov, Stefan S Stanev, Boyka B Stoyanova
OBJECTIVE: Hybrid surgical methods such as remote endarterectomy and endovascular revascularization are fluoroscopy-guided procedures successfully replacing conventional open surgery for treatment of peripheral artery disease (PAD). The aim of this study was to: (1) evaluate the dose parameters describing exposure of patients undergoing endovascular or hybrid revascularization of the lower limb (below the inguinal ligament); (2) compare the data available in the literature with the evaluations of patients' dose values and related factors for patients undergoing such procedures; (3) examine the correlation of doses with certain parameters; (4) estimate the peak skin dose and assess the potential for radiation induced skin injuries during the procedures...
July 20, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/30027631/blood-pressure-targets-for-the-treatment-of-people-with-hypertension-and-cardiovascular-disease
#18
REVIEW
Luis Carlos Saiz, Javier Gorricho, Javier Garjón, Mª Concepción Celaya, Juan Erviti, Leire Leache
BACKGROUND: This is the first update of the review published in 2017. Hypertension is a prominent preventable cause of premature morbidity and mortality. People with hypertension and established cardiovascular disease are at particularly high risk, so reducing blood pressure to below standard targets may be beneficial. This strategy could reduce cardiovascular mortality and morbidity but could also increase adverse events. The optimal blood pressure target in people with hypertension and established cardiovascular disease remains unknown...
July 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30015782/the-role-of-computed-tomography-in-the-planning-of-transcatheter-aortic-valve-implantation-a-retrospective-analysis-in-200-procedures
#19
Marcello Chiocchi, Marco Forcina, Daniele Morosetti, Luca Pugliese, Armando Ugo Cavallo, Daniele Citraro, Vincenzo De Stasio, Matteo Presicce, Roberto Floris, Francesco Romeo
AIM: The aim of our study is to show the importance of multislice computed tomography (CT) assessment in the overall management and diagnostic framework of transcatheter aortic valve replacement (TAVI) procedure candidates. METHODS: Between June 2015 and April 2017, 200 patients with severe aortic stenosis, not eligible for surgery, were enrolled, as defined by EuroSCORE; they were submitted to TAVI at the interventional cardiology department of the Tor Vergata Polyclinic...
July 13, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/30008764/comparison-of-outcomes-in-patients-undergoing-rotational-atherectomy-after-unsuccessful-coronary-angioplasty-versus-elective-rotational-atherectomy
#20
Jaroslaw Gorol, Mateusz Tajstra, Bartosz Hudzik, Andrzej Lekston, Mariusz Gąsior
Introduction: Revascularization of patients with heavily calcified coronary arteries can be a challenge for interventional cardiologists. The procedural success rate in these patients can be improved by using rotational atherectomy (RA). Aim: To compare in-hospital outcomes and those at 12-month follow-up between patients who underwent RA as a bailout procedure secondary to failed conventional angioplasty or as an elective procedure. Material and methods: This is a retrospective analysis of 156 consecutive patients hospitalized at a high-volume percutaneous coronary intervention (PCI) center who underwent RA...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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