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Intravenous Therapy

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https://www.readbyqxmd.com/read/29933095/sorafenib-in-combination-with-gemcitabine-plus-cisplatin-chemotherapy-in-metastatic-renal-collecting-duct-carcinoma-a-prospective-multicentre-single-arm-phase-2-study
#1
Xinan Sheng, Dengfeng Cao, Jianlin Yuan, Fangjian Zhou, Qiang Wei, Xiaodong Xie, Chuanliang Cui, Zhihong Chi, Lu Si, Siming Li, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Yan Kong, Jie Dai, Xue Bai, Li Zhou, Jun Guo
BACKGROUND: Collecting duct carcinoma (CDC) is a rare type of renal cancer with a poor prognosis. As there are no standard guidelines for the management of metastatic CDC (mCDC), we evaluated the efficacy and safety of combined therapies of sorafenib, gemcitabine, plus cisplatin in patients with mCDC. MATERIALS AND METHODS: A prospective, multicentre, single-arm, open-label, phase 2 trial (ClinicalTrials.gov identifier NCT01762150) that enrolled 26 mCDC patients with no prior systemic chemotherapy...
June 19, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29932367/efficacy-of-immediate-replacement-of-cranial-bone-graft-following-drainage-of-intracranial-empyema
#2
Orgest Lajthia, Jerry W Chao, Max Mandelbaum, John S Myseros, Chima Oluigbo, Suresh N Magge, Christopher S Zarella, Albert K Oh, Gary F Rogers, Robert F Keating
OBJECTIVE Intracranial empyema is a life-threatening condition associated with a high mortality rate and residual deleterious neurological effects if not diagnosed and managed promptly. The authors present their institutional experience with immediate reimplantation of the craniotomy flap and clarify the success of this method in terms of cranial integrity, risk of recurrent infection, and need for secondary procedures. METHODS A retrospective analysis of patients admitted for management of intracranial empyema during a 19-year period (1997-2016) identified 33 patients who underwent emergency drainage and decompression with a follow-up duration longer than 6 months, 23 of whom received immediate bone replacement...
June 22, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29931076/effect-of-adding-motolimod-to-standard-combination-chemotherapy-and-cetuximab-treatment-of-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-the-active8-randomized-clinical-trial
#3
Robert L Ferris, Nabil F Saba, Barbara J Gitlitz, Robert Haddad, Ammar Sukari, Prakash Neupane, John C Morris, Krzysztof Misiukiewicz, Julie E Bauman, Moon Fenton, Antonio Jimeno, Douglas R Adkins, Charles J Schneider, Assuntina G Sacco, Keisuke Shirai, Daniel W Bowles, Michael Gibson, Tobenna Nwizu, Raphael Gottardo, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Ezra E W Cohen
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To determine whether motolimod improves outcomes for R/M SCCHN when combined with standard therapy. Design, Setting, and Participants: The Active8 study was a multicenter, randomized, double-blind, placebo-controlled clinical trial enrolling adult patients (age ≥18 years) with histologically confirmed R/M SCCHN of the oral cavity, oropharynx, hypopharynx, or larynx between October 2013 and August 2015...
June 21, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29930932/a-case-of-functional-metastatic-follicular-thyroid-carcinoma-that-presented-with-hip-fracture-and-hypercalcemia
#4
Mozhgan Karimifar
Thyroid follicular cancers are one of the thyroid gland cancers. This cancer can lead to metastases to various areas of the body. We describe a patient with thyroid follicular carcinoma who after total thyroidectomy had severe hypercalcemia, increased creatinine, and thyrotoxicosis due to extensive bone metastases. The patient was a 52-year-old man who had femoral neck fracture as the first manifestation of thyroid cancer. He was hospitalized for some time after orthopedic measures because of thyrotoxicosis and deep-venous thrombosis...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29928947/combination-therapy-of-intravenously-injected-microglia-and-radiotherapy-prolongs-survival-in-a-rat-model-of-spontaneous-malignant-glioma
#5
Noriyuki Okonogi, Yoshiyuki Suzuki, Hiro Sato, Takahiro Oike, Yuya Yoshimoto, Kousaku Mimura, Shin-Ei Noda, Masahiko Okamoto, Tomoaki Tamaki, Yukie Morokoshi, Sumitaka Hasegawa, Hiroko Ohgaki, Hideaki Yokoo, Takashi Nakano
PURPOSE: The aim of this study was to investigate the efficacy of combination therapy with intravenously injected microglia (MI) and radiotherapy (RT) for rat malignant glioma. METHODS AND MATERIALS: Transgenic rats expressing v-erbB and spontaneously developing malignant glioma were used. The rats were divided into four groups: control (n = 19), RT alone (n = 10), MI alone (n = 9), and combination of MI and RT (MI+RT) (n = 10). Cranial X-ray irradiation (8 Gy per fraction; once per week) was performed at 50 and 51 weeks of age...
June 18, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29928290/psychotic-mania-as-the-solitary-manifestation-of-neurosyphilis
#6
Eun Hyun Seo, Hae Jung Yang, Sang Hoon Kim, Jung Hyun Park, Hyung-Jun Yoon
Background: Neurosyphilis remains a diagnostic challenge in current psychiatric practice because of its pleomorphic psychiatric manifestations. Although neurosyphilis can present with a wide range of psychiatric symptoms, psychotic mania as its solitary manifestation is an unusual phenomenon. Case presentation: A 46-year-old man, with no history of any psychiatric disorder, exhibited abruptly developed symptoms of psychotic mania. He was admitted to a psychiatric ward for further evaluation and treatment...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29927948/the-route-of-administration-influences-the-therapeutic-index-of-an-anti-prongf-neutralizing-mab-for-experimental-treatment-of-diabetic-retinopathy
#7
Pablo F Barcelona, Alba Galan, Hinyu Nedev, Yifan Jian, Marinko V Sarunic, H Uri Saragovi
Many neurodegenerative retinal diseases are treated with monoclonal antibodies (mAb) delivered by invasive intravitreal injection (IVT). In Diabetic Retinopathy there is a scarcity of effective agents that can be delivered using non-invasive methods, and there are significant challenges in the validation of novel therapeutic targets. ProNGF represents a potential novel target, and IVT administration of a function-blocking anti-proNGF mAb is therapeutic in a mouse model of DR. We therefore compared invasive IVT to less invasive systemic intravenous (IV) and local subconjunctival (SCJ) administration, for therapy of Diabetic Retinopathy...
2018: PloS One
https://www.readbyqxmd.com/read/29927785/zoledronic-acid-is-superior-to-tenofovir-df-switching-for-low-bone-mineral-density-in-adults-with-hiv-a-randomised-trial
#8
Jennifer F Hoy, Robyn Richardson, Peter R Ebeling, Jhon Rojas, Nicholas Pocock, Stephen J Kerr, Esteban Martinez, Andrew Carr
OBJECTIVE: To compare the effects of switching tenofovir disoproxil fumarate (TDF) or treatment with an intravenous bisphosphonate on bone mineral density (BMD) in HIV-positive adults with low bone mass. DESIGN: Two-year, randomised, open-label study at 10 sites in Australia and Spain. PARTICIPANTS: Of 112 adults on TDF-based antiretroviral therapy (ART) screened, 87 with low BMD (T-score < -1.0 at hip or spine by dual-energy x-ray absorptiometry) and undetectable plasma HIV viral load were randomised to either switch TDF to another active antiretroviral drug or to continue TDF-based ART and receive intravenous zoledronic acid (ZOL) 5 mg annually for 2 years...
June 20, 2018: AIDS
https://www.readbyqxmd.com/read/29927402/-anti-inflammatory-effects-of-neurotrophic-therapy-a-pilot-study
#9
I K Malashenkova, S A Krynskiy, N A Hailov, D P Ogurtsov, N D Selezneva, Y B Fedorova, E V Ponomareva, I V Kolyhalov, S I Gavrilova, N A Didkovsky
AIM: To study clinical effects of cerebrolysin and its impact on systemic inflammation markers and immunity in mild cognitive impairment (MCI). MATERIAL AND METHODS: Twenty patients with MCI were treated with cerebrolysin administered intravenously during 4 weeks. Serum levels of immunoglobulins, inflammatory markers, neurotrophic factors were measured in dynamics in patients and controls using ELISA. RESULTS: An effect of cerebrolysin was found in MCI patients including the older group (mean age 78±1...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29927196/microscopic-polyangiitis-presented-with-biopsy-confirmed-pleuritis
#10
Naoto Ishimaru, Hisashi Ohnishi, Mao Fujii, Masako Yumura, Sho Yoshimura, Saori Kinami
We describe a case of microscopic polyangiitis manifested as pleuritis confirmed by thoracoscopic biopsy. An 80-year-old man presented with a three-day history of shortness of breath and cough. Chest radiography revealed patchy opacities in the lower fields of the bilateral lung and right-sided pleural effusion. Thoracentesis revealed lymphocytic pleural exudates. Thoracoscopic biopsy specimens were compatible with fibrotic pleuritis. He developed rapidly progressive glomerulonephritis with elevated myeloperoxidase anti-neutrophil cytoplasmic antibody titer in blood and pleural effusion...
June 21, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29926832/injection-of-bone-marrow-mesenchymal-stem-cells-by-intravenous-or-intraperitoneal-routes-is-a-viable-alternative-to-spinal-cord-injury-treatment-in-mice
#11
Bruna Dos Santos Ramalho, Fernanda Martins de Almeida, Conrado Mendonça Sales, Silmara de Lima, Ana Maria Blanco Martinez
In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury (SCI) are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells (MSCs) in a compressive SCI model...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29926574/-hypertensive-crisis
#12
P Xhignesse, F Krzesinski, J M Krzesinski
Hypertensive crisis has fortunately become rarer due to a better diagnosis and management of arterial hypertension. However, its development needs urgent management with adapted therapy according to the severity of the blood pressure levels and the associated clinical signs. After confirmation of severe hypertension (blood pressure above or equal to 180/120 mmHg), target organ lesions have to be looked for and according to their pre-sence, an urgent hospitalization has to be immediately organized. Starting active drug therapy often occurs in intensive units with the intravenous route of administration...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29926514/a-pharmacokinetics-phase-1-bioequivalence-study-of-the-trastuzumab-biosimilar-myl-1401o-vs-eu-trastuzumab-and-us-trastuzumab
#13
Cornelius F Waller, Apinya Vutikullird, Tracey E Lawrence, Andrew Shaw, Mark Shiyao Liu, Mark Baczkowski, Rajiv Sharma, Abhijit Barve, Parag Goyal, Charles Donnelly, Nilanjan Sengupta, Eduardo J Pennella
AIMS: Trastuzumab is a humanized monoclonal antibody that binds the human epidermal growth factor receptor 2 (HER2) oncoprotein and is an effective therapy for HER2-overexpressing breast cancer. MYL-1401O is a trastuzumab biosimilar. Here, we report results from a phase 1 study that investigated bioequivalence among MYL-1401O, reference EU-trastuzumab, and US-trastuzumab. METHODS: This single-center, randomized, double-blind, three-arm, parallel-group, phase 1 study was conducted in healthy adult male volunteers...
June 21, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29926359/breakthrough-infection-of-geotrichum-capitatum-during-empirical-caspofungin-therapy-after-umbilical-cord-blood-transplantation
#14
Shuki Oya, Tsuyoshi Muta
We experienced a breakthrough fungal infection caused by Geotrichum capitatum during empirical therapy with caspofungin. A 68-year-old male patient with refractory acute lymphoblastic leukemia had received umbilical cord blood transplantation after two courses of induction therapy. Empirical therapy with caspofungin was initiated 5 days before transplantation. Tacrolimus was continuously infused to prevent graft-versus-host disease. A minidose of methotrexate was intravenously administered on days 1 and 3 post-transplantation, which was changed to prednisolone from day 7 due to severe mucositis...
June 20, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29925559/intravenous-immunoglobulin-therapy-for-dengue-capillary-leak-syndrome-in-a-renal-allograft-recipient
#15
Arunkumar Subbiah, Sandeep Mahajan, Raj Kanwar Yadav, Sanjay Kumar Agarwal
A 45-year-old man presented 4 months after ABOi renal transplantation with febrile illness and bicytopenia necessitating cessation of mycophenolate mofetil. Dengue non-structural protein 1 antigen (NS1 Ag) test was positive. Lowest total leucocyte count was 3.1×109 /L and platelet count was 14×109 /L. As fever subsided, patient became tachypneic with abdominal distention and hypotension. Ultrasonographic evaluation revealed ascites, gall bladder wall oedema and bilateral pleural effusion consistent with dengue capillary leak syndrome...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29925381/current-management-of-juvenile-dermatomyositis-in-germany-and-austria-an-online-survey-of-pediatric-rheumatologists-and-pediatric-neurologists
#16
Claas H Hinze, Fabian Speth, Prasad T Oommen, Johannes-Peter Haas
BACKGROUND: Juvenile Dermatomyositis (JDM) is a rare pediatric autoimmune disease with broad variations of the individual course. Data on the optimal management are mostly lacking. Currently treatment decisions are often based on experts' opinions. In order to develop consensus-based treatment strategies for JDM in Germany a survey was pursued to analyze the current clinical practice. METHODS: An online survey addressing all members of the Society for Pediatric Rheumatology (GKJR) in Germany and Austria and pediatric neurologists with expertise in JDM was performed in February/March of 2016...
June 20, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29925345/induction-therapy-with-paclitaxel-and-bevacizumab-followed-by-switch-maintenance-therapy-with-eribulin-in-japanese-patients-with-her2-negative-metastatic-breast-cancer-a-multicenter-collaborative-open-label-phase-ii-clinical-study-for-the-sbccsg-35-investigators
#17
Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Kei Kimizuka, Masafumi Kurosumi
BACKGROUND: To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese patients with HER2-negative metastatic breast cancer (MBC). METHODS: Patients, who had previously undergone a maximum of 2 regimens of chemotherapy, received 3 cycles of induction therapy with paclitaxel (90 mg/m2 intravenously on days 1, 8, and 15 followed by 1-week drug holiday) and bevacizumab (10 mg/kg intravenously after the completion of paclitaxel administration on days 1 and 15)...
June 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29925142/-clinical-presentations-of-neuromyelitis-optica-spectrum-disorders-with-ultra-longitudinally-extensive-transverse-myelitis
#18
X Huang, F F Xu, H R Qian, X Lei, X K Qi, D Y Xia
Objective: To analyze the clinical presentations of neuromyelitis optica spectrum disorders (NMOSD) with ultra-longitudinally extensive transverse myelitis (uLETM), in order to improve the diagnostic accuracy of this disorder. Methods: Twenty-two uLETM patients was recruited and retrospectively analyzed for general clinical characteristics, laboratory tests and MRI characteristics, as well as therapeutic. Results: (1)The Male-to-female ratio was 1∶6. The median onset age was 31 years old. The duration from the first relapse to the onset was 5...
June 5, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29924717/case-259
#19
Decai Tian, Xiaodong Zhu, Rong Xue, Peng Zhao, Yuanrong Yao
History In November 2012, a previously healthy 31-year-old woman was admitted to our hospital with a 2-month history of right-sided numbness, diplopia, and intermittent nausea and dizziness. She did not have a history of fever, weight loss, headache, photophobia, seizure, or extremity weakness. Physical examination revealed left abduction limitation and right-sided hypoesthesia. Kernig and Brudzinski signs were absent, and pathergy test results were negative. Laboratory evaluation revealed normal complete and differential blood counts, normal serum chemistry, and normal immune function...
July 2018: Radiology
https://www.readbyqxmd.com/read/29924228/exuberant-case-of-cutaneous-metastasis-of-breast-cancer
#20
Vítor Angelo Ferreira, Karla Spelta, Lucia Martins Diniz, Elton Almeida Lucas
Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated. We report the case of a 65-year-old woman with cutaneous metastasis from breast cancer treated 14 years back, manifested by extensive firm and infiltrated red-purple plaques on the sides of the trunk, with a course of six months...
June 2018: Anais Brasileiros de Dermatologia
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